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Article ; Online: Ischemic Core Estimation by CT Perfusion: A Matter of (rCBF) Numbers.

Morelli, Nicola / Colombi, Davide / Michieletti, Emanuele

2023 Volume 221, Issue 2, Page(s) 284

MeSH term(s)	Humans ; Brain Ischemia ; Stroke ; Tomography, X-Ray Computed ; Ischemia ; Perfusion ; Cerebrovascular Circulation ; Perfusion Imaging
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.22.28902
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Epidemic graph diagrams as analytics for epidemic control in the data-rich era.

Valdano, Eugenio / Colombi, Davide / Poletto, Chiara / Colizza, Vittoria

Nature communications

2023 Volume 14, Issue 1, Page(s) 8472

Abstract: COVID-19 highlighted modeling as a cornerstone of pandemic response. But it also revealed that current models may not fully exploit the high-resolution data on disease progression, epidemic surveillance and host behavior, now available. Take the epidemic ...

Abstract	COVID-19 highlighted modeling as a cornerstone of pandemic response. But it also revealed that current models may not fully exploit the high-resolution data on disease progression, epidemic surveillance and host behavior, now available. Take the epidemic threshold, which quantifies the spreading risk throughout epidemic emergence, mitigation, and control. Its use requires oversimplifying either disease or host contact dynamics. We introduce the epidemic graph diagrams to overcome this by computing the epidemic threshold directly from arbitrarily complex data on contacts, disease and interventions. A grammar of diagram operations allows to decompose, compare, simplify models with computational efficiency, extracting theoretical understanding. We use the diagrams to explain the emergence of resistant influenza variants in the 2007-2008 season, and demonstrate that neglecting non-infectious prodromic stages of sexually transmitted infections biases the predicted epidemic risk, compromising control. The diagrams are general, and improve our capacity to respond to present and future public health challenges.
MeSH term(s)	Humans ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pandemics/prevention & control ; Public Health ; COVID-19/epidemiology ; COVID-19/prevention & control
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43856-1
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Article: Systolic spike on transcranial Doppler ultrasound in brain death determination: a matter of numbers.

Morelli, Nicola / Colombi, Davide / Spallazzi, Marco / Rota, Eugenia / Michieletti, Emanuele

Radiologia brasileira

2023 Volume 56, Issue 1, Page(s) 50–51

Language	English
Publishing date	2023-03-16
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078806-X
ISSN	1678-7099 ; 0100-3984
ISSN (online)	1678-7099
ISSN	0100-3984
DOI	10.1590/0100-3984.2022.0125
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Article ; Online: A Monte Carlo Analysis of Actual Maximum Exposure From a 5G Millimeter-Wave Base Station Antenna for EMF Compliance Assessments.

Xu, Bo / Anguiano Sanjurjo, David / Colombi, Davide / Törnevik, Christer

Frontiers in public health

2022 Volume 9, Page(s) 777759

Abstract: International radio frequency (RF) electromagnetic field (EMF) exposure assessment standards and regulatory bodies have developed methods and specified requirements to assess the actual maximum RF EMF exposure from radio base stations enabling massive ... ...

Abstract	International radio frequency (RF) electromagnetic field (EMF) exposure assessment standards and regulatory bodies have developed methods and specified requirements to assess the actual maximum RF EMF exposure from radio base stations enabling massive multiple-input multiple-output (MIMO) and beamforming. Such techniques are based on the applications of power reduction factors (PRFs), which lead to more realistic, albeit conservative, exposure assessments. In this study, the actual maximum EMF exposure and the corresponding PRFs are computed for a millimeter-wave radio base station array antenna. The computed incident power densities based on near-field and far-field approaches are derived using a Monte Carlo analysis. The results show that the actual maximum exposure is well below the theoretical maximum, and the PRFs similar to those applicable for massive MIMO radio base stations operating below 6 GHz are also applicable for millimeter-wave frequencies. Despite the very low power levels that currently characterize millimeter-wave radio base stations, using the far-field approach can also guarantee the conservativeness of the PRFs used to assess the actual maximum exposure close to the antenna.
MeSH term(s)	Electromagnetic Fields ; Radio Waves
Language	English
Publishing date	2022-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2021.777759
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Article ; Online: Are Interstitial Lung Abnormalities a Prognostic Factor of Worse Outcome in COVID-19 Pneumonia?

