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  1. Article ; Online: C

    Zhao, Yulei / Li, Shuai / Fan, Yuhang / Cao, Jun / Dong, Xiaotong / Wang, Ruiqing / Tian, Laijin

    Organic letters

    2023  Volume 25, Issue 31, Page(s) 5911–5915

    Abstract: An unprecedented ... ...

    Abstract An unprecedented C
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c02283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Catalyst-Free

    Dong, Xiaotong / Liu, Xiaonuo / Wang, Lei / Zhang, Yixuan / Li, Jiale / Tian, Laijin / Zhao, Yulei

    Organic letters

    2023  Volume 25, Issue 48, Page(s) 8771–8776

    Abstract: A catalyst- ... ...

    Abstract A catalyst-free
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Electrochemical Syntheses of Polycyclic Aromatic Hydrocarbons (PAHs).

    Wang, Yulei / Zhao, Rong / Ackermann, Lutz

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 35, Issue 49, Page(s) e2300760

    Abstract: Polycyclic aromatic hydrocarbons (PAHs) have surfaced as increasingly viable components in optoelectronics and material sciences. The development of highly efficient and atom-economic tools to prepare PAHs under exceedingly mild conditions constitutes a ... ...

    Abstract Polycyclic aromatic hydrocarbons (PAHs) have surfaced as increasingly viable components in optoelectronics and material sciences. The development of highly efficient and atom-economic tools to prepare PAHs under exceedingly mild conditions constitutes a long-term goal. Traditional syntheses of PAHs have largely relied on multistep approaches or the conventional Scholl reaction. However, Scholl reactions are largely inefficient with electron-deficient substrates, require stoichiometric chemical oxidants, and typically occur in the presence of strong acid. In sharp contrast, electrochemistry has gained considerable momentum during the past decade as an alternative for the facile and straightforward PAHs assembly, generally via electro-oxidative dehydrogenative annulation, releasing molecular hydrogen as the sole stoichiometric byproduct by the hydrogen evolution reaction. This review provides an overview on the recent and significant advances in the field of electrochemical syntheses of various PAHs until January 2023.
    Language English
    Publishing date 2023-10-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202300760
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  4. Article ; Online: Establishment of an induced pluripotent stem cell (SIAISi016-A) line from a 62-years old Chinese Han patient with Alzheimer's disease

    Juan Huang / Ying Wang / Jian Zhao / Yulei Deng / Wenshi Wei

    Stem Cell Research, Vol 69, Iss , Pp 103091- (2023)

    2023  

    Abstract: A 62-years old Alzheimer's disease (AD) male patient donated his Peripheral blood mononuclear cells. The non-integrating episomal vector system used to reprogram PBMCs with Oct3/4, Klf4, Sox2 and c-Myc transcription factors. The pluripotency of transgene- ...

    Abstract A 62-years old Alzheimer's disease (AD) male patient donated his Peripheral blood mononuclear cells. The non-integrating episomal vector system used to reprogram PBMCs with Oct3/4, Klf4, Sox2 and c-Myc transcription factors. The pluripotency of transgene-free pluripotent stem cell (iPSC) was confirmed by immunocytochemistry for pluripotency markers-SOX2, NANOG, OCT3/4, SSEA4, TRA1-60, and TRA1-81. The differentiation capacity of the iPSCs into endoderm, mesoderm and ectoderm was assessed by AFP, SMA and βIII-TUBULIN, respectively. In addition, the iPSC line displayed a normal karyotype. This iPSC line might offer a good cell model to explore the pathological mechanisms and treatment strategies for AD.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: CO

    Fan, Yuhang / Chen, Chao / Zhang, Zhanshuo / Meng, Xiaohan / Liu, Xiaonuo / Cao, Jun / Jiang, Yuan-Ye / Zhao, Yulei

    Organic letters

    2023  Volume 25, Issue 51, Page(s) 9202–9206

    Abstract: An unprecedented transient promotion function (TPF) of ... ...

    Abstract An unprecedented transient promotion function (TPF) of CO
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Path Planning for Autonomous Vehicles in Unknown Dynamic Environment Based on Deep Reinforcement Learning

    Hui Hu / Yuge Wang / Wenjie Tong / Jiao Zhao / Yulei Gu

    Applied Sciences, Vol 13, Iss 10056, p

    2023  Volume 10056

    Abstract: Autonomous vehicles can reduce labor power during cargo transportation, and then improve transportation efficiency, for example, the automated guided vehicle (AGV) in the warehouse can improve the operation efficiency. To overcome the limitations of ... ...

