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Article ; Online: An electrochemical sensing platform based on a modified carbon paste electrode with graphene/Co

Karami-Kolmoti, Parisa / Zaimbashi, Reza

ADMET & DMPK

2023 Volume 11, Issue 2, Page(s) 227–236

Abstract: A simple and sensitive method for the determination of propranolol using a modified carbon paste electrode with graphene/ ... ...

Abstract	A simple and sensitive method for the determination of propranolol using a modified carbon paste electrode with graphene/Co
Language	English
Publishing date	2023-03-15
Publishing country	Croatia
Document type	Journal Article
ISSN	1848-7718
ISSN (online)	1848-7718
DOI	10.5599/admet.1705
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Article ; Online: Potential of cobalt ferrite-graphitic carbon nitride nanocomposite in trace determination of pyrene as one of the priority pollutants in water and food samples.

Karami, Parisa / Khani, Rouhollah

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2023 Volume 301, Page(s) 122969

Abstract: In this research, cobalt ferrite-graphitic carbon nitride ( ... ...

Abstract	In this research, cobalt ferrite-graphitic carbon nitride (CoFe
MeSH term(s)	Water ; Environmental Pollutants ; Spectroscopy, Fourier Transform Infrared ; Solid Phase Extraction/methods ; Nanocomposites/chemistry ; Pyrenes ; Limit of Detection
Chemical Substances	cobalt ferrite ; Water (059QF0KO0R) ; graphitic carbon nitride ; Environmental Pollutants ; Pyrenes
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2023.122969
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Article ; Online: Development of solid lipid nanoparticles-loaded drugs in parasitic diseases.

Nemati, Sara / Mottaghi, Mahsa / Karami, Parisa / Mirjalali, Hamed

Discover nano

2024 Volume 19, Issue 1, Page(s) 7

Abstract: Parasites cause illnesses with broad spectrum of symptoms from mild to severe, and are responsible for a significant number of outbreaks in the world. Current anti-parasitic drugs are toxic and have significant side effects. Nano-carriers are believed to ...

Abstract	Parasites cause illnesses with broad spectrum of symptoms from mild to severe, and are responsible for a significant number of outbreaks in the world. Current anti-parasitic drugs are toxic and have significant side effects. Nano-carriers are believed to obviate the limitations of conventional drugs via decreasing side effects and increasing target delivery and drug permeability with a controlled prolonged release of a drug. Solid lipid nanoparticles (SLNs) are lipid nanoparticles (LNPs), which have frequently been practiced. Suitable release rate, stability, and target delivery make SLNs a good alternative for colloidal carriers. SLNs are supposed to have great potential to deliver natural products with anti-parasitic properties. Nanoparticles have employed to improve stability and capacity loading of SLNs, during recent years. This review describes development of SLNs, the methods of preparation, characterization, and loaded drugs into SLNs in parasitic diseases. In addition, we summarize recent development in anti-parasitic SLNs-loaded drugs.
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2731-9229
ISSN (online)	2731-9229
DOI	10.1186/s11671-023-03955-w
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Article ; Online: The molecular mechanism of the effects of the anti-neuropathic ligands on the modulation of the Sigma-2 receptor: An in-silico study.

Dashtestani, Parisa / Karami, Leila

International journal of biological macromolecules

2023 Volume 254, Issue Pt 2, Page(s) 127925

Abstract: Neuropathic pain (NP) is a prevalent medical condition that lacks an effective treatment. Recently, the Sigma-2 receptor (S2R) has been proposed as a potential therapeutic target for NP. Some highly-selective S2R ligands (UKH1114, CM398, and YTD) have ... ...

