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Book ; Online: Positive Psychology and Learning a Second or Third Language

Padilla, Amado M. / Chen, Xinjie / Lake, J.

2020

Keywords	Science: general issues ; Psychology ; positive psychology ; second language learning and acquisition ; third language learning and acquisition ; bilingualism and multilingualism ; bicultural bilinguals
Size	1 electronic resource (216 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021231606
ISBN	9782889662791 ; 2889662799
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The Power of Partnerships to Identify and Address Mental Health Concerns Experienced by Adults With Intellectual and Developmental Disabilities.

Lunsky, Yona / Lake, Johanna / Thakur, Anupam

American journal on intellectual and developmental disabilities

2024 Volume 129, Issue 2, Page(s) 96–100

Abstract: There are significant research gaps with regard to understanding and addressing the mental health concerns of adults with intellectual and developmental disabilities (IDD) and their families. In this article, we reflect on research we have carried out ... ...

Abstract	There are significant research gaps with regard to understanding and addressing the mental health concerns of adults with intellectual and developmental disabilities (IDD) and their families. In this article, we reflect on research we have carried out about mental health and IDD prior to and during the pandemic in Ontario, Canada. We aim to address how partnering with people with IDD, family caregivers, service providers, and policy makers can help accelerate needed progress in this area. We conclude with some lessons learned during the pandemic about what to emphasize in building and maintaining such partnerships.
MeSH term(s)	Adult ; Child ; Humans ; Mental Health ; Developmental Disabilities ; Ontario/epidemiology ; Intellectual Disability/epidemiology
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2477909-X
ISSN	1944-7558 ; 1944-7515
ISSN (online)	1944-7558
ISSN	1944-7515
DOI	10.1352/1944-7558-129.2.96
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Article ; Online: Sequence similarity between SARS-CoV-2 nucleocapsid and multiple sclerosis-associated proteins provides insight into viral neuropathogenesis following infection.

Lake, Camille M / Breen, Joseph J

Scientific reports

2023 Volume 13, Issue 1, Page(s) 389

Abstract: The novel coronavirus SARS-CoV-2 continues to cause death and disease throughout the world, underscoring the necessity of understanding the virus and host immune response. From the start of the pandemic, a prominent pattern of central nervous system (CNS) ...

Abstract	The novel coronavirus SARS-CoV-2 continues to cause death and disease throughout the world, underscoring the necessity of understanding the virus and host immune response. From the start of the pandemic, a prominent pattern of central nervous system (CNS) pathologies, including demyelination, has emerged, suggesting an underlying mechanism of viral mimicry to CNS proteins. We hypothesized that immunodominant epitopes of SARS-CoV-2 share homology with proteins associated with multiple sclerosis (MS). Using PEPMatch, a newly developed bioinformatics package which predicts peptide similarity within specific amino acid mismatching parameters consistent with published MHC binding capacity, we discovered that nucleocapsid protein shares significant overlap with 22 MS-associated proteins, including myelin proteolipid protein (PLP). Further computational evaluation demonstrated that this overlap may have critical implications for T cell responses in MS patients and is likely unique to SARS-CoV-2 among the major human coronaviruses. Our findings substantiate the hypothesis of viral molecular mimicry in the pathogenesis of MS and warrant further experimental exploration.
MeSH term(s)	Humans ; SARS-CoV-2 ; Multiple Sclerosis ; COVID-19 ; T-Lymphocytes ; Nucleocapsid Proteins ; Nucleocapsid
Chemical Substances	Nucleocapsid Proteins
Language	English
Publishing date	2023-01-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-27348-8
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Article ; Online: Letter: Prioritising osteosarcopenia assessment in the ongoing care of patients with cholestatic liver diseases. Authors' reply.

Thomson, Mary / Scott, Adam / Trost, Suzanne / Lake, Jack / Lim, Nicholas

Alimentary pharmacology & therapeutics

2024 Volume 59, Issue 4, Page(s) 585–586

MeSH term(s)	Humans ; Cholestasis/diagnosis ; Liver Diseases/complications ; Liver Diseases/diagnosis ; Longitudinal Studies
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Letter
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17877
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Article ; Online: Two lateral flow assays for detection of anti-coccidioidal antibodies show similar performance to immunodiffusion in dogs with coccidioidomycosis.

Grill, Francisca J / Jaffey, Jared A / Grys, Thomas E / Rayhel, Laura H / Lake, Douglas F

American journal of veterinary research

2024 , Page(s) 1–8

Abstract: Objective: To compare 2 point-of-care lateral flow assays (LFAs) with immunodiffusion (ID) IgG results for anti-coccidioidal antibody detection in dogs with coccidioidomycosis. A further aim was to compare the quantifiable output of 1 of the LFAs to ID ... ...