    Abstract Autonomous vehicles can reduce labor power during cargo transportation, and then improve transportation efficiency, for example, the automated guided vehicle (AGV) in the warehouse can improve the operation efficiency. To overcome the limitations of traditional path planning algorithms in unknown environments, such as reliance on high-precision maps, lack of generalization ability, and obstacle avoidance capability, this study focuses on investigating the Deep Q-Network and its derivative algorithm to enhance network and algorithm structures. A new algorithm named APF-D3QNPER is proposed, which combines the action output method of artificial potential field (APF) with the Dueling Double Deep Q Network algorithm, and experience sample rewards are considered in the experience playback portion of the traditional Deep Reinforcement Learning (DRL) algorithm, which enhances the convergence ability of the traditional DRL algorithm. A long short-term memory (LSTM) network is added to the state feature extraction network part to improve its adaptability in unknown environments and enhance its spatiotemporal sensitivity to the environment. The APF-D3QNPER algorithm is compared with mainstream deep reinforcement learning algorithms and traditional path planning algorithms using a robot operating system and the Gazebo simulation platform by conducting experiments. The results demonstrate that the APF-D3QNPER algorithm exhibits excellent generalization abilities in the simulation environment, and the convergence speed, the loss value, the path planning time, and the path planning length of the APF-D3QNPER algorithm are all less than for other algorithms in diverse scenarios.
    Keywords deep reinforcement learning ; autonomous vehicle ; path planning ; DQN algorithm ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 629
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Transcriptomic analysis provides an insight into the function of CmGH9B3, a key gene of β-1, 4-glucanase, during the graft union healing of oriental melon scion grafted onto squash rootstock.

    Zhu, Yulei / Hu, Shengwei / Min, Jiahuan / Zhao, Yingtong / Yu, Hanqi / Irfan, Muhammad / Xu, Chuanqiang

    Biotechnology journal

    2024  Volume 19, Issue 4, Page(s) e2400006

    Abstract: The melon (Cucumis melo L.) is a globally cherished and economically significant crop. The grafting technique has been widely used in the vegetative propagation of melon to promote environmental tolerance and disease resistance. However, mechanisms ... ...

    Abstract The melon (Cucumis melo L.) is a globally cherished and economically significant crop. The grafting technique has been widely used in the vegetative propagation of melon to promote environmental tolerance and disease resistance. However, mechanisms governing graft healing and potential incompatibilities in melons following the grafting process remain unknown. To uncover the molecular mechanism of healing of grafted melon seedlings, melon wild type (Control) and TRV-CmGH9B3 lines were obtained and grafted onto the squash rootstocks (C. moschata). Anatomical differences indicated that the healing process of the TRV-CmGH9B3 plants was slower than that of the control. A total of 335 significantly differentially expressed genes (DEGs) were detected between two transcriptomes. Most of these DEGs were down-regulated in TRV-CmGH9B3 grafted seedlings. GO and KEGG analysis showed that many metabolic, physiological, and hormonal responses were involved in graft healing, including metabolic processes, plant hormone signaling, plant MAPK pathway, and sucrose starch pathway. During the healing process of TRV-CmGH9B3 grafted seedlings, gene synthesis related to hormone signal transduction (auxin, cytokinin, gibberellin, brassinolide) was delayed. At the same time, it was found that most of the DEGs related to the sucrose pathway were down-regulated in TRV-CmGH9B3 grafted seedlings. The results showed that sugar was also involved in the healing process of melon grafted onto squash. These results deepened our understanding of the molecular mechanism of GH9B3, a key gene of β-1, 4-glucanase. It also provided a reference for elucidating the gene mechanism and function analysis of CmGH9B3 in the process of graft union healing.
    MeSH term(s) Cucumis melo/genetics ; Cucumis melo/metabolism ; Gene Expression Profiling ; Cucurbita/genetics ; Cucurbita/metabolism ; Cucurbitaceae/genetics ; Sucrose/metabolism
    Chemical Substances Sucrose (57-50-1)
    Language English
    Publishing date 2024-04-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2221885-3
    ISSN 1860-7314 ; 1860-6768
    ISSN (online) 1860-7314
    ISSN 1860-6768
    DOI 10.1002/biot.202400006
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    Zs.A 6349: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Establishment of an induced pluripotent stem cell (SIAISi016-A) line from a 62-years old Chinese Han patient with Alzheimer's disease.

    Huang, Juan / Wang, Ying / Zhao, Jian / Deng, Yulei / Wei, Wenshi

    Stem cell research

    2023  Volume 69, Page(s) 103091

    Abstract: A 62-years old Alzheimer's disease (AD) male patient donated his Peripheral blood mononuclear cells. The non-integrating episomal vector system used to reprogram PBMCs with Oct3/4, Klf4, Sox2 and c-Myc transcription factors. The pluripotency of transgene- ...

    Abstract A 62-years old Alzheimer's disease (AD) male patient donated his Peripheral blood mononuclear cells. The non-integrating episomal vector system used to reprogram PBMCs with Oct3/4, Klf4, Sox2 and c-Myc transcription factors. The pluripotency of transgene-free pluripotent stem cell (iPSC) was confirmed by immunocytochemistry for pluripotency markers-SOX2, NANOG, OCT3/4, SSEA4, TRA1-60, and TRA1-81. The differentiation capacity of the iPSCs into endoderm, mesoderm and ectoderm was assessed by AFP, SMA and βIII-TUBULIN, respectively. In addition, the iPSC line displayed a normal karyotype. This iPSC line might offer a good cell model to explore the pathological mechanisms and treatment strategies for AD.
    MeSH term(s) Humans ; Male ; Middle Aged ; Alzheimer Disease/pathology ; Cell Differentiation ; East Asian People ; Induced Pluripotent Stem Cells/cytology ; Leukocytes, Mononuclear/pathology ; Cell Line
    Language English
    Publishing date 2023-04-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2023.103091
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  9. Article ; Online: Factors associated with clopidogrel resistance and clinical outcomes in ischemic cerebrovascular disease: A retrospective study.

