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Article ; Online: Genetic polymorphism of 19 autosomal STR loci in the Yi ethnic minority of Liangshan Yi autonomous prefecture from Sichuan province in China.

Cheng, Jingliang / Song, Binghui / Fu, Jiewen / Zheng, Xiaoli / He, Tao / Fu, Junjiang

2021 Volume 11, Issue 1, Page(s) 16327

Abstract: The Yi is one of fifty-six ethnic populations and one of the most ancient ethnic groups in China ... The Liangshan Yi Autonomous Prefecture (LYAP) in Sichuan Province has the single largest Yi community in China ... To establish a Yi population database in the LYAP of Sichuan in China, a Goldeneye™ DNA Identification System ...

Abstract	The Yi is one of fifty-six ethnic populations and one of the most ancient ethnic groups in China. The Liangshan Yi Autonomous Prefecture (LYAP) in Sichuan Province has the single largest Yi community in China. To establish a Yi population database in the LYAP of Sichuan in China, a Goldeneye™ DNA Identification System 20A Kit with 19 autosomal STRs (short tandem repeats) was used. As a result, the total discrimination power (TDP) and the cumulative probability of exclusion (CPE) for these STRs in 1016 unrelated individuals were 0.999999999999999999999897 and 0.9999999597, respectively. Totals of 273 alleles for 19 STRs and 8-22 alleles for each locus were found. The allelic frequencies ranged from 0.0005 to 0.5084. The forensic parameter averages of these STRs were as follows: observed heterozygosity (H
MeSH term(s)	Asian Continental Ancestry Group/genetics ; China ; Ethnic Groups/genetics ; Gene Frequency/genetics ; Genetics, Population/methods ; Humans ; Microsatellite Repeats/genetics ; Minority Groups ; Phylogeny ; Polymorphism, Genetic/genetics
Language	English
Publishing date	2021-08-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-95883-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Two Novel Flavonoids with Lipid-Lowering Activity from Yi Medicine Shekaqi.

Lin, Yu-Ping / Fu, Sheng-Nan / Li, Xin-Ping / Wang, Meng-Meng / Fang, Qiong-Lian / Qiao, Xue / Yan, Qi / Hua, Yan

Chemistry & biodiversity

2022 Volume 19, Issue 9, Page(s) e202200363

Abstract: Yi medicine Shekaqi is the most attractive traditional ethnic medicine due to its significant and ... isolated from Yi medicine Shekaqi. Their structures were elucidated based on the analysis ...

Abstract	Yi medicine Shekaqi is the most attractive traditional ethnic medicine due to its significant and diverse pharmacological activities. Two novel flavonoids, including 5,2'-dihydroxy-6-methoxy-7-decyloxyflavone and tenaxin II-7-O-β-D-glucuronopyranosyl acid butyl ester, along with six known flavonoids, were isolated from Yi medicine Shekaqi. Their structures were elucidated based on the analysis of their comprehensive spectral data. The in vitro lipid-lowering activities of the eight compounds showed that all the compounds significantly inhibited the lipopolysaccharide (LPS)-induced increase in the total cholesterol (TC) level, while compounds 1, 4, 6, 7, and 8 significantly inhibited the LPS-induced increase in the triglyceride (TG) level.
MeSH term(s)	Cholesterol ; Esters ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Lipopolysaccharides/pharmacology ; Triglycerides
Chemical Substances	Esters ; Flavonoids ; Lipopolysaccharides ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-08-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202200363
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Article ; Online: Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss.

Yang, Yi-Fang / Yan, Xi-Rui / Wu, Rui-Xin / Li, Ning / Chu, Min / Dong, Yang / Fu, Shu-Ping / Shi, Jian-Rong / Liu, Qing

Pharmaceutical biology

2022 Volume 60, Issue 1, Page(s) 1478–1490

Abstract: Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss ...

Abstract	Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly. Objective: To explore the mechanism of YQCM decoction in the treatment of ARHL. Materials and methods: The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an Results: The main compounds have good affinities with hub targets, especially AKT1, PTGS2, and CASP3. GO and KEGG analysis showed that the main biological process and key targets were related to negative regulation of the apoptotic process. H Conclusions: Our study suggested that YQCM prevents ARHL by modulating the apoptosis process in auditory hair cells. Moreover, this study proved that bioinformatics analysis combined with molecular docking and cell model is a promising method to explore other possible pharmacological interventions of ARHL.
MeSH term(s)	Aged ; Caspase 3 ; Drugs, Chinese Herbal/therapeutic use ; Hearing Loss/drug therapy ; Humans ; Hydrogen Peroxide/toxicity ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Network Pharmacology ; Neurodegenerative Diseases/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Hydrogen Peroxide (BBX060AN9V) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2101671
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Article ; Online: Metabolomics analysis of the potential mechanism of Yi-Guan-Jian decoction to reverse bone loss in glucocorticoid-induced osteoporosis.

