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Article: Xihuang pill induces pyroptosis and inhibits progression of breast cancer cells via activating the cAMP/PKA signalling pathway.

Chen, Cong / Yuan, Shanmin / Chen, Xiaohong / Xie, Jiangping / Wei, Zheng

2023 Volume 13, Issue 4, Page(s) 1347–1362

Abstract: Xihuang pill (XHP), a traditional Chinese medicine, has been shown to be effective for breast cancer (BC) therapy in clinical trials. However, the molecular mechanism of XHP in BC remains unclear. The molecular mechanism of XHP in BC was ... ...

Abstract	Xihuang pill (XHP), a traditional Chinese medicine, has been shown to be effective for breast cancer (BC) therapy in clinical trials. However, the molecular mechanism of XHP in BC remains unclear. The molecular mechanism of XHP in BC was investigated
Language	English
Publishing date	2023-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sources and Risk Characteristics of Heavy Metals in Plateau Soils Predicted by Geo-Detectors

Qiqian Wen / Linsheng Yang / Jiangping Yu / Binggan Wei / Shuhui Yin

Remote Sensing, Vol 15, Iss 1588, p

2023 Volume 1588

Abstract: The ecological environment of the remote plateaus has been a challenge plaguing many countries due to global warming, increased human activities, and frequent occurrence of various heavy metal (HM) pollutants. This paper analyzes the primary factors and ... ...

Abstract	The ecological environment of the remote plateaus has been a challenge plaguing many countries due to global warming, increased human activities, and frequent occurrence of various heavy metal (HM) pollutants. This paper analyzes the primary factors and potential susceptible regions’ characteristics related to soil HMs (As, Cd, Pb, Cr, Ni, and Zn) in the southern Tibet Plateau (TP) using Geo-detectors and a set of multi-source data from remote sensing and geographic and geological information. The geoaccumulation index showed that the As pollution was the most serious. The precipitation, pH, geological age (GA), and rock type (RT) were the most critical factors affecting HMs. Additionally, soil HMs were relatively unaffected by land use and clay. Based on the risk detector, the most key impact types (range) of the predominant factors of HM’s sources were identified. For example, precipitation (100–200 mm), pH (7–7.5), DEM (>5500 m), RT (ophiolite), and GA (Ordovician) had the highest average concentration of As in each type (ranges) of the predominant factors. This work provides new data on the extent of soil HM contamination in the southern TP and predicts vulnerable areas of HM contamination, providing an important scientific basis for monitoring and managing HM in remote areas at high altitudes.
Keywords	Tibet Plateau ; soil heavy metal ; Geo-detector ; influencing factors ; source apportionment ; Science ; Q
Subject code	550
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk factors for postpartum hemorrhage in patients with retained placenta: building a predict model.

Wei, Xiaoning / Wei, Jiangping / Wang, Shaowei

Journal of perinatal medicine

2022 Volume 50, Issue 5, Page(s) 601–607

Abstract: Objectives: Among patients with placenta retention, the risk factors of massive blood loss remain unclear. In this study, a secondary data analysis was conducted to construct a predictive risk model for postpartum hemorrhage (PPH) in this particular ... ...

Abstract	Objectives: Among patients with placenta retention, the risk factors of massive blood loss remain unclear. In this study, a secondary data analysis was conducted to construct a predictive risk model for postpartum hemorrhage (PPH) in this particular population. Methods: A prediction model based on the data of 13 hospitals in the UK, Uganda, and Pakistan, from December 2004, to May 2008 was built. A total of 516 patients and 14 potential risk factors were analyzed. The least absolute shrinkage and selection operator regression (LASSO) model was used to optimize feature selection for the PPH risk model. Multivariable logistic regression analysis was applied to build a prediction model incorporating the LASSO model. Discrimination and calibration were assessed using C-index and calibration plot. Results: Among patients with placenta retention, the incidence of PPH was 62.98% (325/526). Risk factors in the model were country, number of past deliveries, previous manual removal of placenta, place of placenta delivery, and how the placenta was delivered. In these factors, patients in the low-income country (i.e., Uganda) (OR: 1.753, 95% CI=1.055-2.915), retained placentas delivered in the theater (OR: 2.028, 95% CI=1.016-4.050), and having placentas partially removed by controlled cord traction (cct), completely removed manually (OR: 4.722, 95% CI=1.280-17.417) were independent risk factors. The C-statistics was 0.702. Conclusions: By secondary data analysis, our study constructed a prediction model for PPH in patients with placenta retention, and identified the independent risk factors.
MeSH term(s)	Delivery, Obstetric/adverse effects ; Female ; Humans ; Placenta ; Placenta, Retained/epidemiology ; Postpartum Hemorrhage/epidemiology ; Postpartum Hemorrhage/etiology ; Pregnancy ; Risk Factors
Language	English
Publishing date	2022-02-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123512-6
ISSN	1619-3997 ; 0300-5577 ; 0936-174X
ISSN (online)	1619-3997
ISSN	0300-5577 ; 0936-174X
DOI	10.1515/jpm-2021-0632
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Article ; Online: MicroRNA-30a-3p: a potential noncoding RNA target for the treatment of arteriosclerosis obliterans.

