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  1. Article ; Online: Human urinary kallidinogenase may improve the prognosis of acute stroke patients with early neurological deterioration.

    Xie, Yiju / Li, Shengyu / Zhang, Jian / Chen, Shijian / Deng, Xuhui / Cen, Gengyu / Liang, Zhijian

    Brain and behavior

    2022  Volume 12, Issue 3, Page(s) e2524

    Abstract: Objectives: Some acute ischemic stroke (AIS) patients still suffer from early neurological deterioration (END) after receiving intravenous thrombolysis (IVT), and these patients often have a poor prognosis. The purpose of our study is to observe the ... ...

    Abstract Objectives: Some acute ischemic stroke (AIS) patients still suffer from early neurological deterioration (END) after receiving intravenous thrombolysis (IVT), and these patients often have a poor prognosis. The purpose of our study is to observe the efficacy and safety of human urinary kallidinogenase (HUK) treatment in patients with END.
    Methods: This was a retrospective analysis and 49 patients with END who met the inclusion criteria were divided into the observation group and the control group. All patients received routine treatment of AIS, while patients in the observation group were treated with HUK within 24 h after IVT and the other group without HUK.
    Results: There were 24 patients in the observation group and 25 patients in the control group. After treatment, favorable prognosis (mRS scores ≤2) at 3 months in the observation group with 13 cases (54.17%) was significantly better than that in the control group with four cases (16%) (p = .001), and there was no statistical difference between the two groups in any hemorrhagic complication.
    Conclusion: HUK is considered to be safe and may improve the prognosis of AIS patients with END after IVT. More clinical trials are needed to validate these results in the future.
    MeSH term(s) Brain Ischemia/complications ; Brain Ischemia/drug therapy ; Fibrinolytic Agents/therapeutic use ; Humans ; Ischemic Stroke ; Prognosis ; Retrospective Studies ; Stroke/complications ; Stroke/drug therapy ; Tissue Kallikreins/therapeutic use ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents ; Tissue Kallikreins (EC 3.4.21.35)
    Language English
    Publishing date 2022-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.2524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related Stroke.

    Cen, Gengyu / Liu, Liuyu / Wang, Jun / Wang, Xue / Chen, Shijian / Song, Yiting / Liang, Zhijian

    Oxidative medicine and cellular longevity

    2022  Volume 2022, Page(s) 4526022

    Abstract: The purpose of this research was to explore the underlying biological processes causing coronavirus disease 2019- (COVID-19-) related stroke. The Gene Expression Omnibus (GEO) database was utilized to obtain four COVID-19 datasets and two stroke datasets. ...

    Abstract The purpose of this research was to explore the underlying biological processes causing coronavirus disease 2019- (COVID-19-) related stroke. The Gene Expression Omnibus (GEO) database was utilized to obtain four COVID-19 datasets and two stroke datasets. Thereafter, we identified key modules via weighted gene co-expression network analysis, following which COVID-19- and stroke-related crucial modules were crossed to identify the common genes of COVID-19-related stroke. The common genes were intersected with the stroke-related hub genes screened via Cytoscape software to discover the critical genes associated with COVID-19-related stroke. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis for common genes associated with COVID-19-related stroke, and the Reactome database was used to annotate and visualize the pathways involved in the key genes. Two COVID-19-related crucial modules and one stroke-related crucial module were identified. Subsequently, the top five genes were screened as hub genes after visualizing the genes of stroke-related critical module using Cytoscape. By intersecting the COVID-19- and stroke-related crucial modules, 28 common genes for COVID-19-related stroke were identified. ITGA2B and ITGB3 have been further identified as crucial genes of COVID-19-related stroke. Functional enrichment analysis indicated that both ITGA2B and ITGB3 were involved in integrin signaling and the response to elevated platelet cytosolic Ca
    MeSH term(s) COVID-19/complications ; COVID-19/genetics ; Computational Biology ; Gene Expression Profiling ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Integrin alpha2/genetics ; Integrin beta3/genetics ; Stroke/genetics ; Stroke/virology
    Chemical Substances ITGA2B protein, human ; ITGB3 protein, human ; Integrin alpha2 ; Integrin beta3
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2022/4526022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The investigation on the hypercoagulability of hepatocellular carcinoma-related cerebral infarction with thromboelastography.

    Cen, Gengyu / Song, Yiting / Chen, Shijian / Liu, Liuyu / Wang, Jun / Zhang, Jian / Li, Jing / Li, Guohui / Li, Haihua / Liang, Hongbin / Liang, Zhijian

    Brain and behavior

    2023  Volume 13, Issue 4, Page(s) e2961

    Abstract: Aim: To investigate the hypercoagulability of hepatocellular carcinoma (HCC)-related cerebral infarction (HCRCI) with thromboelastography (TEG).: Methods: A multicenter prospective study was conducted in HCRCI patients, HCC patients without cerebral ... ...

