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Article ; Online: Vulnerable Youth and the COVID-19 Pandemic.

Silliman Cohen, Rachel I / Bosk, Emily Adlin

2020 Volume 146, Issue 1

MeSH term(s)	Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Child Abuse/prevention & control ; Child Abuse/psychology ; Coronavirus Infections/psychology ; Coronavirus Infections/therapy ; Female ; Homeless Youth/psychology ; Humans ; Male ; Pandemics ; Pneumonia, Viral/psychology ; Pneumonia, Viral/therapy ; Risk Factors ; SARS-CoV-2 ; Sexual and Gender Minorities/psychology ; Vulnerable Populations/psychology
Keywords	covid19
Language	English
Publishing date	2020-04-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2020-1306
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Article: Vulnerable Youth and the COVID-19 Pandemic

Silliman Cohen, Rachel I / Bosk, Emily Adlin

Pediatrics

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #150224
Database	COVID19

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Article ; Online: Prohibition of Gender-Affirming Care as a Form of Child Maltreatment: Reframing the Discussion.

Georges, Emily / Brown, Emily C B / Cohen, Rachel Silliman

Pediatrics

2023 Volume 153, Issue 1

MeSH term(s)	Child ; Humans ; Gender-Affirming Care ; Transgender Persons ; Child Abuse
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2023-064292
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Article ; Online: A History of Child Abuse Pediatrics: Training, Research, and Clinical Diagnosis.

Kleinle, Sarah / Ngo, Hannah / Goldberg, Amy P / Cohen, Rachel Silliman

Rhode Island medical journal (2013)

2023 Volume 106, Issue 10, Page(s) 10–14

Abstract: This article provides an historical review of child maltreatment, focusing on the three most common subtypes: physical abuse, sexual abuse, and neglect. The evolution of recognizing, evaluating, and accurately diagnosing child maltreatment is described. ... ...

Abstract	This article provides an historical review of child maltreatment, focusing on the three most common subtypes: physical abuse, sexual abuse, and neglect. The evolution of recognizing, evaluating, and accurately diagnosing child maltreatment is described. Over time, the establishment of multidisciplinary teams, mandatory reporting, and Child Abuse Pediatrics as a subspecialty of pediatrics has improved the training, research, and clinical diagnosis for all forms of child maltreatment. These advancements have set clinical standards to ensure accurate diagnosis, prevent the misdiagnosis of child abuse and neglect, and continually improve the systems meant to protect children. The expansion of knowledge of child maltreatment continues with attention on early detection of children at risk of developing lifelong physical, psychological, and behavioral consequences from trauma associated with all forms of child maltreatment.
MeSH term(s)	Child ; Humans ; Child Abuse/diagnosis ; Physical Examination ; Mandatory Reporting
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	419430-5
ISSN	2327-2228 ; 0363-7913
ISSN (online)	2327-2228
ISSN	0363-7913
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Article ; Online: Altered Mental Status in a Young Child: A Case of Child Neglect.

Silliman Cohen, Rachel / Barron, Christine E / Goldberg, Amy

Clinical pediatrics

2018 Volume 58, Issue 1, Page(s) 123–125

MeSH term(s)	Cannabis/poisoning ; Child Abuse/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Infant
Language	English
Publishing date	2018-10-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/0009922818805225
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Article ; Online: Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer.

JAMA oncology

2019 Volume 5, Issue 12, Page(s) 1710–1717

Abstract: Importance: Adjuvant chemotherapy in patients with stage III colon cancer prevents recurrence by eradicating minimal residual disease. However, which patients remain at high risk of recurrence after completing standard adjuvant treatment cannot ... ...