Colombi, Davide / Petrini, Marcello / Morelli, Nicola / Silva, Mario / Milanese, Gianluca / Sverzellati, Nicola / Michieletti, Emanuele

Journal of thoracic imaging

2023 Volume 38, Issue 3, Page(s) 137–144

Abstract: Purpose: To assess the association between interstitial lung abnormalities (ILAs) and worse outcome in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19)-related pneumonia.: Materials and methods: The ...

Abstract	Purpose: To assess the association between interstitial lung abnormalities (ILAs) and worse outcome in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19)-related pneumonia. Materials and methods: The study included patients older than 18 years, who were admitted at the emergency department between February 29 and April 30, 2020 with findings of COVID-19 pneumonia at chest computed tomography (CT), with positive reverse-transcription polymerase chain reaction nasal-pharyngeal swab for SARS-CoV-2, and with the availability of prepandemic chest CT. Prepandemic CTs were reviewed for the presence of ILAs, categorized as fibrotic in cases with associated architectural distortion, bronchiectasis, or honeycombing. Worse outcome was defined as intensive care unit (ICU) admission or death. Cox proportional hazards regression analysis was used to test the association between ICU admission/death and preexisting ILAs. Results: The study included 147 patients (median age 73 y old; 95% CIs: 71-76-y old; 29% females). On prepandemic CTs, ILA were identified in 33/147 (22%) of the patients, 63% of which were fibrotic ILAs. Fibrotic ILAs were associated with higher risk of ICU admission or death in patients with COVID-19 pneumonia (hazard ratios: 2.73, 95% CIs: 1.50-4.97, P =0.001). Conclusions: In patients affected by COVID-19 pneumonia, preexisting fibrotic ILAs were an independent predictor of worse prognosis, with a 2.7 times increased risk of ICU admission or death. Chest CT scans obtained before the diagnosis of COVID-19 pneumonia should be carefully reviewed for the presence and characterization of ILAs.
MeSH term(s)	Female ; Humans ; Aged ; Male ; COVID-19/diagnostic imaging ; COVID-19/complications ; SARS-CoV-2 ; Prognosis ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/complications ; Lung/diagnostic imaging ; Retrospective Studies
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	632900-7
ISSN	1536-0237 ; 0883-5993
ISSN (online)	1536-0237
ISSN	0883-5993
DOI	10.1097/RTI.0000000000000704
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Article ; Online: A Monte Carlo Analysis of Actual Maximum Exposure From a 5G Millimeter-Wave Base Station Antenna for EMF Compliance Assessments

Bo Xu / David Anguiano Sanjurjo / Davide Colombi / Christer Törnevik

Frontiers in Public Health, Vol

2022 Volume 9

Abstract	International radio frequency (RF) electromagnetic field (EMF) exposure assessment standards and regulatory bodies have developed methods and specified requirements to assess the actual maximum RF EMF exposure from radio base stations enabling massive multiple-input multiple-output (MIMO) and beamforming. Such techniques are based on the applications of power reduction factors (PRFs), which lead to more realistic, albeit conservative, exposure assessments. In this study, the actual maximum EMF exposure and the corresponding PRFs are computed for a millimeter-wave radio base station array antenna. The computed incident power densities based on near-field and far-field approaches are derived using a Monte Carlo analysis. The results show that the actual maximum exposure is well below the theoretical maximum, and the PRFs similar to those applicable for massive MIMO radio base stations operating below 6 GHz are also applicable for millimeter-wave frequencies. Despite the very low power levels that currently characterize millimeter-wave radio base stations, using the far-field approach can also guarantee the conservativeness of the PRFs used to assess the actual maximum exposure close to the antenna.
Keywords	5G ; base station antenna ; beamforming ; EMF exposure ; incident power density ; millimeter wave ; Public aspects of medicine ; RA1-1270
Subject code	600
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article: Acute Budd-Chiari Syndrome with Complete Portal Vein Thrombosis Complicated by Hepato-Renal Syndrome Treated Successfully by Emergent TIPS with Rheolytic Thrombectomy.