Zhang, Mao / Chen, Yu / Niu, Fang / Luo, Xiaohui / Li, Jiangping / Hu, Wei

Aging

2023 Volume 15, Issue 21, Page(s) 11875–11890

Abstract: An increasing number of studies have shown that noncoding RNAs are involved in cardiovascular diseases. Our study shows that the expression of microRNA-30a-3p (miR-30a-3p) in patients with arteriosclerosis obliterans (ASO) of the lower extremities is ... ...

Abstract	An increasing number of studies have shown that noncoding RNAs are involved in cardiovascular diseases. Our study shows that the expression of microRNA-30a-3p (miR-30a-3p) in patients with arteriosclerosis obliterans (ASO) of the lower extremities is significantly decreased after endovascular treatment, but its role is unclear. This study aims to explore the role of microRNA-30a-3p in ASO and its related mechanisms. Immunofluorescence and
MeSH term(s)	Humans ; Rats ; Animals ; MicroRNAs/metabolism ; Arteriosclerosis Obliterans/genetics ; Arteriosclerosis Obliterans/metabolism ; Cell Proliferation/genetics ; Cells, Cultured ; RNA, Untranslated/metabolism ; Cell Movement/genetics ; Myocytes, Smooth Muscle/metabolism
Chemical Substances	MicroRNAs ; RNA, Untranslated
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205154
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identifying s-wave pairing symmetry in single-layer FeSe from topologically trivial edge states.

Wei, Zhongxu / Qin, Shengshan / Ding, Cui / Wu, Xianxin / Hu, Jiangping / Sun, Yu-Jie / Wang, Lili / Xue, Qi-Kun

Nature communications

2023 Volume 14, Issue 1, Page(s) 5302

Abstract: Determining the pairing symmetry of single-layer FeSe on ... ...

Abstract	Determining the pairing symmetry of single-layer FeSe on SrTiO
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40931-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Chimeric antigen receptor engineered natural killer cells for cancer therapy.

Zhang, Yalan / Zhou, Weilin / Yang, Jiangping / Yang, Jinrong / Wang, Wei

Experimental hematology & oncology

2023 Volume 12, Issue 1, Page(s) 70

Abstract: Natural killer (NK) cells, a unique component of the innate immune system, are inherent killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells and good tolerance of healthy cells, NK cells have been successfully ... ...

Abstract	Natural killer (NK) cells, a unique component of the innate immune system, are inherent killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells and good tolerance of healthy cells, NK cells have been successfully employed in adoptive cell therapy to treat cancer patients. In recent years, the clinical success of chimeric antigen receptor (CAR)-T cells has proven the vast potential of gene-manipulated immune cells as the main force to fight cancer. Following the lessons learned from mature gene-transfer technologies and advanced strategies in CAR-T therapy, NK cells have been rapidly explored as a promising candidate for CAR-based therapy. An exponentially growing number of studies have employed multiple sources of CAR-NK cells to target a wide range of cancer-related antigens, showing remarkable outcomes and encouraging safety profiles. Clinical trials of CAR-NK cells have also shown their impressive therapeutic efficacy in the treatment of hematological tumors, but CAR-NK cell therapy for solid tumors is still in the initial stages. In this review, we present the favorable profile of NK cells as a potential platform for CAR-based engineering and then summarize the outcomes and strategies of CAR-NK therapies in up-to-date preclinical and clinical investigations. Finally, we evaluate the challenges remaining in CAR-NK therapy and describe existing strategies that can assist us in devising future prospective solutions.
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2669066-4
ISSN	2162-3619
ISSN	2162-3619
DOI	10.1186/s40164-023-00431-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells.

