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  1. Article ; Online: BAX and BAK become killers without a BH3 trigger.

    Adams, Jerry M

    Cell research

    2019  Volume 29, Issue 12, Page(s) 967–968

    MeSH term(s) Apoptosis ; Myeloid Cell Leukemia Sequence 1 Protein ; Proto-Oncogene Proteins c-bcl-2 ; bcl-2-Associated X Protein
    Chemical Substances Myeloid Cell Leukemia Sequence 1 Protein ; Proto-Oncogene Proteins c-bcl-2 ; bcl-2-Associated X Protein
    Language English
    Publishing date 2019-11-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-019-0253-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5283: Show issues Location:
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  2. Article ; Online: BAX mitochondrial integration is regulated allosterically by its α1-α2 loop.

    Dengler, Michael A / Gibson, Leonie / Adams, Jerry M

    Cell death and differentiation

    2021  Volume 28, Issue 12, Page(s) 3270–3281

    Abstract: The conformational changes converting BAX from an inert cytosolic monomer into the homo-oligomers that permeabilize the mitochondrial outer membrane (MOM) are crucial steps toward apoptosis. Here, we have explored the potential role of the BAX α1-α2 loop ...

    Abstract The conformational changes converting BAX from an inert cytosolic monomer into the homo-oligomers that permeabilize the mitochondrial outer membrane (MOM) are crucial steps toward apoptosis. Here, we have explored the potential role of the BAX α1-α2 loop in this process by three mutagenic approaches: replacing loop segments with cognate loop regions from closely related proteins, alanine scanning and analysis of BAX α1-α2 loop missense mutations observed in tumours. Responsiveness to a death signal, such as tBID, was reduced by mutations in the N-terminal but not C-terminal half of the loop. N-terminal loop variants, which were enriched in tumours, impaired MOM integration by allosterically reducing exposure of the BAX α9 transmembrane anchor. Most C-terminal loop variants reduced BAX stability, leading to increased BAX apoptotic function in some variants. Thus, our systematic mutagenesis suggests that the two halves of the α1-α2 loop have distinct functions. We show that the N-terminal half of the loop (its first nine residues) comprises an important allosteric regulator of BAX activation by setting the proportion of MOM-integrated BAX following a death signal. The enrichment of N-terminal loop mutations in tumours indicates that they may promote tumour cell survival and underscore the loop as a target for therapeutic manipulation of BAX function.
    MeSH term(s) Allosteric Site/genetics ; Animals ; Humans ; Mice ; Mitochondria/metabolism ; Models, Molecular ; Transfection ; bcl-2-Associated X Protein/genetics
    Chemical Substances bcl-2-Associated X Protein
    Language English
    Publishing date 2021-06-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-021-00815-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

    Adams, Jerry M / Cory, Suzanne

    Cell death and differentiation

    2018  Volume 25, Issue 1, Page(s) 27–36

    Abstract: Impaired apoptosis plays a central role in cancer development and limits the efficacy of conventional cytotoxic therapies. Deepening understanding of how opposing factions of the BCL-2 protein family switch on apoptosis and of their structures has driven ...

    Abstract Impaired apoptosis plays a central role in cancer development and limits the efficacy of conventional cytotoxic therapies. Deepening understanding of how opposing factions of the BCL-2 protein family switch on apoptosis and of their structures has driven development of a new class of cancer drugs that targets various pro-survival members by mimicking their natural inhibitors, the BH3-only proteins. These 'BH3 mimetic' drugs seem destined to become powerful new weapons in the arsenal against cancer. Successful clinical trials of venetoclax/ABT-199, a specific inhibitor of BCL-2, have led to its approval for a refractory form of chronic lymphocytic leukaemia and to scores of on-going trials for other malignancies. Furthermore, encouraging preclinical studies of BH3 mimetics that target other BCL-2 pro-survival members, particularly MCL-1, offer promise for cancers resistant to venetoclax. This review sketches the impact of the BCL-2 family on cancer development and therapy, describes how interactions of family members trigger apoptosis and discusses the potential of BH3 mimetic drugs to advance cancer therapy.
    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Apoptosis Regulatory Proteins/physiology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Humans ; Mitochondrial Membranes/metabolism ; Neoplasms/drug therapy ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/chemistry ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-bcl-2/physiology ; Sulfonamides/therapeutic use
    Chemical Substances Antineoplastic Agents ; Apoptosis Regulatory Proteins ; BCL2 protein, human ; Bridged Bicyclo Compounds, Heterocyclic ; Proto-Oncogene Proteins c-bcl-2 ; Sulfonamides ; venetoclax (N54AIC43PW)
    Language English
    Publishing date 2018
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/cdd.2017.161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: The contribution of soil science to the development of and implementation of criteria and indicators of sustainable forest management

    Adams, Mary Beth / Bigham, Jerry M.

    proceedings of a symposium sponsored by the S-7 and S-11 divisions of the Soil Science Society of America, the USDA Forest Service Northeastern Forest Experiment Station and the Woods Hole Research Center ; the symposium was held in St. Louis, MO, 31 October, 1995

