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  1. Book: Brenner & Rector's the kidney / Volume 2 / Alan S.L. Yu [und weitere]

    Yu, Alan S. L. / Rector, Floyd C. / Brenner, Barry M.

    (Expert consult)

    2019  

    Author's details ed. by Barry M. Brenner
    Series title Expert consult
    Brenner & Rector's the kidney
    Collection Brenner & Rector's the kidney
    Language English
    Size xxi, Seiten, Seiten 1433 - 2677, I-84 Seiten, Illustrationen, Diagramme
    Edition Eleventh edition
    Publishing country United States
    Document type Book
    HBZ-ID HT020169260
    ISBN 978-0-323-75934-2 ; 978-0-323-53265-5 ; 0-323-75934-3 ; 0-323-53265-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 312 available for loan (reading room) Lesesaal EG

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  2. Book: Brenner & Rector's the kidney / Volume 1 / Alan S.L. Yu [und weitere]

    Yu, Alan S. L. / Rector, Floyd C. / Brenner, Barry M.

    (Expert consult)

    2019  

    Author's details ed. by Barry M. Brenner
    Series title Expert consult
    Brenner & Rector's the kidney
    Collection Brenner & Rector's the kidney
    Language English
    Size xxi, 1431, I-84 Seiten, Illustrationen, Diagramme
    Edition Eleventh edition
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT020169258
    ISBN 978-0-323-75933-5 ; 978-0-323-53265-5 ; 0-323-75933-5 ; 0-323-53265-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 311 available for loan (reading room) Lesesaal EG
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article ; Online: Magnesium Disorders: Core Curriculum 2024.

    Adomako, Emmanuel A / Yu, Alan S L

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2024  

    Abstract: Magnesium is ubiquitous in nature. It sits at the origin of the food chain, occupying the center of chlorophyl in plants. In humans, magnesium is critical to diverse molecular and catalytic processes, including energy transfer and maintenance of the ... ...

    Abstract Magnesium is ubiquitous in nature. It sits at the origin of the food chain, occupying the center of chlorophyl in plants. In humans, magnesium is critical to diverse molecular and catalytic processes, including energy transfer and maintenance of the genome. Despite its abundance, hypomagnesemia is common and often goes undiagnosed. This is in spite of epidemiologic data linking low magnesium with chronic diseases including diabetes mellitus. Clinically significant hypermagnesemia is encountered less frequently, but the presentation may be dramatic. Advances in molecular biology and the elucidation of the genetic causes of magnesium disorders have enhanced our understanding of their pathophysiology. Treatment approaches are also changing. The repurposing of newer medications, such as sodium/glucose cotransporter 2 inhibitors, offers new therapeutic options. In this review we integrate knowledge in this rapidly evolving field to provide clinicians and trainees with a resource for approaching common clinical scenarios involving magnesium disorders.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2023.10.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 468: Show issues

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  4. Article ; Online: Biomarkers in Polycystic Kidney Disease: Are We There?

    Yu, Alan S L / Landsittel, Douglas P

    Advances in kidney disease and health

    2023  Volume 30, Issue 3, Page(s) 285–293

    Abstract: ... surrogate endpoints. The U.S. Food and Drug Administration's Biomarker Qualification Program provides a regulatory ...

    Abstract This article describes the use of prognostic, predictive, and response biomarkers that have been developed for autosomal dominant polycystic kidney disease and their use in clinical care or drug development. We focus on biochemical markers that can be assayed in patients' blood and urine and their association with the outcome of decreased glomerular filtration rate. There have been several studies on prognostic biomarkers. The most promising ones have been markers of tubular injury, inflammation, metabolism, or the vasopressin-urinary concentration axis. So far, none have been shown to be superior to kidney volume-based biomarkers. Several biomarkers are additive to kidney volume and genotype in prognostic models, but there have been few direct comparisons between the biochemical markers to identify the best ones. Moreover, there is a lack of uniformity in the statistical tools used to assess and compare biomarkers. There have been few reports of predictive and response biomarkers, and none are suitable surrogate endpoints. The U.S. Food and Drug Administration's Biomarker Qualification Program provides a regulatory pathway to approve biomarkers for use across multiple drug-development programs.
    MeSH term(s) Humans ; Disease Progression ; Glomerular Filtration Rate ; Polycystic Kidney Diseases/diagnosis ; Biomarkers/metabolism ; Prognosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 3156601-7
    ISSN 2949-8139
    ISSN (online) 2949-8139
    DOI 10.1053/j.akdh.2022.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The role of claudin-2 in kidney function and dysfunction.