Michieletti, Emanuele / Bodini, Flavio C / Morelli, Nicola / Rossi, Beatrice / Bossalini, Margherita / Colombi, Davide

Journal of clinical and experimental hepatology

2022 Volume 13, Issue 3, Page(s) 549–551

Abstract: We described a case of a 73-year-old female admitted to the emergency department with acute hepatic and renal failure (hepato-renal syndrome, HRS) due to acute Budd-Chiari syndrome associated with complete portal vein thrombosis (BCS-PVT) for an unknown ... ...

Abstract	We described a case of a 73-year-old female admitted to the emergency department with acute hepatic and renal failure (hepato-renal syndrome, HRS) due to acute Budd-Chiari syndrome associated with complete portal vein thrombosis (BCS-PVT) for an unknown cause. Despite the initial therapy with anticoagulants, a sudden impairment of the renal function requiring hemodialysis was observed. The hepatic transplant was excluded for patient age and clinical conditions. Thus, the patient was successfully treated by emergent transjugular intrahepatic portosystemic shunt (TIPS) previous rheolytic thrombectomy of the PVT with AngioJet Ultra PE Thrombectomy System (Boston Scientific, Marlborough, MA, USA). After the procedure, the sudden resolution of the HRS was observed, and the patient is alive 13 months after hospital dismission with no TIPS dysfunction. In conclusion, emergent extended TIPS with the usage of rheolytic thrombectomy device in patient with acute BCS-PVT complicated by HRS is feasible by experienced operators and provide resolution of the HRS.
Language	English
Publishing date	2022-11-19
Publishing country	India
Document type	Journal Article
ISSN	0973-6883
ISSN	0973-6883
DOI	10.1016/j.jceh.2022.11.007
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Article: Software-Based Assessment of Well-Aerated Lung at CT for Quantification of Predicted Pulmonary Function in Resected NSCLC.

Colombi, Davide / Risoli, Camilla / Delfanti, Rocco / Chiesa, Sara / Morelli, Nicola / Petrini, Marcello / Capelli, Patrizio / Franco, Cosimo / Michieletti, Emanuele

Life (Basel, Switzerland)

2023 Volume 13, Issue 1

Abstract: Background: To test the agreement between postoperative pulmonary function tests 12 months after surgery (mpo-PFTs) for non-small cell lung cancer (NSCLC) and predicted lung function based on the quantification of well-aerated lung (WAL) at staging CT ( ... ...

Abstract	Background: To test the agreement between postoperative pulmonary function tests 12 months after surgery (mpo-PFTs) for non-small cell lung cancer (NSCLC) and predicted lung function based on the quantification of well-aerated lung (WAL) at staging CT (sCT). Methods: We included patients with NSCLC who underwent lobectomy or segmentectomy without a history of thoracic radiotherapy or chemotherapy treatment with the availability of PFTs at 12 months follow-up. Postoperative predictive (ppo) lung function was calculated using the resected lobe WAL (the lung volume between −950 and −750 HU) at sCT. The Spearman correlation coefficient (rho) and intraclass correlation coefficient (ICC) were used to the test the agreement between WAL ppo-PFTs and mpo-PFTs. Results: the study included 40 patients (68 years-old, IQR 62−74 years-old; 26/40, 65% males). The WAL ppo-forced expiratory volume in 1 s (FEV1) and the ppo-diffusing capacity of the lung for carbon monoxide (%DLCO) were significantly correlated with corresponding mpo-PFTs (rho = 0.842 and 0.717 respectively; p < 0.001). The agreement with the corresponding mpo-PFTs of WAL ppo-FEV1 was excellent (ICC 0.904), while it was good (ICC 0.770) for WAL ppo-%DLCO. Conclusions: WAL ppo-FEV1 and WAL ppo-%DLCO at sCT showed, respectively, excellent and good agreement with corresponding mpo-PFTs measured 12 months after surgery for NSCLC. WAL is an easy parameter obtained by staging CT that can be used to estimate post-resection lung function for patients with borderline pulmonary function undergoing lung surgery.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13010198
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Article: Quantitative CT at Follow-Up of COVID-19 Pneumonia: Relationship with Pulmonary Function Tests.