Abstract	Importance: Adjuvant chemotherapy in patients with stage III colon cancer prevents recurrence by eradicating minimal residual disease. However, which patients remain at high risk of recurrence after completing standard adjuvant treatment cannot currently be determined. Postsurgical circulating tumor DNA (ctDNA) analysis can detect minimal residual disease and is associated with recurrence in colorectal cancers. Objective: To determine whether serial postsurgical and postchemotherapy ctDNA analysis could provide a real-time indication of adjuvant therapy efficacy in stage III colon cancer. Design, setting, and participants: This multicenter, Australian, population-based cohort biomarker study recruited 100 consecutive patients with newly diagnosed stage III colon cancer planned for 24 weeks of adjuvant chemotherapy from November 1, 2014, through May 31, 2017. Patients with another malignant neoplasm diagnosed within the last 3 years were excluded. Median duration of follow-up was 28.9 months (range, 11.6-46.4 months). Physicians were blinded to ctDNA results. Data were analyzed from December 10, 2018, through June 23, 2019. Exposures: Serial plasma samples were collected after surgery and after chemotherapy. Somatic mutations in individual patients' tumors were identified via massively parallel sequencing of 15 genes commonly mutated in colorectal cancer. Personalized assays were designed to quantify ctDNA. Main outcomes and measures: Detection of ctDNA and recurrence-free interval (RFI). Results: After 4 exclusions, 96 eligible patients were eligible; median patient age was 64 years (range, 26-82 years); 49 (51%) were men. At least 1 somatic mutation was identified in the tumor tissue of all 96 evaluable patients. Circulating tumor DNA was detectable in 20 of 96 (21%) postsurgical samples and was associated with inferior recurrence-free survival (hazard ratio [HR], 3.8; 95% CI, 2.4-21.0; P < .001). Circulating tumor DNA was detectable in 15 of 88 (17%) postchemotherapy samples. The estimated 3-year RFI was 30% when ctDNA was detectable after chemotherapy and 77% when ctDNA was undetectable (HR, 6.8; 95% CI, 11.0-157.0; P < .001). Postsurgical ctDNA status remained independently associated with RFI after adjusting for known clinicopathologic risk factors (HR, 7.5; 95% CI, 3.5-16.1; P < .001). Conclusions and relevance: Results suggest that ctDNA analysis after surgery is a promising prognostic marker in stage III colon cancer. Postchemotherapy ctDNA analysis may define a patient subset that remains at high risk of recurrence despite completing standard adjuvant treatment. This high-risk population presents a unique opportunity to explore additional therapeutic approaches.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Australia ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Chemotherapy, Adjuvant/methods ; Circulating Tumor DNA/blood ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Disease-Free Survival ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasm Staging ; Neoplasm, Residual ; Precision Medicine ; Prognosis ; Risk Factors ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor ; Circulating Tumor DNA
Language	English
Publishing date	2019-10-16
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2019.3616
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Article ; Online: Prognostic significance of postsurgery circulating tumor DNA in nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies.

Tie, Jeanne / Cohen, Joshua D / Lo, Serigne N / Wang, Yuxuan / Li, Lu / Christie, Michael / Lee, Margaret / Wong, Rachel / Kosmider, Suzanne / Skinner, Iain / Wong, Hui Li / Lee, Belinda / Burge, Matthew E / Yip, Desmond / Karapetis, Christos S / Price, Timothy J / Tebbutt, Niall C / Haydon, Andrew M / Ptak, Janine /

Schaeffer, Mary J / Silliman, Natalie / Dobbyn, Lisa / Popoli, Maria / Tomasetti, Cristian / Papadopoulos, Nickolas / Kinzler, Kenneth W / Vogelstein, Bert / Gibbs, Peter

International journal of cancer

2020 Volume 148, Issue 4, Page(s) 1014–1026

Abstract: Studies in multiple solid tumor types have demonstrated the prognostic significance of ctDNA analysis after curative intent surgery. A combined analysis of data across completed studies could further our understanding of circulating tumor DNA (ctDNA) as ... ...

