LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 874

Search options

  1. Article: The contributors to Volume 1 (1891) of The Journal of Comparative Neurology: C.L. Herrick, C.H. Turner, H.R. Pemberton, B.G. Wilder, F.W. Langdon, C.J. Herrick, C. von Kupffer, O.S. Strong, T.B. Stowell.

    Haines, D E

    The Journal of comparative neurology

    1991  Volume 314, Issue 1, Page(s) 9–33

    Abstract: ... to this volume, and their affiliations, were: C.L. Herrick (University of Cincinnati-UC), C.H. Turner (UC), B.G ... Wilder (Cornell), F.W. Langdon (Miami Medical College, Cincinnati), C.J. Herrick (UC) H.R. Pemberton ... Princeton), T.B. Stowell (State Normal and Training School, Potsdam), and O.S. Strong of Columbia ...

    Abstract The concept of a truly innovative "neurology" journal germinated in the mind of Clarence Luther Herrick and then flowered, in March of 1891, as the first issue of Volume 1 of The Journal of Comparative Neurology. The other parts appeared in June, October, and December of the same year. The contributors to this volume, and their affiliations, were: C.L. Herrick (University of Cincinnati-UC), C.H. Turner (UC), B.G. Wilder (Cornell), F.W. Langdon (Miami Medical College, Cincinnati), C.J. Herrick (UC) H.R. Pemberton (Princeton), T.B. Stowell (State Normal and Training School, Potsdam), and O.S. Strong of Columbia who translated a large paper by Carl von Kupffer, the famous German anatomist. In 1890-91 some of these scientists (e.g., Wilder, Langdon, Stowell, von Kupffer) were well known and had already made notable contributions in their chosen fields. However, several were students (e.g., Turner, C.J. Herrick, Pemberton, Strong), most of whom would make important contributions in later years. The founder of JCN, Clarence Luther Herrick, by 1891 had an excellent reputation in geology and natural science and had already established a successful scientific journal. Based on the totality of their contributions, the authors of the papers that made up Volume 1 of JCN were a unique group. Textbooks that went through several editions came from Wilder, C.J. Herrick, and Strong; the latter is currently going into its 9th edition. Structures were named in recognition of the original descriptions by von Kupffer and C.L. Herrick, a type of insect behavior recognized Turner's discovery, and after their deaths several had university buildings, one a scientific club, and one a research award, named in their honor. There were also interesting and important links between these nine men. Turner and C.J. Herrick were students of C.L. Herrick, and Stowell served as a member of the Association of American Anatomists nomenclature committee which was chaired by Wilder. C.J. Herrick became a student (for his Ph.D.) of Strong's, and Strong became an associate editor of JCN under C.J. Herrick. Of the nine, two practiced medicine; Langdon in an academic setting, Pemberton in private practice. The lives of the nine scientists whose work made up Volume 1 of JCN are reviewed. Many of these individuals were notable, not only for their work in the first volume of JCN, but for their larger and enduring contributions in the biomedical sciences.
    MeSH term(s) Anatomy, Comparative ; Histology, Comparative ; History, 19th Century ; Neurology/history ; Periodicals as Topic/history ; United States
    Language English
    Publishing date 1991-12-01
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.903140103
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: From Classical Methods to Generative Models: Tackling the Unreliability of Neuroscientific Measures in Mental Health Research.

    Haines, Nathaniel / Sullivan-Toole, Holly / Olino, Thomas

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2023  Volume 8, Issue 8, Page(s) 822–831

    Abstract: Advances in computational statistics and corresponding shifts in funding initiatives over the past few decades have led to a proliferation of neuroscientific measures being developed in the context of mental health research. Although such measures have ... ...

    Abstract Advances in computational statistics and corresponding shifts in funding initiatives over the past few decades have led to a proliferation of neuroscientific measures being developed in the context of mental health research. Although such measures have undoubtedly deepened our understanding of neural mechanisms underlying cognitive, affective, and behavioral processes associated with various mental health conditions, the clinical utility of such measures remains underwhelming. Recent commentaries point toward the poor reliability of neuroscientific measures to partially explain this lack of clinical translation. Here, we provide a concise theoretical overview of how unreliability impedes clinical translation of neuroscientific measures; discuss how various modeling principles, including those from hierarchical and structural equation modeling frameworks, can help to improve reliability; and demonstrate how to combine principles of hierarchical and structural modeling within the generative modeling framework to achieve more reliable, generalizable measures of brain-behavior relationships for use in mental health research.
    MeSH term(s) Humans ; Brain ; Mental Disorders/psychology ; Mental Health ; Reproducibility of Results
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2023.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Community preferences for the allocation of scarce healthcare resources during the COVID-19 pandemic: a review of the literature.

