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Article ; Online: The positioning of ceftobiprole in Staphylococcus aureus bacteremia.

Membrillo de Novales, Francisco Javier / Bravo de Pablo, Olga / Estella García, Ángel / Morata Ruiz, Laura / Oltra Sempere, Maria Rosa / Salavert Lleti, Miguel / Estébanez Muñoz, Miriam / Hidalgo-Tenorio, Carmen

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae123
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Article ; Online: Time from symptoms onset to remdesivir is associated with the risk of ICU admission: a multicentric analyses.

Alonso-Navarro, Rodrigo / Ramírez, Margarita / Masiá, Mar / Paredes, Roger / Montejano, Rocío / Povar-Echeverria, Marina / Carratalà, Jordi / Salavert, Miguel / Bernal, Enrique / Dueñas, Carlos / Flores, Juan / Fanjul, Francisco / Gutiérrez, Isabel / Rico, Verónica / Mateu, Lourdes / Cadiñanos, Julen / Berenguer, Juan / Soriano, Alex

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 286

Abstract: Background: Shorter duration of symptoms before remdesivir has been associated with better outcomes. Our goal was to evaluate variables associated with the need of ICU admission in a cohort of hospitalized patients for COVID-19 under remdesivir ... ...

Abstract	Background: Shorter duration of symptoms before remdesivir has been associated with better outcomes. Our goal was to evaluate variables associated with the need of ICU admission in a cohort of hospitalized patients for COVID-19 under remdesivir including the period from symptoms onset to remdesivir. Methods: We conducted a retrospective multicentric study analysing all patients admitted with COVID-19 in 9 Spanish hospitals who received treatment with remdesivir in October 2020. The main outcome was the need of ICU admission after 24 h of the first dose of remdesivir. Results: In our cohort of 497 patients, the median of days from symptom onset to remdesivir was 5 days, and 70 of them (14.1%) were later admitted into ICU. The clinical outcomes associated with ICU admission were days from symptoms onset (5 vs. 6; p = 0.023), clinical signs of severe disease (respiratory rate, neutrophil count, ferritin levels and very-high mortality rate in SEIMC-Score) and the use of corticosteroids and anti-inflammatory drugs before ICU. The only variable significatively associated with risk reduction in the Cox-regression analyses was ≤ 5 days from symptoms onset to RDV (HR: 0.54, CI95%: 0.31-0.92; p = 0.024). Conclusion: For patients admitted to the hospital with COVID-19, the prescription of remdesivir within 5 days from symptoms onset diminishes the need of ICU admission.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Retrospective Studies ; COVID-19 Drug Treatment ; Intensive Care Units
Chemical Substances	remdesivir (3QKI37EEHE)
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08222-y
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Article ; Online: Treatment and prevention of monkeypox.

de la Calle-Prieto, Fernando / Estébanez Muñoz, Miriam / Ramírez, Germán / Díaz-Menéndez, Marta / Velasco, María / Azkune Galparsoro, Harkaitz / Salavert Lletí, Miguel / Mata Forte, Tatiana / Blanco, José Luis / Mora-Rillo, Marta / Arsuaga, Marta / de Miguel Buckley, Rosa / Arribas, Jose Ramón / Membrillo, Francisco Javier

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 41, Issue 10, Page(s) 629–634

Abstract: Monkeypox is a zoonosis that is spread mainly through direct contact with fluids and skin lesions of infected people with vesicles still active. Although the virus was isolated for the first time in 1958 and the first human case was identified in a child ...

Abstract	Monkeypox is a zoonosis that is spread mainly through direct contact with fluids and skin lesions of infected people with vesicles still active. Although the virus was isolated for the first time in 1958 and the first human case was identified in a child in 1970, in the Democratic Republic of the Congo, the disease has progressively increased its incidence in Africa reaching in May 2022 sustained transmission outside this continent. As it is a newly introduced virus in our health system, it is necessary to learn the epidemiological pattern in a different environment from that of traditionally endemic areas and to know the available antiviral treatments, as well as the prophylactic measures that could be considered, knowing that as a virus emerging in our regions, scientific evidence is still limited. There are antivirals that have been shown, in animal models, to effectively combat the disease with very good clinical tolerance. This disease has also forced us to review the characteristics of smallpox vaccines, because they have shown a protective effect against monkeypox. For this reason, it is important to have a document that compiles all the scientific information published in this regard.
MeSH term(s)	Child ; Animals ; Humans ; Mpox (monkeypox)/drug therapy ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/prevention & control ; Monkeypox virus ; Smallpox Vaccine/therapeutic use ; Africa ; Incidence
Chemical Substances	Smallpox Vaccine
Language	English
Publishing date	2023-01-07
Publishing country	Spain
Document type	Journal Article ; Review
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.12.010
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Article ; Online: Cytokine response as a biomarker for early diagnosis and outcome prediction of stem cell transplant recipients and acute leukemia patients with invasive aspergillosis.

