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  1. Book ; Online: Soil-Structure Interaction

    Ong, Dominic E.L / Cheng, Wen-Chieh / Zhou, Hannah

    2023  

    Keywords Research and information: general ; Earth Sciences, Geography, Environment, Planning ; large diameter bored pile ; finite element method ; load transfer ; failure mechanism ; overconsolidated stiff clay ; two dimensional axisymmetric ; drained and undrained conditions ; deep excavation ; contiguous bored pile wall ; capping beam ; groundwater ; wall permeability ; elastic settlement ; shallow foundations ; rigid footings ; contact pressure ; equivalent shape ; seismic response analysis ; soil structure interaction ; continuum mechanics ; structural mechanics ; soil spring ; high performance computing ; unbound granular materials (UGMs) ; degree of saturation (DOS) ; repeated load triaxial test (RLT) ; resilient modulus ; plastic strain ; dispersion curve ; shear wave ; seismic dilatometer ; soil mechanics ; in situ test ; biopolymer-treated soils ; soil improvement ; geotechnical properties ; biopolymer soil interaction ; soft soil behaviour ; soft soil stabilisation ; silt content ; unconfined compressive strength ; consolidated undrained strength ; microstructure analysis ; interface shear test ; surface roughness ; critical roughness ; random or ribbed surface roughness ; friction development ; PIV technology ; load-settlement response ; bi-directional static load test ; supercell ; analytical solution ; Randolph method ; the modified closed-form analytical solutions ; n/a
    Language English
    Size 1 electronic resource (246 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030722315
    ISBN 9783036568270 ; 3036568271
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: We are all on the same team: the impact of COVID-19 on small businesses in Canada.

    Ong, Dominic

    Canadian medical education journal

    2021  Volume 12, Issue 2, Page(s) e134–e135

    Language English
    Publishing date 2021-04-30
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2689512-2
    ISSN 1923-1202
    ISSN 1923-1202
    DOI 10.36834/cmej.72120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: We are all on the same team

    Dominic Ong

    Canadian Medical Education Journal, Vol 12, Iss

    the impact of COVID-19 on small businesses in Canada

    2021  Volume 2

    Keywords Education (General) ; L7-991 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Canadian Medical Education Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Effects of Particle Size Distribution and Moisture Variation on Mechanical Strength of Biopolymer-Treated Soil

    Hadi Fatehi / Dominic E. L. Ong / Jimmy Yu / Ilhan Chang

    Polymers, Vol 15, Iss 1549, p

    2023  Volume 1549

    Abstract: Biopolymers have recently shown great potential to replace traditional binding materials in geotechnical engineering; however, more research is required to reach a deeper understanding of biopolymer-treated soil behavior. The objective of this study was ... ...

    Abstract Biopolymers have recently shown great potential to replace traditional binding materials in geotechnical engineering; however, more research is required to reach a deeper understanding of biopolymer-treated soil behavior. The objective of this study was to investigate the most important parameters that affect the behavior of biopolymer-treated soil, including biopolymer content, dehydration time, soil type effect, and durability. Sodium alginate and agar biopolymers were used due to their stability under severe conditions and the reasonable costs to study these parameters. A broad range of soil particle sizes was used to optimize the kaolinite-sand combination. As one of the main concerns in the behavior of biotreated soils, durability was investigated under five cycles of wetting and drying. In addition, a comprehensive microstructural study was performed by FTIR analysis and SEM images, as well as chemical interaction analysis. The results indicated that the optimized biopolymer content was in the range of 0.5–1% (to soil weight) and the dehydration time was 14 days. A soil combination of 25% kaolinite and 75% sand provided the highest compressive strength. Under wetting and drying conditions, biopolymers significantly increased soil resistance against strength reduction and soil mass loss. This study provides an understanding how agar and sodium alginate changes the behavior of the soil and can be used as a reference for further studies in the future.
    Keywords biopolymer-treated soil ; biopolymer ; durability under wetting and drying ; agar ; sodium alginate ; Organic chemistry ; QD241-441
    Subject code 630
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Effects of Particle Size Distribution and Moisture Variation on Mechanical Strength of Biopolymer-Treated Soil.

    Fatehi, Hadi / Ong, Dominic E L / Yu, Jimmy / Chang, Ilhan

    Polymers

    2023  Volume 15, Issue 6

    Abstract: Biopolymers have recently shown great potential to replace traditional binding materials in geotechnical engineering; however, more research is required to reach a deeper understanding of biopolymer-treated soil behavior. The objective of this study was ... ...