Abstract	Objective: To compare 2 point-of-care lateral flow assays (LFAs) with immunodiffusion (ID) IgG results for anti-coccidioidal antibody detection in dogs with coccidioidomycosis. A further aim was to compare the quantifiable output of 1 of the LFAs to ID antibody titers. Sample: Serum banked from 73 client-owned dogs diagnosed with pulmonary or disseminated coccidioidomycosis. Methods: ID was used to determine antibody presence and titer against a coccidioidal antigen preparation. All sera were subsequently tested on an LFA based on recombinant chitinase 1 (CTS1) and the commercially available sōna LFA. LFA results were analyzed and compared to ID IgG results and clinical diagnosis. Results: All assays showed similar sensitivities in detecting anti-coccidioidal antibodies (83.6% to 89.0%). When compared with ID IgG, the CTS1 LFA had a positive percent agreement of 100%, while the sōna LFA had a positive percent agreement of 91.4%. Since the CTS1 LFA is semiquantitative, we were able to compare test line densities with ID titers and found a strong correlation between the 2 assays (Spearman ρ = 0.82). Clinical relevance: This is the first side-by-side evaluation of a commercially available LFA (sōna) and a newer more rapid anti-CTS1 antibody LFA using serum from dogs with coccidioidomycosis. Both LFAs tested have similar sensitivity to ID IgG results. The CTS1 LFA can be read after 10 minutes and is semiquantitative, while the sōna LFA is read after 30 minutes, and the results are subject to interpretation. Accurate and fast detection of anti-coccidioidal antibodies allows clinicians to initiate appropriate treatment without diagnostic delay.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.23.12.0272
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Article ; Online: Process evaluation of a primary care-based type 2 diabetes remission project in the North East of England.

Boocock, Ruth C / Moore, Helen J / Lake, Amelia A / Haste, Anna

Nutrition bulletin

2023 Volume 49, Issue 1, Page(s) 52–62

Abstract: A type 2 diabetes remission project, Remission in Diabetes (REMI.D), funded by Sport England, was developed by stakeholders based in the North East of England and begun in early 2020. This local delivery pilot sought to tackle health inequalities by ... ...

Abstract	A type 2 diabetes remission project, Remission in Diabetes (REMI.D), funded by Sport England, was developed by stakeholders based in the North East of England and begun in early 2020. This local delivery pilot sought to tackle health inequalities by working with multiple organisations to demonstrate a way of scaling up an effective type 2 diabetes remission strategy which included both physical activity and dietary components. The intended delivery of the original project was impacted by the COVID-19 pandemic and changes were made to the project delivery in 2022. The aim of this process evaluation was to learn from the reactive decisions taken by stakeholders which altered the REMI.D project in response to the COVID-19 pandemic. Twelve stakeholders (from local authorities, secondary care, universities, NHS England commissioning, Diabetes UK, Sport England, Everyone Active and Active Partnerships) involved in the design and delivery of the intervention took part in a semi-structured interview lasting up to 60 min. Interviews were recorded and transcribed verbatim. Thematic analysis used the pre-determined 'core content' themes from the Medical Research Council and National Institute for Health Research framework for developing and evaluating complex interventions. Three topics for discussion emerged as follows: (a) lack of effective collaboration, (b) perception of change and (c) scalability of the intervention. Hierarchy within the stakeholder group initially hampered collaboration. Change was reactive as a result of the COVID-19 pandemic. Project changes reduced project sustainability and scalability but offered valuable learning about the need for explicit project theory for partnership working, co-production with service users and project flexibility for long-term health behaviour change.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/epidemiology ; Pandemics ; England/epidemiology ; Primary Health Care ; COVID-19/epidemiology
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2020505-3
ISSN	1467-3010 ; 1471-9827
ISSN (online)	1467-3010
ISSN	1471-9827
DOI	10.1111/nbu.12655
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Article ; Online: Effects of 56-Kilogram Kettlebell Swing Endpoint on Total Body Mechanics.

Ross, James A / Keogh, Justin W L / Lorenzen, Christian / Lake, Jason

Journal of strength and conditioning research

2023 Volume 37, Issue 12, Page(s) 2333–2338

Abstract: Abstract: Ross, JA, Keogh, JWL, Lorenzen, C, and Lake, J. Effects of 56-kilogram kettlebell swing ... endpoint on total body mechanics. J Strength Cond Res 37(12): 2333-2338, 2023-In the past 2 decades ...