Puerta-Alcalde, Pedro / Ruiz-Camps, Isabel / Gudiol, Carlota / Salavert, Miquel / Barba, Pere / Morandeira, Francisco / Jarque, Isidro / Cuervo, Guillermo / Ayats, Josefina / Carratalà, Jordi / Garcia-Vidal, Carolina

Medical mycology

2022 Volume 60, Issue 7

Abstract: We aimed to determine the role of serum cytokine expression in invasive aspergillosis (IA) diagnosis and outcome prediction in hematologic patients. In this multicenter study, serum cytokines (IL6, IL10, INF-gamma, IL12, IL4, TNF-alpha, IL17, and IL23) ... ...

Abstract	We aimed to determine the role of serum cytokine expression in invasive aspergillosis (IA) diagnosis and outcome prediction in hematologic patients. In this multicenter study, serum cytokines (IL6, IL10, INF-gamma, IL12, IL4, TNF-alpha, IL17, and IL23) were prospectively recruited from all consecutive patients with hematologic malignances at IA diagnosis and compared to control patients matched by center, age, baseline disease, and therapeutic regimen. We included 36 patients with IA and 36 controls. Serum levels of IL6 and IL10 cytokines on day 0 were significantly increased in patients with IA when compared to controls (P = 0.001 and P = 0.025, respectively), even in those who were neutropenic. No differences were observed for the other cytokines. IL6 and IL10 predicted IA with an area under the ROC curve of 0.74 (95% CI 0.62-0.86) and 0.64 (95% CI 0.51-0.77), respectively. The best cutoff point in predicting IA was 20.85 pg/ml for IL6 (sensitivity 72.2%; specificity 77.8%; PPV 76.5% and NPV 73.7%), and 0.045 pg/ml for IL10 (sensitivity 62.9%; specificity 63.9%; PPV 62.9% and NPV 63.9%). IL6 levels were associated with increased mortality, with the best cutoff value being 65.59 pg/ml in mortality prediction. In conclusion, in addition to current tests in place, IL6 and IL10 levels-as measured in plasma-may help clinicians diagnose IA. High levels of IL6 at IA diagnosis are related with worse outcomes. Lay summary: We evaluated the role of serum cytokine expression in invasive aspergillosis (IA) diagnosis and outcome. Serum levels of IL6 and IL10 are increased in patients with IA compared to controls, and IL6 levels are associated with mortality.
MeSH term(s)	Animals ; Aspergillosis/diagnosis ; Aspergillosis/veterinary ; Biomarkers ; Cytokines ; Early Diagnosis ; Interleukin-10 ; Interleukin-6 ; Invasive Fungal Infections/diagnosis ; Invasive Fungal Infections/veterinary ; Leukemia/veterinary ; Stem Cell Transplantation/veterinary
Chemical Substances	Biomarkers ; Cytokines ; Interleukin-6 ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2022-06-02
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.1093/mmy/myac038
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Article: Current Positioning against Severe Infections Due to

Vidal-Cortés, Pablo / Martin-Loeches, Ignacio / Rodríguez, Alejandro / Bou, Germán / Cantón, Rafael / Diaz, Emili / De la Fuente, Carmen / Torre-Cisneros, Julián / Nuvials, Francisco Xavier / Salavert, Miguel / Aguilar, Gerardo / Nieto, Mercedes / Ramírez, Paula / Borges, Marcio / Soriano, Cruz / Ferrer, Ricard / Maseda, Emilio / Zaragoza, Rafael

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 9

Abstract: Infections due ... ...