Li, Jiangping / Xiao, Zhiwen / Wang, Donghui / Jia, Lei / Nie, Shihong / Zeng, Xingda / Hu, Wei

Molecular cancer

2023 Volume 22, Issue 1, Page(s) 141

Abstract: Recent advances in neoantigen research have accelerated the development of tumor immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody-based therapies, particularly for solid tumors. With the development of next- ... ...

Abstract	Recent advances in neoantigen research have accelerated the development of tumor immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody-based therapies, particularly for solid tumors. With the development of next-generation sequencing and bioinformatics technology, the rapid identification and prediction of tumor-specific antigens (TSAs) has become possible. Compared with tumor-associated antigens (TAAs), highly immunogenic TSAs provide new targets for personalized tumor immunotherapy and can be used as prospective indicators for predicting tumor patient survival, prognosis, and immune checkpoint blockade response. Here, the identification and characterization of neoantigens and the clinical application of neoantigen-based TCR-T immunotherapy strategies are summarized, and the current status, inherent challenges, and clinical translational potential of these strategies are discussed.
MeSH term(s)	Humans ; Prospective Studies ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Cancer Vaccines ; T-Lymphocytes ; Receptors, Antigen, T-Cell/genetics
Chemical Substances	Cancer Vaccines ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-08-30
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2091373-4
ISSN	1476-4598 ; 1476-4598
ISSN (online)	1476-4598
ISSN	1476-4598
DOI	10.1186/s12943-023-01844-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Relationship of neutrophil/lymphocyte ratio with cerebral small vessel disease and its common imaging markers.

Cai, Jiangping / Zeng, Xiaoyi / Huang, Xiaojin / Dong, Hansheng / Liu, Junyi / Lin, Jie / Xie, Meirong / Wei, Xiaolan

Immunity, inflammation and disease

2024 Volume 12, Issue 4, Page(s) e1228

Abstract: Background: High neutrophil/lymphocyte ratio (NLR) is associated with poor prognosis in ischemic stroke. However, the role of NLR in cerebral small vessel disease (CSVD) is controversial. Herein, we evaluated the value of NLR in identifying CSVD and its ...

Abstract	Background: High neutrophil/lymphocyte ratio (NLR) is associated with poor prognosis in ischemic stroke. However, the role of NLR in cerebral small vessel disease (CSVD) is controversial. Herein, we evaluated the value of NLR in identifying CSVD and its relationship with the common imaging markers of CSVD. Methods: A total of 667 patients were enrolled in this study, including 368 in the CSVD group and 299 in the non-CSVD group. Clinical, laboratory, and imaging data were collected. The relationship of NLR with CSVD and common imaging markers of CSVD were analyzed with univariate and multivariate logistic regression analysis. The predictive value of NLR was assessed with the receiver operating characteristic curve. Results: NLR (odds ratio [OR] = 1.929, 95% confidence interval [CI] = 1.599-2.327, p < .001) was an independent risk factor for CSVD. NLR was also independently associated with moderate to severe white matter hyperintensity (WMH) (OR = 2.136, 95% CI = 1.768-2.580, p < .001), moderate to severe periventricular WMH (OR = 2.138, 95% CI = 1.771-2.579, p < .001), and moderate to severe deep WMH (OR = 1.654, 95% CI = 1.438-1.902, p < .001), moderately to severely enlarged perivascular spaces (EPVS) (OR = 1.248, 95% CI = 1.110-1.402, p < .001), moderately to severely EPVS in the basal ganglia (OR = 1.136, 95% CI = 1.012-1.275, p = .030), and moderately to severely EPVS in the centrum semiovale (OR = 1.140, 95% CI = 1.027-1.266, p = .014). However, NLR was not statistically significantly associated with lacune. The optimal cutoff point of NLR in predicting CSVD was 2.47, with sensitivity and specificity of 84.2% and 66.9%, respectively (p < .01). The diagnostic effect was maximized when NLR was combined with other risk factors. Conclusions: NLR is an independent risk factor for CSVD and is independently associated with common imaging markers of CSVD. NLR may serve as a valid and convenient biomarker for assessing CSVD.
MeSH term(s)	Humans ; Neutrophils ; Magnetic Resonance Imaging ; Cerebral Small Vessel Diseases/diagnostic imaging ; Cerebral Small Vessel Diseases/complications ; Basal Ganglia ; Risk Factors
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2740382-8
ISSN	2050-4527 ; 2050-4527
ISSN (online)	2050-4527
ISSN	2050-4527
DOI	10.1002/iid3.1228
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Article: Thiamethoxam Application Improves Yield and Drought Resistance of Potatoes (

Qiu, Hailong / Sun, Chao / Dormatey, Richard / Bai, Jiangping / Bi, Zhenzhen / Liu, Yuhui / Liu, Zhen / Wei, Jingui / Mao, Shoufa / Yao, Panfeng

Plants (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: 1) Background: Potato is the most important tuber crop in the world that can contribute to food security. However, the crop has been shown to be sensitive to drought and its yields decline significantly during successive periods of stress. Drought ... ...

