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  1. Article ; Online: Lu

    Shen, Wangqiang / Zhang, Li / Zheng, Shushu / Xie, Yunpeng / Lu, Xing

    ACS applied materials & interfaces

    2017  Volume 9, Issue 34, Page(s) 28838–28843

    Abstract: One-dimensional (1D) single-crystalline hexagonal nanorods of Lu ...

    Abstract One-dimensional (1D) single-crystalline hexagonal nanorods of Lu
    Language English
    Publishing date 2017-08-30
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.7b05180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lu

    Shen, Wangqiang / Bao, Lipiao / Wu, Yongbo / Pan, Changwang / Zhao, Shasha / Fang, Hongyun / Xie, Yunpeng / Jin, Peng / Peng, Ping / Li, Fang-Fang / Lu, Xing

    Journal of the American Chemical Society

    2017  Volume 139, Issue 29, Page(s) 9979–9984

    Abstract: Although most of the ... ...

    Abstract Although most of the M
    Language English
    Publishing date 2017-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.7b04421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  3. Article: A Watt-Level Pulsed Er:Lu

    Liang, Yangyang / Zhang, Lu

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: ... ...

    Abstract TiB
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14040379
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  4. Article ; Online: Steering Lu

    Yu, Pengwei / Hu, Shuaifeng / Tian, Xinyue / Shen, Wangqiang / Yu, Pengyuan / Guo, Kun / Xie, Yunpeng / Bao, Lipiao / Lu, Xing

    Nanoscale

    2022  Volume 14, Issue 46, Page(s) 17290–17296

    Abstract: ... to-compare cluster configuration and cage arrangement, namely Lu ...

    Abstract While the strong interaction between the internal unit and the fullerene cage inside metallofullerenes is widely acknowledged, how the cage transformation interacts with the cluster configuration remains elusive. For this purpose, we herein synthesized three metallofullerene molecules with an easy-to-compare cluster configuration and cage arrangement, namely Lu
    Language English
    Publishing date 2022-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d2nr05049h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Self-Q-switched Er:Lu

    Zhang, Meng / Yin, Yanru / Zhang, Lu / Zhang, Baitao / Yang, Kejian / He, Jingliang / Li, Tao

    Applied optics

    2023  Volume 62, Issue 6, Page(s) 1462–1466

    Abstract: A diode-pumped self-Q-switched 2.74 µm Er:Lu ...

    Abstract A diode-pumped self-Q-switched 2.74 µm Er:Lu
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.481607
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  6. Article: Lutetium Lu 177 vipivotide tetraxetan for prostate cancer.

    Liu, Xing / Fang, Gao-Chuan / Lu, Hao / Shi, Zhen-Duo / Chen, Zhe-Sheng / Han, Cong-Hui

    Drugs of today (Barcelona, Spain : 1998)

    2023  Volume 59, Issue 1, Page(s) 37–49

    Abstract: On March 23, 2022, the U.S. Food and Drug Administration (FDA) approved Pluvicto (lutetium Lu 177 ... therapy for eligible men with PSMA-positive mCRPC. Lutetium Lu 177 vipivotide tetraxetan is a radioligand ... and clinical studies of the novel drug lutetium Lu 177 vipivotide tetraxetan for the treatment ...

    Abstract On March 23, 2022, the U.S. Food and Drug Administration (FDA) approved Pluvicto (lutetium Lu 177 vipivotide tetraxetan), also known as 177Lu-PSMA-617, for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) who have highly expressed prostate-specific membrane antigen (PSMA) and have at least one metastatic lesion. It is the first FDA-approved targeted radioligand therapy for eligible men with PSMA-positive mCRPC. Lutetium Lu 177 vipivotide tetraxetan is a radioligand that strongly binds to PSMA, making it ideal for treating cancers of the prostate by targeted radiation, resulting in DNA damage and cell death. PSMA is overexpressed in cancer cells while being lowly expressed in normal tissues, which makes it an ideal theranostic target. As precision medicine advances, this is a thrilling turning point for highly individualized treatments. This review aims to summarize the pharmacology and clinical studies of the novel drug lutetium Lu 177 vipivotide tetraxetan for the treatment of mCRPC, emphasizing its mechanism of action, pharmacokinetics and safety.
    MeSH term(s) Male ; Humans ; Lutetium/adverse effects ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostate-Specific Antigen/therapeutic use ; Treatment Outcome
    Chemical Substances 177Lu-PSMA-617 ; 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid (1HTE449DGZ) ; Lutetium (5H0DOZ21UJ) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-02-22
    Publishing country Spain
    Document type Review ; Journal Article
    ISSN 1699-3993
    ISSN 1699-3993
    DOI 10.1358/dot.2023.59.1.3476574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In conversation with Xin Lu.

    Howe, Françoise S / Lu, Xin

    The FEBS journal

    2020  Volume 287, Issue 24, Page(s) 5254–5259

    Abstract: Xin Lu is Professor of Cancer Biology at the University of Oxford, UK, and Director of the Oxford ...

