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  1. Article: James Mackenzie.

    McCormick, J

    The British journal of general practice : the journal of the Royal College of General Practitioners

    1993  Volume 43, Issue 371, Page(s) 262–263

    MeSH term(s) Coronary Disease/history ; History, 20th Century ; Humans ; United Kingdom
    Language English
    Publishing date 1993-06
    Publishing country England
    Document type Biography ; Historical Article ; Letter
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0960-1643 ; 0035-8797
    ISSN (online) 1478-5242
    ISSN 0960-1643 ; 0035-8797
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  2. Article ; Online: Regulation of the water channel Aquaporin-2 by Cullin E3 ubiquitin ligases.

    Murali, Sathish K / McCormick, James A / Fenton, Robert A

    American journal of physiology. Renal physiology

    2024  

    Abstract: Aquaporin 2 (AQP2) is a vasopressin (VP) regulated water channel in the renal collecting duct. Phosphorylation and ubiquitylation of AQP2 play essential roles in controlling the cellular abundance of AQP2 and its accumulation on the plasma membrane in ... ...

    Abstract Aquaporin 2 (AQP2) is a vasopressin (VP) regulated water channel in the renal collecting duct. Phosphorylation and ubiquitylation of AQP2 play essential roles in controlling the cellular abundance of AQP2 and its accumulation on the plasma membrane in response to VP. Cullin-RING ubiquitin ligases (CRLs) are multi-subunit E3 ligases involved in ubiquitylation and degradation of their target proteins, eight of which are expressed in the collecting duct. Here, we utilized an established cell model of the collecting duct (mpkCCD14 cells) to study the role of Cullins in modulating AQP2. Western blotting identified Cul-1 to -5 in mpkCCD14 cells. Treatment of cells for 4 h with a pan-cullin inhibitor (MLN4924) decreased AQP2 abundance, prevented a VP-induced reduction in AQP2 Ser
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00049.2024
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  3. Article: James Mackenzie and coronary heart disease.

    McCormick, J S

    The Journal of the Royal College of General Practitioners

    1981  Volume 31, Issue 222, Page(s) 26–30

    Abstract: Sir James Mackenzie's writings, especially his Diseases of the Heart, suggest ...

    Abstract Sir James Mackenzie's writings, especially his Diseases of the Heart, suggest that ischaemic heart disease, including myocardial infarction, was common in England at the beginning of the twentieth century.
    MeSH term(s) Adolescent ; Adult ; Aged ; Coronary Disease/history ; England ; Family Practice/history ; Female ; History, 19th Century ; History, 20th Century ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 1981-01
    Publishing country England
    Document type Biography ; Case Reports ; Historical Article ; Journal Article
    ZDB-ID 800732-9
    ISSN 0035-8797
    ISSN 0035-8797
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  4. Article ; Online: Engineering Proteins Using Statistical Models of Coevolutionary Sequence Information.

    Dinan, Jerry C / McCormick, James W / Reynolds, Kimberly A

    Cold Spring Harbor perspectives in biology

    2024  Volume 16, Issue 4

    Abstract: Homologous protein sequences are wonderfully diverse, indicating many possible evolutionary "solutions" to the encoding of function. Consequently, one can construct statistical models of protein sequence by analyzing amino acid frequency across a large ... ...

    Abstract Homologous protein sequences are wonderfully diverse, indicating many possible evolutionary "solutions" to the encoding of function. Consequently, one can construct statistical models of protein sequence by analyzing amino acid frequency across a large multiple sequence alignment. A central premise is that covariance between amino acid positions reflects coevolution due to a shared functional or biophysical constraint. In this review, we describe the implementation and discuss the advantages, limitations, and recent progress on two coevolution-based modeling approaches: (1) Potts models of protein sequence (direct coupling analysis [DCA]-like), and (2) the statistical coupling analysis (SCA). Each approach detects interesting features of protein sequence and structure-the former emphasizes local physical contacts throughout the structure, while the latter identifies larger evolutionarily coupled networks of residues. Recent advances in large-scale gene synthesis and high-throughput functional selection now motivate additional work to benchmark model performance across quantitative function prediction and de novo design tasks.
    MeSH term(s) Proteins/metabolism ; Amino Acids/genetics ; Models, Statistical ; Evolution, Molecular ; Biological Evolution
    Chemical Substances Proteins ; Amino Acids
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a041463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: mTORC2, a Novel " Twist " on the Epithelial Sodium Channel (ENaC).

    Ellison, David H / McCormick, James A

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 6, Page(s) 937–938

    MeSH term(s) Mechanistic Target of Rapamycin Complex 2 ; Epithelial Sodium Channels/genetics ; Epithelial Sodium Channels/metabolism ; Signal Transduction ; Protein Serine-Threonine Kinases/metabolism
    Chemical Substances Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; Epithelial Sodium Channels ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000131
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  6. Article ; Online: Cullin 3 and Blood Pressure Regulation: Insights From Familial Hyperkalemic Hypertension.