    Nyimanu, Duuamene / Behm, Christine / Choudhury, Sonali / Yu, Alan S L

    Biochemical Society transactions

    2023  Volume 51, Issue 4, Page(s) 1437–1445

    Abstract: Claudin-2 is a tight junction protein expressed in leaky epithelia where it forms paracellular pores permeable to cations and water. The paracellular pore formed by claudin-2 is important in energy-efficient cation and water transport in the proximal ... ...

    Abstract Claudin-2 is a tight junction protein expressed in leaky epithelia where it forms paracellular pores permeable to cations and water. The paracellular pore formed by claudin-2 is important in energy-efficient cation and water transport in the proximal tubules of the kidneys. Mounting evidence now suggests that claudin-2 may modulate cellular processes often altered in disease, including cellular proliferation. Also, dysregulation of claudin-2 expression has been linked to various diseases, including kidney stone disease and renal cell carcinoma. However, the mechanisms linking altered claudin-2 expression and function to disease are poorly understood and require further investigation. The aim of this review is to discuss the current understanding of the role of claudin-2 in kidney function and dysfunction. We provide a general overview of the claudins and their organization in the tight junction, the expression, and function of claudin-2 in the kidney, and the evolving evidence for its role in kidney disease.
    MeSH term(s) Claudin-2/metabolism ; Kidney Tubules, Proximal/metabolism ; Biological Transport/physiology ; Kidney/metabolism ; Tight Junctions/metabolism ; Water/metabolism
    Chemical Substances Claudin-2 ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20220639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 944: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Brief Report: Atypical Temporal Sensitivity in Coarticulation in Autism: Evidence from Sibilant-Vowel Interaction in Cantonese.

    Yu, Alan C L / McAllister, Robert / Mularoni, Nicholas / To, Carol K S

    Journal of autism and developmental disorders

    2024  

    Abstract: Purpose: Atypicalities in the prosodic aspects of speech are commonly considered in clinical assessments of autism. While there is an increasing number of studies using objective measures to assess prosodic deficits, such studies have primarily focused ... ...

    Abstract Purpose: Atypicalities in the prosodic aspects of speech are commonly considered in clinical assessments of autism. While there is an increasing number of studies using objective measures to assess prosodic deficits, such studies have primarily focused on the intonational and rhythmic aspects of prosody. Little is known about prosodic deficits that are reflected at the segmental level, despite the strong connection between prosody and segmental realization. This study examines the nature of sibilant-vowel coarticulation among male adult native speakers of Cantonese with autism and those without.
    Methods: Fifteen Cantonese-speaking autistic (ASD) adults (mean age = 25 years) and 23 neuro-typical (NT) adults (mean age = 20 years) participated. Each participant read aloud 42 syllables with a sibilant onset in carrier phrase. Spectral means and variance, skewness and kurtosis were measured, and regressed by vocalic rounding (rounded vs. unrounded), cohort (ASD vs. NT), sibilant duration, and articulation rate.
    Results: While neurotypical participants exhibit sibilant-vowel coarticulation that are sensitive to variation in sibilant duration, autistic participants show no sensitivity to segmental temporal changes.
    Conclusion: These findings point to the potential for atypicalities in prosody-segment interaction as an important characteristic of autistic speech.
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-024-06258-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 765: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Contribution of phosphate and FGF23 to CKD progression.

    Jansson, Kyle P / Yu, Alan S L / Stubbs, Jason R

    Current opinion in nephrology and hypertension

    2022  Volume 31, Issue 4, Page(s) 306–311

    Abstract: Purpose of review: Progressive forms of chronic kidney disease (CKD) exhibit kidney inflammation and fibrosis that drive continued nephron loss; however, factors responsible for the development of these common pathologic features remain poorly defined. ... ...