    Abstract Biopolymers have recently shown great potential to replace traditional binding materials in geotechnical engineering; however, more research is required to reach a deeper understanding of biopolymer-treated soil behavior. The objective of this study was to investigate the most important parameters that affect the behavior of biopolymer-treated soil, including biopolymer content, dehydration time, soil type effect, and durability. Sodium alginate and agar biopolymers were used due to their stability under severe conditions and the reasonable costs to study these parameters. A broad range of soil particle sizes was used to optimize the kaolinite-sand combination. As one of the main concerns in the behavior of biotreated soils, durability was investigated under five cycles of wetting and drying. In addition, a comprehensive microstructural study was performed by FTIR analysis and SEM images, as well as chemical interaction analysis. The results indicated that the optimized biopolymer content was in the range of 0.5-1% (to soil weight) and the dehydration time was 14 days. A soil combination of 25% kaolinite and 75% sand provided the highest compressive strength. Under wetting and drying conditions, biopolymers significantly increased soil resistance against strength reduction and soil mass loss. This study provides an understanding how agar and sodium alginate changes the behavior of the soil and can be used as a reference for further studies in the future.
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15061549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Sustainability of Using DuraCrete as Cement Additive to Estuarine Soft Soil Stabilization

    Ali N. Al-Gemeel / Noor Al-Hayo / Dominic E. L. Ong / Yan Zhuge

    Sustainability, Vol 16, Iss 1, p

    2023  Volume 231

    Abstract: Large areas of estuarine deposits exist on the coastal plains of the southeast Queensland coast with a countered depth of up to 30 m. These deposits are categorized as sediments that originated during the Holocene Age. The sediments have not been ... ...

    Abstract Large areas of estuarine deposits exist on the coastal plains of the southeast Queensland coast with a countered depth of up to 30 m. These deposits are categorized as sediments that originated during the Holocene Age. The sediments have not been consolidated or subjected to considerable pressure since the end of the Ice Age. The structure of these deposits consists of large ratios of porosity, causing high soil compressibility, which lowers the bearing capacity of the soils. Therefore, the soils of the region cannot maintain sufficient support for construction loads, and consequent malfunctions could occur in short-term and long-term periods. The objective of this paper is to investigate the suitability of new soil stabilization additives in the southeast Queensland region and the optimum additive content of cementitious materials and an advanced mixing modifier branded as DuraCrete. A combination of Portland cement and DuraCrete was used as a soil additive. Three DuraCrete-to-cement ratios were used: 2%, 3%, and 4% by weight. Soil collected from the Port of Brisbane region was treated by adding the additives as a percentage of its weight; four percentages were considered: 10%, 20%, 25%, and 30% for each combination of additives. The performance of the treated soils was examined under unconfined compression after 28 days of curing. The results revealed that increases in the unconfined compressive strength were detected as DuraCrete was added to the mixtures. For 30% additives, increases of about 15%, 34%, and 17% were detected when DuraCrete was added as 2%, 3%, and 4%, respectively. The results also revealed that 3% DuraCrete content provided significant stabilization compared to 2% and 4% for 25% and 30% additive-treated soils; such behavior was also observed for the specimens of 25% content of additives. Additionally, DuraCrete can be considered a promising material that can be combined with cement to obtain the desired stabilization of soft soils.
    Keywords DuraCrete ; EvoCrete ; stabilization ; unconfined ; additives ; southeast Queensland ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 630
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Irreversible Electroporation for Prostate Cancer.

    Ong, Sean / Leonardo, Matthew / Chengodu, Thilakavathi / Bagguley, Dominic / Lawrentschuk, Nathan

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 6

    Abstract: Although it can be lethal in its advanced stage, prostate cancer can be effectively treated when it is localised. Traditionally, radical prostatectomy (RP) or radiotherapy (RT) were used to treat all men with localised prostate cancer; however, this has ... ...

    Abstract Although it can be lethal in its advanced stage, prostate cancer can be effectively treated when it is localised. Traditionally, radical prostatectomy (RP) or radiotherapy (RT) were used to treat all men with localised prostate cancer; however, this has significant risks of post-treatment side effects. Focal therapy has emerged as a potential form of treatment that can achieve similar oncological outcomes to radical treatment while preserving functional outcomes and decreasing rates of adverse effects. Irreversible electroporation (IRE) is one such form of focal therapy which utilises pulsatile electrical currents to ablate tissue. This modality of treatment is still in an early research phase, with studies showing that IRE is a safe procedure that can offer good short-term oncological outcomes whilst carrying a lower risk of poor functional outcomes. We believe that based on these results, future well-designed clinical trials are warranted to truly assess its efficacy in treating men with localised prostate cancer.
    Language English
    Publishing date 2021-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11060490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Irreversible Electroporation for Prostate Cancer

    Sean Ong / Matthew Leonardo / Thilakavathi Chengodu / Dominic Bagguley / Nathan Lawrentschuk

    Life, Vol 11, Iss 490, p

    2021  Volume 490

    Abstract: Although it can be lethal in its advanced stage, prostate cancer can be effectively treated when it is localised. Traditionally, radical prostatectomy (RP) or radiotherapy (RT) were used to treat all men with localised prostate cancer; however, this has ... ...

