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Article ; Online: Dexamethason für die postoperative Schmerztherapie in der Bandscheibenchirurgie.

Schreiber, Nikolaus / Gebauer, David / Schittek, Gregor / Sandner-Kiesling, Andreas

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

2022 Volume 57, Issue 2, Page(s) 138–141

Abstract: Intervertebral disc operations are already among the most common and their frequency is increasing. The pain associated with these operations is one of the most common postoperative discomforts, has a significant impact on psychosocial aspects, and ... ...

Title translation	Role of Dexamethasone for Pain Management in Intervertebral Disc Surgery.
Abstract	Intervertebral disc operations are already among the most common and their frequency is increasing. The pain associated with these operations is one of the most common postoperative discomforts, has a significant impact on psychosocial aspects, and should therefore be treated effectively. Therefore, we present the importance of dexamethasone for multimodal pain management after intervertebral disc surgery.
MeSH term(s)	Dexamethasone/therapeutic use ; Humans ; Intervertebral Disc/surgery ; Intervertebral Disc Displacement/surgery ; Lumbar Vertebrae/surgery ; Pain Management
Chemical Substances	Dexamethasone (7S5I7G3JQL)
Language	German
Publishing date	2022-02-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-1483-9092
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Article ; Online: Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients - A randomized controlled trial.

Soukup, Jens / Michel, Peter / Christel, Annett / Schittek, Gregor Alexander / Wagner, Nana-Maria / Kellner, Patrick

Journal of critical care

2023 Volume 74, Page(s) 154251

Abstract: Background: Volatile anesthetics are used more commonly for sedation in the intensive-care-unit (ICU). However, evidence for long-term use remains low. We therefore conducted a randomized-controlled trial comparing sevoflurane with intravenous sedation ... ...

Abstract	Background: Volatile anesthetics are used more commonly for sedation in the intensive-care-unit (ICU). However, evidence for long-term use remains low. We therefore conducted a randomized-controlled trial comparing sevoflurane with intravenous sedation with particular focus on efficacy and safety. Methods: In this prospective, randomized-controlled phase-IIb monocentric clinical-trial ICU patients requiring at least 48 h of sedation were randomized to receive sevoflurane (S) or propofol/midazolam (P). Sedation quality was monitored using the Richmond-Agitation-Sedation-Scale. Following termination of sedation, the time to spontaneous breathing and extubation, opioid consumption, hemodynamics, ICU and hospital length of stay (LOS) and adverse events were recorded. Results: 79 patients were eligible to randomization. Sedation quality was comparable between sevoflurane (n = 39) and propofol (n = 40). However, the use of sevoflurane lead to a reduction in time to spontaneous breathing (26 min vs. 375 min, P < 0.001). Patients sedated with propofol had lower opioid requirements (remifentanil:400 μg/h vs. 500 μg/h, P = 0.007; sufentanil:40 μg/h vs. 30 μg/h, P = 0.007) while hemodynamics, LOS or the occurrence of adverse events did not differ. Conclusion: ICU patients sedated with sevoflurane >48 h may return to spontaneous breathing faster, while the quality of sedation is comparable to a propofol-based sedation regime. Sevoflurane might be considered to be safe for long-term sedation in this patient population, while being non-inferior compared to propofol.
MeSH term(s)	Humans ; Propofol/adverse effects ; Sevoflurane ; Anesthetics, Intravenous ; Analgesics, Opioid ; Respiration, Artificial ; Prospective Studies ; Critical Illness ; Hypnotics and Sedatives
Chemical Substances	Propofol (YI7VU623SF) ; Sevoflurane (38LVP0K73A) ; Anesthetics, Intravenous ; Analgesics, Opioid ; Hypnotics and Sedatives
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2022.154251
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Article ; Online: Das Post-Polio-Syndrom in der perioperativen Phase.

Gebauer, David / Schittek, Gregor A / Zoidl, Philipp / Sandner-Kiesling, Andreas

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

2021 Volume 56, Issue 9, Page(s) 628–634

Abstract: Due to the numerous poliomyelitis epidemics that have continued over the last decades and the post-polio syndrome (PPS) that occurs 10 - 30 years after poliomyelitis infection, the prevalence of PPS is also expected to increase in Europe. At the same ... ...

