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Article ; Online: Industry versus academia - a mid-life career switch.

Sherwood, Victoria

2022 Volume 606, Issue 7914, Page(s) 463

MeSH term(s)	Age Factors ; Career Choice ; Career Mobility ; Industry ; Universities
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Letter
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/d41586-022-01624-z
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Article: Water, land use change and 'new forests': what are the challenges for south-western Victoria?

Clifton, C / Daamen, C / Horne, A / Sherwood, J

Australian forestry. 2006 June, v. 69, no. 2

2006

Keywords	Eucalyptus globulus ; forest plantations ; land use change ; land use ; water resources ; water flow ; forests ; afforestation ; vegetation ; vegetation cover ; Victoria (Australia)
Language	English
Dates of publication	2006-06
Size	p. 95-100.
Document type	Article
ZDB-ID	349560-7
ISSN	0004-9158
ISSN	0004-9158
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: WNT signaling: an emerging mediator of cancer cell metabolism?

Sherwood, Victoria

Molecular and cellular biology

2015 Volume 35, Issue 1, Page(s) 2–10

Abstract: WNT signaling was discovered in tumor models and has been recognized as a regulator of cancer development and progression for over 3 decades. Recent work has highlighted a critical role for WNT signaling in the metabolic homeostasis of mammals, where its ...

Abstract	WNT signaling was discovered in tumor models and has been recognized as a regulator of cancer development and progression for over 3 decades. Recent work has highlighted a critical role for WNT signaling in the metabolic homeostasis of mammals, where its misregulation has been heavily implicated in diabetes. While the majority of WNT metabolism research has focused on nontransformed tissues, the role of WNT in cancer metabolism remains underinvestigated. Cancer is also a metabolic disease where oncogenic signaling pathways regulate energy production and macromolecular synthesis to fuel rapidly proliferating tumors. This review highlights the emerging evidence for WNT signaling in the reprogramming of cancer cell metabolism and examines the role of these signaling pathways as mediators of tumor bioenergetics.
MeSH term(s)	Animals ; Carbohydrates/chemistry ; Cell Proliferation ; Energy Metabolism ; Gene Expression Regulation, Neoplastic ; Homeostasis ; Humans ; Neoplasms/metabolism ; Phosphorylation ; Wnt Proteins/metabolism ; Wnt Signaling Pathway
Chemical Substances	Carbohydrates ; Wnt Proteins
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.00992-14
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Article: How-I-do-it: Clinical fMRI: Where do I start?

Sherwood, Victoria / Pavlin, Tina

Magnetom flash

2019 Volume -, Issue 4 = Nr. 75, Page(s) 55

Language	English
Document type	Article
ZDB-ID	2465783-9
Database	Current Contents Medicine

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Book ; Online: Range chart of calcareous nannofossils in samples of sediment core CRP-3 (Table 1), supplementary data to: Watkins, David K; Wise, Sherwood W; Villa, Giuliana (2001): Calcareous nannofossils from Cape Roberts Project drillhole CRP-3 Victoria Land Basin, Antarctica. Terra Antartica, 8(4), 339-346

Watkins, David K / Villa, Giuliana / Wise, Sherwood W

2001

Abstract: ... with the almost total exclusion of Coccolithus pelagicus, indicates cold surface water conditions in the Victoria ...

Abstract	Fossil specimens of the exclusively oceanic calcareous nannoplankton were found only in the upper 200 m of the Cape Roberts Project 3 (CRP-3) cores. These assemblages are depauperate and sporadic in occurrence. The majority of the assemblages contain fewer than 4 species, indicating a severe palaeoecological restriction. The clear domination of these assemblages by reticulofenestrid species, coupled with the almost total exclusion of Coccolithus pelagicus, indicates cold surface water conditions in the Victoria Land Basin during the lives of these poor algae. These cold surface water conditions, perhaps coupled with abnormal surface water chemistry, excluded almost all of the age-diagnostic species from the area. The occurrence of Transversopontis pulcheroides, however, suggests a biostratigraphic assignment of lower Oligocene for this part of the core. The CRP-3 assemblages occur within fine-grained clastic sedimentary rocks, but only those that are in close stratigraphical proximity with coarser-grained lithologies.
Language	English
Dates of publication	2001-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to hdl:10013/epic.28238.d001
DOI	10.1594/PANGAEA.484682
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism?

