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Article ; Online: Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity.

Guo, Yajing / Lu, Qiongqiong / Yang, Xiao-Jun / He, Yuxi / Wu, Yue / Qin, Baijun / Li, Ting / Duan, Min / Liu, Nvping / Wu, Xin / He, Yuanjun

PloS one

2024 Volume 19, Issue 4, Page(s) e0299376

Abstract: Aim of the study: To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq).: Materials and methods: A rat model of IBS-D was constructed ... ...

Abstract	Aim of the study: To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq). Materials and methods: A rat model of IBS-D was constructed to elucidate the effects of SYNC. Abdominal withdrawal reflex (AWR), fecal water content (FWC), and recording body weight were calculated to assess visceral sensitivity in rats. Histopathological changes in the colon and alterations in mast cell (MC) count were determined. Immunohistochemistry was employed to assess mast cell tryptase (MCT) expression in rat colons. Serum levels of corticotropin-releasing Hormone (CRH), interleukin-6 (IL-6), calcitonin gene-related peptide (CGRP), and 5-hydroxytryptamine (5-HT) were quantified using ELISA. RNA-Seq of colon tissue was performed, followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Western blot analysis was conducted to quantify the expression levels of key proteins in the Nr4a3 pathway in the colon and hypothalamus tissues of rats. Results: SYNC alleviated visceral hypersensitivity and mood disorders in rats with IBS-D. Moreover, it was positively correlated with its dosage and the observed effects, such as the enhancement of the colon's mucosal lining condition and reduction in the number and activation of MCs within the model group. SYNC reduced the expression levels of factors related to the brain-gut axis and inflammatory markers in the bloodstream. RNA-Seq analysis indicated that SYNC down-regulated the expression of Nr4a3 and PI3K. These SYNC-targeted genes primarily played roles in immune regulation and inflammatory responses, correlating with the modulation of Nr4a3 and the PI3K/AKT pathway. Western blot analysis further confirmed SYNC's influence on inflammation-related MC activation by downregulating key proteins in the Nr4a3/PI3K pathway. Conclusions: SYNC inhibited mast cell activation and attenuated visceral hypersensitivity in the colon tissues of IBS-D rats. These effects were mediated by the Nr4a3/PI3K signaling pathway.
MeSH term(s)	Rats ; Animals ; Irritable Bowel Syndrome/pathology ; Rats, Sprague-Dawley ; Phosphatidylinositol 3-Kinases ; Diarrhea ; Corticotropin-Releasing Hormone/metabolism ; DNA-Binding Proteins ; Nerve Tissue Proteins
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Corticotropin-Releasing Hormone (9015-71-8) ; Nr4a3 protein, rat ; DNA-Binding Proteins ; Nerve Tissue Proteins
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Integrating Network Pharmacology, Transcriptome and Artificial Intelligence for Investigating Into the Effect and Mechanism of Ning Fei Ping Xue Decoction Against the Acute Respiratory Distress Syndrome.

Lu, Xiaoxiao / Ma, Wentao / Fan, Baofeng / Li, Peng / Gao, Jing / Liu, Qiuhong / Hu, Chunling / Li, Yong / Yao, Mengying / Ning, Hanbing / Xing, Lihua

Frontiers in pharmacology

2021 Volume 12, Page(s) 731377

Abstract: ... pharmacotherapy. A traditional Chinese medicine (TCM) formula, Ning Fei Ping Xue (NFPX) decoction, was ...

