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Article: Reply to the ‘Comment on “Exposure to mercury and Aroclor 1268 congeners in least terns (Sternula antillarum) in coastal Georgia, USA”’ by P. C. Fuchsman, M. H. Henning and V. S. Magar, Environmental Science: Processes & Impacts, 2016, 18, DOI: 10.1039/C5EM00489F

Robinson, Gabrielle L / Mills, Gary L / Schweitzer, Sara / Hernandez, Sonia

Environmental science. 2016 Feb. 17, v. 18, no. 2

2016

Abstract: ... of results presented in our recent publication (Robinson et al., Environmental Science: Processes & Impacts ...

Abstract	This article provides our response to the comment by Fuchsman et al. regarding the interpretation of results presented in our recent publication (Robinson et al., Environmental Science: Processes & Impacts, 2015, 17, 1424) reporting on concentrations of Aroclor 1268 congeners in least tern eggs in coastal Georgia, USA.
Keywords	Sternula antillarum ; aroclors ; eggs ; environmental science ; mercury ; Georgia
Language	English
Dates of publication	2016-0217
Size	p. 292-293.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2703814-2
ISSN	2050-7895 ; 2050-7887
ISSN (online)	2050-7895
ISSN	2050-7887
DOI	10.1039/c5em00663e
Database	NAL-Catalogue (AGRICOLA)

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Article: Elevated levels of a specific class of nuclear phosphoproteins in cells transformed with v-ras and v-mos oncogenes and by cotransfection with c-myc and polyoma middle T genes.

Giancotti, V / Pani, B / D'Andrea, P / Berlingieri, M T / Di Fiore, P P / Fusco, A / Vecchio, G / Philp, R / Crane-Robinson, C / Nicolas, R H

The EMBO journal

1987 Volume 6, Issue 7, Page(s) 1981–1987

Abstract: ... when transformed by the myeloproliferative sarcoma virus (carrying the v-mos oncogene) and when transformed ... by transfection with the c-myc proto-oncogene followed by infection with the polyoma leukaemia virus (PyMuLV ... carry the polyoma middle T antigen gene. Neither c-myc or PyMuLV alone induced high levels of the three ...

Abstract	Transformation of a rat thyroid epithelial cell line (FRTL5-C12) with Kirsten and Harvey murine sarcoma viruses (carrying the ras oncogenes) results in elevated levels of three perchloric acid-soluble nuclear phosphoproteins. These three proteins are also induced to high levels in the PC-C13 thyroid epithelial cell line when transformed by the myeloproliferative sarcoma virus (carrying the v-mos oncogene) and when transformed by transfection with the c-myc proto-oncogene followed by infection with the polyoma leukaemia virus (PyMuLV) carry the polyoma middle T antigen gene. Neither c-myc or PyMuLV alone induced high levels of the three nuclear proteins. Untransformed thyroid fibroblasts have high levels of two of the three proteins and can be transformed by PyMuLV alone resulting in the appearance of the third protein. Transformation with Harvey sarcoma virus also results in the induction of the third protein. The three phosphoproteins have been purified by h.p.l.c. and shown to be related to the HeLa protein HMGI already described. The results of these studies indicate that elevated levels of these HMGI-like proteins are associated with neoplastic transformation and/or with an undifferentiated phenotype.
MeSH term(s)	Animals ; Antigens, Polyomavirus Transforming/genetics ; Cell Line ; Cell Nucleus/metabolism ; Cell Transformation, Neoplastic ; Genes ; Genes, Viral ; Harvey murine sarcoma virus/genetics ; High Mobility Group Proteins/metabolism ; Oncogenes ; Phosphoproteins/metabolism ; Polyomavirus/genetics ; Protein Kinases/genetics ; Proto-Oncogenes ; Rats ; Transfection
Chemical Substances	Antigens, Polyomavirus Transforming ; High Mobility Group Proteins ; Phosphoproteins ; Protein Kinases (EC 2.7.-)
Language	English
Publishing date	1987-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1002/j.1460-2075.1987.tb02461.x
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Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Usage of human T-cell receptor V beta, J beta, C beta, and V alpha gene segments is not proportional to gene number.

Robinson, M A

Human immunology

1992 Volume 35, Issue 1, Page(s) 60–67

Abstract: Certain T-cell receptor (TCR) beta-chain variable (V), joining (J), and constant (C) gene segments ... to contain unique combinations of V, J, and C gene segments or to display diversity in N region nucleotides ... The frequency of the V, J, and C genes used in the assembly of unique transcripts was ascertained. Of the 24 ...