Title translation	Post-polio Syndrome in the Perioperative Phase.
Abstract	Due to the numerous poliomyelitis epidemics that have continued over the last decades and the post-polio syndrome (PPS) that occurs 10 - 30 years after poliomyelitis infection, the prevalence of PPS is also expected to increase in Europe. At the same time, due to the musculoskeletal disorders associated with the underlying disease, PPS patients often require surgery for which special anaesthetic requirements must be taken into account. In this analysis we summarise the current evidence and recommendations.
MeSH term(s)	Europe ; Humans ; Poliomyelitis ; Postpoliomyelitis Syndrome/diagnosis ; Postpoliomyelitis Syndrome/epidemiology ; Prevalence
Language	German
Publishing date	2021-09-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-1220-4689
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Article ; Online: Wellbeing of ICU patients with COVID-19.

Schittek, Gregor Alexander / Bornemann-Cimenti, Helmar / Sandner-Kiesling, Andreas

Intensive & critical care nursing

2021 Volume 65, Page(s) 103050

MeSH term(s)	COVID-19/psychology ; Humans ; Inpatients ; Intensive Care Units ; Mental Health
Language	English
Publishing date	2021-03-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1105892-4
ISSN	1532-4036 ; 0964-3397
ISSN (online)	1532-4036
ISSN	0964-3397
DOI	10.1016/j.iccn.2021.103050
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Article ; Online: The Austrian ICU survey : A questionnaire-based evaluation of intensive care medicine in Austria.

Schlömmer, Christine / Schittek, Gregor A / Meier, Jens / Hasibeder, Walter / Valentin, Andreas / Dünser, Martin W

Wiener klinische Wochenschrift

2022 Volume 134, Issue 9-10, Page(s) 351–360

Abstract: Background: While structures of intensive care medicine in Austria are well defined, data on organisational and medical practice in intensive care units (ICUs) have not been systematically evaluated.: Methods: In this explorative survey, ... ...

Abstract	Background: While structures of intensive care medicine in Austria are well defined, data on organisational and medical practice in intensive care units (ICUs) have not been systematically evaluated. Methods: In this explorative survey, organisational and medical details of ICUs in Austria were collected using an online questionnaire consisting of 147 questions. Results: Out of 249 registered ICUs 73 (29.3%) responded, 60 were adult, 10 pediatric/neonatal ICUs and 19, 25 and 16 ICUs were located in level I, II and III hospitals, respectively. Of the respondents 89% reported that the ICU director was board-certified in intensive care medicine. Consultants were constantly present in 78% of ICUs during routine working hours and in 45% during nights and weekends. The nurse:bed ratio varied between 1:1 and 1:2 in 74% during day shifts and 60% during night shifts. Routine physiotherapist rounds were reported to take place daily except weekends in 67% of ICUs. Common monitoring techniques were reported to be in routine or occasional use in 85% and 83% of ICUs, respectively. The majority of ICUs provided daily visiting hours ranging between 2-12 h. Waiting rooms for relatives were available in 66% and an electronic documentation system in 66% of ICUs. Written protocols were available in 70% of ICUs. Conclusion: The Austrian ICU survey suggests that ICUs in Austria are clearly structured, well-organized and well-equipped and have a high nurse:bed ratio. In view of the relatively low return rate we cannot exclude that a selection bias has led to overestimation of the survey findings.
MeSH term(s)	Adult ; Austria ; Child ; Critical Care ; Humans ; Infant, Newborn ; Intensive Care Units ; Intensive Care Units, Neonatal ; Surveys and Questionnaires
Language	English
Publishing date	2022-01-27
Publishing country	Austria
Document type	Journal Article
ZDB-ID	200462-8
ISSN	1613-7671 ; 0043-5325 ; 0300-5178
ISSN (online)	1613-7671
ISSN	0043-5325 ; 0300-5178
DOI	10.1007/s00508-021-02002-x
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Article ; Online: Less Induction Time and Postoperative Pain Using Spinal Anesthesia Versus General Anesthesia With or Without the Use of Peripheral Nerve Blocks in Total Knee Arthroplasty.