Abstract	Acute respiratory distress syndrome (ARDS) is a high-mortality disease and lacks effective pharmacotherapy. A traditional Chinese medicine (TCM) formula, Ning Fei Ping Xue (NFPX) decoction, was demonstrated to play a critical role in alleviating inflammatory responses of the lung. However, its therapeutic effectiveness in ARDS and active compounds, targets, and molecular mechanisms remain to be elucidated. The present study investigates the effects of NFPX decoction on ARDS mice induced by lipopolysaccharides (LPS). The results revealed that NFPX alleviated lung edema evaluated by lung ultrasound, decreased lung wet/Dry ratio, the total cell numbers of bronchoalveolar lavage fluid (BALF), and IL-1β, IL-6, and TNF-α levels in BALF and serum, and ameliorated lung pathology in a dose-dependent manner. Subsequently, UPLC-HRMS was performed to establish the compounds of NFPX. A total of 150 compounds in NFPX were characterized. Moreover, integrating network pharmacology approach and transcriptional profiling of lung tissues were performed to predict the underlying mechanism. 37 active components and 77 targets were screened out, and a herbs-compounds-targets network was constructed. Differentially expressed genes (DEGs) were identified from LPS-treated mice compared with LPS combined with NFPX mice. GO, KEGG, and artificial intelligence analysis indicated that NFPX might act on various drug targets. At last, potential targets, HRAS, SMAD4, and AMPK, were validated by qRT-PCR in ARDS murine model. In conclusion, we prove the efficacy of NFPX decoction in the treatment of ARDS. Furthermore, integrating network pharmacology, transcriptome, and artificial intelligence analysis contributes to illustrating the molecular mechanism of NFPX decoction on ARDS.
Language	English
Publishing date	2021-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.731377
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Article ; Online: Systematic review of randomized controlled trials on Gong Liu Ning as a complimentary therapy in the treatment of uterine fibroids

Lu Fan / Jiahui Hu / Mei Han / Guoyan Yang / Shibo Cong / Min Xiong / Ruiting Wang / Gansheng Zhong

Journal of Traditional Chinese Medical Sciences, Vol 10, Iss 4, Pp 415-

2023 Volume 426

Abstract: Objective: To systematically evaluate the efficacy and safety of Gong Liu Ning as a complimentary ... therapy in treatment for uterine fibroids. Methods: Randomized controlled trials on Gong Liu Ning ... with 1907 patients were analyzed. The meta-analysis results of 15 studies showed that Gong Liu Ning combined ...

Abstract	Objective: To systematically evaluate the efficacy and safety of Gong Liu Ning as a complimentary therapy in treatment for uterine fibroids. Methods: Randomized controlled trials on Gong Liu Ning for uterine fibroids from China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, PubMed, Cochrane Library, Embase, Web of Science, Chinese Clinical Trial Registry, and ClinicalTrials.gov were retrieved from inception to March 20, 2023. The risk of bias tool was used to evaluate the quality of the selected studies after they met inclusion and exclusion criteria. The GRADE tool was used to evaluate the quality of evidence, and the RevMan5.3 software was used for data analysis. Results: Twenty studies with 1907 patients were analyzed. The meta-analysis results of 15 studies showed that Gong Liu Ning combined with mifepristone was more efficacious than those observed in controls taking only Western medicine (risk ratio [RR] = 1.22, 95% confidence interval [CI] = [1.11, 1.33], P < .001). Owing to the large heterogeneity, a random-effects model was used to merge the included studies. Gong Liu Ning combined with mifepristone was better in reducing the volume of uterine fibroids (mean difference [MD] = −4.09 cm3, 95%CI [−5.16, −3.02], P < .001), uterine volume (MD = −23.22 cm3, 95%CI [−29.10, −17.33], P < .001), and the levels of female hormones, including progesterone, estrogen, follicle-stimulating hormone, and luteinizing hormone (all P < .001). Ten studies reported adverse events. The methodological quality of the included studies was not high, and a moderate risk of bias was observed. Conclusion: Compared with conventional Western medicine alone, the combined use of Gong Liu Ning has certain advantages in improving efficacy. It shows a certain advanced tendency to reduce the volume of uterine fibroids, uterine volume, and female hormones; however, more high-quality and rigorously designed studies are required for validation.
Keywords	Gong Liu Ning ; Uterine fibroids ; Chinese patent medicine ; Meta-analysis ; Systematic review ; Miscellaneous systems and treatments ; RZ409.7-999
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Investigation of the Cellular Pharmacological Mechanism and Clinical Evidence of the Multi-Herbal Antiarrhythmic Chinese Medicine Xin Su Ning.

Ma, Yu-Ling / Hu, Rou-Mu / Yang, Xinchun / Wang, Taiyi / Noble, Penelope J / Wilkins, Robert / Ellory, Clive / Carr, Carolyn / Noble, Denis / Yang, Jiefu / Lu, Weixing / Zhang, Junhua / Hu, Hongde / Guo, Xiaomei / Chen, Min / Wu, Yang / Wei, Meng / Mao, Jingyuan / Ma, Xiaochang /

Qin, Ling / Wu, Huanlin / Lu, Feng / Cao, Ying / Gao, Sheng / Gu, Wanli

Frontiers in pharmacology

2020 Volume 11, Page(s) 600

Abstract: Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available ...