    Abstract Xin Lu is Professor of Cancer Biology at the University of Oxford, UK, and Director of the Oxford Branch of the Ludwig Institute for Cancer Research, Co-director of the Cancer Research UK Oxford Centre, NIHR Oxford Biomedical Research Centre Multi-Modal Cancer Therapies Theme Lead and Director of the Oxford Centre for Early Cancer Detection. She has a long-standing interest in mechanisms of tumour suppression and cellular plasticity, centred on studies of p53 and the ASPP family of proteins (apoptosis-stimulating protein of p53; ankyrin repeats, SH3 domain and proline-rich sequence-containing proteins). Her laboratory's discovery of ASPPs, regulators or 'molecular switches' of the apoptotic function of p53 led to key insights into the role of cell plasticity in cancer and other diseases, and these could pave the way to new diagnostic and therapeutic interventions. Xin has received many awards and honours in recognition of her significant contributions to cancer biology, including being elected as a Fellow of the Royal Society in 2020. Here, she outlines how her breakthrough discovery of ASPPs came about and its impact on the cancer field, as well as highlighting the importance of mentors including Min Wu, Birgit Lane and Sir David Lane in shaping her early career and helping her to navigate a new research world, having moved to the UK from China in the 80s.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Awards and Prizes ; Female ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology
    Chemical Substances Adaptor Proteins, Signal Transducing ; Apoptosis Regulatory Proteins ; PPP1R13B protein, human
    Language English
    Publishing date 2020-11-16
    Publishing country England
    Document type Editorial ; Interview
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.15591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Meet the authors: Ying Lu, Donghoon Lee, and Yanan Zhu.

    Lu, Ying / Lee, Donghoon / Zhu, Yanan

    Molecular cell

    2023  Volume 83, Issue 16, Page(s) 2829–2831

    Abstract: We talk to co-first authors Donghoon Lee and Yanan Zhu and co-corresponding author Ying Lu ...

    Abstract We talk to co-first authors Donghoon Lee and Yanan Zhu and co-corresponding author Ying Lu about their paper "Molecular mechanism for activation of the 26S proteasome by ZFAND5" (this issue of Molecular Cell), the challenges of the project, their scientific pathways, and the late Dr. Alfred Goldberg.
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.07.027
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Meet the authors: Yuxuan Zhao, Enmeng Lu, and Yi Zeng.

    Zhao, Yuxuan / Lu, Enmeng / Zeng, Yi

    Patterns (New York, N.Y.)

    2023  Volume 4, Issue 12, Page(s) 100891

    Abstract: Yuxuan Zhao, associate professor, Enmeng Lu, research engineer, and Yi Zeng, professor and lab ...

    Abstract Yuxuan Zhao, associate professor, Enmeng Lu, research engineer, and Yi Zeng, professor and lab director, have proposed a brain-inspired bodily self-perception model based on biological findings on monkeys and humans. This model can reproduce various rubber hand illusion (RHI) experiments, which helps reveal the RHI's computational and biological mechanisms. They talk about their view of data science and research plans for brain-inspired robot self-modeling and ethical robots.
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type News
    ISSN 2666-3899
    ISSN (online) 2666-3899
    DOI 10.1016/j.patter.2023.100891
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  10. Article ; Online: Uranium Oxide Hydrate Frameworks with Dy(III) or Lu(III) Ions: Insights into the Framework Structures with Lanthanide Ions.

    Zhang, Yingjie / Lu, Kimbal T / Ablott, Timothy A / Zheng, Rongkun

    Chemistry, an Asian journal

    2024  , Page(s) e202400101

    Abstract: ... 10UO13(OH)4] (UOHF-Dy) or Lu2(H2O)8[(UO2)10UO14(OH)3] (UOHF-Lu), were synthesized hydrothermally and ... the same atomic ratio of ~5.5 for U:Dy and U:Lu, they displayed different crystal morphologies, needles ... for UOHF-Dy in the orthorhombic C2221 space group and plates for UOHF-Lu in the triclinic P-1 space group ...

    Abstract Two uranium oxide hydrate frameworks (UOHFs) with either Dy3+ or Lu3+ ions, Dy1.36(H2O)6[(UO2)10UO13(OH)4] (UOHF-Dy) or Lu2(H2O)8[(UO2)10UO14(OH)3] (UOHF-Lu), were synthesized hydrothermally and characterized with a range of structural and spectroscopic techniques. Although SEM-EDS analysis confirmed the same atomic ratio of ~5.5 for U:Dy and U:Lu, they displayed different crystal morphologies, needles for UOHF-Dy in the orthorhombic C2221 space group and plates for UOHF-Lu in the triclinic P-1 space group. Both frameworks are composed of β-U3O8 type layers linked by pentagonal bipyramidal uranium polyhedra, with the Dy3+/Lu3+ ions inside the channels. However, the arrangements of Dy3+/Lu3+ ions are different, with disordered Dy3+ ions well aligned at the centers of the channels and single Lu3+ ions well-separated in a zigzag pattern in the channels. While the characteristic vibrational modes were revealed by Raman spectroscopy, the presence of a pentavalent uranium center in UOHF-Lu was confirmed with diffuse reflectance spectroscopy. The formation of two types of UOHFs with lanthanide ions, high or low symmetry, and the structure trend were discussed regards to synthesis conditions and lanthanide ionic radius. This work highlights the complex chemistry driving the formation of UOHFs with lanthanide ions and has implications to the spent nuclear fuel under geological disposal.
    Language English
    Publishing date 2024-04-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202400101
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