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  1. Article ; Online: Small is beautiful-a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism.

    Otto, Angela M

    Signal transduction and targeted therapy

    2020  Volume 5, Issue 1, Page(s) 259

    MeSH term(s) Animals ; Dihydroxyacetone Phosphate/metabolism ; Glucose/metabolism ; Glycolysis ; Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Neoplasm Proteins/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Second Messenger Systems
    Chemical Substances Neoplasm Proteins ; Dihydroxyacetone Phosphate (57-04-5) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-11-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-020-00371-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Metabolic Constants and Plasticity of Cancer Cells in a Limiting Glucose and Glutamine Microenvironment-A Pyruvate Perspective.

    Otto, Angela M

    Frontiers in oncology

    2020  Volume 10, Page(s) 596197

    Abstract: The metabolism of cancer cells is an issue of dealing with fluctuating and limiting levels of nutrients in a precarious microenvironment to ensure their vitality and propagation. Glucose and glutamine are central metabolites for catabolic and anabolic ... ...

    Abstract The metabolism of cancer cells is an issue of dealing with fluctuating and limiting levels of nutrients in a precarious microenvironment to ensure their vitality and propagation. Glucose and glutamine are central metabolites for catabolic and anabolic metabolism, which is in the limelight of numerous diagnostic methods and therapeutic targeting. Understanding tumor metabolism in conditions of nutrient depletion is important for such applications and for interpreting the readouts. To exemplify the metabolic network of tumor cells in a model system, the fate
    Language English
    Publishing date 2020-12-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.596197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism

    Angela M. Otto

    Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-

    2020  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Investigation of the first reported outbreak of New Delhi metallo-β-lactamase-1-producing

    Sopirala, Madhuri M / Hartless, Kathleen / Reid, Sherry / Christie-Smith, Angela / Fiveash, Jeanette / Badejogbin, Aderonke / Psenicka, Andrew Otto

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2024  Volume 3, Issue 1, Page(s) e251

    Abstract: We describe an epidemiologic investigation and successful control measures for the first reported outbreak of ... ...

    Abstract We describe an epidemiologic investigation and successful control measures for the first reported outbreak of bla
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Conversion of Hyperpolarized [1-

    Grashei, Martin / Biechl, Philipp / Schilling, Franz / Otto, Angela M

    Cancers

    2022  Volume 14, Issue 7

    Abstract: Hyperpolarized magnetic resonance spectroscopy (MRS) is a technology for characterizing tumors in vivo based on their metabolic activities. The conversion rates ( ...

    Abstract Hyperpolarized magnetic resonance spectroscopy (MRS) is a technology for characterizing tumors in vivo based on their metabolic activities. The conversion rates (
    Language English
    Publishing date 2022-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14071845
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  6. Article: Warburg effect(s)-a biographical sketch of Otto Warburg and his impacts on tumor metabolism.

    Otto, Angela M

    Cancer & metabolism

    2016  Volume 4, Page(s) 5

    Abstract: ... of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are ... a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical ... continued until his death in 1970. The legacy of Otto Warburg is not only the Warburg effect, but also ...

    Abstract Virtually everyone working in cancer research is familiar with the "Warburg effect", i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s-1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg's reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. World politics and world wars heavily affected Warburg's scientific survival in Berlin. But, after his second postwar recovery, Warburg's drive for unraveling the energetic processes of life, both in plants and in tumor cells, continued until his death in 1970. The legacy of Otto Warburg is not only the Warburg effect, but also the identification of the "respiratory ferment" and hydrogen-transferring cofactors and the isolation of glycolytic enzymes. His hypothesis of respiratory damage being the cause of cancer remains to be a provocative scientific issue, along with its implications for cancer treatment and prevention. Warburg is therefore still stimulating our thinking, as documented in a soaring increase in publications citing his name in the context of tumor metabolism.
    Language English
    Publishing date 2016-03-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2700141-6
    ISSN 2049-3002
    ISSN 2049-3002
    DOI 10.1186/s40170-016-0145-9
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  7. Article ; Online: Investigation of the first reported outbreak of New Delhi metallo-β-lactamase-1-producing Pseudomonas aeruginosa in Texas

