Article ; Online: Chimeric Antigen Receptor T - Cell Therapy for Large B-Cell Lymphoma Patients with Central Nervous System Involvement, a Systematic Review and Meta-analysis.
Clinical lymphoma, myeloma & leukemia
2024 Volume 24, Issue 4, Page(s) e142–e151
Abstract: Chimeric Antigen Receptor T-cell (CAR T-cell) therapy is an effective treatment for relapsed/refractory (R/R) large B cell lymphoma (LBCL). However, patients with central nervous system (CNS) lymphoma were excluded in most of the CAR T-cell therapy ... ...
| Abstract | Chimeric Antigen Receptor T-cell (CAR T-cell) therapy is an effective treatment for relapsed/refractory (R/R) large B cell lymphoma (LBCL). However, patients with central nervous system (CNS) lymphoma were excluded in most of the CAR T-cell therapy trials. This meta-analysis assesses the efficacy with CAR T-cell therapy in LBCL patients with CNS involvement. Two reviewers independently searched PubMed and Cochrane Library to identify all published literature associated with United States Food and Drug Administration approved CAR T-cell therapies for LBCL. Patients with CNS LBCL were included. Meta-analysis of proportion was performed to evaluate the overall response (ORR), complete response (CR) for efficacy, and cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome for safety assessment. Nineteen studies were qualified for inclusion with 141 CNS LBCL patients. The ORR and CR rates were 61% and 55% respectively. The median overall survival (OS) was 8.8 months, and the median progression free survival (PFS) was 4.4 months. Severe immune effector cell-associated neurotoxicity syndrome (grade≥3) were reported in 25% (32/130) patients and severe cytokine release syndrome (grade≥3) were found in 10% (13/124) of the patients. The safety and efficacy of CAR T-cell therapy in CNS LBCL patients appears comparable to patients without CNS involvement. |
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| MeSH term(s) | Humans ; Immunotherapy, Adoptive/adverse effects ; Receptors, Chimeric Antigen ; Cytokine Release Syndrome ; Lymphoma, Large B-Cell, Diffuse/therapy ; Lymphoma, Non-Hodgkin ; Neurotoxicity Syndromes/etiology ; Central Nervous System ; Cell- and Tissue-Based Therapy ; Antigens, CD19 |
| Chemical Substances | Receptors, Chimeric Antigen ; Antigens, CD19 |
| Language | English |
| Publishing date | 2024-01-12 |
| Publishing country | United States |
| Document type | Meta-Analysis ; Systematic Review ; Journal Article ; Review |
| ZDB-ID | 2540992-X |
| ISSN | 2152-2669 ; 2152-2650 |
| ISSN (online) | 2152-2669 |
| ISSN | 2152-2650 |
| DOI | 10.1016/j.clml.2023.12.012 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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