Abstract	(1) Background: Potato is the most important tuber crop in the world that can contribute to food security. However, the crop has been shown to be sensitive to drought and its yields decline significantly during successive periods of stress. Drought triggers a number of responses in potato, ranging from physiological changes to fluctuations in growth rates and yields. In light of global climate change, it is important to understand the effects of thiamethoxam on potato growth and yield under drought conditions. (2) Methods: The objective was to evaluate the impact of thiamethoxam on improving drought resistance and yield of potato under drought conditions. The drought-tolerant and sensitive-genotypes Qingshu No. 9 and Atlantic were used for a two-year pot experiment. Potato seeds were coated with 70% thiamethoxam before sowing (treatment group (T)), with a control group without treatment (NT). Two experimental treatments were applied: normal irrigation (ND) and drought stress (D). (3) Results: The results showed that root length, plant yield, chlorophyll content and superoxide dismutase (SOD) activity significantly increased under both genotypes, while malondialdehyde (MDA) and proline (Pro) content were reduced under thiamethoxam under drought stress. The best indicators were obtained in the comprehensive evaluation for the T-D treatment, suggesting that the application of thiamethoxam under drought stress was more effective than normal irrigation. (4) Conclusions: Our results suggest that the application of thiamethoxam improves potato growth, thereby increasing drought tolerance and potato yield. However, thiamethoxam is a neonicotinoid pesticide, and the limitation of this study is that it did not explore the ecological effects of thiamethoxam, which need to be systematically studied in the future. Moreover, considering the potential risks of thiamethoxam to the environment, specific agronomic measures to effectively degrade thiamethoxam residue should be taken when it is applied in agricultural production.
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13040477
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Article ; Online: Monthly variations of groundwater arsenic risk under future climate scenarios in 2081-2100.

Wei, Binggan / Yin, Shuhui / Yu, Jiangping / Yang, Linsheng / Wen, Qiqian / Wang, Ting / Yuan, Xing

Environmental science and pollution research international

2023 Volume 30, Issue 58, Page(s) 122230–122244

Abstract: The seasonal variations of shallow groundwater arsenic have been widely documented. To gain insight into the monthly variations and mechanisms behind high groundwater arsenic and arsenic exposure risk in different climate scenarios, the monthly ... ...

Abstract	The seasonal variations of shallow groundwater arsenic have been widely documented. To gain insight into the monthly variations and mechanisms behind high groundwater arsenic and arsenic exposure risk in different climate scenarios, the monthly probability of high groundwater arsenic in Hetao Basin was simulated through random forest model. The model was based on arsenic concentrations obtained from 566 groundwater sample sites, and the variables considered included soil properties, climate, topography, and landform parameters. The results revealed that spatial patterns of high groundwater arsenic showed some fluctuations among months under different future climate scenarios. The probability of high total arsenic and trivalent arsenic was found to be elevated at the start of the rainy season, only to rapidly decrease with increasing precipitation and temperature. The probability then increased again after the rainy season. The areas with an increased probability of high total arsenic and trivalent arsenic and arsenic exposure risk under SSP126 were typically found in the high-arsenic areas of 2019, while those with decreased probabilities were observed in low-arsenic areas. Under SSP585, which involves a significant increase in precipitation and temperature, the probability of high total arsenic and trivalent arsenic and arsenic exposure risk was widely reduced. However, the probability of high total arsenic and trivalent arsenic and arsenic exposure risk was mainly observed in low-arsenic areas from SSP126 to SSP585. In conclusion, the consumption of groundwater for human and livestock drinking remains a threat to human health due to high arsenic exposure under future climate scenarios.
MeSH term(s)	Humans ; Arsenic/analysis ; Groundwater ; Climate ; Seasons ; Temperature ; Water Pollutants, Chemical/analysis ; Environmental Monitoring
Chemical Substances	Arsenic (N712M78A8G) ; Water Pollutants, Chemical
Language	English
Publishing date	2023-11-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-30965-z
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