    (SSSA special publication ; 53)

    1998  

    Author's details organizing committee: Mary Beth Adams ... Ed.-in-Chief: Jerry M. Bigham
    Series title SSSA special publication ; 53
    Collection
    Keywords Bodenkunde ; Waldboden ; Forstwirtschaft ; Nachhaltigkeit
    Subject Nachhaltige Entwicklung ; Langfristige Entwicklung ; Sustainable Development ; Dauerhafte Entwicklung ; Zukunftsfähige Entwicklung ; Waldwirtschaft ; Forstwesen ; Forstkultur ; Waldbewirtschaftung ; Wald ; Waldböden ; Bodenlehre ; Pedologie
    Language English
    Size XVII, 156 S. : graph. Darst., Kt.
    Publishing place Madison, Wis
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT010502810
    ISBN 0-89118-831-2 ; 978-0-89118-831-5
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    998/1187 available for loan (reading room) Freihandmagazin (U1)

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  5. Article ; Online: Therapeutic potential of a peptide targeting BCL-2 cell guardians in cancer.

    Adams, Jerry M

    The Journal of clinical investigation

    2012  Volume 122, Issue 6, Page(s) 1965–1967

    Abstract: A promising approach to cancer therapy is to elicit apoptosis with "BH3 mimetic" drugs, which target proteins of the BCL-2 family. As of yet, however, such drugs can target only certain BCL-2 family proteins. Hence, in this issue of the JCI, LaBelle et ... ...

    Abstract A promising approach to cancer therapy is to elicit apoptosis with "BH3 mimetic" drugs, which target proteins of the BCL-2 family. As of yet, however, such drugs can target only certain BCL-2 family proteins. Hence, in this issue of the JCI, LaBelle et al. assess instead the therapeutic potential of a "stapled" BH3 peptide from the BIM protein, which inactivates all its prosurvival relatives. The peptide killed cultured hematologic tumor cells and abated growth of a leukemia xenograft, without perturbing the hematopoietic compartment. Hence, such peptides might eventually provide a new way to treat refractory leukemias.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/pharmacology ; Bcl-2-Like Protein 11 ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/metabolism ; Membrane Proteins/pharmacology ; Peptides/pharmacology ; Proto-Oncogene Proteins/pharmacology
    Chemical Substances Apoptosis Regulatory Proteins ; BCL2L11 protein, human ; Bcl-2-Like Protein 11 ; Membrane Proteins ; Peptides ; Proto-Oncogene Proteins
    Language English
    Publishing date 2012-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI64120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Donald Metcalf: The father of modern hematology.

    Adams, Jerry M / Cory, Suzanne

    Proceedings of the National Academy of Sciences of the United States of America

    2015  Volume 112, Issue 9, Page(s) 2628–2629

    MeSH term(s) Animals ; Hematology/history ; History, 20th Century ; Male ; Portraits as Topic
    Language English
    Publishing date 2015-03-03
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1500346112
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    Zs.A 1148: Show issues Location:
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  7. Article ; Online: Solution structure of zinc-seamed

    Kumari, Harshita / Wycoff, Wei G / M Mayhan, Collin / Kline, Steven R / So, Joshua R / Deakyne, Carol A / Adams, John E / Atwood, Jerry L

    RSC advances

    2021  Volume 11, Issue 6, Page(s) 3342–3345

    Abstract: The structural stability and solution geometry of zinc-seamed- ...

    Abstract The structural stability and solution geometry of zinc-seamed-
    Language English
    Publishing date 2021-01-15
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d0ra10053f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Organization of immunoglobulin genes

    Adams, Jerry M.

    (Immunological reviews ; 59)

    1981  

    Author's details [Jerry M. Adams ...]
    Series title Immunological reviews ; 59
    Collection
    Keywords GENES, MHC CLASS II ; Immunglobuline ; Gen
    Subject Erbanlage ; Erbeinheit ; Erbfaktor ; Gamma-Globuline ; Ig ; Immunoglobuline ; Immunglobulin vom Menschen ; Beriglotin
    Language English
    Size 91 S.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT002480761
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    SE 160 -59- verfügbar in Königswinter Königswinter

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  9. Article ; Online: By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737.

    Tailler, Maximilien / Lindqvist, Lisa M / Gibson, Leonie / Adams, Jerry M

    Cell death and differentiation

    2018  Volume 26, Issue 9, Page(s) 1766–1781

    Abstract: Drugs targeting various pro-survival BCL-2 family members (''BH3 mimetics'') have efficacy in hemopoietic malignancies, but the non-targeted pro-survival family members can promote resistance. Pertinently, the sensitivity of some tumor cell lines to BH3 ... ...