    Dowling, Alison / Lane, Haylee / Haines, Terry

    Public health

    2022  Volume 209, Page(s) 75–81

    Abstract: Objective: The purpose of this thematic review is to examine the literature on the publics' preferences of scarce medical resource allocation during COVID-19.: Study design: Literature review.: Methods: A review of Ovid MEDLINE, Embase, CINAHL and ...

    Abstract Objective: The purpose of this thematic review is to examine the literature on the publics' preferences of scarce medical resource allocation during COVID-19.
    Study design: Literature review.
    Methods: A review of Ovid MEDLINE, Embase, CINAHL and Scopus was performed between December 2019 and June 2022 for eligible articles.
    Results: Fifteen studies using three methodologies and spanning five continents were included. Five key themes were identified: (1) prioritise the youngest; (2) save the most lives; (3) egalitarian allocation approaches; (4) prioritise healthcare workers; and (5) bias against particular groups. The public gave high priority to allocation that saved the most lives, particularly to patients who are younger and healthcare workers. Themes present but not supported as broadly were giving priority to individuals with disabilities, high frailty or those with behaviours that may have contributed to their ill-health (e.g. smokers). Allocation involving egalitarian approaches received the least support among community members.
    Conclusion: The general public prefer rationing scarce medical resources in the COVID-19 pandemic based on saving the most lives and giving priority to the youngest and frontline healthcare workers rather than giving preference to patients with disabilities, frailty or perceived behaviours that may have contributed to their own ill-health. There is also little public support for allocation based on egalitarian strategies.
    MeSH term(s) COVID-19 ; Delivery of Health Care ; Frailty ; Health Care Rationing ; Health Personnel ; Humans ; Pandemics
    Language English
    Publishing date 2022-06-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 427333-3
    ISSN 1476-5616 ; 0033-3506
    ISSN (online) 1476-5616
    ISSN 0033-3506
    DOI 10.1016/j.puhe.2022.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: The Cost-Effectiveness of Adjunctive Lifestyle Interventions for the Management of Cancer: A Systematic Review.

    Gallagher, Andrew / Shersher, Violetta / Mortimer, Duncan / Truby, Helen / Haines, Terry

    Applied health economics and health policy

    2022  Volume 21, Issue 2, Page(s) 225–242

    Abstract: Objective: There is a paucity of papers synthesizing the cost-effectiveness (CE) of lifestyle interventions to support cancer patients, and the synthesis papers available have used analytic methods that do not permit easy comparison between studies. We ... ...

    Abstract Objective: There is a paucity of papers synthesizing the cost-effectiveness (CE) of lifestyle interventions to support cancer patients, and the synthesis papers available have used analytic methods that do not permit easy comparison between studies. We therefore evaluated the CE of adjunctive lifestyle interventions compared with usual care.
    Methods: A systematic literature search of Scopus, MEDLINE, EMBASE, PsycINFO, CINAHL and the Cochrane Library databases was conducted from database inception until June 2021. Eligible studies were economic evaluations from randomised controlled trials or modelled economic evaluations that recruited subjects with a confirmed diagnosis of cancer and were allocated to a lifestyle intervention as an adjunct or supportive treatment, or usual care. Studies were excluded if there was no cost-effectiveness analysis or if costs were identified but not related back to measures of effectiveness. CE of the included interventions was recalculated, adjusting for key differences (with respect to absolute resource costs and timing) between the broad range of study settings and a common 'target' setting. All CE data were converted into incremental net monetary benefit using a common cost-effectiveness threshold to facilitate comparison. The quality of the studies was evaluated for risk of bias using the ECOBIAS check list.
    Results: Nine studies were included in our review. Seven studies investigated the benefits of physical exercise in combination with cancer treatment and two studies investigated the combination of exercise and psychosocial counselling alongside cancer treatment. Six studies with an exercise intervention reported larger quality-adjusted life year (QALY) gains compared with usual care and when cost per QALY gained was considered, three of the interventions were cost effective. One of the two interventions combining exercise with psychosocial counselling was cost effective. All studies were considered of good quality but all had some limitations.
    Conclusions: The evidence to support the cost effectiveness of lifestyle interventions in patients with cancer is mixed with four of the nine interventions found to be cost effective and two remaining cost effective when uncertainty was taken into account. Sensitivity analysis showed the influence of the CE threshold on the results, highlighting the importance of selecting a CE threshold that is appropriate to the setting.
    Systematic review registration: PROSPERO Registration Number: CRD42020185376.
    MeSH term(s) Humans ; Cost-Effectiveness Analysis ; Cost-Benefit Analysis ; Exercise ; Health Services ; Life Style ; Neoplasms/therapy
    Language English
    Publishing date 2022-09-27
    Publishing country New Zealand
    Document type Systematic Review
    ZDB-ID 2171420-4
    ISSN 1179-1896 ; 1175-5652
    ISSN (online) 1179-1896
    ISSN 1175-5652
    DOI 10.1007/s40258-022-00759-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Correction to "Light Directs Monomer Coordination in Catalyst-Free Grignard Photopolymerization".

