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  1. Article ; Online: Synthesis and evaluation of NHC derivatives and 4'-fluorouridine prodrugs.

    Xiang, Li / Hu, Tianwen / Xue, Haitao / Pan, Wenfang / Xie, Yuanchao / Shen, Jingshan

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 13, Page(s) 2754–2767

    Abstract: ... β-D- ... ...

    Abstract β-D-N
    MeSH term(s) Rats ; Animals ; Prodrugs/chemistry ; Antiviral Agents/chemistry ; Nucleosides ; Respiratory Syncytial Virus, Human ; Esters
    Chemical Substances Prodrugs ; 4'-fluorouridine ; Antiviral Agents ; Nucleosides ; Esters
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00268c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Enhanced Piezoelectric Properties in a Single-Phase Region of Sm-Modified Lead-Free (Ba,Ca)(Zr,Ti)O

    Xiao, Andong / Xie, Xuefan / He, Liqiang / Yang, Yang / Ji, Yuanchao

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 21

    Abstract: In ferroelectric materials, phase boundaries such as the morphotropic phase boundary (MPB) and polymorphic phase boundary (PPB) have been widely utilized to enhance the piezoelectric properties. However, for a single-ferroelectric-phase system, there are ...

    Abstract In ferroelectric materials, phase boundaries such as the morphotropic phase boundary (MPB) and polymorphic phase boundary (PPB) have been widely utilized to enhance the piezoelectric properties. However, for a single-ferroelectric-phase system, there are few effective paradigms to achieve the enhancement of piezoelectric properties. Herein, we report an unexpected finding that largely enhanced piezoelectric properties occur in a single-tetragonal-ferroelectric-phase region in the Sm-modified (Ba
    Language English
    Publishing date 2022-11-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15217839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Practical and Highly Efficient Synthesis of Remdesivir from GS-441524.

    Hu, Tianwen / Zhu, Fuqiang / Xiang, Li / Shen, Jingshan / Xie, Yuanchao / Aisa, Haji A

    ACS omega

    2022  Volume 7, Issue 31, Page(s) 27516–27522

    Abstract: A three-step sequence for preparing remdesivir, an important anti-SARS-CoV-2 drug, is described. ... ...

    Abstract A three-step sequence for preparing remdesivir, an important anti-SARS-CoV-2 drug, is described. Employing
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c02835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of L-carnitine supplementation on glucolipid metabolism: a systematic review and meta-analysis.

    Li, Yanfei / Xie, Yuchen / Qiu, Chensheng / Yu, Bowen / Yang, Fangzheng / Cheng, Yuanchao / Zhong, Weizhen / Yuan, Junhua

    Food & function

    2023  Volume 14, Issue 5, Page(s) 2502–2517

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Adult ; Humans ; Carnitine ; Insulin ; Insulin Resistance ; Dietary Supplements
    Chemical Substances Carnitine (S7UI8SM58A) ; Insulin
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d2fo02930h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  5. Article ; Online: Numerical Simulation of radon migration influenced by heat-moisture coupled transfer in aerated concrete wall under different outdoor temperature and humidity conditions

    Chen Yuanchao / Xie Dong / Chen Guojie / Dai Shiliang / Liu Suyao

    E3S Web of Conferences, Vol 356, p

    2022  Volume 05030

    Abstract: It is of great significance for indoor radon radiation protection to study the mechanism of radon migration systematically caused by heat-moisture coupled transfer in building walls. The radon migration model of porous building walls under the influence ... ...

    Abstract It is of great significance for indoor radon radiation protection to study the mechanism of radon migration systematically caused by heat-moisture coupled transfer in building walls. The radon migration model of porous building walls under the influence of the heat-moisture coupled model is built. On the base of it, four types of different temperature and humidity conditions, including high temperature and high humidity, high temperature and low humidity, low temperature and high humidity and low temperature and low humidity, and the real ambient temperature, relative humidity conditions in a southern city of China in July, are set for the numerical simulation. The migration mechanism of the radon through the wall influenced by outdoor temperature and humidity conditions, including its emanation, diffusion and condensation, is studied by numerical simulation, and the main factors leading the results are analyzed, which provides some reference for indoor radon radiation protection.
    Keywords heat-moisture coupled transfer ; radon ; wall ; Environmental sciences ; GE1-350
    Subject code 669 ; 690
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Polysaccharide isolated from

    Li, Xiangmin / Ruan, Qinzhao / Yang, Weining / Tian, Huixiang / Wu, Nan / Qadir, Javeria / Wang, Juan / Hu, Huiping / Liu, Yuanchao / Cai, Manjun / Yang, Burton B / Xie, Yizhen / Wu, Qingping

    International journal of biological sciences

    2024  Volume 20, Issue 2, Page(s) 664–679

    Abstract: Myeloid derived suppressor cells (MDSCs) are known to accumulate in cancer patients and tumor-bearing mice, playing a significant role in promoting tumor growth. Depleting MDSCs has emerged as a potential therapeutic strategy for cancer. Here, we ... ...

    Abstract Myeloid derived suppressor cells (MDSCs) are known to accumulate in cancer patients and tumor-bearing mice, playing a significant role in promoting tumor growth. Depleting MDSCs has emerged as a potential therapeutic strategy for cancer. Here, we demonstrated that a fungal polysaccharide, extracted from
    MeSH term(s) Humans ; Mice ; Animals ; Female ; Myeloid-Derived Suppressor Cells/metabolism ; Grifola ; Breast Neoplasms/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Polysaccharides/pharmacology
    Chemical Substances Polysaccharides
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.85276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs.