    Abstract Drugs targeting various pro-survival BCL-2 family members (''BH3 mimetics'') have efficacy in hemopoietic malignancies, but the non-targeted pro-survival family members can promote resistance. Pertinently, the sensitivity of some tumor cell lines to BH3 mimetic ABT737, which targets BCL-2, BCL-XL, and BCL-W but not MCL-1, is enhanced by 2-deoxyglucose (2DG). We found that 2DG augmented apoptosis induced by ABT737 in 3 of 8 human hemopoietic tumor cell lines, most strongly in pre-B acute lymphocytic leukemia cell line NALM-6, the focus of our mechanistic studies. Although 2DG can lower MCL-1 translation, how it does so is incompletely understood, in part because 2DG inhibits both glycolysis and protein glycosylation in the endoplasmic reticulum (ER). Its glycolysis inhibition lowered ATP and, through the AMPK/mTORC1 pathway, markedly reduced global protein synthesis, as did an ER integrated stress response. A dual reporter assay revealed that 2DG impeded not only cap-dependent translation but also elongation or cap-independent translation. MCL-1 protein fell markedly, whereas 12 other BCL-2 family members were unaffected. We ascribe the MCL-1 drop to the global fall in translation, exacerbated for mRNAs with a structured 5' untranslated region (5'UTR) containing potential regulatory motifs like those in MCL-1 mRNA and the short half-life of MCL-1 protein. Pertinently, 2DG downregulated two other short-lived oncoproteins, MYC and MDM2. Thus, our results support MCL-1 as a critical 2DG target, but also reveal multiple effects on global translation that may well also affect its promotion of apoptosis.
    MeSH term(s) Apoptosis/drug effects ; Apoptosis Regulatory Proteins ; Biomimetics ; Biphenyl Compounds ; Cell Line, Tumor ; Deoxyglucose/pharmacology ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Peptide Fragments/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Protein Biosynthesis ; Protein Kinases/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA, Messenger/genetics
    Chemical Substances Apoptosis Regulatory Proteins ; BCL2 protein, human ; Bax protein (53-86) ; Biphenyl Compounds ; MCL1 protein, human ; Myeloid Cell Leukemia Sequence 1 Protein ; Peptide Fragments ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Messenger ; Deoxyglucose (9G2MP84A8W) ; Protein Kinases (EC 2.7.-) ; AMP-activated protein kinase kinase (EC 2.7.1.-)
    Language English
    Publishing date 2018-12-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-018-0244-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A SEROLOGIC SURVEY OF FRANCISELLA TULARENSIS EXPOSURE IN WILDLIFE ON THE ARCTIC COASTAL PLAIN OF ALASKA, USA.

    Smith, Matthew M / Van Hemert, Caroline / Atwood, Todd C / Sinnett, David R / Hupp, Jerry W / Meixell, Brandt W / Gustine, Dave D / Adams, Layne G / Ramey, Andrew M

    Journal of wildlife diseases

    2022  Volume 58, Issue 4, Page(s) 746–755

    Abstract: Tularemia is an infectious zoonotic disease caused by one of several subspecies of Francisella tularensis bacteria. Infections by F. tularensis are common throughout the northern hemisphere and have been detected in more than 250 wildlife species. In ... ...

    Abstract Tularemia is an infectious zoonotic disease caused by one of several subspecies of Francisella tularensis bacteria. Infections by F. tularensis are common throughout the northern hemisphere and have been detected in more than 250 wildlife species. In Alaska, US, where the pathogen was first identified in 1938, studies have identified F. tularensis antibodies in a diverse suite of taxa, including insects, birds, and mammals. However, few such investigations have been conducted recently and knowledge about the current distribution and disease ecology of F. tularensis is limited, particularly in Arctic Alaska, an area undergoing rapid environmental changes from climate warming. To help address these information gaps and provide insights about patterns of exposure among wildlife, we assessed the seroprevalence of F. tularensis antibodies in mammals and tundra-nesting geese from the Arctic Coastal Plain of Alaska, 2014-17. With a commercially available slide agglutination test, we detected antibodies in 14.7% of all individuals sampled (n=722), with titers ranging from 1:20 to 1:320. We detected significant differences in seroprevalence between family groups, with Canidae (foxes, Vulpes spp.) and Sciuridae (Arctic ground squirrel, Spermophilus parryii) having the highest seroprevalence at 21.5% and 33.3%, respectively. Mean seroprevalence for Ursidae (polar bears, Ursus maritimus) was 13.3%, whereas Cervidae (caribou, Rangifer tarandus) had comparatively low seroprevalence at 6.5%. Antibodies were detected in all Anatidae species sampled, with Black Brant (Branta bernicla nigricans) having the highest seroprevalence at 13.6%. The detection of F. tularensis antibodies across multiple taxa from the Arctic Coastal Plain and its nearshore marine region provides evidence of exposure to this pathogen throughout the region and highlights the need for renewed surveillance in Alaska.
    MeSH term(s) Animals ; Francisella tularensis ; Sciuridae ; Seroepidemiologic Studies ; Alaska/epidemiology
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410709-3
    ISSN 1943-3700 ; 0090-3558
    ISSN (online) 1943-3700
    ISSN 0090-3558
    DOI 10.7589/JWD-D-21-00162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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