    Abstract Although it can be lethal in its advanced stage, prostate cancer can be effectively treated when it is localised. Traditionally, radical prostatectomy (RP) or radiotherapy (RT) were used to treat all men with localised prostate cancer; however, this has significant risks of post-treatment side effects. Focal therapy has emerged as a potential form of treatment that can achieve similar oncological outcomes to radical treatment while preserving functional outcomes and decreasing rates of adverse effects. Irreversible electroporation (IRE) is one such form of focal therapy which utilises pulsatile electrical currents to ablate tissue. This modality of treatment is still in an early research phase, with studies showing that IRE is a safe procedure that can offer good short-term oncological outcomes whilst carrying a lower risk of poor functional outcomes. We believe that based on these results, future well-designed clinical trials are warranted to truly assess its efficacy in treating men with localised prostate cancer.
    Keywords prostate cancer ; irreversible electroporation ; focal therapy ; surgery ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Re: Enzalutamide and Survival in Non-metastatic Castration-resistant Prostate Cancer.

    Bagguley, Dominic / Ong, Sean / Lawrentschuk, Nathan / Murphy, Declan G

    European urology

    2020  Volume 79, Issue 2, Page(s) 320–321

    MeSH term(s) Humans ; Male ; Phenylthiohydantoin/adverse effects ; Phenylthiohydantoin/analogs & derivatives ; Prostate-Specific Antigen ; Prostatic Neoplasms, Castration-Resistant/drug therapy
    Chemical Substances Phenylthiohydantoin (2010-15-3) ; enzalutamide (93T0T9GKNU) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2020-09-17
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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  10. Article ; Online: Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups.

    Clark, Kristina Elizabeth Neergaard / Xu, Shiwen / Attah, Moustafa / Ong, Voon H / Buckley, Christopher Dominic / Denton, Christopher P

    Annals of the rheumatic diseases

    2023  Volume 82, Issue 12, Page(s) 1568–1579

    Abstract: Objectives: The severity of skin involvement in diffuse cutaneous systemic sclerosis (dcSSc) depends on stage of disease and differs between anti-RNA-polymerase III (ARA) and anti-topoisomerase antibody (ATA) subsets. We have investigated cellular ... ...

    Abstract Objectives: The severity of skin involvement in diffuse cutaneous systemic sclerosis (dcSSc) depends on stage of disease and differs between anti-RNA-polymerase III (ARA) and anti-topoisomerase antibody (ATA) subsets. We have investigated cellular differences in well-characterised dcSSc patients compared with healthy controls (HCs).
    Methods: We performed single-cell RNA sequencing on 4 mm skin biopsy samples from 12 patients with dcSSc and HCs (n=3) using droplet-based sequencing (10× genomics). Patients were well characterised by stage (>5 or <5 years disease duration) and autoantibody (ATA+ or ARA+). Analysis of whole skin cell subsets and fibroblast subpopulations across stage and ANA subgroup were used to interpret potential cellular differences anchored by these subgroups.
    Results: Fifteen forearm skin biopsies were analysed. There was a clear separation of SSc samples, by disease, stage and antibody, for all cells and fibroblast subclusters. Further analysis revealed differing cell cluster gene expression profiles between ATA+ and ARA+ patients. Cell-to-cell interaction suggest differing interactions between early and late stages of disease and autoantibody. TGFβ response was mainly seen in fibroblasts and smooth muscle cells in early ATA+dcSSc skin samples, whereas in early ARA+dcSSc patient skin samples, the responding cells were endothelial, reflect broader differences between clinical phenotypes and distinct skin score trajectories across autoantibody subgroups of dcSSc.
    Conclusions: We have identified cellular differences between the two main autoantibody subsets in dcSSc (ARA+ and ATA+). These differences reinforce the importance of considering autoantibody and stage of disease in management and trial design in SSc.
    MeSH term(s) Humans ; Autoantibodies ; Scleroderma, Systemic/pathology ; Scleroderma, Diffuse/pathology ; Skin/pathology ; Single-Cell Analysis
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-224184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.114: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 167: Show issues

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