    Zheng, Wei / Hu, Tianwen / Zhang, Yumin / Wei, Daibao / Xie, Yuanchao / Shen, Jingshan

    Tetrahedron letters

    2022  Volume 104, Page(s) 154012

    Abstract: The COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to spread around the world. GS-441524 is the parent nucleoside of remdesivir which is the first drug approved for the treatment of COVID-19, and ... ...

    Abstract The COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to spread around the world. GS-441524 is the parent nucleoside of remdesivir which is the first drug approved for the treatment of COVID-19, and demonstrates strong activity against SARS-Cov-2 in vitro and in vivo. Herein, we reported the synthesis of a series of deuterated GS-441524 analogs, which had deuterium atoms up to five at the ribose and the nucleobase moieties. Compared to GS-441524, all the deuterated compounds showed similar inhibitory activities against SARS-CoV-2 in vitro.
    Language English
    Publishing date 2022-07-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2022.154012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Experimental analysis and research on flexural properties of reinforced concrete composite beams

    Xie Ruqiang / Hu Yuanchao / Shen Xiaopu

    E3S Web of Conferences, Vol 165, p

    2020  Volume 04023

    Abstract: In order to further study the flexural properties of reinforced concrete beams after composite reinforcement, three composite beams and one cast-in-situ beam were tested under static load focusing on the bearing capacity, the law of crack development and ...

    Abstract In order to further study the flexural properties of reinforced concrete beams after composite reinforcement, three composite beams and one cast-in-situ beam were tested under static load focusing on the bearing capacity, the law of crack development and the change of deflection. Test results demonstrate the yield strength, ultimate bending strength, and deflection of the composite beams are similar to those of the cast-in-situ beam, which confirms that the reinforced concrete composite beams can be used for reinforcement purposes in engineering projects.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Combination of miR159 Mimics and Irinotecan Utilizing Lipid Nanoparticles for Enhanced Treatment of Colorectal Cancer.

    Yang, Rulei / Liu, Yiran / Yang, Ning / Zhang, Tian / Hou, Jiazhen / He, Zongyan / Wang, Yutong / Sun, Xujie / Shen, Jingshan / Jiang, Hualiang / Xie, Yuanchao / Lang, Tianqun

    Pharmaceutics

    2024  Volume 16, Issue 4

    Abstract: Colorectal cancer (CRC) ranks as the third most prevalent global malignancy, marked by significant metastasis and post-surgical recurrence, posing formidable challenges to treatment efficacy. The integration of oligonucleotides with chemotherapeutic ... ...

    Abstract Colorectal cancer (CRC) ranks as the third most prevalent global malignancy, marked by significant metastasis and post-surgical recurrence, posing formidable challenges to treatment efficacy. The integration of oligonucleotides with chemotherapeutic drugs emerges as a promising strategy for synergistic CRC therapy. The nanoformulation, lipid nanoparticle (LNP), presents the capability to achieve co-delivery of oligonucleotides and chemotherapeutic drugs for cancer therapy. In this study, we constructed lipid nanoparticles, termed as LNP-I-V by microfluidics to co-deliver oligonucleotides miR159 mimics (VDX05001SI) and irinotecan (IRT), demonstrating effective treatment of CRC both in vitro and in vivo. The LNP-I-V exhibited a particle size of 118.67 ± 1.27 nm, ensuring excellent stability and targeting delivery to tumor tissues, where it was internalized and escaped from the endosome with a pH-sensitive profile. Ultimately, LNP-I-V significantly inhibited CRC growth, extended the survival of tumor-bearing mice, and displayed favorable safety profiles. Thus, LNP-I-V held promise as an innovative platform to combine gene therapy and chemotherapy for improving CRC treatment.
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16040570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir.

    Zhang, Yumin / Sun, Yuan / Xie, Yuanchao / Shang, Weijuan / Wang, Zhen / Jiang, Hualiang / Shen, Jingshan / Xiao, Gengfu / Zhang, Leike

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 360

    Abstract: During the ongoing pandemic, providing treatment consisting of effective, low-cost oral antiviral drugs at an early stage of SARS-CoV-2 infection has been a priority for controlling COVID-19. Although Paxlovid and molnupiravir have received emergency ... ...

    Abstract During the ongoing pandemic, providing treatment consisting of effective, low-cost oral antiviral drugs at an early stage of SARS-CoV-2 infection has been a priority for controlling COVID-19. Although Paxlovid and molnupiravir have received emergency approval from the FDA, some side effect concerns have emerged, and the possible oral agents are still limited, resulting in optimized drug development becoming an urgent requirement. An oral remdesivir derivative, VV116, has been reported to have promising antiviral effects against SARS-CoV-2 and positive therapeutic outcomes in clinical trials. However, whether VV116 has broad-spectrum anti-coronavirus activity and potential synergy with other drugs is not clear. Here, we uncovered the broad-spectrum antiviral potency of VV116 against SARS-CoV-2 variants of concern (VOCs), HCoV-OC43, and HCoV-229E in various cell lines. In vitro drug combination screening targeted RdRp and proteinase, highlighting the synergistic effect of VV116 and nirmatrelvir on HCoV-OC43 and SARS-CoV-2. When co-administrated with ritonavir, the combination of VV116 and nirmatrelvir showed significantly enhanced antiviral potency with noninteracting pharmacokinetic properties in mice. Our findings will facilitate clinical treatment with VV116 or VV116+nirmatrelvir combination to fight coronavirus infection.
    MeSH term(s) Humans ; Animals ; Mice ; COVID-19 ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Coronavirus OC43, Human
    Chemical Substances nirmatrelvir and ritonavir drug combination ; GS-621763 (83BU3492RP) ; Antiviral Agents
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01587-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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