Abstract	Infections due to
Language	English
Publishing date	2022-08-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11091160
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Article: Ten Issues to Update in Nosocomial or Hospital-Acquired Pneumonia: An Expert Review.

Journal of clinical medicine

2023 Volume 12, Issue 20

Abstract: Nosocomial pneumonia, or hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP) are important health problems worldwide, with both being associated with substantial morbidity and mortality. HAP is currently the main cause of death ... ...

Abstract	Nosocomial pneumonia, or hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP) are important health problems worldwide, with both being associated with substantial morbidity and mortality. HAP is currently the main cause of death from nosocomial infection in critically ill patients. Although guidelines for the approach to this infection model are widely implemented in international health systems and clinical teams, information continually emerges that generates debate or requires updating in its management. This scientific manuscript, written by a multidisciplinary team of specialists, reviews the most important issues in the approach to this important infectious respiratory syndrome, and it updates various topics, such as a renewed etiological perspective for updating the use of new molecular platforms or imaging techniques, including the microbiological diagnostic stewardship in different clinical settings and using appropriate rapid techniques on invasive respiratory specimens. It also reviews both Intensive Care Unit admission criteria and those of clinical stability to discharge, as well as those of therapeutic failure and rescue treatment options. An update on antibiotic therapy in the context of bacterial multiresistance, in aerosol inhaled treatment options, oxygen therapy, or ventilatory support, is presented. It also analyzes the out-of-hospital management of nosocomial pneumonia requiring complete antibiotic therapy externally on an outpatient basis, as well as the main factors for readmission and an approach to management in the emergency department. Finally, the main strategies for prevention and prophylactic measures, many of them still controversial, on fragile and vulnerable hosts are reviewed.
Language	English
Publishing date	2023-10-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12206526
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Article: Ten Issues for Updating in Community-Acquired Pneumonia: An Expert Review.

Candel, Francisco Javier / Salavert, Miguel / Basaras, Miren / Borges, Marcio / Cantón, Rafael / Cercenado, Emilia / Cilloniz, Catian / Estella, Ángel / García-Lechuz, Juan M / Garnacho Montero, José / Gordo, Federico / Julián-Jiménez, Agustín / Martín-Sánchez, Francisco Javier / Maseda, Emilio / Matesanz, Mayra / Menéndez, Rosario / Mirón-Rubio, Manuel / Ortiz de Lejarazu, Raúl / Polverino, Eva /

Retamar-Gentil, Pilar / Ruiz-Iturriaga, Luis Alberto / Sancho, Susana / Serrano, Leyre

Journal of clinical medicine

2023 Volume 12, Issue 21

Abstract: Community-acquired pneumonia represents the third-highest cause of mortality in industrialized countries and the first due to infection. Although guidelines for the approach to this infection model are widely implemented in international health schemes, ... ...

Abstract	Community-acquired pneumonia represents the third-highest cause of mortality in industrialized countries and the first due to infection. Although guidelines for the approach to this infection model are widely implemented in international health schemes, information continually emerges that generates controversy or requires updating its management. This paper reviews the most important issues in the approach to this process, such as an aetiologic update using new molecular platforms or imaging techniques, including the diagnostic stewardship in different clinical settings. It also reviews both the Intensive Care Unit admission criteria and those of clinical stability to discharge. An update in antibiotic, in oxygen, or steroidal therapy is presented. It also analyzes the management out-of-hospital in CAP requiring hospitalization, the main factors for readmission, and an approach to therapeutic failure or rescue. Finally, the main strategies for prevention and vaccination in both immunocompetent and immunocompromised hosts are reviewed.
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12216864
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Article ; Online: Tratamiento y prevención de la viruela del mono.

Enfermedades infecciosas y microbiologia clinica

2022

Title translation	Treatment and prevention of monkeypox.
Abstract	Monkeypox is a zoonosis that is spread mainly through direct contact with fluids and skin lesions of infected people with vesicles still active. Although the virus was isolated for the first time in 1958 and the first human case was identified in a child in 1970, in the Democratic Republic of the Congo, the disease has progressively increased its incidence in Africa reaching in May 2022 sustained transmission outside this continent. As it is a newly introduced virus in our health system, it is necessary to learn the epidemiological pattern in a different environment from that of traditionally endemic areas and to know the available antiviral treatments, as well as the prophylactic measures that could be considered, knowing that as a virus emerging in our regions, scientific evidence is still limited. There are antivirals that have been shown, in animal models, to effectively combat the disease with very good clinical tolerance. This disease has also forced us to review the characteristics of smallpox vaccines, because they have shown a protective effect against monkeypox. For this reason, it is important to have a document that compiles all the scientific information published in this regard.
Language	Spanish
Publishing date	2022-09-22
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2022.08.001
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Article ; Online: Expert Consensus: Main Risk Factors for Poor Prognosis in COVID-19 and the Implications for Targeted Measures against SARS-CoV-2.