    Madhuri M. Sopirala / Kathleen Hartless / Sherry Reid / Angela Christie-Smith / Jeanette Fiveash / Aderonke Badejogbin / Andrew Otto Psenicka

    Antimicrobial Stewardship & Healthcare Epidemiology, Vol

    2023  Volume 3

    Abstract: We describe an epidemiologic investigation and successful control measures for the first reported outbreak of blaNDM-1-carrying Pseudomonas aeruginosa in Texas occurring in a veteran with transmission of the same organism and a blaNDM-5-carrying ... ...

    Abstract We describe an epidemiologic investigation and successful control measures for the first reported outbreak of blaNDM-1-carrying Pseudomonas aeruginosa in Texas occurring in a veteran with transmission of the same organism and a blaNDM-5-carrying Escherichia coli, respectively, to two roommates and blaNDM-carrying organism/s to a patient cared for by common staff.
    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Updated reference values for static lung volumes from a healthy population in Austria.

    Mraz, Tobias / Asgari, Shervin / Karimi, Ahmad / Breyer, Marie-Kathrin / Hartl, Sylvia / Sunanta, Owat / Ofenheimer, Alina / Burghuber, Otto C / Zacharasiewicz, Angela / Lamprecht, Bernd / Schiffers, Caspar / Wouters, Emiel F M / Breyer-Kohansal, Robab

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 155

    Abstract: Background: Reference values for lung volumes are necessary to identify and diagnose restrictive lung diseases and hyperinflation, but the values have to be validated in the relevant population. Our aim was to investigate the Global Lung Function ... ...

    Abstract Background: Reference values for lung volumes are necessary to identify and diagnose restrictive lung diseases and hyperinflation, but the values have to be validated in the relevant population. Our aim was to investigate the Global Lung Function Initiative (GLI) reference equations in a representative healthy Austrian population and create population-derived reference equations if poor fit was observed.
    Methods: We analysed spirometry and body plethysmography data from 5371 respiratory healthy subjects (6-80 years) from the Austrian LEAD Study. Fit with the GLI equations was examined using z-scores and distributions within the limits of normality. LEAD reference equations were then created using the LMS method and the generalized additive model of location shape and scale package according to GLI models.
    Results: Good fit, defined as mean z-scores between + 0.5 and -0.5,was not observed for the GLI static lung volume equations, with mean z-scores > 0.5 for residual volume (RV), RV/TLC (total lung capacity) and TLC in both sexes, and for expiratory reserve volume (ERV) and inspiratory capacity in females. Distribution within the limits of normality were shifted to the upper limit except for ERV. Population-derived reference equations from the LEAD cohort showed superior fit for lung volumes and provided reproducible results.
    Conclusion: GLI lung volume reference equations demonstrated a poor fit for our cohort, especially in females. Therefore a new set of Austrian reference equations for static lung volumes was developed, that can be applied to both children and adults (6-80 years of age).
    MeSH term(s) Male ; Adult ; Child ; Female ; Humans ; Lung ; Austria/epidemiology ; Reference Values ; Lung Volume Measurements/methods ; Total Lung Capacity ; Spirometry/methods ; Forced Expiratory Volume ; Vital Capacity
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-024-02782-6
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  9. Article ; Online: Diverse Roads Taken by

    Gkiouli, Maria / Biechl, Philipp / Eisenreich, Wolfgang / Otto, Angela M

    Cells

    2019  Volume 8, Issue 10

    Abstract: In cancers, tumor cells are exposed to fluctuating nutrient microenvironments with limiting supplies of glucose and glutamine. While the metabolic program has been related to the expression of oncogenes, only fractional information is available on how ... ...