    Yun, Young Ju / Lorenzo, Emmaline R / Berl, Alexandra J / Sklar, Jonathan H / Fuller, Ethan J / Woods, Eliot F / Kantt, Leanna P / Eckdahl, Christopher T / Wasielewski, Michael R / Haines, Brandon E / Kalow, Julia A

    Journal of the American Chemical Society

    2023  Volume 145, Issue 29, Page(s) 16285–16286

    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c06271
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Of Mouse and Man: Cross-Species Characterization of Hypertensive Cardiac Remodeling.

    Cooper, Susanna T E / Westaby, Joseph D / Haines, Zoe H R / Malone, Giles O / Sheppard, Mary N / Meijles, Daniel N

    International journal of molecular sciences

    2022  Volume 23, Issue 14

    Abstract: Hypertension is a major public health concern and poses a significant risk for sudden cardiac death (SCD). However, the characterisation of human tissues tends to be macroscopic, with little appreciation for the quantification of the pathological ... ...

    Abstract Hypertension is a major public health concern and poses a significant risk for sudden cardiac death (SCD). However, the characterisation of human tissues tends to be macroscopic, with little appreciation for the quantification of the pathological remodelling responsible for the advancement of the disease. While the components of hypertensive remodelling are well established, the timeline and comparative quantification of pathological changes in hypertension have not been shown before. Here, we sought to identify the phasing of cardiac remodelling with hypertension using post-mortem tissue from SCD patients with early and advanced hypertensive heart disease (HHD). In order to study and quantify the progression of phenotypic changes, human specimens were contrasted to a well-described angiotensin-II-mediated hypertensive mouse model. While cardiomyocyte hypertrophy is an early adaptive response in the mouse that stabilises in established hypertension and declines as the disease progresses, this finding did not translate to the human setting. In contrast, optimising fibrosis quantification methods and applying them to each setting identified perivascular fibrosis as the prevailing possible cause for overall disease progression. Indeed, assessing myocardial inflammation highlights CD45+ inflammatory cell infiltration that precedes fibrosis and is an early-phase event in response to elevated arterial pressures that may underscore perivascular remodelling. Along with aetiology insight, we highlight cross-species comparison for quantification of cardiac remodelling in human hypertension. As such, this platform could assist with the development of therapies specific to the disease phase rather than targeting global components of hypertension, such as blood pressure lowering.
    MeSH term(s) Angiotensin II/physiology ; Animals ; Blood Pressure ; Disease Models, Animal ; Fibrosis ; Heart ; Humans ; Hypertension ; Mice ; Myocardium/pathology ; Myocytes, Cardiac/pathology ; Ventricular Remodeling
    Chemical Substances Angiotensin II (11128-99-7)
    Language English
    Publishing date 2022-07-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23147709
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: A new look at Cardiolipin.

    Haines, T H

    Biochimica et biophysica acta

    2009  Volume 1788, Issue 10, Page(s) 1997–2002

    MeSH term(s) Cardiolipins/chemistry ; Cardiolipins/physiology ; Humans
    Chemical Substances Cardiolipins
    Language English
    Publishing date 2009-10
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2009.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: A model for transition state dynamics in bilayers: implications for the role of lipids in biomembrane transport.

    Haines, T H

    Biophysical journal

    2009  Volume 37, Issue 1, Page(s) 147–148

    Language English
    Publishing date 2009-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/S0006-3495(82)84644-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Use of computer vision for analysis of image datasets from high temperature plasma experiments.

    Kozlowski, P M / Kim, Y / Haines, B M / Robey, H F / Murphy, T J / Johns, H M / Perry, T S

    The Review of scientific instruments

    2021  Volume 92, Issue 3, Page(s) 33532

    Abstract: Great strides have been made in improving the quality of x-ray radiographs in high energy density plasma experiments, enabled in part by innovations in engineering and manufacturing of integrated circuits and materials. As a consequence, the radiographs ... ...