    Wu, Yanzi / Shen, Huachao / Cai, Biyang / Chen, Chen / Yin, Qiong / Zhao, Yulei / Zhou, Guohua

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2024  Volume 33, Issue 6, Page(s) 107684

    Abstract: Objective: Clopidogrel resistance may lead to the recurrence of cerebrovascular diseases. We aimed to identify potential factors associated with clopidogrel resistance and evaluate the clinical outcomes of the patients.: Materials and methods: In ... ...

    Abstract Objective: Clopidogrel resistance may lead to the recurrence of cerebrovascular diseases. We aimed to identify potential factors associated with clopidogrel resistance and evaluate the clinical outcomes of the patients.
    Materials and methods: In this retrospective study, patients with ischemic cerebrovascular disease treated with clopidogrel were included and classified into 2 groups according to the adenosine diphosphate (ADP)-induced platelet aggregation. Patients with the ADP inhibition rate of <30 % were included in clopidogrel resistance group, otherwise were included in clopidogrel sensitive group. CYP2C19 genotype and other clinical data were analyzed to identify factors and clinical features in the multivariate analysis. The outcomes were vascular events in 6 months.
    Results: In total, 139 patients were enrolled with 81 (58.27 %) in clopidogrel sensitive group and 58 (41.73 %) in clopidogrel resistance group. Female and CYP2C19 *2*3 carrying were risk factors for clopidogrel resistance, and female was an independent risk factor (OR 2.481, 95 % CI 1.066-5.771, P=0.035). The clopidogrel resistance group showed a higher use rate of argatroban (P=0.030) and a lower arachidonic acid-induced inhibition of platelet aggregation (P=0.036). Clopidogrel resistance was related to the progressing stroke (HR 3.521, 95 % CI 1.352-9.170, P=0.010), but had no influence on the bleeding events (P>0.05).
    Conclusions: The risk of clopidogrel resistance increased significantly in female patients. Patients with clopidogrel resistance may have an increased incidence of stroke progression in the acute phase.
    MeSH term(s) Humans ; Clopidogrel/therapeutic use ; Clopidogrel/adverse effects ; Female ; Retrospective Studies ; Male ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Drug Resistance ; Aged ; Middle Aged ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2C19/metabolism ; Risk Factors ; Treatment Outcome ; Platelet Aggregation/drug effects ; Pharmacogenomic Variants ; Time Factors ; Platelet Function Tests ; Risk Assessment ; Sex Factors ; Brain Ischemia/drug therapy ; Brain Ischemia/diagnosis ; Recurrence ; Ischemic Stroke/drug therapy ; Ischemic Stroke/diagnosis
    Chemical Substances Clopidogrel (A74586SNO7) ; Platelet Aggregation Inhibitors ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; CYP2C19 protein, human (EC 1.14.14.1)
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2024.107684
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Expressions of interferon-stimulated genes in peripheral blood mononuclear cells from patients with secondary syphilis.

    Zhao, Yulei / Liu, Danmin

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2021  Volume 96, Page(s) 105137

    Abstract: Background: Syphilis is a sexually transmitted disease that threatens human health worldwide. However, the immune regulation cascade caused by treponemia pallidum (TP) infection remains still largely unclear.: Methods: To investigate the expression ... ...

    Abstract Background: Syphilis is a sexually transmitted disease that threatens human health worldwide. However, the immune regulation cascade caused by treponemia pallidum (TP) infection remains still largely unclear.
    Methods: To investigate the expression of ISGs in secondary syphilis (SS), we recruited 64 patients with SS and equal number of healthy participants to obtain their peripheral blood mononuclear cells (PBMCs). qRT-PCR was performed to estimate the expression of interferon-stimulated genes (ISGs) including CXCL10, OAS3, OAS1, MX1, IFIT3, IFIT2, IFI6 and AIM2. Receiver-operating characteristic (ROC) analysis was adapted to diagnostic value of these genes to distinguish healthy controls and patients with SS.
    Results: ISGs including CXCL10, OAS3, OAS1, MX1, IFIT3, IFIT2, IFI6 and AIM2 were all upregulated in PBMCs of patients with SS. Area under the ROC curve (AUC) of the 8 ISGs were all more than 0.5. IFIT3 exhibited the highest diagnostic value, followed by AIM2, IFIT2 and CXCL10, according to the Yoden Index.
    Conclusion: ISGs including CXCL10, OAS3, OAS1, MX1, IFIT3, IFIT2, IFI6 and AIM2 were upregulated in patients with SS and they have diagnostic value for syphilis.
    MeSH term(s) Adult ; Female ; Humans ; Interferons/metabolism ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Syphilis/genetics ; Syphilis/microbiology ; Up-Regulation ; Young Adult
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2021-11-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2021.105137
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    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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