Candel, Francisco Javier / Barreiro, Pablo / Salavert, Miguel / Cabello, Alfonso / Fernández-Ruiz, Mario / Pérez-Segura, Pedro / San Román, Jesús / Berenguer, Juan / Córdoba, Raúl / Delgado, Rafael / España, Pedro Pablo / Gómez-Centurión, Ignacio Alberto / González Del Castillo, Juan María / Heili, Sarah Béatrice / Martínez-Peromingo, Francisco Javier / Menéndez, Rosario / Moreno, Santiago / Pablos, José Luís / Pasquau, Juan /

Piñana, José Luis / On Behalf Of The Modus Investigators Adenda

Viruses

2023 Volume 15, Issue 7

Abstract: The clinical evolution of patients infected with the Severe Acute Respiratory Coronavirus type 2 (SARS-CoV-2) depends on the complex interplay between viral and host factors. The evolution to less aggressive but better-transmitted viral variants, and the ...

Abstract	The clinical evolution of patients infected with the Severe Acute Respiratory Coronavirus type 2 (SARS-CoV-2) depends on the complex interplay between viral and host factors. The evolution to less aggressive but better-transmitted viral variants, and the presence of immune memory responses in a growing number of vaccinated and/or virus-exposed individuals, has caused the pandemic to slowly wane in virulence. However, there are still patients with risk factors or comorbidities that put them at risk of poor outcomes in the event of having the coronavirus infectious disease 2019 (COVID-19). Among the different treatment options for patients with COVID-19, virus-targeted measures include antiviral drugs or monoclonal antibodies that may be provided in the early days of infection. The present expert consensus is based on a review of all the literature published between 1 July 2021 and 15 February 2022 that was carried out to establish the characteristics of patients, in terms of presence of risk factors or comorbidities, that may make them candidates for receiving any of the virus-targeted measures available in order to prevent a fatal outcome, such as severe disease or death. A total of 119 studies were included from the review of the literature and 159 were from the additional independent review carried out by the panelists a posteriori. Conditions found related to strong recommendation of the use of virus-targeted measures in the first days of COVID-19 were age above 80 years, or above 65 years with another risk factor; antineoplastic chemotherapy or active malignancy; HIV infection with CD4+ cell counts < 200/mm
MeSH term(s)	Humans ; Aged, 80 and over ; COVID-19 ; SARS-CoV-2 ; HIV Infections/drug therapy ; Risk Factors ; Prognosis
Language	English
Publishing date	2023-06-27
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15071449
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Article ; Online: High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes.

Hidalgo, Marta R / Cubuk, Cankut / Amadoz, Alicia / Salavert, Francisco / Carbonell-Caballero, José / Dopazo, Joaquin

Oncotarget

2017 Volume 8, Issue 3, Page(s) 5160–5178

Abstract: Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is a main challenge for precision medicine. Here we propose a new method that models cell signaling using biological knowledge on signal transduction. ... ...

Abstract	Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is a main challenge for precision medicine. Here we propose a new method that models cell signaling using biological knowledge on signal transduction. The method recodes individual gene expression values (and/or gene mutations) into accurate measurements of changes in the activity of signaling circuits, which ultimately constitute high-throughput estimations of cell functionalities caused by gene activity within the pathway. Moreover, such estimations can be obtained either at cohort-level, in case/control comparisons, or personalized for individual patients. The accuracy of the method is demonstrated in an extensive analysis involving 5640 patients from 12 different cancer types. Circuit activity measurements not only have a high diagnostic value but also can be related to relevant disease outcomes such as survival, and can be used to assess therapeutic interventions.
Language	English
Publishing date	2017-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.14107
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