    Maeoka, Yujiro / Cornelius, Ryan J / McCormick, James A

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 80, Issue 5, Page(s) 912–923

    Abstract: The study of rare monogenic forms of hypertension has led to the elucidation of important physiological pathways controlling blood pressure. Mutations in several genes cause familial hyperkalemic hypertension (also known as Gordon syndrome or ... ...

    Abstract The study of rare monogenic forms of hypertension has led to the elucidation of important physiological pathways controlling blood pressure. Mutations in several genes cause familial hyperkalemic hypertension (also known as Gordon syndrome or pseudohypoaldosteronism type II). The most severe form of familial hyperkalemic hypertension is caused by mutations in
    MeSH term(s) Humans ; Blood Pressure/genetics ; Protein Serine-Threonine Kinases/metabolism ; Cullin Proteins/genetics ; Pseudohypoaldosteronism/genetics ; Hypertension/metabolism
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Cullin Proteins
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.20525
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  7. Article: [Besprechung von:] Meade,James E.: Stagflation. Vol. 1. London 1982

    McCormick, Barry / Meade, James E

    The economic journal : the journal of the Royal Economic Society Vol. 92 , p. 967-969

    1982  Volume 92, Page(s) 967–969

    Author's details Barry McCormick
    Publisher Blackwell
    Publishing place Oxford [u.a.]
    Document type Article
    ZDB-ID 3025-9
    Database ECONomics Information System

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  8. Article ; Online: Renal effects of cullin 3 mutations causing familial hyperkalemic hypertension.

    Cornelius, Ryan J / Maeoka, Yujiro / McCormick, James A

    Current opinion in nephrology and hypertension

    2023  Volume 32, Issue 4, Page(s) 335–343

    Abstract: Purpose of review: Mutations in the E3 ubiquitin ligase scaffold cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt) by hyperactivating the NaCl cotransporter (NCC). The effects of these mutations are complex and still being ... ...

    Abstract Purpose of review: Mutations in the E3 ubiquitin ligase scaffold cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt) by hyperactivating the NaCl cotransporter (NCC). The effects of these mutations are complex and still being unraveled. This review discusses recent findings revealing the molecular mechanisms underlying the effects of CUL3 mutations in the kidney.
    Recent findings: The naturally occurring mutations that cause deletion of exon 9 (CUL3-Δ9) from CUL3 generate an abnormal CUL3 protein. CUL3-Δ9 displays increased interaction with multiple ubiquitin ligase substrate adaptors. However, in-vivo data show that the major mechanism for disease pathogenesis is that CUL3-Δ9 promotes degradation of itself and KLHL3, the specific substrate adaptor for an NCC-activating kinase. CUL3-Δ9 displays dysregulation via impaired binding to the CSN and CAND1, which cause hyperneddylation and compromised adaptor exchange, respectively. A recently discovered CUL3 mutant (CUL3-Δ474-477) displays many similarities to CUL3-Δ9 mutations but some key differences that likely account for the milder FHHt phenotype it elicits. Furthermore, recent work suggests that CUL3 mutations could have unidentified complications in patients and/or a predisposition to renal injury.
    Summary: This review summarizes recent studies highlighting advances in our understanding of the renal mechanisms by which CUL3 mutations modulate blood pressure in FHHt.
    MeSH term(s) Humans ; Protein Serine-Threonine Kinases/metabolism ; Cullin Proteins/genetics ; Adaptor Proteins, Signal Transducing/genetics ; Kidney/metabolism ; Mutation ; Hypertension/genetics ; Hypertension/metabolism
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Cullin Proteins ; Adaptor Proteins, Signal Transducing
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000891
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  9. Article: James Mackenzie Lecture 1974. Fifty years of progress.

    McCormick, J

    The Journal of the Royal College of General Practitioners

    1975  Volume 25, Issue 150, Page(s) 9–19

    MeSH term(s) Family Practice/history ; History, 19th Century ; United Kingdom
    Language English
    Publishing date 1975-01
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 800732-9
    ISSN 0035-8797
    ISSN 0035-8797
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  10. Article: James Mackenzie lecture. Fifty years of progress.

    McCormick, J

    The Practitioner

    1975  Volume 214, Issue 1279, Page(s) 87–98

    MeSH term(s) Angina Pectoris/history ; Diagnosis ; Drug-Related Side Effects and Adverse Reactions ; Family Practice/history ; History, 19th Century ; History, 20th Century ; Humans ; Myocardial Infarction/prevention & control ; Personal Health Services ; Philosophy, Medical ; Physician-Patient Relations ; Preventive Health Services ; United Kingdom
    Language English
    Publishing date 1975-01
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 124095-x
    ISSN 0032-6518
    ISSN 0032-6518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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