Abstract	Certain T-cell receptor (TCR) beta-chain variable (V), joining (J), and constant (C) gene segments, as well as TCR alpha-chain V gene segments, are disproportionally represented in TCR alpha and beta cDNA libraries derived from PHA-stimulated peripheral blood lymphocytes. Sequences of 138 TCR alpha clones and 96 TCR beta clones were determined and of these 128 TCR alpha clones and 88 TCR beta clones were found to contain unique combinations of V, J, and C gene segments or to display diversity in N region nucleotides. The frequency of the V, J, and C genes used in the assembly of unique transcripts was ascertained. Of the 24 reported V beta gene families, 21 were observed among the 88 TCR beta clones including four V beta families (V beta 1, V beta 2, V beta 3, and V beta 4) that were represented in the sample 2 1/2-5 times more frequently than would be expected on the basis of copy number within the gene complex. Seventy-eight percent of the clones were positive for C beta 2 and more than half of the clones (53%) used one of two J beta 2 genes: J beta 2.1 was present in 27 clones and J beta 2.7 in 20 clones. TCR V alpha families were also disproportionately represented in this sample. Twenty-five of 30 V alpha families were observed in the sample of 128 clones including six recently reported V alpha families. Three V alpha families, V alpha 2, V alpha 8, and V alpha 23, accounted for approximately 40% of the TCR alpha clones and were represented at 18%, 9.4%, and 13.3%, respectively. Both V alpha 2 and V alpha 8 gene families contain more than one gene; thus the number of clones observed in these families may, in part, be related to gene number. However, V alpha 23, which appears to be a single-copy gene family, is significantly overrepresented in this sample. Although disproportional usage of V beta genes may be accounted for by superantigen exposure, reasons for disproportional usage of J beta, C beta, and V alpha genes are presently unknown.
MeSH term(s)	Base Sequence ; Gene Library ; Genes, Regulator/genetics ; Humans ; Lymphocyte Activation/genetics ; Molecular Sequence Data ; Polymerase Chain Reaction ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; T-Lymphocytes/immunology
Chemical Substances	Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	1992-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/0198-8859(92)90095-5
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Article ; Online: Teaching Queer Concepts to Graduate Students in Communication Sciences and Disorders: Culturally Responsive Pedagogy to Foster Affirmative Clinical Practice.

Robinson, Gregory C / Toliver-Smith, Andrea / Stigar, Lorraine V

Seminars in speech and language

2023 Volume 44, Issue 2, Page(s) 104–118

Abstract: There is a growing body of literature informing pedagogical content and strategies of diversity, equity, and inclusion in the education of speech-language pathologists. However, little discussion has included content related to LGBTQ+ people, even though ...

Abstract	There is a growing body of literature informing pedagogical content and strategies of diversity, equity, and inclusion in the education of speech-language pathologists. However, little discussion has included content related to LGBTQ+ people, even though LGBTQ+ people exist across all racial/ethnic groups. This article seeks to fill that void and provide instructors of speech-language pathology with practical information to educate their graduate students. The discussion uses a critical epistemology and invokes theoretical models, such as Queer/Quare theory, DisCrit, the Minority Stress Model, the Ethics of Care, and Culturally Responsive Pedagogy. Information is organized according to developing graduate students' awareness, knowledge, and skills and challenges instructors to modify current course content to disrupt systemic oppression.
MeSH term(s)	Humans ; Communication ; Knowledge ; Sexual and Gender Minorities ; Speech-Language Pathology ; Students
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	604960-6
ISSN	1098-9056 ; 0734-0478
ISSN (online)	1098-9056
ISSN	0734-0478
DOI	10.1055/s-0043-1761947
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Article ; Online: Muscle and joint mechanics during maximum force biting following total temporomandibular joint replacement surgery.

Woodford, Sarah C / Robinson, Dale L / Abduo, Jaafar / Lee, Peter V S / Ackland, David C

Biomechanics and modeling in mechanobiology

2024

Abstract: Total temporomandibular joint replacement (TMJR) surgery is the established treatment for severe temporomandibular joint disorders. While TMJR surgery is known to increase mouth-opening capacity, reduce pain and improve quality of life, little is known ... ...