    Abstract Aim: To investigate the hypercoagulability of hepatocellular carcinoma (HCC)-related cerebral infarction (HCRCI) with thromboelastography (TEG).
    Methods: A multicenter prospective study was conducted in HCRCI patients, HCC patients without cerebral infarction, and acute cerebral infarction (ACI) patients without HCC between January 2016 and December 2019. TEG parameters and laboratory and clinical data were collected and compared among the three groups. To confirm the independent risk factors of HCRCI, multivariate analyses were conducted. Receiver operating characteristic (ROC) curves were utilized to evaluate the area under the curve (AUC) plotted by each independent risk factor.
    Results: There were 38 patients recruited in the HCRCI group, and 152 patients were recruited to the HCC group and the ACI group. The levels of plasma neutrophil count, D-dimer, α-fetoprotein (AFP), carcinoembryonic antigen, and maximum amplitude (MA)-a parameter of TEG-were significantly higher in the HCRCI group than HCC and ACI groups. Multivariate logistic regression analysis showed that increased neutrophile count, D-dimer, AFP, and MA were independently associated with HCRCI. ROC curve analysis showed first that AUC of MA for HCRCI was .875, which was larger than the other risk factors, and second that the optimal cutoff value for MA was 61.35, with a sensitivity of 89.50% and specificity of 66.40%.
    Conclusion: It was suggested that TEG disclosed that the pathogenesis of HCRIC is exactly related to the hypercoagulability. And with a cutoff value of MA equaling to 61.35, TEG facilitates clinicians to identify HCC patients at high risk of HCRIC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/pathology ; Thrombelastography ; alpha-Fetoproteins ; Liver Neoplasms/complications ; Liver Neoplasms/pathology ; Prospective Studies ; Cerebral Infarction/etiology ; ROC Curve ; Stroke ; Thrombophilia/diagnosis ; Thrombophilia/etiology ; Brain Ischemia ; Acute Disease
    Chemical Substances alpha-Fetoproteins
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.2961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cancer Related Subarachnoid Hemorrhage: A Multicenter Retrospective Study Using Propensity Score Matching Analysis.

    Chen, Shijian / Zhang, Jian / Lu, Xianfu / Cen, Gengyu / Song, Yiting / Deng, Xuhui / Xie, Yiju / Liu, Liuyu / Liu, Qianqian / Huang, Junling / Li, Jing / Yang, Hong / Shi, Shengliang / Pan, Liya / Liang, Zhijian

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 813084

    Abstract: Objective: To investigate the clinical features, risk factors and underlying pathogenesis of cancer related subarachnoid hemorrhage (SAH).: Methods: Clinical data of SAH in patients with active cancer from January 2010 to December 2020 at four ... ...

    Abstract Objective: To investigate the clinical features, risk factors and underlying pathogenesis of cancer related subarachnoid hemorrhage (SAH).
    Methods: Clinical data of SAH in patients with active cancer from January 2010 to December 2020 at four centers were retrospectively reviewed. Patients with active cancer without SAH were matched to SAH patients with active cancer group. Logistic regression was applied to investigate the independent risk factors of SAH in patients with active cancer, after a 1:1 propensity score matching (PSM). A receiver operator characteristic curve was configured to calculate the optimal cut-off value of the joint predictive factor for cancer related SAH.
    Results: A total of 82 SAH patients with active cancer and 309 patients with active cancer alone were included. Most SAH patients with cancer had poor outcomes, with 30-day mortality of 41.5%, and with 90-day mortality of 52.0%. The PSM yielded 75 pairs of study participants. Logistic regression revealed that a decrease in platelet and prolonged prothrombin time were the independent risk factors of cancer related SAH. In addition, receiver operator characteristic curve of the joint predictive factor showed the largest AUC of 0.8131, with cut-off value equaling to 11.719, with a sensitivity of 65.3% and specificity of 89.3%.
    Conclusion: Patients with cancer related SAH often have poor outcomes. The decrease in platelet and prolonged prothrombin time are the independent risk factors of cancer related SAH, and the joint predictive factor with cutoff value equal to 11.719 should hence serve as a novel biomarker of cancer related SAH.
    Language English
    Publishing date 2022-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.813084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical features of intracerebral hemorrhage in patients with colorectal cancer and its underlying pathogenesis.