Yin, Mengxing / Zhou, Dezhi / Jia, Fu / Su, Xiaosan / Li, Xiufang / Sun, Ruifen / Li, Junmin

Journal of orthopaedic surgery and research

2023 Volume 18, Issue 1, Page(s) 409

Abstract: ... hypotaurine metabolism, with - log10 (P) > 2.0 and Impact > 0.4.: Conclusions: Yi-Guan-Jian decoction ...

Abstract	Background: Glucocorticoid-induced osteoporosis (GIOP) is a disease in which long-term use of glucocorticoid causes bone loss, deterioration of bone microstructure and fracture. Currently, clinical drugs targeting this disease have certain side effects. There is still a need to find effective drugs with fewer side effects. The theory of traditional Chinese medicine suggests that YGJ has therapeutic effect on GIOP, but it has not been explained. Therefore, this study aims to explore the protective effect of YGJ on GIOP mouse models and elucidate the underlying mechanism through LC-MS-based metabolomics analysis. Methods: The general condition of 8 week age male C57BL/6J mice was recorded after 8 weeks of treatment with dexamethasone (DEX) and YGJ. Bone-related parameters and bone morphology were determined by Micro-CT. HE staining was used to observe the pathological changes of bone tissue. Serum levels of bone metabolism markers were detected by ELISA. Liver metabolomics analysis was conducted to search for the significant markers of anti-GIOP of YGJ and the metabolic pathway affecting it. Results: After treatment, YGJ significantly reversed the weight loss caused by DEX; increase the number of bone trabecular in ROI region, significantly improve the bone-related parameters of GIOP mice, and increase the levels of alkaline phosphatase and osteocalcin. In the study of metabolic mechanism, YGJ reversed 24 potential markers in GIOP mice. These included cortisol, 3-hydroxybutyric acid, taurine, esculin and uric acid, which are closely associated with osteoporosis. Topological analysis results showed that YGJ had the most significant effect on taurine and hypotaurine metabolism, with - log10 (P) > 2.0 and Impact > 0.4. Conclusions: Yi-Guan-Jian decoction can increase bone density and improve bone microstructure by regulating the levels of alkaline phosphatase and osteocalcin and reverse bone loss in GIOP mouse model. The underlying metabolic mechanism may be related to taurine and hypotaurine metabolic pathway.
MeSH term(s)	Mice ; Male ; Animals ; Glucocorticoids/adverse effects ; Alkaline Phosphatase/metabolism ; Osteocalcin ; Mice, Inbred C57BL ; Osteoporosis/chemically induced ; Osteoporosis/diagnostic imaging ; Osteoporosis/drug therapy ; Metabolomics/methods ; Taurine/adverse effects ; Disease Models, Animal
Chemical Substances	Glucocorticoids ; hypotaurine (5L08GE4332) ; Alkaline Phosphatase (EC 3.1.3.1) ; Osteocalcin (104982-03-8) ; Taurine (1EQV5MLY3D)
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-023-03778-6
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Article ; Online: Genetic polymorphism of 19 autosomal STR loci in the Yi ethnic minority of Liangshan Yi autonomous prefecture from Sichuan province in China

Jingliang Cheng / Binghui Song / Jiewen Fu / Xiaoli Zheng / Tao He / Junjiang Fu

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract The Yi is one of fifty-six ethnic populations and one of the most ancient ethnic groups ... in China. The Liangshan Yi Autonomous Prefecture (LYAP) in Sichuan Province has the single largest Yi ... community in China. To establish a Yi population database in the LYAP of Sichuan in China, a Goldeneye™ DNA ...

Abstract	Abstract The Yi is one of fifty-six ethnic populations and one of the most ancient ethnic groups in China. The Liangshan Yi Autonomous Prefecture (LYAP) in Sichuan Province has the single largest Yi community in China. To establish a Yi population database in the LYAP of Sichuan in China, a Goldeneye™ DNA Identification System 20A Kit with 19 autosomal STRs (short tandem repeats) was used. As a result, the total discrimination power (TDP) and the cumulative probability of exclusion (CPE) for these STRs in 1016 unrelated individuals were 0.999999999999999999999897 and 0.9999999597, respectively. Totals of 273 alleles for 19 STRs and 8–22 alleles for each locus were found. The allelic frequencies ranged from 0.0005 to 0.5084. The forensic parameter averages of these STRs were as follows: observed heterozygosity (Hobs) of 78.44%, expected heterozygosity (Hexp) of 79.89%, discrimination power (DP) of 92.66%, and probability of exclusion (PE) of 57.68%. Penta E presented the highest levels of Hobs and DP, whereas TPOX showed the lowest Hobs and DP values. Nei’s standard genetic distance matrix among 31 populations found that the nearest genetic distance to the Yi population was the Sichuan Han (0.0056). Altogether, we first reported the forensic parameters and allele frequencies of 19 autosomal STRs of the Yi group in Liangshan. These 19 STR makers could provide highly informative polymorphisms for individual identification, paternity testing and genetic population analyses.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss

