Article: HLA-G remains a mystery.
2001 Volume 22, Issue 10, Page(s) 548–552
Abstract: In this brief summary, we argue that many widely held beliefs about HLA-G are questionable. Recent ... research has led to a re-evaluation of many of the characteristics that were thought to make HLA-G unusual ... among the MHC class I molecules. First, contrary to reports suggesting that the gene encoding HLA-G exhibits ...
| Abstract | In this brief summary, we argue that many widely held beliefs about HLA-G are questionable. Recent research has led to a re-evaluation of many of the characteristics that were thought to make HLA-G unusual among the MHC class I molecules. First, contrary to reports suggesting that the gene encoding HLA-G exhibits marked polymorphism in some human populations, recent data have shown that the HLA-G gene has comparatively little polymorphism - a feature that might allow it to be expressed in the placenta without causing rejection by the maternal immune system. Second, although truncated forms of HLA-G are generated in the placenta, most of them are unlikely to have significant biological effects as they do not reach the cell surface. Third, the hypothesis that a major role of HLA-G is to prevent attack of the placenta by maternal natural killer cells is now the subject of renewed scrutiny. Finally, there is little evidence that the induction of expression of HLA-G is a major mechanism by which tumor cells avoid immune attack. HLA-G has once again become as mysterious as when it was discovered: an MHC class I molecule expressed at a challengingly extraordinary site--the immunologically uneasy interface between mother and fetus. |
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| MeSH term(s) | Animals ; HLA Antigens/immunology ; HLA-G Antigens ; Histocompatibility Antigens Class I/immunology ; Humans ; Killer Cells, Natural/immunology ; Neoplasms/immunology ; Polymorphism, Genetic/immunology ; Protein Isoforms/immunology |
| Chemical Substances | HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I ; Protein Isoforms |
| Language | English |
| Publishing date | 2001-09-04 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 2036831-8 |
| ISSN | 1471-4981 ; 1471-4906 |
| ISSN (online) | 1471-4981 |
| ISSN | 1471-4906 |
| DOI | 10.1016/s1471-4906(01)02031-2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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