Abstract	Abstract: Ross, JA, Keogh, JWL, Lorenzen, C, and Lake, J. Effects of 56-kilogram kettlebell swing endpoint on total body mechanics. J Strength Cond Res 37(12): 2333-2338, 2023-In the past 2 decades, kettlebell training popularity has increased and the range of kettlebells has expanded to 2-92 kg. However, commercially available kettlebells above 56 kg have 12 kg increments, so alternatives to load are required to provide a suitable way of increasing training stimulus until the athlete is strong enough for a load increase. This study aimed to determine the differences in the force plate-derived biomechanical characteristics of heavy kettlebell swings to 3 different heights, as altering the height of the kettlebell swing may be one way to alter the mechanical demands with the same kettlebell mass. Fifteen resistance-trained men performed the kettlebell swing to acromion process height (AH), acromion process height + 20% (AH+20), and acromion process height-20% (AH-20). Swing height significantly affected vertical braking and propulsion phase net impulse and displacement, vertical braking velocity, and braking and propulsion work but not braking and propulsion duration. Altering kettlebell swing trajectory endpoint is a method to regress/progress the demands of kettlebell training. Coaches may be able to alter the acute demands and likely chronic adaptations of kettlebell training by prescribing different swing heights and kettlebell masses to their athletes.
MeSH term(s)	Male ; Humans ; Resistance Training/methods ; Athletes
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0000000000004568
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Article ; Online: Environmental drivers of obesity: Individual willpower versus societal responsibility.

Lake, Amelia A / O'Malley, Claire / Moore, Helen J

Nutrition bulletin

2022 Volume 47, Issue 3, Page(s) 277–281

MeSH term(s)	Humans ; Obesity/epidemiology ; Social Behavior ; Volition
Language	English
Publishing date	2022-07-15
Publishing country	England
Document type	Editorial
ZDB-ID	2020505-3
ISSN	1467-3010 ; 1471-9827
ISSN (online)	1467-3010
ISSN	1471-9827
DOI	10.1111/nbu.12574
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Article: Alcohol-induced locomotor activation in C57BL/6J, A/J, and AXB/BXA recombinant inbred mice: strain distribution patterns and quantitative trait loci analysis.

Gill, K / Boyle, A / Lake, K / Desaulniers, N

Psychopharmacology

2000 Volume 150, Issue 4, Page(s) 412–421

Abstract: ... aimed to characterize the C57BL/6J, A/J, and AXB/BXA recombinant inbred (RI) strains of mice for basal ... location of QTLs for these phenotypes.: Methods: A/J and C57BL/6J mice were habituated to handling and ...

Abstract	Rationale: Quantitative trait loci (QTLs) for initial sensitivity to alcohol have been identified in a number of mouse strains (e.g. BXD); however, confirmation is required. Objectives: The present paper aimed to characterize the C57BL/6J, A/J, and AXB/BXA recombinant inbred (RI) strains of mice for basal and ethanol-induced locomotor activation as measured in an open field and to provide provisional location of QTLs for these phenotypes. Methods: A/J and C57BL/6J mice were habituated to handling and then randomly assigned to receive one of four alcohol doses (0, 0.5, 1.0, 2.0 g/kg). Subsequently, all available strains of the AXB/BXA RI were tested with the 2 g/kg dose of ethanol or vehicle control. Results: Simple regression and interval mapping were used initially to identify significant gene markers associated with ethanol-induced activation (calculated as total activity on alcohol day-total activity on saline day). Subsequently, composite interval mapping (CIM) was used to increase the accuracy in mapping individual loci. Genetic markers on chromosomes 2, 3, 8, 13, 16, 18 and 19 were associated with ethanol-induced activation. Conclusions: Three significant markers identified through CIM accounted for 86% of the genetic variance in the ethanol-induced activation. QTLs on chromosome 16 (45.6 cM) and 19 (24 cM) previously associated with alcohol consumption in the AXB/BXA RI mice were found to overlap with QTLs for ethanol-induced activation identified in the present study.
MeSH term(s)	Animals ; Chromosome Mapping ; Ethanol/pharmacology ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Motor Activity/drug effects ; Quantitative Trait, Heritable ; Recombination, Genetic ; Species Specificity
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2000-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s002130000458
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Article ; Online: Youth civic development amid the pandemic.

Wilf, Sara / Wray-Lake, Laura / Saavedra, J Abigail

Current opinion in psychology

2023 Volume 52, Page(s) 101627

Abstract: During the COVID-19 pandemic, youth experienced abrupt closures of in-person spaces that were vital for their civic development, like schools and community organizations. Social media became the primary context for youth to make their voices heard and ... ...

Abstract	During the COVID-19 pandemic, youth experienced abrupt closures of in-person spaces that were vital for their civic development, like schools and community organizations. Social media became the primary context for youth to make their voices heard and mobilize around important sociopolitical issues like anti-Asian racism, police violence, and elections. However, youth experienced civic development in different ways during the pandemic. Some youth gained a critical awareness of societal inequities, while others were radicalized into far-right ideologies. Racially minoritized youth experienced vicarious trauma and racism while civically engaging in 2020, and their civic development must be viewed in the context of the dual pandemics of COVID-19 and structural racism.
MeSH term(s)	Humans ; Adolescent ; Pandemics ; COVID-19 ; Adolescent Behavior ; Adolescent Development ; Politics
Language	English
Publishing date	2023-06-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2831565-0
ISSN	2352-2518 ; 2352-250X ; 2352-250X
ISSN (online)	2352-2518 ; 2352-250X
ISSN	2352-250X
DOI	10.1016/j.copsyc.2023.101627
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