    Abstract In cancers, tumor cells are exposed to fluctuating nutrient microenvironments with limiting supplies of glucose and glutamine. While the metabolic program has been related to the expression of oncogenes, only fractional information is available on how variable precarious nutrient concentrations modulate the cellular levels of metabolites and their metabolic pathways. We thus sought to obtain an overview of the metabolic routes taken by
    MeSH term(s) Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carbon Isotopes/pharmacokinetics ; Citric Acid Cycle/drug effects ; Dose-Response Relationship, Drug ; Female ; Glucose/pharmacokinetics ; Glucose/pharmacology ; Glutamic Acid/metabolism ; Glutamine/pharmacology ; Glycolysis/drug effects ; Humans ; Lactic Acid/metabolism ; MCF-7 Cells ; Malates/metabolism ; Metabolic Networks and Pathways/drug effects ; Metabolic Networks and Pathways/physiology ; Pyruvic Acid/metabolism ; Tumor Microenvironment/drug effects
    Chemical Substances Carbon Isotopes ; Malates ; Glutamine (0RH81L854J) ; Lactic Acid (33X04XA5AT) ; Glutamic Acid (3KX376GY7L) ; malic acid (817L1N4CKP) ; Pyruvic Acid (8558G7RUTR) ; Carbon-13 (FDJ0A8596D) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-09-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells8101113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical Characterization and Underlying Genetic Findings in Brazilian Patients with Syndromic Microcephaly Associated with Neurodevelopmental Disorders.

    Tolezano, Giovanna Cantini / Bastos, Giovanna Civitate / da Costa, Silvia Souza / Scliar, Marília de Oliveira / de Souza, Carolina Fischinger Moura / Van Der Linden, Hélio / Fernandes, Walter Luiz Magalhães / Otto, Paulo Alberto / Vianna-Morgante, Angela M / Haddad, Luciana Amaral / Honjo, Rachel Sayuri / Yamamoto, Guilherme Lopes / Kim, Chong Ae / Rosenberg, Carla / Jorge, Alexander Augusto de Lima / Bertola, Débora Romeo / Krepischi, Ana Cristina Victorino

    Molecular neurobiology

    2024  

    Abstract: Microcephaly is characterized by an occipitofrontal circumference at least two standard deviations below the mean for age and sex. Neurodevelopmental disorders (NDD) are commonly associated with microcephaly, due to perturbations in brain development and ...

    Abstract Microcephaly is characterized by an occipitofrontal circumference at least two standard deviations below the mean for age and sex. Neurodevelopmental disorders (NDD) are commonly associated with microcephaly, due to perturbations in brain development and functioning. Given the extensive genetic heterogeneity of microcephaly, managing patients is hindered by the broad spectrum of diagnostic possibilities that exist before conducting molecular testing. We investigated the genetic basis of syndromic microcephaly accompanied by NDD in a Brazilian cohort of 45 individuals and characterized associated clinical features, as well as evaluated the effectiveness of whole-exome sequencing (WES) as a diagnostic tool for this condition. Patients previously negative for pathogenic copy number variants underwent WES, which was performed using a trio approach for isolated index cases (n = 31), only the index in isolated cases with parental consanguinity (n = 8) or affected siblings in familial cases (n = 3). Pathogenic/likely pathogenic variants were identified in 19 families (18 genes) with a diagnostic yield of approximately 45%. Nearly 86% of the individuals had global developmental delay/intellectual disability and 51% presented with behavioral disturbances. Additional frequent clinical features included facial dysmorphisms (80%), brain malformations (67%), musculoskeletal (71%) or cardiovascular (47%) defects, and short stature (54%). Our findings unraveled the underlying genetic basis of microcephaly in half of the patients, demonstrating a high diagnostic yield of WES for microcephaly and reinforcing its genetic heterogeneity. We expanded the phenotypic spectrum associated with the condition and identified a potentially novel gene (CCDC17) for congenital microcephaly.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03894-8
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