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  1. Article ; Online: Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection.

    McGary, Lisa H F / Vardhana, Santosha A

    Cancer discovery

    2021  Volume 12, Issue 4, Page(s) 892–894

    Abstract: Summary: Fahrner and colleagues investigated the immune response of patients with cancer and cancer-free individuals to SARS-CoV-2 and found that a propensity toward an IL5-predominant Th2/Tc2 response was predictive of susceptibility to infection. The ... ...

    Abstract Summary: Fahrner and colleagues investigated the immune response of patients with cancer and cancer-free individuals to SARS-CoV-2 and found that a propensity toward an IL5-predominant Th2/Tc2 response was predictive of susceptibility to infection. The results of this study also suggest that a cellular response against the Spike 1 protein receptor binding domain (S1-RBD) region of the SARS-CoV-2 proteome contributes to protection and that mutations in this region may drive viral evolution and immune escape. See related article by Fahrner et al., p. 958 (8).
    MeSH term(s) COVID-19/genetics ; Humans ; Membrane Glycoproteins/genetics ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics ; T-Lymphocytes/metabolism ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology ; Viral Envelope Proteins/metabolism
    Chemical Substances Membrane Glycoproteins ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-22-0080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
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  2. Article ; Online: Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib.

    Peretz, Cheryl A C / McGary, Lisa H F / Kumar, Tanya / Jackson, Hunter / Jacob, Jose / Durruthy-Durruthy, Robert / Levis, Mark J / Perl, Alexander / Huang, Benjamin J / Smith, Catherine C

    Blood advances

    2021  Volume 5, Issue 5, Page(s) 1437–1441

    MeSH term(s) Benzothiazoles ; Phenylurea Compounds ; Sequence Analysis, DNA
    Chemical Substances Benzothiazoles ; Phenylurea Compounds ; quizartinib (7LA4O6Q0D3)
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2020003398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7153: Show issues Location:
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  3. Article ; Online: Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia.

    McMahon, Christine M / Ferng, Timothy / Canaani, Jonathan / Wang, Eunice S / Morrissette, Jennifer J D / Eastburn, Dennis J / Pellegrino, Maurizio / Durruthy-Durruthy, Robert / Watt, Christopher D / Asthana, Saurabh / Lasater, Elisabeth A / DeFilippis, RosaAnna / Peretz, Cheryl A C / McGary, Lisa H F / Deihimi, Safoora / Logan, Aaron C / Luger, Selina M / Shah, Neil P / Carroll, Martin /
    Smith, Catherine C / Perl, Alexander E

    Cancer discovery

    2019  Volume 9, Issue 8, Page(s) 1050–1063

    Abstract: Gilteritinib is a potent and ... ...

    Abstract Gilteritinib is a potent and selective
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Aniline Compounds/pharmacology ; Aniline Compounds/therapeutic use ; Clonal Evolution/genetics ; Drug Resistance, Neoplasm/genetics ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Male ; Middle Aged ; Mutation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Pyrazines/pharmacology ; Pyrazines/therapeutic use ; Signal Transduction/drug effects ; Single-Cell Analysis ; Young Adult ; fms-Like Tyrosine Kinase 3/antagonists & inhibitors ; fms-Like Tyrosine Kinase 3/genetics ; fms-Like Tyrosine Kinase 3/metabolism ; ras Proteins/metabolism
    Chemical Substances Aniline Compounds ; Protein Kinase Inhibitors ; Pyrazines ; gilteritinib ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2019-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-18-1453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
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