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  1. Article ; Online: What Should Be the Ideal Definite Coronavirus Disease 2019 (COVID-19) Case Definition?

    Sipahi, Oguz Resat

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 2, Page(s) e434–e436

    MeSH term(s) COVID-19 ; Consensus ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1179
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  3. Article ; Online: Comparison of the effectiveness of ceftobiprole and vancomycin in a rabbit model of methicillin-resistant Staphylococcus aureus induced meningitis.

    Mermer, Sinan / Turhan, Tuncer / Bolat, Elif / Aydemir, Sohret / Sipahi, Hilal / Sipahi, Oguz Resat

    Chemotherapy

    2024  , Page(s) 1

    Abstract: Introduction: Nosocomial meningitis may occur after procedures affecting the central nervous system or following traumatic injury. The causative infectious organism is commonly Staphylococcus aureus, a gram-positive bacterium. The aim of the present ... ...

    Abstract Introduction: Nosocomial meningitis may occur after procedures affecting the central nervous system or following traumatic injury. The causative infectious organism is commonly Staphylococcus aureus, a gram-positive bacterium. The aim of the present study was to compare the effectiveness of two antibacterial agents, ceftobiprole and vancomycin in an animal model of methicillin-resistant Staphylococcus aureus (MRSA) meningitis.
    Method: The strain of MRSA used was ATCC 43300. The animals were divided into three groups and infected intracisternally with MRSA. Controls received no antibiotherapy while the ceftobiprole group received 25 mg/kg and the vancomycin group received 20 mg/kg intravenously. Blood and cerebrospinal fluid (CSF) samples were collected at three time points. All animals were euthanased at 73 hours after start of treatment.
    Results: There was a significant difference (p<0.05) between both treatment groups and the control animals at 24 hours (drug trough) and 73 hours (one hour after third dose) after start of treatment in terms of CSF bacterial levels. At 73 hours there was a significant difference in survival between the control group and the two treatment groups but no difference between the treated animal survival rates.
    Conclusion: In conclusion, intravenous treatment with ceftobiprole and vancomycin appears to be equally effective in a rabbit model of MRSA meningitis.
    Language English
    Publishing date 2024-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 6708-8
    ISSN 1421-9794 ; 0009-3157
    ISSN (online) 1421-9794
    ISSN 0009-3157
    DOI 10.1159/000527531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: What Should Be the Ideal Definite Coronavirus Disease 2019 (COVID-19) Case Definition?

    Sipahi, Oguz Resat

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa1179
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A travel-related infection case associated with triple vector-associated infections: Malaria-Dengue-Zika virus.

    Şanlıdağ, Gamze / Sipahi, Oĝuz Reşat

    Tropical doctor

    2021  Volume 51, Issue 4, Page(s) 606–607

    Abstract: As international travels and destinations increase, travel-related infections increase. It is reported that 6-87% of the travellers contract travel-related infection during or after the trip. Vector-associated pathogens comprise a significant percentage ... ...

    Abstract As international travels and destinations increase, travel-related infections increase. It is reported that 6-87% of the travellers contract travel-related infection during or after the trip. Vector-associated pathogens comprise a significant percentage of travel-related infections. Apart from the ubiquitous COVID19, threats such as Dengue, Chikungunya and Zika virus and tick-borne agents have emerged or re-emerged in recent years. The fact that these infections are carried with similar vectors and cause similar symptoms makes diagnosis difficult. Herein, a case of travel-associated infection with nonspecific symptoms is presented.
    MeSH term(s) COVID-19 ; Chikungunya Fever/diagnosis ; Dengue/diagnosis ; Humans ; Malaria/diagnosis ; SARS-CoV-2 ; Travel ; Travel-Related Illness ; Zika Virus/genetics ; Zika Virus Infection/diagnosis
    Language English
    Publishing date 2021-06-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 193169-6
    ISSN 1758-1133 ; 0049-4755
    ISSN (online) 1758-1133
    ISSN 0049-4755
    DOI 10.1177/00494755211020899
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  6. Article ; Online: Farewell

    Oğuz Reşat SİPAHİ

    Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol 2019, Iss

    2019  Volume 1

    Keywords editorial process ; scientific journalism ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language Turkish
    Publishing date 2019-12-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: EDITORIAL

    Oğuz Reşat SİPAHİ

    Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol

    2018  Volume 7

    Keywords scientometrics ; citation ; theses ; quality ; impact factor ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language Turkish
    Publishing date 2018-12-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Can daily bathing with 4% chlorhexidine + daily chlorhexidine wipe for 1 week be effective in decolonizing Candida auris colonization?