Sherwood, Victoria

Molecular and Cellular Biology. 2015 Jan. 1, v. 35, no. 1 p.2-10

2015

Abstract	WNT signaling was discovered in tumor models and has been recognized as a regulator of cancer development and progression for over 3 decades. Recent work has highlighted a critical role for WNT signaling in the metabolic homeostasis of mammals, where its misregulation has been heavily implicated in diabetes. While the majority of WNT metabolism research has focused on nontransformed tissues, the role of WNT in cancer metabolism remains underinvestigated. Cancer is also a metabolic disease where oncogenic signaling pathways regulate energy production and macromolecular synthesis to fuel rapidly proliferating tumors. This review highlights the emerging evidence for WNT signaling in the reprogramming of cancer cell metabolism and examines the role of these signaling pathways as mediators of tumor bioenergetics.
Keywords	carcinogenesis ; diabetes ; energy ; energy metabolism ; homeostasis ; neoplasm cells ; neoplasms
Language	English
Dates of publication	2015-0101
Size	p. 2-10.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.00992-14
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

Sherwood, Victoria / Leigh, Irene M

The Journal of investigative dermatology

2016 Volume 136, Issue 9, Page(s) 1760–1767

Abstract: The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than those for other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and ... ...

Abstract	The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than those for other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cutaneous squamous cell carcinoma. WNT pathways are aberrantly regulated in multiple tumor types (albeit in a context-dependent manner), and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cutaneous squamous cell carcinoma and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.
MeSH term(s)	Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/physiopathology ; Forecasting ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Molecular Targeted Therapy/methods ; Molecular Targeted Therapy/trends ; Risk Assessment ; Skin Neoplasms/drug therapy ; Skin Neoplasms/genetics ; Skin Neoplasms/physiopathology ; Treatment Outcome ; Wnt Signaling Pathway/genetics
Language	English
Publishing date	2016-07-19
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2016.05.108
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Article ; Online: Paracetamol-induced liver injury modelled in Xenopus laevis embryos.

Saide, Katy / Sherwood, Victoria / Wheeler, Grant N

Toxicology letters

2018 Volume 302, Page(s) 83–91

Abstract: Introduction: Failure to predict drug-induced liver injury (DILI) remains a major contributing factor to lead compound drop-out during drug development. Xenopus embryos are amenable for early stage medium throughput small molecule screens and so have ... ...

Abstract	Introduction: Failure to predict drug-induced liver injury (DILI) remains a major contributing factor to lead compound drop-out during drug development. Xenopus embryos are amenable for early stage medium throughput small molecule screens and so have the potential to be used in pre-clinical screens. To begin to assess the usefulness and limitations of Xenopus embryos for safety assessment in the early phases of drug development, paracetamol was used as a model hepatotoxin. Paracetamol overdose is associated with acute liver injury. In mammals, the main mechanism of paracetamol-induced acute liver injury is an increased amount of the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) combined with a reduction of free glutathione (GSH). Humans that have taken an overdose of paracetamol are often treated with N-acetyl cysteine (NAC). Method: Xenopus laevis embryos were treated with up to 5 mM paracetamol from stage 38 to stage 45 during development, when the liver is functional. The presence of paracetamol-induced liver injury was assessed by: (1) microRNA-122 (miR-122) expression (a hepatic marker), (2) free GSH concentration (a marker of oxidative stress) and (3) NAC antioxidant intervention. Results: The amount of free GSH decreased significantly in embryos exposed to increasing paracetamol concentration. In embryos exposed to 5 mM paracetamol, 22.57 ± 4.25 nmol/mg GSH was detected compared to 47.11 ± 7.31 nmol/mg untreated embryos (mean ± SEM). In tail tissue, miRNA-122 expression increased 6.3-fold with 3 mM paracetamol concentration treatment compared to untreated embryos. NAC treatment altered the free GSH decline for embryos treated with up to 5 mM. Embryos exposed to 1 mM paracetamol and then exposed to 0.5 mM NAC 24 h prior to harvest, had a significantly higher amount of GSH compared to embryos that were only exposed to 1 mM paracetamol (mean ± SEM; 97.1 ± 9.6 nmol/mg and 54.5 ± 6.6 nmol/mg respectively). Conclusion: Xenopus laevis embryos exhibit similar characteristics of paracetamol-induced liver injury observed in mammalian models. These data indicate that the Xenopus embryo could be a useful in vivo model to assess DILI and aid lead compound prioritisation during the early phase of drug development, in combination with pre-clinical in vitro studies. Consequently, the Xenopus embryo could contribute to the reduction principle as defined by the National Centre for the Replacement, Refinement and Reduction of Animals in Research.
MeSH term(s)	Acetaminophen/toxicity ; Analgesics, Non-Narcotic/toxicity ; Animals ; Antioxidants/pharmacology ; Biomarkers/metabolism ; Chemical and Drug Induced Liver Injury/embryology ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Dose-Response Relationship, Drug ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/metabolism ; Embryo, Nonmammalian/pathology ; Glutathione/metabolism ; Liver/drug effects ; Liver/embryology ; Liver/metabolism ; Liver/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Oxidative Stress/drug effects ; Xenopus laevis/embryology
Chemical Substances	Analgesics, Non-Narcotic ; Antioxidants ; Biomarkers ; MicroRNAs ; Acetaminophen (362O9ITL9D) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2018-09-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2018.09.016
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Book ; Online: (Table 1) Description of grain size, cement, and matrix in sediment core CRP-3 sandstones, supplementary data to: Wise, Sherwood W; Smellie, John L; Aghib, Fulvia Sharon; Jarrard, Richard D; Krissek, Lawrence A (2001): Authigenic smectite clay coats in CRP-3 drillcore, Victoria Land Basin, Antarctica, as a possible indicator of fluid flow: a progress report. Terra Antartica, 8(3), 281-298