Abstract	Studies in multiple solid tumor types have demonstrated the prognostic significance of ctDNA analysis after curative intent surgery. A combined analysis of data across completed studies could further our understanding of circulating tumor DNA (ctDNA) as a prognostic marker and inform future trial design. We combined individual patient data from three independent cohort studies of nonmetastatic colorectal cancer (CRC). Plasma samples were collected 4 to 10 weeks after surgery. Mutations in ctDNA were assayed using a massively parallel sequencing technique called SafeSeqS. We analyzed 485 CRC patients (230 Stage II colon, 96 Stage III colon, and 159 locally advanced rectum). ctDNA was detected after surgery in 59 (12%) patients overall (11.0%, 12.5% and 13.8% for samples taken at 4-6, 6-8 and 8-10 weeks; P = .740). ctDNA detection was associated with poorer 5-year recurrence-free (38.6% vs 85.5%; P < .001) and overall survival (64.6% vs 89.4%; P < .001). The predictive accuracy of postsurgery ctDNA for recurrence was higher than that of individual clinicopathologic risk features. Recurrence risk increased exponentially with increasing ctDNA mutant allele frequency (MAF) (hazard ratio, 1.2, 2.5 and 5.8 for MAF of 0.1%, 0.5% and 1%). Postsurgery ctDNA was detected in 3 of 20 (15%) patients with locoregional and 27 of 60 (45%) with distant recurrence (P = .018). This analysis demonstrates a consistent long-term impact of ctDNA as a prognostic marker across nonmetastatic CRC, where ctDNA outperforms other clinicopathologic risk factors and MAF further stratifies recurrence risk. ctDNA is a better predictor of distant vs locoregional recurrence.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Circulating Tumor DNA/blood ; Circulating Tumor DNA/genetics ; Cohort Studies ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/surgery ; Female ; High-Throughput Nucleotide Sequencing/methods ; High-Throughput Nucleotide Sequencing/statistics & numerical data ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local ; Prognosis ; Proportional Hazards Models ; Young Adult
Chemical Substances	Biomarkers, Tumor ; Circulating Tumor DNA
Language	English
Publishing date	2020-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.33312
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Article ; Online: Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study.

Tie, Jeanne / Cohen, Joshua D / Wang, Yuxuan / Li, Lu / Christie, Michael / Simons, Koen / Elsaleh, Hany / Kosmider, Suzanne / Wong, Rachel / Yip, Desmond / Lee, Margaret / Tran, Ben / Rangiah, David / Burge, Matthew / Goldstein, David / Singh, Madhu / Skinner, Iain / Faragher, Ian / Croxford, Matthew /

Bampton, Carolyn / Haydon, Andrew / Jones, Ian T / S Karapetis, Christos / Price, Timothy / Schaefer, Mary J / Ptak, Jeanne / Dobbyn, Lisa / Silliman, Natallie / Kinde, Isaac / Tomasetti, Cristian / Papadopoulos, Nickolas / Kinzler, Kenneth / Volgestein, Bert / Gibbs, Peter

Gut

2018 Volume 68, Issue 4, Page(s) 663–671

Abstract: Objective: For patients with locally advanced rectal cancer (LARC), adjuvant chemotherapy selection following surgery remains a major clinical dilemma. Here, we investigated the ability of circulating tumour DNA (ctDNA) to improve risk stratification in ...

Abstract	Objective: For patients with locally advanced rectal cancer (LARC), adjuvant chemotherapy selection following surgery remains a major clinical dilemma. Here, we investigated the ability of circulating tumour DNA (ctDNA) to improve risk stratification in patients with LARC. Design: We enrolled patients with LARC (T3/T4 and/or N+) planned for neoadjuvant chemoradiotherapy. Plasma samples were collected pretreatment, postchemoradiotherapy and 4-10 weeks after surgery. Somatic mutations in individual patient's tumour were identified via massively parallel sequencing of 15 genes commonly mutated in colorectal cancer. We then designed personalised assays to quantify ctDNA in plasma samples. Patients received adjuvant therapy at clinician discretion, blinded to the ctDNA results. Results: We analysed 462 serial plasma samples from 159 patients. ctDNA was detectable in 77%, 8.3% and 12% of pretreatment, postchemoradiotherapy and postsurgery plasma samples. Significantly worse recurrence-free survival was seen if ctDNA was detectable after chemoradiotherapy (HR 6.6; P<0.001) or after surgery (HR 13.0; P<0.001). The estimated 3-year recurrence-free survival was 33% for the postoperative ctDNA-positive patients and 87% for the postoperative ctDNA-negative patients. Postoperative ctDNA detection was predictive of recurrence irrespective of adjuvant chemotherapy use (chemotherapy: HR 10.0; P<0.001; without chemotherapy: HR 22.0; P<0.001). Postoperative ctDNA status remained an independent predictor of recurrence-free survival after adjusting for known clinicopathological risk factors (HR 6.0; P<0.001). Conclusion: Postoperative ctDNA analysis stratifies patients with LARC into subsets that are either at very high or at low risk of recurrence, independent of conventional clinicopathological risk factors. ctDNA analysis could potentially be used to guide patient selection for adjuvant chemotherapy.
MeSH term(s)	Australia ; Biomarkers, Tumor/blood ; Circulating Tumor DNA/blood ; Combined Modality Therapy ; Diagnostic Imaging ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prospective Studies ; Rectal Neoplasms/blood ; Rectal Neoplasms/genetics ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Registries ; Risk Factors ; Survival Analysis
Chemical Substances	Biomarkers, Tumor ; Circulating Tumor DNA
Language	English
Publishing date	2018-02-02
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2017-315852
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Article ; Online: Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers.