Abstract	Total temporomandibular joint replacement (TMJR) surgery is the established treatment for severe temporomandibular joint disorders. While TMJR surgery is known to increase mouth-opening capacity, reduce pain and improve quality of life, little is known about post-surgical jaw function during activities of daily living such as biting and chewing. The aim of this study was to use subject-specific 3D bite force measurements to evaluate the magnitude and direction of joint loading in unilateral total TMJR patients and compare these data to those in healthy control subjects. An optoelectronic tracking system was used to measure jaw kinematics while biting a rubber sample for 5 unilateral total TMJR patients and 8 controls. Finite element simulations driven by the measured kinematics were employed to calculate the resultant bite force generated when compressing the rubber between teeth during biting tasks. Subject-specific musculoskeletal models were subsequently used to calculate muscle and TMJ loading. Unilateral total TMJR patients generated a bite force of 249.6 ± 24.4 N and 164.2 ± 62.3 N when biting on the contralateral and ipsilateral molars, respectively. In contrast, controls generated a bite force of 317.1 ± 206.6 N. Unilateral total TMJR patients biting on the contralateral molars had a significantly higher lateral TMJ force direction (median difference: 63.6°, p = 0.028) and a significantly lower ratio of working TMJ force to bite force (median difference: 0.17, p = 0.049) than controls. Results of this study may guide TMJ prosthesis design and evaluation of dental implants.
Language	English
Publishing date	2024-03-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2093052-5
ISSN	1617-7940 ; 1617-7959
ISSN (online)	1617-7940
ISSN	1617-7959
DOI	10.1007/s10237-023-01807-1
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Zs.A 5966: Show issues

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Article: Molecular signatures of cortical expansion in the human fetal brain.

Ball, G / Oldham, S / Kyriakopoulou, V / Williams, L Z J / Karolis, V / Price, A / Hutter, J / Seal, M L / Alexander-Bloch, A / Hajnal, J V / Edwards, A D / Robinson, E C / Seidlitz, J

bioRxiv : the preprint server for biology

2024

Abstract: The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. A growing catalogue of cells in the prenatal brain has revealed remarkable molecular diversity across cortical areas. ...

Abstract	The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. A growing catalogue of cells in the prenatal brain has revealed remarkable molecular diversity across cortical areas.
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.13.580198
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Article: Drug-Induced Hidradenitis Suppurativa: A Case Report.

Kisule, Abraham / Kak, Vivek / Alamelumangapuram, Chidamber / Robinson, Ciji

Cureus

2023 Volume 15, Issue 11, Page(s) e49637

Abstract: Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory disorder of the hair follicles that localizes to the intertriginous and anogenital regions of the body. Lesions are characterized by inflammatory nodules, subcutaneous abscesses, ... ...

Abstract	Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory disorder of the hair follicles that localizes to the intertriginous and anogenital regions of the body. Lesions are characterized by inflammatory nodules, subcutaneous abscesses, fibrosis, and sinus tracts. Crohn's disease (CD) is an idiopathic chronic inflammatory bowel disease that affects any part of the gastrointestinal tract. Multiple treatment options exist for CD, including monoclonal anti-tumor necrosis factor alpha (TNF-α) antibodies like adalimumab (Humira). Adalimumab is an anti-TNF agent that has been approved by the United States Food and Drug Administration (FDA) for the treatment of HS. A 35-year-old African American male with a history of fistulizing CD presented to the hospital for evaluation of severe pain and purulent drainage from open sores in his bilateral axillary regions, groin, buttocks, and face for four days. He was on adalimumab for two years, during which time he noted the development of Hurley stage III HS. The physical exam was remarkable for a cachectic, painful-appearing male, with multiple abscesses on his lower jaw extending to his upper neck draining thick serosanguinous fluid, with similar findings in his bilateral axillary regions, bilateral groin, and perianal regions. He was treated with intravenous antibiotics consisting of a fourth-generation cephalosporin and vancomycin. While the etiology of HS in this patient is inconclusive, the timing of its development closely aligns with the initiation of Humira and is not a manifestation of CD. Paradoxical adverse effects describe a phenomenon in which a medication can induce a condition that it classically can be used to treat. In this patient's case, it was HS.
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.49637
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Article ; Online: Kinematics of the jaw following total temporomandibular joint replacement surgery.

Woodford, Sarah C / Robinson, Dale L / Abduo, Jaafar / Lee, Peter V S / Ackland, David C

Journal of biomechanics

2023 Volume 159, Page(s) 111741

Abstract: Total temporomandibular joint (TMJ) replacement surgery aims to improve mandibular function, reduce pain and enhance quality of life in patients suffering from end-stage TMJ disorders. Traditional post-operative jaw evaluation is carried out using ... ...