Wise, Sherwood W / Aghib, Fulvia Sharon / Jarrard, Richard D / Krissek, Lawrence A / Smellie, John L

2001

Abstract: ... core CRP-3 from the Victoria Land Basin of Antarctica is confirmed by scanning electron, scanning ...

Abstract	The presence of authigenic smectite in the lower Oligocene sandstones of the Cape Roberts Project core CRP-3 from the Victoria Land Basin of Antarctica is confirmed by scanning electron, scanning-transmission electron, and light microscopy. It was emplaced as a single generation of cement within the lower portion of the Oligocene section. This section has undergone no discernible compaction since cementation. Permeabilities measured on fifty core plugs show that the lower portion of the Oligocene (from 370-766 meters below sea floor) also has systematically higher values than sediment in uppermost CRP-3 and all of CRP-2 and CRP-1. Three models for smectite authigenesis are considered as multiple working hypotheses to be tested: 1) Burial diagenesis with necessary components sourced from volcanogenic materials and heavy minerals within the drilled sequence: 2) Precipitation from hydrothermal waters associated with possible igneous intrusion(s) and nearby faults; 3) Mobilization and injection of regionally compactive 'thermobaric' fluids along a nearby fault that bounds a major graben parallel to the Transantarctic Mountain Front. The preponderance of the available evidence and Occum's Razor favors the first model, although special circumstances dictated by the position of the drill site along a rapidly subsiding rift basin require that all three models be considered equally until our analyses are complete.
Language	English
Dates of publication	2001-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to hdl:10013/epic.28200.d001
DOI	10.1594/PANGAEA.466043
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Quantification and correction of distortion in diffusion-weighted MRI at 1.5 and 3 T in a muscle-invasive bladder cancer phantom for radiotherapy planning.

Rogers, Jane / Sherwood, Victoria / Wayte, Sarah C / Duffy, Jonathan A / Manolopoulos, Spyros

The British journal of radiology

2020 Volume 93, Issue 1114, Page(s) 20190710

Abstract: Objective: Limited visibility of post-resection muscle-invasive bladder cancer (MIBC) on CT hinders radiotherapy dose escalation of the residual tumour. Diffusion-weighted MRI (DW-MRI) visualises areas of high tumour burden and is increasingly used ... ...

Abstract	Objective: Limited visibility of post-resection muscle-invasive bladder cancer (MIBC) on CT hinders radiotherapy dose escalation of the residual tumour. Diffusion-weighted MRI (DW-MRI) visualises areas of high tumour burden and is increasingly used within diagnosis and as a biomarker for cancer. DW-MRI could, therefore, facilitate dose escalation, potentially via dose-painting and/or accommodating response. However, the distortion inherent in DW-MRI could limit geometric accuracy. Therefore, this study aims to quantify DW-MRI distortion via imaging of a bladder phantom. Methods: A phantom was designed to mimic MIBC and imaged using CT, DW-MRI and T2W-MRI. Fiducial marker locations were compared across modalities and publicly available software was assessed for correction of magnetic susceptibility-related distortion. Results: Fiducial marker locations on CT and T2W-MRI agreed within 1.2 mm at 3 T and 1.8 mm at 1.5 T. The greatest discrepancy between CT and apparent diffusion coefficient (ADC) maps was 6.3 mm at 3 T, reducing to 1.8 mm when corrected for distortion. At 1.5 T, these values were 3.9 mm and 1.7 mm, respectively. Conclusions: Geometric distortion in DW-MRI of a model bladder was initially >6 mm at 3 T and >3 mm at 1.5 T; however, established correction methods reduced this to <2 mm in both cases. Advances in knowledge: A phantom designed to mimic MIBC has been produced and used to show distortion in DW-MRI can be sufficiently mitigated for incorporation into the radiotherapy pathway. Further investigation is therefore warranted to enable individually adaptive image-guided radiotherapy of MIBC based upon DW-MRI.
MeSH term(s)	Diffusion Magnetic Resonance Imaging/methods ; Fiducial Markers ; Humans ; Image Enhancement/methods ; Neoplasm Invasiveness ; Phantoms, Imaging ; Radiotherapy, Image-Guided ; Tomography, X-Ray Computed ; Urinary Bladder Neoplasms/diagnostic imaging ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/radiotherapy
Language	English
Publishing date	2020-08-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20190710
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