    Abstract Purpose of review: Progressive forms of chronic kidney disease (CKD) exhibit kidney inflammation and fibrosis that drive continued nephron loss; however, factors responsible for the development of these common pathologic features remain poorly defined. Recent investigations suggest pathways involved in maintaining urinary phosphate excretion in CKD may be contributing to kidney function decline. This review provides an update on recent evidence linking altered phosphate homeostasis to CKD progression.
    Recent findings: High dietary phosphate intake and increased serum concentrations of fibroblast growth factor 23 (FGF23) both increase urinary phosphate excretion and are associated with increased risk of kidney function decline. Recent investigations have discovered high concentrations of tubular phosphate promote phosphate-based nanocrystal formation that drives tubular injury, cyst formation, and fibrosis.
    Summary: Studies presented in this review highlight important scientific discoveries that have molded our current understanding of the contribution of altered phosphate homeostasis to CKD progression. The collective observations from these investigations implicate phosphaturia, and the resulting formation of phosphate-based crystals in tubular fluid, as unique risk factors for kidney function decline. Developing a better understanding of the relationship between tubular phosphate handling and kidney pathology could result in innovative strategies for improving kidney outcomes in patients with CKD.
    MeSH term(s) Chronic Disease ; Fibroblast Growth Factors/metabolism ; Fibrosis ; Humans ; Kidney/metabolism ; Phosphates/metabolism ; Renal Insufficiency, Chronic/complications
    Chemical Substances Phosphates ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Response to "Fibroblast Growth Factor 23 Is a Valuable Predictor of Autosomal Dominant Polycystic Kidney Disease Progression".

    Yu, Alan S L / El Ters, Mireille / Stubbs, Jason R

    Kidney international reports

    2021  Volume 6, Issue 5, Page(s) 1482–1483

    Language English
    Publishing date 2021-03-27
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.03.878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Regulation of Epithelial Cell Functions by the Osmolality and Hydrostatic Pressure Gradients: A Possible Role of the Tight Junction as a Sensor.

    Tokuda, Shinsaku / Yu, Alan S L

    International journal of molecular sciences

    2019  Volume 20, Issue 14

    Abstract: Epithelia act as a barrier to the external environment. The extracellular environment constantly changes, and the epithelia are required to regulate their function in accordance with the changes in the environment. It has been reported that a difference ... ...

    Abstract Epithelia act as a barrier to the external environment. The extracellular environment constantly changes, and the epithelia are required to regulate their function in accordance with the changes in the environment. It has been reported that a difference of the environment between the apical and basal sides of epithelia such as osmolality and hydrostatic pressure affects various epithelial functions including transepithelial transport, cytoskeleton, and cell proliferation. In this paper, we review the regulation of epithelial functions by the gradients of osmolality and hydrostatic pressure. We also examine the significance of this regulation in pathological conditions especially focusing on the role of the hydrostatic pressure gradient in the pathogenesis of carcinomas. Furthermore, we discuss the mechanism by which epithelia sense the osmotic and hydrostatic pressure gradients and the possible role of the tight junction as a sensor of the extracellular environment to regulate epithelial functions.
    MeSH term(s) Animals ; Biological Transport ; Cytoskeleton/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Humans ; Hydrostatic Pressure ; Neoplasms/metabolism ; Neoplasms/pathology ; Osmolar Concentration ; Tight Junctions/metabolism
    Language English
    Publishing date 2019-07-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20143513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Paracellular transport as a strategy for energy conservation by multicellular organisms?

    Yu, Alan S L

    Tissue barriers

    2017  Volume 5, Issue 2, Page(s) e1301852

    Abstract: Paracellular transport of solutes and water accompanies transcellular transport across epithelial barriers and together they serve to maintain internal body composition. However, whether paracellular transport is necessary and why it evolved is unknown. ... ...

    Abstract Paracellular transport of solutes and water accompanies transcellular transport across epithelial barriers and together they serve to maintain internal body composition. However, whether paracellular transport is necessary and why it evolved is unknown. In this commentary I discuss our recent studies to address this question in the proximal tubule of the kidney. Paracellular reabsorption of sodium occurs in the proximal tubule and is mediated by claudin-2. However, deletion of claudin-2 in mice does not affect whole kidney sodium excretion because it can be completely compensated by downtream transcellular transport mechanisms. This occurs at the expense of increased oxygen consumption, tissue hypoxia and increased susceptibility to ischemic injury. It is concluded that paracellular transport acts as an energy saving mechanism to increase transport without consuming additional oxygen. It is speculated that this might be why paracellular transport evolved in leaky epithelia with high transport needs.
    Language English
    Publishing date 2017-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 2168-8370
    ISSN (online) 2168-8370
    DOI 10.1080/21688370.2017.1301852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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