    Deng, Xu-Hui / Li, Jing / Chen, Shi-Jian / Xie, Yi-Ju / Zhang, Jian / Cen, Geng-Yu / Song, Yi-Ting / Liang, Zhi-Jian

    World journal of gastrointestinal oncology

    2022  Volume 13, Issue 12, Page(s) 2180–2189

    Abstract: Background: The diagnosis of both cancer and intracerebral hemorrhage (ICH) in the same patient is not uncommon, but the clinical features and pathogenesis of patients with colorectal cancer (CRC) and ICH are still not well known.: Aim: To ... ...

    Abstract Background: The diagnosis of both cancer and intracerebral hemorrhage (ICH) in the same patient is not uncommon, but the clinical features and pathogenesis of patients with colorectal cancer (CRC) and ICH are still not well known.
    Aim: To investigate the clinical features and underlying pathogenesis of ICH in patients with CRC.
    Methods: A retrospective review of CRC patients complicated with ICH from three centers between January 2014 and December 2020 was performed. Clinical data such as laboratory examinations, imaging features, prognosis, and underlying pathogenesis were analyzed.
    Results: Of 16673 identified CRC patients, 20 (0.12%) suffered from ICH. There were 13 males and 7 females, with an average age (mean ± SD) of 68.45 ± 10.66 years. Fourteen patients (70%) had distant metastases and most patients (85%) showed an elevation of one or more cancer biomarkers. The hemorrhagic lesions in 13 patients (65%) were in the intracerebral lobe. Four patients were completely dependent and 4 died within 30 days after hemorrhage. Intratumoral hemorrhage (50%) and coagulopathy (50%) accounted for the majority of hemorrhages.
    Conclusion: Patients with ICH and CRC often have clinical features with lobar hemorrhage, distant metastases and poor prognosis. Intratumoral hemorrhage and coagulopathy are the main causes of ICH in patients with CRC.
    Language English
    Publishing date 2022-01-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v13.i12.2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Upregulation of CCNB2 and Its Perspective Mechanisms in Cerebral Ischemic Stroke and All Subtypes of Lung Cancer: A Comprehensive Study.

    Li, Ming-Jie / Yan, Shi-Bai / Chen, Gang / Li, Guo-Sheng / Yang, Yue / Wei, Tao / He, De-Shen / Yang, Zhen / Cen, Geng-Yu / Wang, Jun / Liu, Liu-Yu / Liang, Zhi-Jian / Chen, Li / Yin, Bin-Tong / Xu, Ruo-Xiang / Huang, Zhi-Guang

    Frontiers in integrative neuroscience

    2022  Volume 16, Page(s) 854540

    Abstract: Cyclin B2 (CCNB2) belongs to type B cell cycle family protein, which is located on chromosome 15q22, and it binds to cyclin-dependent kinases (CDKs) to regulate their activities. In this study, 103 high-throughput datasets related to all subtypes of lung ...

    Abstract Cyclin B2 (CCNB2) belongs to type B cell cycle family protein, which is located on chromosome 15q22, and it binds to cyclin-dependent kinases (CDKs) to regulate their activities. In this study, 103 high-throughput datasets related to all subtypes of lung cancer (LC) and cerebral ischemic stroke (CIS) with the data of CCNB2 expression were collected. The analysis of standard mean deviation (SMD) and summary receiver operating characteristic (SROC) reflecting expression status demonstrated significant up-regulation of CCNB2 in LC and CIS (Lung adenocarcinoma: SMD = 1.40, 95%CI [0.98-1.83], SROC = 0.92, 95%CI [0.89-0.94]. Lung squamous cell carcinoma: SMD = 2.56, 95%CI [1.64-3.48]. SROC = 0.97, 95%CI [0.95-0.98]. Lung small cell carcinoma: SMD = 3.01, 95%CI [2.01-4.01]. SROC = 0.98, 95%CI [0.97-0.99]. CIS: SMD = 0.29, 95%CI [0.05-0.53], SROC = 0.68, 95%CI [0.63-0.71]). Simultaneously, protein-protein interaction (PPI) analysis indicated that CCNB2 is the hub molecule of crossed high-expressed genes in CIS and LC. Through Multiscale embedded gene co-expression network analysis (MEGENA), a gene module of CIS including 76 genes was obtained and function enrichment analysis of the CCNB2 module genes implied that CCNB2 may participate in the processes in the formation of CIS and tissue damage caused by CIS, such as "cell cycle," "protein kinase activity," and "glycosphingolipid biosynthesis." Afterward,
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452962-X
    ISSN 1662-5145
    ISSN 1662-5145
    DOI 10.3389/fnint.2022.854540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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