Abstract	Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available in China since 2005 for treating cardiac ventricular arrhythmia including arrhythmia induced by ischemic heart diseases and viral myocarditis, without adverse reactions being reported. It is vitally important to discover pharmacologically how XSN as a multicomponent medicine exerts its clinical efficacy, and whether the therapeutic effect of XSN can be verified by standard clinical trial studies. In this paper we report our discoveries in a cellular electrophysiological study and in a three-armed, randomized, double-blind, placebo-controlled, parallel-group, multicenter trial. Conventional electrophysiological techniques were used to study the cellular antiarrhythmic mechanism of XSN. Data was then modeled with computational simulation of human action potential (AP) of the cardiac ventricular myocytes. The clinical trial was conducted with a total of 861 eligible participants randomly assigned in a ratio of 2:2:1 to receive XSN, mexiletine, or the placebo for 4 weeks. The primary and secondary endpoint was the change of premature ventricular contraction (PVC) counts and PVC-related symptoms, respectively. This trial was registered in the Chinese Clinical Trial Register Center (ChiCTR-TRC-14004180). We found that XSN prolonged AP duration of the ventricular myocytes in a dose-dependent, reversible manner and blocked potassium channels. Patients in XSN group exhibited significant total effective responses in the reduction of PVCs compared to those in the placebo group (65.85% vs. 27.27%, P < 0.0001). No severe adverse effects attributable to XSN were observed. In conclusion, XSN is an effective multicomponent antiarrhythmic medicine to treat PVC without adverse effect in patients, which is convincingly supported by its class I & III pharmacological antiarrhythmic mechanism of blocking hERG potassium channels and hNaV1.5 sodium channel reported in our earlier publication and prolongs AP duration both in ventricular myocytes and with computational simulation of human AP presented in this report.
Language	English
Publishing date	2020-05-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00600
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Article ; Online: Liao ning virus in China.

Lu, Zhi / Liu, Hong / Fu, Shihong / Lu, Xinjun / Dong, Qiang / Zhang, Song / Tong, Suxiang / Li, Minghua / Li, Wenjuan / Tang, Qing / Liang, Guodong

Virology journal

2011 Volume 8, Page(s) 282

Abstract: Background: Liao ning virus is in the genus Seadornavirus within the family Reoviridae and has ...

Abstract	Background: Liao ning virus is in the genus Seadornavirus within the family Reoviridae and has a genome composed of 12 segments of double-stranded RNA (dsRNA). It is transmitted by mosquitoes and only isolated in China to date and it is the only species within the genus Seadornavirus which was reported to have been propagated in mammalian cell lines. In the study, we report 41 new isolates from northern and southern Xinjiang Uygur autonomous region in China and describe the phylogenetic relationships among all 46 Chinese LNV isolates. Findings: The phylogenetic analysis indicated that all the isolates evaluated in this study can be divided into 3 different groups that appear to be related to geographic origin based on partial nucleotide sequence of the 10th segment which is predicted to encode outer coat proteins of LNV. Bayesian coalescent analysis estimated the date of the most recent common ancestor for the current Chinese LNV isolates to be 318 (with a 95% confidence interval of 30-719) and the estimated evolutionary rates is 1.993 × 10-3 substitutions per site per year. Conclusions: The results indicated that LNV may be an emerging virus at a stage that evaluated rapidly and has been widely distributed in the north part of China.
MeSH term(s)	Animals ; China ; Cluster Analysis ; Culicidae/virology ; Evolution, Molecular ; Genotype ; Phylogeny ; Phylogeography ; Polymorphism, Genetic ; RNA, Viral/genetics ; Reoviridae/classification ; Reoviridae/genetics ; Reoviridae/isolation & purification
Chemical Substances	RNA, Viral
Language	English
Publishing date	2011-06-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/1743-422X-8-282
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Article ; Online: Investigation of the Cellular Pharmacological Mechanism and Clinical Evidence of the Multi-Herbal Antiarrhythmic Chinese Medicine Xin Su Ning