    Abstract Great strides have been made in improving the quality of x-ray radiographs in high energy density plasma experiments, enabled in part by innovations in engineering and manufacturing of integrated circuits and materials. As a consequence, the radiographs of today are filled with a great deal of detail, but few of these features are extracted in a systematic way. Analysis techniques familiar to plasma physicists tend toward brittle 1D lineout or Fourier transform type analyses. The techniques applied to process our data have not kept pace with improvements in the quality of our data. Fortunately, the field of computer vision has a wealth of tools to offer, which have been widely used in industrial imaging and, more recently, adopted in biological imaging. We demonstrate the application of computer vision techniques to the analysis of x-ray radiographs from high energy density plasma experiments, as well as give a brief tutorial on the computer vision techniques themselves. These tools robustly extract 2D contours of shocks, boundaries of inhomogeneities, and secondary flows, thereby allowing for increased automation of analysis, as well as direct and quantitative comparisons with simulations.
    Language English
    Publishing date 2021-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0040285
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Change to Mixed-Lipid Emulsion From Soybean Oil-Based Lipid Emulsion in Pediatric Patients.

    Haines, Krista L / Ohnuma, Tetsu / Hornik, Chi Dang / Grisel, Braylee / Leraas, Harold / Trujillo, Charles N / Krishnamoorthy, Vijay / Raghunathan, Karthik / Wischmeyer, Paul E

    JAMA network open

    2023  Volume 6, Issue 9, Page(s) e2332389

    Abstract: Importance: Critically ill pediatric patients often require parenteral nutrition (PN) in the intensive care unit (ICU). Literature suggests mixed lipid emulsions (LE) with soybean oil reduction strategies may improve outcomes.: Objective: To examine ... ...

    Abstract Importance: Critically ill pediatric patients often require parenteral nutrition (PN) in the intensive care unit (ICU). Literature suggests mixed lipid emulsions (LE) with soybean oil reduction strategies may improve outcomes.
    Objective: To examine the association of a hospital-wide switch to a mixed-lipid formula (4-OLE) with pediatric outcomes.
    Design, setting, and participants: Retrospective cohort study at a large US academic referral center. Pediatric patients aged 1 month to 17 years requiring parenteral nutrition from May 2016 to September 2019 were included. Data were analyzed from October 2020 to February 2023.
    Exposure: In 2017, Duke University Health System fully converted to a soybean oil/MCT/olive/fish oil lipid (4-OLE) from pure soybean oil-based LE in pediatric patients. Pediatric patients before the change (Intralipid [IL] group) were compared with patients after (4-OLE group).
    Main outcomes and measures: Clinical outcomes were compared between treatment periods via multivariable regression models. The primary outcome was hospital length of stay (LOS). Fourteen secondary outcomes included hospital mortality of any cause, 30-day or 90-day readmission, pneumonia, urinary tract infections (UTIs), total caloric delivery, and liver function tests (aspartate aminotransferase, alanine transaminase, alkaline phosphatase, and total bilirubin).
    Results: A total of 684 children dependent on PN were identified (342 were critically ill), with 30% (206 children) in the preswitch (IL) period and 70% (478 children) in the postswitch (4-OLE) period; 123 were male (59.7%). In comparing IL vs 4-OLE, there was a significant difference in median (IQR) age (4.0 [1.2-13.0] vs 3.0 [0.8-9.0] years, respectively; P = .04), without difference in body mass index or baseline comorbidities except for significant differences in cancer diagnosis (26 patients in the IL group [12.6%] vs 29 patients in the 4-OLE group [6.1%]; P = .004) and chronic obstructive pulmonary disease (24 patients in the IL group [11.7%] vs 30 patients in the 4-OLE group [6.3%]; P = .02). In the all children cohort, 4-OLE was associated with shorter hospital LOS (IRR, 0.81; 95% CI, 0.05-0.78), and reduced UTI risk (OR, 0.33; 95% CI, 0.18-0.64). In the ICU cohort, 4-OLE was associated with shorter hospital LOS (IRR, 0.81; 95% CI, 0.78-0.83), and reduced UTI risk (OR, 0.23; 95% CI, 0.11-0.51). Other secondary outcomes were not significant.
    Conclusions and relevance: In this observational study of clinical outcomes among children dependent on PN, a switch to 4-OLE in a large academic hospital was associated with a significant decrease in hospital LOS in ICU and non-ICU patients. These findings suggest switching to a soy-LE sparing strategy using 4-OLE is feasible, safe, and associated with improved clinical outcomes in pediatric PN patients.
    MeSH term(s) Female ; Humans ; Male ; Alanine Transaminase ; Critical Illness/therapy ; Emulsions ; Retrospective Studies ; Soybean Oil ; Infant ; Child, Preschool ; Child ; Adolescent
    Chemical Substances Alanine Transaminase (EC 2.6.1.2) ; Emulsions ; Soybean Oil (8001-22-7)
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.32389
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top