Colombi, Davide / Petrini, Marcello / Risoli, Camilla / Mangia, Angelo / Milanese, Gianluca / Silva, Mario / Franco, Cosimo / Sverzellati, Nicola / Michieletti, Emanuele

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 21

Abstract: Background: The role of quantitative chest computed tomography (CT) is controversial in the follow-up of patients with COVID-19 pneumonia. The aim of this study was to test during the follow-up of COVID-19 pneumonia the association between pulmonary ... ...

Abstract	Background: The role of quantitative chest computed tomography (CT) is controversial in the follow-up of patients with COVID-19 pneumonia. The aim of this study was to test during the follow-up of COVID-19 pneumonia the association between pulmonary function tests (PFTs) and quantitative parameters extrapolated from follow-up (FU) CT scans performed at least 6 months after COVID-19 onset. Methods: The study included patients older than 18 years old, admitted to the emergency department of our institution between 29 February 2020 and 31 December 2020, with a diagnosis of COVID-19 pneumonia, who underwent chest CT at admission and FU CT at least 6 months later; PFTs were performed within 6 months of FU CT. At FU CT, quantitative parameters of well-aerated lung and pneumonia extent were identified both visually and by software using CT density thresholds. The association between PFTs and quantitative parameters was tested by the calculation of the Spearman's coefficient of rank correlation (rho). Results: The study included 40 patients (38% females; median age 63 years old, IQR, 56-71 years old). A significant correlation was identified between low attenuation areas% (%LAAs) <950 Hounsfield units (HU) and both forced expiratory volume in 1s/forced vital capacity (FEV1/FVC) ratio (rho -0.410, 95% CIs -0.639--0.112, Conclusions: At follow-up, CT scans performed at least 6 months after COVID-19 pneumonia onset showed %LAAs that were inversely associated with %DLCO and could be considered a marker of irreversible lung damage.
Language	English
Publishing date	2023-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13213328
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Article: Association between Mortality and Lung Low Attenuation Areas in NSCLC Treated by Surgery.

Colombi, Davide / Adebanjo, Ganiyat Adenike Ralitsa / Delfanti, Rocco / Chiesa, Sara / Morelli, Nicola / Capelli, Patrizio / Franco, Cosimo / Michieletti, Emanuele

Life (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: Background: to test the association with overall survival (OS) of low attenuation areas (LAAs) quantified by staging computed tomography (CT) of patients who underwent radical surgery for nonsmall-cell lung cancer (NSCLC).: Methods: patients who ... ...

Abstract	Background: to test the association with overall survival (OS) of low attenuation areas (LAAs) quantified by staging computed tomography (CT) of patients who underwent radical surgery for nonsmall-cell lung cancer (NSCLC). Methods: patients who underwent radical surgery for NSCLC at our institution between 1 January 2017 and 30 November 2021 were retrospectively evaluated. Patients who performed staging or follow-up CTs in other institutions, who received lung radiotherapy or chemotherapy, and who underwent previous lung surgery were excluded. At staging and 12-months follow-up CT, LAAs defined as voxels <-950 Hounsfield units, were extracted by software. The percent of LAAs relative to whole-lung volume (%LAAs) and the ratio between LAAs in the lobe to resect and whole-lung LAAs (%LAAs lobe ratio) were calculated. Cox proportional hazards regression analysis was used to test the association between OS and LAAs. Results: the final sample included 75 patients (median age 70 years, IQR 63-75 years; females 29/75, 39%). It identified a significant association with OS for pathological stage III (HR, 6.50; 95%CI, 1.11-37.92; Conclusions: in patients with NSCLC who underwent radical surgery, a %LAAs ≥ 5% and a %LAA lobe ratio > 10% at staging CT are predictors, respectively, of shorter and longer OS. The LAA ratio to the whole lung at staging CT could be a critical factor to predict the overall survival of the NSCLC patients treated by surgery.
Language	English
Publishing date	2023-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13061377
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