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  1. Article ; Online: Igniting the slow burn of post-COVID conditions.

    Henderson, Jeffrey P

    mBio

    2023  Volume 14, Issue 5, Page(s) e0148923

    Abstract: Post-COVID conditions (PCCs) are persistent new patient symptoms occurring after acute COVID-19 infection and are an increasingly appreciated dimension of the COVID-19 pandemic. The factors that cause PCCs are not well understood. In recent work, Gebo et ...

    Abstract Post-COVID conditions (PCCs) are persistent new patient symptoms occurring after acute COVID-19 infection and are an increasingly appreciated dimension of the COVID-19 pandemic. The factors that cause PCCs are not well understood. In recent work, Gebo et al. identify a connection between acute IL-6 levels, early COVID-19 convalescent plasma (CP) administration, and later PCCs in subjects from a randomized controlled trial of acutely ill subjects enrolled in 2020 to 2021 (K. A. Gebo, S. L. Heath, Y. Fukuta, X. Zhu, et al., mBio e00618-23, 2023, https://doi.org/10.1128/mbio.00618-23). These results may be viewed as part of an emerging picture linking the intensity of inflammatory responses during acute infection to later PCCs.
    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Pandemics ; COVID-19 Serotherapy ; Inflammation ; Antibodies ; Immunization, Passive/methods
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01489-23
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  2. Article ; Online: Convalescent Plasma for Covid-19-Induced ARDS.

    Senefeld, Jonathon W / Henderson, Jeffrey P / Joyner, Michael J

    The New England journal of medicine

    2024  Volume 390, Issue 4, Page(s) 385

    MeSH term(s) Humans ; Respiration, Artificial ; COVID-19 ; COVID-19 Serotherapy ; Plasma ; Respiratory Distress Syndrome
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2313675
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  3. Article: Uropathogenic

    Zou, Zongsen / Robinson, John I / Steinberg, Lindsey K / Henderson, Jeffrey P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... ...

    Abstract Uropathogenic
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.25.550588
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  4. Article ; Online: COVID-19 Convalescent Plasma and Concomitant Therapies in PassITON.

    Casadevall, Arturo / Henderson, Jeffrey P

    Chest

    2022  Volume 162, Issue 5, Page(s) e284–e285

    MeSH term(s) Humans ; COVID-19/therapy ; SARS-CoV-2 ; Immunization, Passive ; Treatment Outcome ; COVID-19 Serotherapy
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.07.028
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  5. Article ; Online: What are protective antibody responses to pandemic SARS-CoV-2?

    Henderson, Jeffrey P

    The Journal of clinical investigation

    2020  Volume 130, Issue 12, Page(s) 6232–6234

    Abstract: Human antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hold intense interest, with research efforts directed at optimizing antibody-based interventions and monitoring immune status. By relating individual variations in ... ...

    Abstract Human antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hold intense interest, with research efforts directed at optimizing antibody-based interventions and monitoring immune status. By relating individual variations in antibody response to coronavirus disease 2019 (COVID-19) severity, beneficial antiviral immune responses may be identified in detail. In this issue of the JCI, Secchi and collaborators describe antibody response profiles in 509 patients with COVID-19 from Italy during the 2020 pandemic. The research team found that multiple antibody types to multiple SARS-CoV-2 antigens developed over four weeks. Notably, IgG against the spike receptor binding domain (RBD) was predictive of survival and IgA against the viral spike protein (S protein) associated with rapid virologic clearance. These results may help guide selection of convalescent plasma, hyperimmune products, monoclonal antibodies, and vaccine strategies for COVID-19.
    MeSH term(s) Antibodies, Viral ; Antibody Formation ; Betacoronavirus/immunology ; COVID-19/therapy ; Humans ; Immunization, Passive ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Antibodies, Viral ; Spike Glycoprotein, Coronavirus
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI143466
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  6. Article ; Online: Convalescent plasma in oncohematological patients.