Koutp, Amir / Hauer, Georg / Leitner, Lukas / Kaltenegger, Lucas / Fischerauer, Stefan / Clar, Clemens / Reinbacher, Patrick / Schittek, Gregor / Leithner, Andreas / Sadoghi, Patrick

The Journal of arthroplasty

2023 Volume 39, Issue 4, Page(s) 904–909

Abstract: Background: Our aim was to analyze anesthetic induction time and postoperative pain using spinal anesthesia versus general anesthesia with or without the use of peripheral nerve blocks (PNBs) in total knee arthroplasty. The hypothesis was that spinal ... ...

Abstract	Background: Our aim was to analyze anesthetic induction time and postoperative pain using spinal anesthesia versus general anesthesia with or without the use of peripheral nerve blocks (PNBs) in total knee arthroplasty. The hypothesis was that spinal anesthesia would be beneficial with respect to induction time and postoperative pain and that PNBs would complement this effect. Methods: Patients were stratified according to demographics, American Society of Anesthesiologists physical status classification system (ASA), and opioid intake and divided into: (A) general anesthesia without PNB; (B) general anesthesia with PNB; (C) spinal anesthesia without PNB; and (D) spinal anesthesia with PNB. Endpoints were anesthetic induction time, opioid consumption, and pain. Of 559 patients, 348 (62.3%) received general anesthesia (consisting of group A with 46 and group B with 302 patients), and 211 (37.7%) spinal anesthesia (consisting of group C with 117 and group D with 94 patients). Results: We observed significantly lower total opioid intake 48 hours postoperative when applying spinal anesthesia by 2.08 mg (P < .05) of intravenous morphine-equivalent, and a reduction of 7.0 minutes (P < .05) until skin incision. The application of a PNB achieved a reduction of piritramide intake of 3.59 mg (P < .05) 48 hours postoperative and lengthened induction time by 8.5 minutes (P < .05). Conclusions: Statistically shorter anesthetic induction times without clinical relevance, but lower postoperative opioid dosages with clinical relevance were observed for patients undergoing total knee arthroplasty with spinal anesthesia. The additional application of PNBs led to a lower need for opioids and lower pain levels in the early postoperative phase.
MeSH term(s)	Humans ; Anesthesia, Spinal/methods ; Arthroplasty, Replacement, Knee/adverse effects ; Analgesics, Opioid/therapeutic use ; Peripheral Nerves ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Pain, Postoperative/etiology ; Anesthesia, General/methods ; Anesthetics/therapeutic use
Chemical Substances	Analgesics, Opioid ; Anesthetics
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2023.10.018
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Article: Dexamethason für die postoperative Schmerztherapie in der Bandscheibenchirurgie

Schreiber, Nikolaus / Gebauer, David / Schittek, Gregor / Sandner-Kiesling, Andreas

AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie

2022 Volume 57, Issue 02, Page(s) 138–141

Abstract: Bandscheibenoperationen gehören in Deutschland zu den häufigen Operationen und eine effektive perioperative Schmerztherapie ist entscheidend für die rasche Genesung der Patient*innen. In ... diesem Beitrag präsentieren wir die aktuelle Studienlage zum ... ...

Abstract	Bandscheibenoperationen gehören in Deutschland zu den häufigen Operationen und eine effektive perioperative Schmerztherapie ist entscheidend für die rasche Genesung der Patient*innen. In diesem Beitrag präsentieren wir die aktuelle Studienlage zum Einfluss einer perioperativen Dexamethason-Gabe auf den postoperativen Opioidbedarf sowie das Schmerzempfinden nach Bandscheibenoperationen.
Keywords	Dexamethason ; Reduktion des Opioidbedarfs ; Schmerztherapie ; Bandscheibenchirurgie ; dexamethasone ; opioid sparing ; pain management ; lumbar disc surgery
Language	German
Publishing date	2022-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-1483-9092
Database	Thieme publisher's database

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Article ; Online: Web-based survey of the importance and effectiveness of personal protective equipment during the COVID-19 pandemic.