Yu-ling Ma / Rou-Mu Hu / Xinchun Yang / Taiyi Wang / Penelope J. Noble / Robert Wilkins / Clive Ellory / Carolyn Carr / Denis Noble / Jiefu Yang / Weixing Lu / Junhua Zhang / Hongde Hu / Xiaomei Guo / Min Chen / Yang Wu / Meng Wei / Jingyuan Mao / Xiaochang Ma /

Ling Qin / Huanlin Wu / Feng Lu / Ying Cao / Sheng Gao / Wanli Gu

Frontiers in Pharmacology, Vol

2020 Volume 11

Abstract: Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available ...

Abstract	Xin Su Ning (XSN), a China patented and certified multi-herbal medicine, has been available in China since 2005 for treating cardiac ventricular arrhythmia including arrhythmia induced by ischemic heart diseases and viral myocarditis, without adverse reactions being reported. It is vitally important to discover pharmacologically how XSN as a multicomponent medicine exerts its clinical efficacy, and whether the therapeutic effect of XSN can be verified by standard clinical trial studies. In this paper we report our discoveries in a cellular electrophysiological study and in a three-armed, randomized, double-blind, placebo-controlled, parallel-group, multicenter trial. Conventional electrophysiological techniques were used to study the cellular antiarrhythmic mechanism of XSN. Data was then modeled with computational simulation of human action potential (AP) of the cardiac ventricular myocytes. The clinical trial was conducted with a total of 861 eligible participants randomly assigned in a ratio of 2:2:1 to receive XSN, mexiletine, or the placebo for 4 weeks. The primary and secondary endpoint was the change of premature ventricular contraction (PVC) counts and PVC-related symptoms, respectively. This trial was registered in the Chinese Clinical Trial Register Center (ChiCTR-TRC-14004180). We found that XSN prolonged AP duration of the ventricular myocytes in a dose-dependent, reversible manner and blocked potassium channels. Patients in XSN group exhibited significant total effective responses in the reduction of PVCs compared to those in the placebo group (65.85% vs. 27.27%, P < 0.0001). No severe adverse effects attributable to XSN were observed. In conclusion, XSN is an effective multicomponent antiarrhythmic medicine to treat PVC without adverse effect in patients, which is convincingly supported by its class I & III pharmacological antiarrhythmic mechanism of blocking hERG potassium channels and hNaV1.5 sodium channel reported in our earlier publication and prolongs AP duration both in ventricular ...
Keywords	Xin Su Ning ; traditional Chinese medicine ; multicomponent antiarrhythmic medicine ; cellular electrophysiology ; premature ventricular contraction ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Liao ning virus in China

Tang Qing / Li Wenjuan / Tong Suxiang / Li Minghua / Zhang Song / Dong Qiang / Lu Xinjun / Fu Shihong / Liu Hong / Lu Zhi / Liang Guodong

Virology Journal, Vol 8, Iss 1, p

2011 Volume 282

Abstract: Abstract Background Liao ning virus is in the genus Seadornavirus within the family Reoviridae and ...

Abstract	Abstract Background Liao ning virus is in the genus Seadornavirus within the family Reoviridae and has a genome composed of 12 segments of double-stranded RNA (dsRNA). It is transmitted by mosquitoes and only isolated in China to date and it is the only species within the genus Seadornavirus which was reported to have been propagated in mammalian cell lines. In the study, we report 41 new isolates from northern and southern Xinjiang Uygur autonomous region in China and describe the phylogenetic relationships among all 46 Chinese LNV isolates. Findings The phylogenetic analysis indicated that all the isolates evaluated in this study can be divided into 3 different groups that appear to be related to geographic origin based on partial nucleotide sequence of the 10th segment which is predicted to encode outer coat proteins of LNV. Bayesian coalescent analysis estimated the date of the most recent common ancestor for the current Chinese LNV isolates to be 318 (with a 95% confidence interval of 30-719) and the estimated evolutionary rates is 1.993 × 10 -3 substitutions per site per year. Conclusions The results indicated that LNV may be an emerging virus at a stage that evaluated rapidly and has been widely distributed in the north part of China.
Keywords	Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	580
Language	English
Publishing date	2011-06-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Selecting the dose metric in reverse dosimetry based QIVIVE : Reply to 'Comment on 'Use of an in vitro-in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine' by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7', Arch Toxicol doi: https://doi.org/10.1007/s0020 4-019-02421-w.