Abstract	Neuropathic pain (NP) is a prevalent medical condition that lacks an effective treatment. Recently, the Sigma-2 receptor (S2R) has been proposed as a potential therapeutic target for NP. Some highly-selective S2R ligands (UKH1114, CM398, and YTD) have shown promising results in vivo, but the molecular interaction between the S2R and these ligands has been scarcely investigated. This work explores changes in the S2R upon interaction with the three mentioned ligands using in silico approaches. The results indicated that the ICL1, H1, ICL2, and ECL are the most dynamic regions of S2R in all systems. Binding interaction analysis identified amino acids with significant contribution to the binding free energy. Notably, the UKH1114-S2R simulation trajectory revealed that small alterations in the ICL1, H1, ICL2, and ECL form a new stable opening in the S2R, linking the occluded S2R binding pocket to the endoplasmic reticulum lumen, providing more evidence for the assumptions about the EBP and S2R mechanism of function. Further, the agreement between the membrane parameters in our study and experimental values confirms the validity of the MD simulations. Overall, this study provides new insights into the interaction between anti-NP ligands and the S2R.
MeSH term(s)	Receptors, sigma/chemistry ; Receptors, sigma/metabolism ; Ligands ; Computer Simulation ; Molecular Dynamics Simulation
Chemical Substances	sigma-2 receptor ; Receptors, sigma ; Ligands
Language	English
Publishing date	2023-11-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.127925
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Article: Electrochemical Sensor for Simple and Sensitive Determination of Hydroquinone in Water Samples Using Modified Glassy Carbon Electrode.

Karami-Kolmoti, Parisa / Beitollahi, Hadi / Modiri, Sina

Biomedicines

2023 Volume 11, Issue 7

Abstract: This study addressed the use of manganese dioxide nanorods/graphene oxide nanocomposite ( ... ...

Abstract	This study addressed the use of manganese dioxide nanorods/graphene oxide nanocomposite (MnO
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11071869
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Article ; Online: Voltammetric detection of catechol in real samples using MnO2 nanorods-graphene oxide nanocomposite modified electrode

Karami-Kolmoti, Parisa / Beitollahi, Hadi / Modiri, Sina

Food Measure. 2023 Apr., v. 17, no. 2 p.1974-1984

2023

Abstract: The current effort benefited from a simple hydrothermal production protocol to fabricate a nanocomposite using graphene oxide nanosheets anchored with manganese dioxide nanorods (MnO₂ NRs-GO) that was applied to construct a sensitive electrochemical ... ...

Abstract	The current effort benefited from a simple hydrothermal production protocol to fabricate a nanocomposite using graphene oxide nanosheets anchored with manganese dioxide nanorods (MnO₂ NRs-GO) that was applied to construct a sensitive electrochemical catechol sensing system. As-produced nanocomposite was characterized by Field emission-scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and Fourier transformed-infrared spectroscopy (FT-IR), which was then drop-casted on glassy carbon electrode (MnO₂ NRs-GO/GCE) for sensor application. The MnO₂ NRs-GO/GCE showed remarkable electrocatalytic capacity for the redox reaction of catechol, with minimized redox overpotentials and boosted voltammetric peak currents. As-fabricated sensor displayed an admirable electrocatalytic behavior to catechol, with a narrow limit of detection (0.02 µΜ), a broad linear range (0.5–400.0 µM) and an impressive sensitivity (0.0503 µA/µΜ). The MnO₂ NRs-GO/GCE was also successful in sensing catechol in real specimens, with appreciable recovery rates.
Keywords	X-ray diffraction ; catechol ; detection limit ; electrochemistry ; electron microscopy ; glassy carbon electrode ; graphene oxide ; manganese dioxide ; nanocomposites ; nanorods ; nanosheets ; redox reactions ; spectroscopy ; voltammetry
Language	English
Dates of publication	2023-04
Size	p. 1974-1984.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	2754612-3
ISSN	2193-4134 ; 2193-4126
ISSN (online)	2193-4134
ISSN	2193-4126
DOI	10.1007/s11694-022-01692-9
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Article ; Online: Efficient Inhibition of Pathologic Angiogenesis using Combination Therapy of Anti-Epcam and Anti-VEGFR2 Nanobodies.

Karami, Elmira / Azizi, Parisa / Behdani, Mahdi / Kazemi-Lomedasht, Fatemeh

Current pharmaceutical design

2023 Volume 29, Issue 13, Page(s) 1059–1066

Abstract: Background: EpCAM and VEGFR2 play an important role in angiogenesis and tumorigenesis. It is currently of paramount importance to produce new drugs that can inhibit the angiogenesis and proliferation of tumor cells. Nanobodies are potential drug ... ...