Abstract	Total temporomandibular joint (TMJ) replacement surgery aims to improve mandibular function, reduce pain and enhance quality of life in patients suffering from end-stage TMJ disorders. Traditional post-operative jaw evaluation is carried out using measurement of maximum interincisal opening distance; however, this can correlate poorly to joint function. The present study aimed to evaluate three-dimensional (3D) jaw motion during border movements and chewing in unilateral total TMJ replacement patients and healthy controls. Motion analysis experiments were performed on six unilateral total TMJ replacement patients and ten age-matched healthy controls. Subject-specific motion tracking plates worn by each participant were registered to CT scans of each participant's skull and mandible to enable anatomical mandibular kinematics measurement using an optoelectronic system. Participants performed 15 repetitions of maximal opening, protrusion, lateral excursions, and chewing cycles. Total TMJ replacement patients had significantly smaller incisal displacements at maximum mouth opening relative to the controls (median difference: 7.1 mm, p = 0.002) and decreased anterior translation of the prosthetic condyle (median difference: 10.5 mm, p = 0.002). When TMJ replacement subjects chewed using their contralateral molars, there was a significant increase in inferior condylar translation of the non-working condyle (median difference: 9.7 mm, p = 0.016). This study found that unilateral total TMJ replacement surgery was associated with mouth opening capacity within the range of healthy individuals, but reduced anterior movement of the prosthetic condyle and restricted protrusion and lateral excursions. The results provide future direction for prosthetic TMJ design to enhance postsurgical implant functionality and improve long-term clinical outcomes for prosthesis recipients.
MeSH term(s)	Humans ; Biomechanical Phenomena ; Quality of Life ; Temporomandibular Joint/diagnostic imaging ; Temporomandibular Joint/surgery ; Joint Prosthesis ; Mandible ; Range of Motion, Articular ; Mandibular Condyle
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2023.111741
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Zs.A 700: Show issues

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Article ; Online: Development and psychometric validation of the gum health experience questionnaire.

Broomhead, T / Gibson, B J / Parkinson, C / Robinson, P G / Vettore, M V / Baker, S R

Journal of clinical periodontology

2023 Volume 51, Issue 1, Page(s) 33–42

Abstract: Aim: To develop and validate a new health-related quality of life measure to capture a wide range of gum-related impacts.: Materials and methods: The measure was developed using a multi-stage approach and a theoretical model. Development involved ... ...

Abstract	Aim: To develop and validate a new health-related quality of life measure to capture a wide range of gum-related impacts. Materials and methods: The measure was developed using a multi-stage approach and a theoretical model. Development involved semi-structured interviews, pilot testing, cross-sectional analysis among a general population (n = 152) to assess psychometric properties and test-retest reliability among a subsample (n = 27). Results: Psychometric analysis supports the validity and reliability of the measure's impact scale. The measure has excellent internal reliability (nearly all item-total correlations above .4; Cronbach's alpha between .84 and .91 for subscales), with test-retest reliability also performing well (Intra-class correlation coefficient [ICC] of .91-.97 for subscales). Good content validity (indicated by large standard deviations for item and total scores) and construct validity (correlations of .54-.73 with global gum health rating for subscales, all p < .05) were also observed. Qualitative and quantitative data indicate that people with gum health-related symptoms experience different degrees of discomfort and impacts caused by their condition. Conclusions: The gum health experience questionnaire holds substantial promise as a measure of gum-related quality of life in people across the gum health-disease continuum. Further face validity, refining and reducing the number of items and longitudinal studies to test evaluative properties are required before the measure can be used with confidence.
MeSH term(s)	Humans ; Quality of Life ; Reproducibility of Results ; Psychometrics ; Cross-Sectional Studies ; Surveys and Questionnaires ; Gingival Diseases
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/jcpe.13878
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Zs.A 1003: Show issues

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Article: Teaching Queer Concepts to Graduate Students in Communication Sciences and Disorders: Culturally Responsive Pedagogy to Foster Affirmative Clinical Practice

Robinson, Gregory C. / Toliver-Smith, Andrea / Stigar, Lorraine V.

Seminars in Speech and Language

(Innovations in Voice Care for Trans and Non-Binary People)

2023 Volume 44, Issue 02, Page(s) 104–118

Series title	Innovations in Voice Care for Trans and Non-Binary People
Abstract	There is a growing body of literature informing pedagogical content and strategies of diversity, equity, and inclusion in the education of speech-language pathologists. However, little discussion has included content related to LGBTQ+ people, even though LGBTQ+ people exist across all racial/ethnic groups. This article seeks to fill that void and provide instructors of speech-language pathology with practical information to educate their graduate students. The discussion uses a critical epistemology and invokes theoretical models, such as Queer/Quare theory, DisCrit, the Minority Stress Model, the Ethics of Care, and Culturally Responsive Pedagogy. Information is organized according to developing graduate students' awareness, knowledge, and skills and challenges instructors to modify current course content to disrupt systemic oppression.
Keywords	queer theory ; culturally responsive pedagogy ; LGBTQ + ; transgender ; speech-language pathology
Language	English
Publishing date	2023-03-01
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	604960-6
ISSN	1098-9056 ; 0734-0478
ISSN (online)	1098-9056
ISSN	0734-0478
DOI	10.1055/s-0043-1761947
Database	Thieme publisher's database

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