Wang, Yuxuan / Li, Lu / Douville, Christopher / Cohen, Joshua D / Yen, Ting-Tai / Kinde, Isaac / Sundfelt, Karin / Kjær, Susanne K / Hruban, Ralph H / Shih, Ie-Ming / Wang, Tian-Li / Kurman, Robert J / Springer, Simeon / Ptak, Janine / Popoli, Maria / Schaefer, Joy / Silliman, Natalie / Dobbyn, Lisa / Tanner, Edward J /

Angarita, Ana / Lycke, Maria / Jochumsen, Kirsten / Afsari, Bahman / Danilova, Ludmila / Levine, Douglas A / Jardon, Kris / Zeng, Xing / Arseneau, Jocelyne / Fu, Lili / Diaz, Luis A / Karchin, Rachel / Tomasetti, Cristian / Kinzler, Kenneth W / Vogelstein, Bert / Fader, Amanda N / Gilbert, Lucy / Papadopoulos, Nickolas

Science translational medicine

2018 Volume 10, Issue 433

Abstract: We report the detection of endometrial and ovarian cancers based on genetic analyses of DNA recovered from the fluids obtained during a routine Papanicolaou (Pap) test. The new test, called PapSEEK, incorporates assays for mutations in 18 genes as well ... ...

Abstract	We report the detection of endometrial and ovarian cancers based on genetic analyses of DNA recovered from the fluids obtained during a routine Papanicolaou (Pap) test. The new test, called PapSEEK, incorporates assays for mutations in 18 genes as well as an assay for aneuploidy. In Pap brush samples from 382 endometrial cancer patients, 81% [95% confidence interval (CI), 77 to 85%] were positive, including 78% of patients with early-stage disease. The sensitivity in 245 ovarian cancer patients was 33% (95% CI, 27 to 39%), including 34% of patients with early-stage disease. In contrast, only 1.4% of 714 women without cancer had positive Pap brush samples (specificity, ~99%). Next, we showed that intrauterine sampling with a Tao brush increased the detection of malignancy over endocervical sampling with a Pap brush: 93% of 123 (95% CI, 87 to 97%) patients with endometrial cancer and 45% of 51 (95% CI, 31 to 60%) patients with ovarian cancer were positive, whereas none of the samples from 125 women without cancer were positive (specificity, 100%). Finally, in 83 ovarian cancer patients in whom plasma was available, circulating tumor DNA was found in 43% of patients (95% CI, 33 to 55%). When plasma and Pap brush samples were both tested, the sensitivity for ovarian cancer increased to 63% (95% CI, 51 to 73%). These results demonstrate the potential of mutation-based diagnostics to detect gynecologic cancers at a stage when they are more likely to be curable.
MeSH term(s)	Adolescent ; Adult ; Aged ; Endometrial Neoplasms/diagnosis ; Female ; Humans ; Liquid Biopsy/methods ; Middle Aged ; Ovarian Neoplasms/diagnosis ; Papanicolaou Test/methods ; Retrospective Studies ; Vaginal Smears/methods ; Young Adult
Language	English
Publishing date	2018-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.aap8793
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Article ; Online: Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy.

Springer, Simeon U / Chen, Chung-Hsin / Rodriguez Pena, Maria Del Carmen / Li, Lu / Douville, Christopher / Wang, Yuxuan / Cohen, Joshua David / Taheri, Diana / Silliman, Natalie / Schaefer, Joy / Ptak, Janine / Dobbyn, Lisa / Papoli, Maria / Kinde, Isaac / Afsari, Bahman / Tregnago, Aline C / Bezerra, Stephania M / VandenBussche, Christopher / Fujita, Kazutoshi /

eLife

2018 Volume 7

Language	English
Publishing date	2018-11-12
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.43237
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