Yang, Yi-Fang / Yan, Xi-Rui / Wu, Rui-Xin / Li, Ning / Zhu, Min / Dong, Yang / Fu, Shu-Ping / Shi, Jian-Rong / Liu, Qing

Pharmaceutical Biology. 2022 Dec. 31, v. 60, no. 1 p.1478-1490

2022

Abstract: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL ...

Abstract	Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly. To explore the mechanism of YQCM decoction in the treatment of ARHL. The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an in vitro model of ARHL by exposing auditory cells with 100 μM H₂O₂ for 3 h were applied. Cell viability and mitochondrial membrane potential (ΔΨM) were detected by CCK-8 and high-content analysis. γH2AX and cleaved caspase-3 were detected by Western blot. The main compounds have good affinities with hub targets, especially AKT1, PTGS2, and CASP3. GO and KEGG analysis showed that the main biological process and key targets were related to negative regulation of the apoptotic process. H₂O₂ treatment could reduce the cell viability by 68% and impaired ΔΨM, while 90 μg/mL YQCM pre-treatment could restore the cell viability by 97.45% and increase ΔΨM (2-fold higher). YQCM pre-treatment also reduced γH2AX and cleaved caspase-3 protein levels. Our study suggested that YQCM prevents ARHL by modulating the apoptosis process in auditory hair cells. Moreover, this study proved that bioinformatics analysis combined with molecular docking and cell model is a promising method to explore other possible pharmacological interventions of ARHL.
Keywords	Oriental traditional medicine ; Western blotting ; apoptosis ; bioinformatics ; caspase-3 ; cell viability ; databases ; elderly ; membrane potential ; mitochondrial membrane ; models ; neurodegenerative diseases ; pharmacology ; Molecular docking ; molecular dynamics simulation ; HEI-OC1 ; mitochondrial membrane potential ; AKT1
Language	English
Dates of publication	2022-1231
Size	p. 1478-1490.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2101671
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Clinical Yi-guan decoction for liver cirrhosis: A protocol for systematic review and meta analysis.

Hu, Xingyao / Shang, Guangbin / Zhang, Jie / Chen, Zhong / Fu, Liu / Li, Jun / Lu, Xiaonan

Medicine

2021 Volume 100, Issue 13, Page(s) e24530

Abstract: ... have shown that Yi-guan decoction has become a complementary treatment for LC ... Therefore, this systematic review will aim to explore the safety and feasibility of Yi-guan decoction in the treatment of LC ... searched: "Yi-guan decoction" "cirrhosis" "LC". Data entry will be performed by 2 researchers separately ...

Abstract	Background: At present, Liver Cirrhosis (LC) is common in most later liver and gallbladder diseases that its morbidity and mortality seriously affect human health. The limitation and effectiveness of western medicine on LC have become a huge clinical challenge. However, a large number of clinical studies have shown that Yi-guan decoction has become a complementary treatment for LC. Therefore, this systematic review will aim to explore the safety and feasibility of Yi-guan decoction in the treatment of LC. Methods: We will conduct a comprehensive literature search in Medline, PubMed, Cochrane Database of Systematic Reviews, Embase, Chinese Biomedical Literatures Database, China National Knowledge Infrastructure, Wang Fang Database, Chinese Scientific Journal Database from inception to December 2020 without any language restriction, In addition, relevant literature will be searched manually. The main subject terms searched: "Yi-guan decoction" "cirrhosis" "LC". Data entry will be performed by 2 researchers separately. Primary outcomes will be concluded: Liver function indicators: Total bilirubin, Alanine transaminase, Aspartate aminotransferase, etc. Secondary outcome indicators: Total effective rate, Nutrition index, Survival analysis, Adverse events; All randomized controlled trials collected in this study will be evaluated and rated using the Cochrane risk-of-biasassessment tool. Meta-analysis will be performed using RevMan 5.4.0 software. The heterogeneity test will be conducted between the studies, P < .1 and I2 > 50% are the thresholds for the tests. Using solid effect model or random effect model will be based on its heterogeneity value. Results: This systematic review provides a theoretical basis for Yi-guan decoction to treat LC, we will report this result soon. Conclusion: This study will explore Yi-guan decoction can will be used as one of the non drug therapies to prevent or treat LC. Trial registration number: INPLASY2020120114.
MeSH term(s)	Drugs, Chinese Herbal/therapeutic use ; Humans ; Liver Cirrhosis/drug therapy ; Meta-Analysis as Topic ; Randomized Controlled Trials as Topic ; Research Design ; Systematic Reviews as Topic ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal ; yiguan
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024530
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Article: Professor da-yi hu.

