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  1. Article ; Online: GSK3β and the aging kidney.

    Kreidberg, Jordan A / Schumacher, Valerie A

    The Journal of clinical investigation

    2022  Volume 132, Issue 4

    Abstract: Kidney function decreases with age and may soon limit millions of lives as the proportion of the population over 70 years of age increases. Glycogen synthase kinase 3β (GSK3β) is involved with metabolism and may have a role in kidney senescence, ... ...

    Abstract Kidney function decreases with age and may soon limit millions of lives as the proportion of the population over 70 years of age increases. Glycogen synthase kinase 3β (GSK3β) is involved with metabolism and may have a role in kidney senescence, positioning it as a target for complications from chronic kidney disease. However, different studies suggest GSK3 has contrasting effects. In this issue of the JCI, Fang et al. explored the function of GSK3β and the interplay with lithium using human tissue and mouse models. Notably, GSK3β was overexpressed and activated in aging mice, and depleting GSK3β reduced senescence and glomerular aging. In this Commentary, we explore the similarities and differences between Fang et al. and previous findings by Hurcombe et al. These findings should prompt further study of lithium and other GSK3β inhibitors as a means of extending glomerular function in individuals with chronic kidney disease.
    MeSH term(s) Aging ; Animals ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Kidney ; Kidney Glomerulus/metabolism ; Mice
    Chemical Substances Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26)
    Language English
    Publishing date 2022-01-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI155885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: GSK3β and the aging kidney

    Jordan A. Kreidberg / Valerie A. Schumacher

    The Journal of Clinical Investigation, Vol 132, Iss

    2022  Volume 4

    Abstract: Kidney function decreases with age and may soon limit millions of lives as the proportion of the population over 70 years of age increases. Glycogen synthase kinase 3β (GSK3β) is involved with metabolism and may have a role in kidney senescence, ... ...

    Abstract Kidney function decreases with age and may soon limit millions of lives as the proportion of the population over 70 years of age increases. Glycogen synthase kinase 3β (GSK3β) is involved with metabolism and may have a role in kidney senescence, positioning it as a target for complications from chronic kidney disease. However, different studies suggest GSK3 has contrasting effects. In this issue of the JCI, Fang et al. explored the function of GSK3β and the interplay with lithium using human tissue and mouse models. Notably, GSK3β was overexpressed and activated in aging mice, and depleting GSK3β reduced senescence and glomerular aging. In this Commentary, we explore the similarities and differences between Fang et al. and previous findings by Hurcombe et al. These findings should prompt further study of lithium and other GSK3β inhibitors as a means of extending glomerular function in individuals with chronic kidney disease.
    Keywords Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Bmp7 drives proximal tubule expansion and determines nephron number in the developing kidney.

    Taglienti, Mary / Graf, Daniel / Schumacher, Valerie / Kreidberg, Jordan A

    Development (Cambridge, England)

    2022  Volume 149, Issue 14

    Abstract: The mammalian kidney is composed of thousands of nephrons that are formed through reiterative induction of a mesenchymal-to-epithelial transformation by a population of nephron progenitor cells. The number of nephrons in human kidneys ranges from several ...

    Abstract The mammalian kidney is composed of thousands of nephrons that are formed through reiterative induction of a mesenchymal-to-epithelial transformation by a population of nephron progenitor cells. The number of nephrons in human kidneys ranges from several hundred thousand to nearly a million, and low nephron number has been implicated as a risk factor for kidney disease as an adult. Bmp7 is among a small number of growth factors required to support the proliferation and self-renewal of nephron progenitor cells, in a process that will largely determine the final nephron number. Once induced, each nephron begins as a simple tubule that undergoes extensive proliferation and segmental differentiation. Bmp7 is expressed both by nephron progenitor cells and the ureteric bud derivative branches that induce new nephrons. Here, we show that, in mice, Bmp7 expressed by progenitor cells has a major role in determining nephron number; nephron number is reduced to one tenth its normal value in its absence. Postnatally, Bmp7 also drives proliferation of the proximal tubule cells, and these ultimately constitute the largest segment of the nephron. Bmp7 appears to act through Smad 1,5,9(8), p38 and JNK MAP kinase. In the absence of Bmp7, nephrons undergo a hypertrophic process that involves p38. Following a global inactivation of Bmp7, we also see evidence for Bmp7-driven growth of the nephron postnatally. Thus, we identify a role for Bmp7 in supporting the progenitor population and driving expansion of nephrons to produce a mature kidney.
    MeSH term(s) Animals ; Bone Morphogenetic Protein 7/metabolism ; Cell Differentiation ; Humans ; Kidney ; Kidney Tubules, Proximal ; Mammals ; Mice ; Nephrons/metabolism ; Stem Cells
    Chemical Substances BMP7 protein, human ; Bone Morphogenetic Protein 7 ; bmp7 protein, mouse
    Language English
    Publishing date 2022-07-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.200773
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  4. Article ; Online: siRNA therapy for glomerulonephritis.

    Kreidberg, Jordan A

    Journal of the American Society of Nephrology : JASN

    2010  Volume 21, Issue 4, Page(s) 549–551

    MeSH term(s) Animals ; Genetic Therapy/methods ; Glomerulonephritis/genetics ; Glomerulonephritis/therapy ; RNA, Small Interfering
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2010-04
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2010020177
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  5. Article ; Online: Introduction to the 12th International Workshop on Developmental Nephrology.

