Article: Ventriculo-arterial (un)coupling in septic shock: Impact of current and upcoming hemodynamic drugs.
Frontiers in cardiovascular medicine
2023 Volume 10, Page(s) 1172703
Abstract: Sepsis is an archetype of distributive shock and combines different levels of alterations in preload, afterload, and often cardiac contractility. The use of hemodynamic drugs has evolved over the past few years, along with the invasive and non-invasive ... ...
Abstract | Sepsis is an archetype of distributive shock and combines different levels of alterations in preload, afterload, and often cardiac contractility. The use of hemodynamic drugs has evolved over the past few years, along with the invasive and non-invasive tools used to measure these components in real time. However, none of them is impeccable, which is why the mortality of septic shock remains too high. The concept of ventriculo-arterial coupling (VAC) allows for the integration of these three fundamental macroscopic hemodynamic components. In this mini review, we discuss the knowledge, tools, and limitations of VAC measurement, along with the evidence supporting ventriculo-arterial uncoupling in septic shock. Finally, the impact of recommended hemodynamic drugs and molecules on VAC is detailed. |
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Language | English |
Publishing date | 2023-05-30 |
Publishing country | Switzerland |
Document type | Journal Article ; Review |
ZDB-ID | 2781496-8 |
ISSN | 2297-055X |
ISSN | 2297-055X |
DOI | 10.3389/fcvm.2023.1172703 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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