Abstract	Background: EpCAM and VEGFR2 play an important role in angiogenesis and tumorigenesis. It is currently of paramount importance to produce new drugs that can inhibit the angiogenesis and proliferation of tumor cells. Nanobodies are potential drug candidates for cancer therapy due to their unique properties. Objective: This study aimed to investigate the combined inhibitory effect of anti-EpCAM and anti-VEGFR2 nanobodies in cancer cell lines. Methods: Inhibitory activity of anti-EpCAM and anti-VEGFR2 nanobodies on MDA-MB231, MCF7, and HUVEC cells was investigated using both in vitro (MTT, migration, and tube formation assays) and in vivo assays. Results: Results showed that the combination of anti-EpCAM and anti-VEGFR2 nanobodies efficiently inhibited proliferation, migration, and tube formation of MDA-MB-231 cells compared to each individual nanobodies (p < 0.05). In addition, the combination of anti-EpCAM and anti-VEGFR2 nanobodies efficiently inhibited tumor growth and volume of Nude mice bearing MDA-MB-231 cells (p < 0.05). Conclusion: Taken together, the results indicate the potential of combination therapy as an efficient approach to cancer therapy.
MeSH term(s)	Mice ; Animals ; Humans ; Single-Domain Antibodies/pharmacology ; Mice, Nude ; Signal Transduction ; Neovascularization, Pathologic/drug therapy ; Neoplasms/drug therapy ; Vascular Endothelial Growth Factor Receptor-2 ; Human Umbilical Vein Endothelial Cells/metabolism ; Cell Proliferation ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Cell Line, Tumor
Chemical Substances	Single-Domain Antibodies ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; Angiogenesis Inhibitors
Language	English
Publishing date	2023-04-19
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612829666230420083431
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Article: Evaluating the Necessity and Radiation Risk of Brain CT Scans Requested by the Trauma Emergency Department.

Moradi, Hadi / Chehre, Hossein / Ghaderi, Behzad / Saghatchi, Faranak / Najafi, Masoud / Karami, Parisa / Rezaeejam, Hamed

Journal of biomedical physics & engineering

2023 Volume 13, Issue 6, Page(s) 515–522

Abstract: Background: Numerous Computed Tomography (CT) scan requests for trauma patients have raised serious concern about the impacts of radiation such as radiation-induced cancers.: Objective: This study aimed to evaluate the necessity rate of requested ... ...

Abstract	Background: Numerous Computed Tomography (CT) scan requests for trauma patients have raised serious concern about the impacts of radiation such as radiation-induced cancers. Objective: This study aimed to evaluate the necessity rate of requested head CT scans for traumatic patients and to ultimately estimate the risk of radiation-induced brain cancer. Material and methods: In this retrospective analytical study, traumatic patients, who had undergone a head CT scan in a two-month period from August 23 to October 22, 2018, were considered as the study population. Two radiologists reviewed each patient individually to evaluate the rate of normal and abnormal cases. Dose length product in milligrays (mGy) was utilized to calculate the effective dose (ED) in millisieverts (mSv), resulting in an assessment of the risk of radiation-induced brain cancer using ICRP 103. Results: Among 523 scans, 460 patients (88%) received normal reviews, while only 47 patients (9%) had findings related to their current trauma. The mean effective dose value was 1.05±0.36 mSv. Risk of the radiation induced brain cancer was calculated to be 0.037 and 0.030 new cancer cases in 10000 males and females per Gy, respectively. Conclusion: Final results demonstrated that a significant number of traumatic patients undergoing a CT scan are in fact, healthy. Such reckless usage of CT and consequently the excess exposure could result in a dramatic rise in cancer rates. The need to limit unnecessary CT scan usage and keeping the radiation given to patients as low as reasonably achievable (ALARA) when collecting essential diagnostic data is more critical than ever.
Language	English
Publishing date	2023-12-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2673599-4
ISSN	2251-7200
ISSN	2251-7200
DOI	10.31661/jbpe.v0i0.2012-1251
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Article ; Online: Global prevalence of depression, anxiety, and stress in cardiac patients: A systematic review and meta-analysis.

Karami, Nastaran / Kazeminia, Mohsen / Karami, Ahmad / Salimi, Yahya / Ziapour, Arash / Janjani, Parisa

Journal of affective disorders

2022 Volume 324, Page(s) 175–189

Abstract: Background: Cardiovascular disease is one of the most common chronic and life-threatening diseases. Due to the changes made in the normal living conditions of people after suffering from cardiovascular diseases, the appearance of symptoms of depression, ...