Rietjens, Ivonne M C M / Ning, Jia / Chen, Lu / Wesseling, Sebastiaan / Strikwold, Marije / Louisse, Jochem

Archives of toxicology

2019 Volume 93, Issue 5, Page(s) 1467–1469

MeSH term(s)	Humans ; Liver ; Pyrrolizidine Alkaloids
Chemical Substances	Pyrrolizidine Alkaloids ; riddelliine (23246-96-0) ; lasiocarpine (S770100Q96)
Language	English
Publishing date	2019-05-07
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-019-02438-1
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Article ; Online: Chemical composition differentiation of Shen-Shuai-Ning granule between combined decoction and separated decoction using HPLC-DAD-ESI-QTOF-MS.

Liu, Jianli / Zhang, Yu / Hao, Yimeng / Zhao, Ying / Li, Yanjiao / Qin, Rulan / Lv, Chongning / Lu, Jincai

Biomedical chromatography : BMC

2017 Volume 31, Issue 9

Abstract: Shen-Shuai-Ning (SSN) granule, a traditional Chinese medicine formula, is widely used in clinical ...

Abstract	Shen-Shuai-Ning (SSN) granule, a traditional Chinese medicine formula, is widely used in clinical practice for treating chronic renal failure. However, its detailed chemical profile is unknown. Here, HPLC-ESI-QTOF-MS was employed for the systematic chemical analysis of SSN. A total of 52 compounds were identified and the characteristic ions of the compounds were described. Furthermore, chemical consistency between the combined decoction and the separated decoction of SSN was evaluated using HPLC-DAD. A chemical comparison between two preparations of SSN granule (combined decoction and separated decoction of Coptides Rhizoma) indicated a significant difference in the content of many compounds, including salvianolic acid A, salvianolic acid B, berberine, palmatine and epiberberine. As a result, separated decoction of Coptides Rhizoma would lead to a significantly decrease in depsides in Salviae Miltiorrhizae Radix et Rhizoma and an increase in alkaloids in Coptidis Rhizoma.
MeSH term(s)	Benzofurans ; Berberine Alkaloids ; Caffeic Acids ; Chromatography, High Pressure Liquid/methods ; Drug Compounding ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/chemistry ; Flavones ; Lactates ; Saponins ; Spectrometry, Mass, Electrospray Ionization/methods
Chemical Substances	Benzofurans ; Berberine Alkaloids ; Caffeic Acids ; Drugs, Chinese Herbal ; Flavones ; Lactates ; Saponins ; Shenshuaining ; salvianolic acid A (51622542XO) ; salvianolic acid B (C1GQ844199)
Language	English
Publishing date	2017-09
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.3949
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Article: A clinical trial of tang shen ning for treatment of diabetic nephropathy.

Gao, Y / Lü, R / Wang, X / Geng, J / Ren, K / Wang, Y / Zhao, J / Yu, X / Chen, D

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

1998 Volume 18, Issue 4, Page(s) 247–252

Abstract: This paper reports the clinical trial of Tang Shen Ning ([symbol: see text], TSN) for treating ...

Abstract	This paper reports the clinical trial of Tang Shen Ning ([symbol: see text], TSN) for treating diabetic nephropathy (incipient and clinical, as divided by Mogensen). The results showed that the total effective rate in treatment group (TSN + western medicine) was 90.0%, and that in the control group (simply with western medicine), 56.7%. TSN plays important roles in decreasing proteinuria and improving renal functions.
MeSH term(s)	Adult ; Aged ; Antihypertensive Agents/therapeutic use ; Captopril/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Nephropathies/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Qi ; Yin Deficiency/drug therapy
Chemical Substances	Antihypertensive Agents ; Drugs, Chinese Herbal ; Captopril (9G64RSX1XD)
Language	English
Publishing date	1998-12
Publishing country	China
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial
ZDB-ID	603186-9
ISSN	0254-6272 ; 0255-2922
ISSN (online)	0254-6272
ISSN	0255-2922
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