Schittek, Gregor A / Köstenberger, Markus / Allerberger, Franz / Schaden, Eva

Intensive & critical care nursing

2020 Volume 63, Page(s) 102996

MeSH term(s)	COVID-19/prevention & control ; Humans ; Internet/statistics & numerical data ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Personal Protective Equipment/statistics & numerical data ; SARS-CoV-2 ; Surveys and Questionnaires/statistics & numerical data
Language	English
Publishing date	2020-12-03
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1105892-4
ISSN	1532-4036 ; 0964-3397
ISSN (online)	1532-4036
ISSN	0964-3397
DOI	10.1016/j.iccn.2020.102996
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Article ; Online: Electrogustometry: Normative data for stimulus duration, tongue site and age decline.

Pavlidis, Pavlos / Schittek, Gregor Alexander / Saratziotis, Athanasios / Ferfeli, Maria / Kekes, Georgios / Gouveris, Haralampos

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

2021 Volume 46, Issue 4, Page(s) 767–774

Abstract: Objectives: Our primary goal was to evaluate the effect of stimulus duration on electrogustometry (EGM) thresholds. Additionally, we sought to evaluate any sex-related influences and compare the above results to those of taste strips.: Design: ... ...

Abstract	Objectives: Our primary goal was to evaluate the effect of stimulus duration on electrogustometry (EGM) thresholds. Additionally, we sought to evaluate any sex-related influences and compare the above results to those of taste strips. Design: Electrogustometry thresholds of various stimulus durations (0.5, 1.0, 1.5 and 2.0 seconds) were measured in 212 non-smokers (age range: 10-80 years, divided into eight age-groups) without self-reported gustatory impairment. Furthermore, taste strips chemogustometry measurements in 132 participants were performed. Setting: Tertiary referral medical centre. Participants: 212 non-smokers, divided into eight age-groups participated in the study. Main outcome measures: Electrogustometry thresholds and taste strips, duration of EGM stimuli. Results: Electrogustometry thresholds increased progressively with age and with stimulus duration from 0.5 to 2 seconds. This pattern was consistent in all six anatomic areas, irrespective of sex. In contrast, when using chemogustometry, no age- or sex-related differences were observed. Conclusions: Electrogustometry-threshold values increase progressively with age and with stimulus duration. Therefore, we recommend documenting stimulus duration in the future EGM recordings as it may significantly affect EGM amplitude threshold values.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Electrodiagnosis/methods ; Female ; Humans ; Male ; Middle Aged ; Reference Values ; Taste Threshold/physiology
Language	English
Publishing date	2021-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2205891-6
ISSN	1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
ISSN (online)	1749-4486
ISSN	1749-4478 ; 0307-7772 ; 1365-2273
DOI	10.1111/coa.13731
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Article ; Online: Schwere Schocksymptomatik infolge anaphylaktoider Reaktion auf Ticagrelor.

Schittek, Gregor A / Simonis, Holger / Fischer, Matthias / Soukup, Jens

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

2019 Volume 54, Issue 10, Page(s) 630–634

Abstract: Background: Ticagrelor as a P2Y12 receptor antagonist is recommended in patients with acute coronary syndrome without a primary cardiosurgical therapy. Severe relevant side effects, especially anaphylactic reactions, have not yet been described in the ... ...

Title translation	Severe Shock Symptoms Due to Ticagrelor Related Anaphylactoid Reaction Following ST Elevation Myocardial Infarction.
Abstract	Background: Ticagrelor as a P2Y12 receptor antagonist is recommended in patients with acute coronary syndrome without a primary cardiosurgical therapy. Severe relevant side effects, especially anaphylactic reactions, have not yet been described in the current literature. Case presentation: We describe the first documented case in the current literature with a severe anaphylaxis after ticagrelor in a 76-year-old male patient with ST-elevation myocardial infarction. The diagnosis seems to be objectivated by the observed time-related life-threatening event after repetitive administration of ticagrelor and the rapid stabilization after adequate anaphylactic treatment. Conclusion: This case should raise the awareness that a supposedly safe drug can still cause an anaphylactic shock.
MeSH term(s)	Adenosine ; Aged ; Humans ; Male ; Platelet Aggregation Inhibitors/adverse effects ; ST Elevation Myocardial Infarction/drug therapy ; Shock/chemically induced ; Ticagrelor/adverse effects
Chemical Substances	Platelet Aggregation Inhibitors ; Ticagrelor (GLH0314RVC) ; Adenosine (K72T3FS567)
Language	German
Publishing date	2019-10-22
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-0901-6613
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