    Elbahr, Umran / Khairy, Amira / Dayyab, Farouq / Delos Reyes, Clark Steven / Pastrana, Jennie / Vineeth, Chithra / Hejres, Suha / Sudha, Shruti Prem / Keskin, Ozge / Rana, Shiv Singh / Fadel, Elias / Erdem, Hakan / Sipahi, Oguz Resat

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2023  Volume 43, Issue 2, Page(s) 243–247

    Abstract: Background: Herein, it is aimed to present the decolonizing rates of Candida auris colonized cases after daily bathing with 4% chlorhexidine plus daily cleaning with 4% chlorhexidine wipe for 1 week (will be mentioned as DCHX).: Methods: The study ... ...

    Abstract Background: Herein, it is aimed to present the decolonizing rates of Candida auris colonized cases after daily bathing with 4% chlorhexidine plus daily cleaning with 4% chlorhexidine wipe for 1 week (will be mentioned as DCHX).
    Methods: The study period was from October, 2021, to November, 2022. Inclusion criteria were (i) age > 18, (ii) receiving DCHX, (iii) proven C. auris carrier on auricular, or axillar or inguinal swab surveillance cultures up to 5-day period before DCHX. Cases with three consecutive negative surveillance cultures 3 days apart were considered to be decolonized.
    Results: A total of 38 cases [14 female, aged 61.8 ± 15.5 years] fulfilled the inclusion criteria. Six (15.8%), 23 (60.1%), and 22 cases (57.8%) were postauricular, inguinal, and axillary culture positive, respectively. Only three cases (7.9%) were triple culture positive. Nine cases (23.7%) had three consequent negative surveillance cultures after DCHX and were considered to be decolonized. There was no significant difference in decolonization rates of concomitant only antibiotic receiving cohort vs. concomitant antifungal + antibiotic receiving cohort (5/16 vs. 2/8, p = 1) were decolonized similarly. Of the nine C. auris decolonized cases, two developed C. auris infection in 30 days follow-up after decolonization. However, 10 (34.5%) of 29 non-decolonized cases developed C. auris infection (p: 0.450) within 30 days after surveillance culture positivity. Over all cohorts, day 30 mortality was 23.7% (9/38).
    Conclusion: In conclusion, based on our observational and relatively small uncontrolled series, it appears that DCHX is not very effective in decolonizing C. auris carriers (especially in cases who are C. auris colonized in > 1 areas), although it is not completely ineffective.
    MeSH term(s) Adult ; Female ; Humans ; Middle Aged ; Anti-Bacterial Agents ; Antifungal Agents/therapeutic use ; Candida auris ; Candidiasis, Invasive ; Chlorhexidine/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Antifungal Agents ; Chlorhexidine (R4KO0DY52L)
    Language English
    Publishing date 2023-11-28
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-023-04723-5
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    Zs.A 1732: Show issues Location:
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  9. Article ; Online: Editorial

    Oğuz Reşat SİPAHİ

    Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol

    2017  Volume 6

    Keywords Scientomtrics ; citation ; theses ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language Turkish
    Publishing date 2017-12-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Economics of antibiotic resistance.

    Sipahi, Oguz Resat

    Expert review of anti-infective therapy

    2008  Volume 6, Issue 4, Page(s) 523–539

    Abstract: Antibiotics are developed to kill microorganisms; however, microorganisms develop and disseminate resistance as a reaction to antimicrobials in accordance with the laws of evolution and natural selection. Resistant and multidrug-resistant bacterial ... ...

    Abstract Antibiotics are developed to kill microorganisms; however, microorganisms develop and disseminate resistance as a reaction to antimicrobials in accordance with the laws of evolution and natural selection. Resistant and multidrug-resistant bacterial infections comprise a great problem in both the community and hospital setting. Increasing values of health expenditures, including antibiotics, is a global problem. Antibiotic resistance is not always, but usually, associated with significant morbidity, longer hospitalization, excess costs and mortality. Excess costs associated with resistant microorganisms may be due to: obligation to use more expensive antibiotics, longer hospital stay, higher mortality, delayed appropriate antibiotic therapy or a necessity to perform surgery. Optimal use of existing antimicrobial agents, using alternative treatment options (where possible), reducing the need for antimicrobials by increasing immunity, reducing the use of antimicrobials without providing an alternative form of treatment through education of health professionals and patients, antibiotic policies (including antibiotic stewardship and regulations for restricted use), implementation of infection control measures (e.g., hand washing, screening and isolation) are the strategies aimed at prevention of emergence and spread of antibiotic resistance.
    MeSH term(s) Anti-Bacterial Agents/economics ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacterial Infections/drug therapy ; Bacterial Infections/economics ; Bacterial Infections/mortality ; Drug Resistance, Bacterial ; Economics, Pharmaceutical ; Health Care Costs ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2008-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1586/14787210.6.4.523
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