Li, Lai-Fu / Zhang, He

Journal of geriatric cardiology : JGC

2013 Volume 10, Issue 1, Page(s) 1–2

Language	English
Publishing date	2013-01-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2421391-3
ISSN	1671-5411
ISSN	1671-5411
DOI	10.3969/j.issn.1671-5411.2013.01.001
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Article ; Online: Effects of the Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor-associated musculoskeletal symptoms: A randomized, controlled clinical trial.

Peng, Nan / Yu, Mingwei / Yang, Guowang / Fu, Qi / Xu, Yongmei / Yu, Jie / Liu, Qiang / Li, Chen / Xu, Weiru / Zhang, Yi / Ma, Cong / Yang, Lin / Yu, Rencun / Wang, Xiaomin

Breast (Edinburgh, Scotland)

2018 Volume 37, Page(s) 18–27

Abstract: ... whether Yi Shen Jian Gu granules (YSJG) is effective and safe to relieve AIMSS in patients with breast cancer ...

Abstract	Aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) are prevalent among patients on AI therapy, which leads to a lower quality of life and poor adherence to AI treatment. We evaluated whether Yi Shen Jian Gu granules (YSJG) is effective and safe to relieve AIMSS in patients with breast cancer. Eligible participants were randomly assigned to the YSJG group or the placebo group. Both groups had a 12-week treatment period and a 12-week follow-up period. Brief Pain Inventory-Short Form (BPI-SF), Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index, and the Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH) were obtained at baseline and at 4, 8, 12 and 24 weeks. Of 146 participants enrolled, 84 were randomly assigned, and 77 were evaluable at 12 weeks. Baseline characteristics were comparable between two groups. The primary outcome was the differences in mean BPI-SF scores at 12 weeks. The worst pain scores decreased by 3.10 points (50.2%; 95% CI, 2.50 to 3.65) for YSJG group compared with a 1.63-point decrease (26.9%; 95% CI, 3.86 to 4.97) for the placebo group (P = 0.001). Significantly improvements were also observed for the WOMAC and M-SACRAH. Possibly YSJG-related side effects were grade 1 nausea (10%) and grade 2 diarrhea (2%). Serum follicle-stimulating hormone and serum estradiol were kept in the postmenopausal range before and after YSJG treatment. Patients with AIMSS treated with YSJG granules had significant improvements in musculoskeletal symptoms. YSJG is effective, safe and well-tolerated in managing AIMSS. Trial registration: ISCTN: ISRCTN06129599 (assigned 14 August 2013).
MeSH term(s)	Adult ; Aged ; Antineoplastic Agents/adverse effects ; Aromatase Inhibitors/adverse effects ; Bone Density ; Breast Neoplasms/drug therapy ; Diarrhea/chemically induced ; Double-Blind Method ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/therapeutic use ; Estradiol/blood ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Medication Adherence ; Middle Aged ; Musculoskeletal Pain/chemically induced ; Musculoskeletal Pain/drug therapy ; Nausea/chemically induced ; Pain Measurement ; Quality of Life ; Surveys and Questionnaires
Chemical Substances	Antineoplastic Agents ; Aromatase Inhibitors ; Drugs, Chinese Herbal ; yi shen jian gu ; Estradiol (4TI98Z838E) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2018-02
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	1143210-x
ISSN	1532-3080 ; 0960-9776
ISSN (online)	1532-3080
ISSN	0960-9776
DOI	10.1016/j.breast.2017.08.003
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Article: Qing-Yi Decoction in the Treatment of Acute Pancreatitis: An Integrated Approach Based on Chemical Profile, Network Pharmacology, Molecular Docking and Experimental Evaluation.

Wei, Tian-Fu / Zhao, Liang / Huang, Peng / Hu, Feng-Lin / Jiao, Ju-Ying / Xiang, Kai-Lai / Wang, Zhi-Zhou / Qu, Jia-Lin / Shang, Dong

Frontiers in pharmacology

2021 Volume 12, Page(s) 590994

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.590994
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