    Kreidberg, Jordan

    Pediatric nephrology (Berlin, Germany)

    2014  Volume 29, Issue 4, Page(s) 497–498

    MeSH term(s) Animals ; Humans ; Kidney/embryology ; Nephrology
    Language English
    Publishing date 2014-04
    Publishing country Germany
    Document type Editorial ; Overall
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-013-2739-6
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  6. Article ; Online: WT1 and kidney progenitor cells.

    Kreidberg, Jordan A

    Organogenesis

    2010  Volume 6, Issue 2, Page(s) 61–70

    Abstract: Kidney development has been studied over the past sixty years as a model of embryonic induction during organogenesis. Wilms' tumor-1 (WT1), that encodes a transcription factor and RNA-binding protein, was one of the first tumor suppressor genes ... ...

    Abstract Kidney development has been studied over the past sixty years as a model of embryonic induction during organogenesis. Wilms' tumor-1 (WT1), that encodes a transcription factor and RNA-binding protein, was one of the first tumor suppressor genes identified, and was soon thereafter shown to be associated with syndromic forms of childhood kidney disease and gonadal dysgenesis. Kidney agenesis, resulting from a null mutation in the WT1 gene, was one of the first examples of organ agenesis resulting from a gene targeting experiment. Thus, the study of the WT1 gene and its encoded proteins has been at the forefront of developmental biology, tumor biology and the molecular basis for disease. WT1 is now known to have an important role in kidney progenitor cells during development. This review will discuss recent advances in our understanding of kidney progenitor cells, and the recent identification of WT1 target genes in these cells.
    MeSH term(s) Gene Expression Regulation, Developmental ; Humans ; Kidney/cytology ; Kidney/embryology ; Kidney/metabolism ; Nephrons/cytology ; Nephrons/embryology ; Nephrons/metabolism ; Signal Transduction/genetics ; Stem Cells/cytology ; Stem Cells/metabolism ; WT1 Proteins/genetics ; WT1 Proteins/metabolism
    Chemical Substances WT1 Proteins
    Language English
    Publishing date 2010-09-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2159583-5
    ISSN 1555-8592 ; 1555-8592
    ISSN (online) 1555-8592
    ISSN 1555-8592
    DOI 10.4161/org.6.2.11928
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  7. Article ; Online: Integrins and matrix in the glomerulus: old mysteries and new insights.

    Kreidberg, Jordan A

    Journal of the American Society of Nephrology : JASN

    2008  Volume 19, Issue 4, Page(s) 650–651

    MeSH term(s) Animals ; Extracellular Matrix/physiology ; Humans ; Integrins/physiology ; Kidney Glomerulus/physiology
    Chemical Substances Integrins
    Language English
    Publishing date 2008-04
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2008020160
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  8. Article ; Online: The long and short of microRNAs in the kidney.

    Ho, Jacqueline / Kreidberg, Jordan A

    Journal of the American Society of Nephrology : JASN

    2012  Volume 23, Issue 3, Page(s) 400–404

    Abstract: MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that ...

    Abstract MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that up to half of all transcripts are regulated by miRNAs. Recent studies also demonstrate a critical role for miRNAs in renal development, physiology, and pathophysiology. Understanding the function of miRNAs in the kidney may lead to innovative approaches to renal disease.
    MeSH term(s) Animals ; Disease Models, Animal ; Gene Expression Regulation/physiology ; Humans ; Kidney/embryology ; Kidney/physiology ; Kidney/physiopathology ; Kidney Diseases/physiopathology ; MicroRNAs/physiology ; Transcription, Genetic/physiology
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2012-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2011080797
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  9. Article ; Online: MicroRNAs in renal development.

    Ho, Jacqueline / Kreidberg, Jordan A

    Pediatric nephrology (Berlin, Germany)

    2012  Volume 28, Issue 2, Page(s) 219–225

    Abstract: The discovery of microRNAs (miRNAs) as novel regulators of gene expression has led to a marked change in how gene regulation is viewed, with important implications for development and disease. MiRNAs are endogenous, small, noncoding RNAs that largely ... ...

    Abstract The discovery of microRNAs (miRNAs) as novel regulators of gene expression has led to a marked change in how gene regulation is viewed, with important implications for development and disease. MiRNAs are endogenous, small, noncoding RNAs that largely repress their target mRNAs post-transcriptionally. The regulation of gene expression by miRNAs represents an evolutionarily conserved mechanism that is broadly applicable to most biological processes. Recent studies have begun to define the role of miRNAs in different cell lineages during kidney development, and to implicate specific miRNAs in developmental and pathophysiological processes in the kidney. This review will focus on novel insights into the role(s) of miRNAs in kidney development, and discuss the implications for pediatric renal disease.
    MeSH term(s) Gene Expression Regulation ; Humans ; Kidney/embryology ; Kidney/metabolism ; Kidney Diseases/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2012-06-02
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-012-2204-y
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  10. Article: Podocyte differentiation and glomerulogenesis.

    Kreidberg, Jordan A

    Journal of the American Society of Nephrology : JASN

    2003  Volume 14, Issue 3, Page(s) 806–814

    MeSH term(s) Animals ; Cell Differentiation/physiology ; Humans ; Kidney Glomerulus/cytology ; Kidney Glomerulus/embryology
    Language English
    Publishing date 2003-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1097/01.asn.0000054887.42550.14
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