Abstract	Background: Cardiovascular disease is one of the most common chronic and life-threatening diseases. Due to the changes made in the normal living conditions of people after suffering from cardiovascular diseases, the appearance of symptoms of depression, anxiety, and stress is common among these patients. The results of the studies show the different prevalence of these disorders, so this study aimed to standardize the global prevalence of depression, anxiety, and stress in Cardiac patients by a systematic review and meta-analysis approach. Methods: The present systematic review and meta-analysis were conducted from 2000 to 2022. National and international databases were considered to retrieve related studies, including SID, Magiran, Scopus, Embase, PubMed, and Web of Science (WoS). Joanna Briggs Institute (JBI) checklist was used to evaluate studies qualitatively. Heterogeneity between studies was assessed by I2 index, and data analysis was performed in Comprehensive Meta-Analysis software. Results: After reviewing the retrieved studies, finally 68 studies on the prevalence of depression with a sample size of 110,219, 36 studies on the prevalence of anxiety with a sample size of 72,374 and 5 studies on the prevalence of stress with a sample size of 533 considered for the meta-analysis. Based on the results of the Meta-Analysis, the overall estimation of the prevalence of depression was 31.3 % (95 % confidence interval: 25.4/0.38 %), anxiety prevalence; 32.9 % (95 % confidence interval: 21.9-46.6 %) and stress prevalence was 57.7 % (95 % confidence interval: 45.3-3.3 %). Conclusion: The result of the present study shows the high prevalence rate of depression, anxiety, and stress in cardiac patients. Therefore, it is recommended that health professionals and policymakers pay more attention to preventing and controlling these disorders.
MeSH term(s)	Humans ; Depression/epidemiology ; Prevalence ; Anxiety/epidemiology ; Anxiety Disorders/epidemiology ; Health Personnel
Language	English
Publishing date	2022-12-28
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2022.12.055
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Article ; Online: Does coping with pain help the elderly with cardiovascular disease? The association of sense of coherence, spiritual well-being and self-compassion with quality of life through the mediating role of pain self-efficacy.

Salehi, Nahid / Afrashteh, Majid Yousefi / Majzoobi, Mohammad Reza / Ziapour, Arash / Janjani, Parisa / Karami, Sahar

BMC geriatrics

2023 Volume 23, Issue 1, Page(s) 393

Abstract: Background: Population ageing is considered one of the biggest challenges facing the world, and the status of the elderly in society and their quality of life (QOL) have proved to be a concern in professional and scientific research circles. As a result, ...

Abstract	Background: Population ageing is considered one of the biggest challenges facing the world, and the status of the elderly in society and their quality of life (QOL) have proved to be a concern in professional and scientific research circles. As a result, the current study sought to investigate the role of pain self-efficacy (PSE) as a moderator in the relationship between sense of coherence (SOC), spiritual well-being, and self-compassion with QOL in Iranian elderly with cardiovascular disease (CVD). Method: This was a correlational study of the path analysis type. The statistical population included all elderly people with CVD who were at least 60 years of age in Kermanshah Province, Iran, in 2022, of whom 298 (181 men and 117 women) were selected using convenience sampling and according to the inclusion and exclusion criteria. The participants answered questionnaires from the World Health Organization on QOL, Paloutzian and Ellison's spiritual well-being, Nicholas's PSE, Antonovsky's SOC, and Raes et al.'s self-compassion. Results: The results of path analysis demonstrated that the hypothesized model of this study has a good fit in the studied sample. There were significant paths between SOC (β = 0.39), spiritual well-being (β = 0.13) and self-compassion (β = 0.44) with PSE. Although there were significant paths between SOC (β = 0.16) and self-compassion (β = 0.31) with QOL, there was no significant path between spiritual well-being and QOL (β = 0.06). Besides, there was a significant path between PSE and QOL (β = 0.35). Finally, PSE was found to mediate the relationship of SOC, spiritual well-being and self-compassion with QOL. Conclusion: The results may provide psychotherapists and counselors working in this field of inquiry with advantageous information to choose or create a useful therapeutic method to work with the elderly with CVD. Meanwhile, other researchers are suggested to examine other variables which may serve a mediating role in the mentioned model.
MeSH term(s)	Aged ; Male ; Female ; Humans ; Sense of Coherence ; Quality of Life ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/therapy ; Iran ; Self Efficacy ; Self-Compassion ; Adaptation, Psychological ; Pain/epidemiology
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-023-04083-x
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