    Focosi, Daniele / Franchini, Massimo / Joyner, Michael J / Henderson, Jeffrey P / Casadevall, Arturo

    Hematological oncology

    2022  Volume 41, Issue 1, Page(s) 208–209

    Language English
    Publishing date 2022-08-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3069
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  7. Article ; Online: Yersiniabactin is a quorum-sensing autoinducer and siderophore in uropathogenic

    Heffernan, James R / Wildenthal, John A / Tran, Hung / Katumba, George L / McCoy, William H / Henderson, Jeffrey P

    mBio

    2024  Volume 15, Issue 2, Page(s) e0027723

    Abstract: Siderophores are secreted ferric ion chelators used to obtain iron in nutrient-limited environmental niches, including human hosts. While ... ...

    Abstract Siderophores are secreted ferric ion chelators used to obtain iron in nutrient-limited environmental niches, including human hosts. While all
    MeSH term(s) Humans ; Siderophores/metabolism ; Uropathogenic Escherichia coli/genetics ; Uropathogenic Escherichia coli/metabolism ; Enterobactin/metabolism ; Iron/metabolism ; Urinary Tract Infections/microbiology ; Phenols ; Thiazoles
    Chemical Substances Siderophores ; Enterobactin (28384-96-5) ; yersiniabactin ; Iron (E1UOL152H7) ; Phenols ; Thiazoles
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00277-23
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  8. Article ; Online: The

    Katumba, George L / Tran, Hung / Henderson, Jeffrey P

    mBio

    2022  Volume 13, Issue 1, Page(s) e0239121

    Abstract: Siderophores are iron chelators used by microbes to bind and acquire iron, which, once in the cell, inhibits siderophore production through feedback repression mediated by the ferric uptake repressor (Fur). Yersiniabactin (Ybt), a siderophore associated ... ...

    Abstract Siderophores are iron chelators used by microbes to bind and acquire iron, which, once in the cell, inhibits siderophore production through feedback repression mediated by the ferric uptake repressor (Fur). Yersiniabactin (Ybt), a siderophore associated with enhanced pathogenic potential among
    MeSH term(s) Animals ; Humans ; Mice ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Copper/metabolism ; Enterobacteriaceae/genetics ; Enterobactin ; Ferric Compounds ; Genomic Islands/genetics ; Genomic Islands/immunology ; Siderophores/genetics ; Siderophores/metabolism ; Uropathogenic Escherichia coli/genetics ; Uropathogenic Escherichia coli/metabolism ; Yersinia/genetics ; Yersinia/metabolism ; Yersinia/pathogenicity
    Chemical Substances Bacterial Proteins ; Copper (789U1901C5) ; Enterobactin (28384-96-5) ; Ferric Compounds ; Siderophores ; yersiniabactin
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02391-21
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  9. Article: Yersiniabactin is a quorum sensing autoinducer and siderophore in uropathogenic

    Heffernan, James R / Katumba, George L / McCoy, William H / Henderson, Jeffrey P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Siderophores are secreted ferric ion chelators used to obtain iron in nutrient-limited environmental niches, including human hosts. While all : Importance: Urinary tract infections (UTIs) are one of the most common human bacterial infections ... ...

    Abstract Siderophores are secreted ferric ion chelators used to obtain iron in nutrient-limited environmental niches, including human hosts. While all
    Importance: Urinary tract infections (UTIs) are one of the most common human bacterial infections encountered by physicians. Adaptations that increase the pathogenic potential of commensal microbes such as
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.09.527953
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  10. Article ; Online: Uropathogenic Escherichia coli wield enterobactin-derived catabolites as siderophores.

    Zou, Zongsen / Robinson, John I / Steinberg, Lindsey K / Henderson, Jeffrey P

    The Journal of biological chemistry

    2023  Volume 300, Issue 1, Page(s) 105554

    Abstract: Uropathogenic Escherichia coli (UPEC) secrete multiple siderophore types to scavenge extracellular iron(III) ions during clinical urinary tract infections, despite the metabolic costs of biosynthesis. Here, we find the siderophore enterobactin (Ent) and ... ...

    Abstract Uropathogenic Escherichia coli (UPEC) secrete multiple siderophore types to scavenge extracellular iron(III) ions during clinical urinary tract infections, despite the metabolic costs of biosynthesis. Here, we find the siderophore enterobactin (Ent) and its related products to be prominent components of the iron-responsive extracellular metabolome of a model UPEC strain. Using defined Ent biosynthesis and import mutants, we identify lower molecular weight dimeric exometabolites as products of incomplete siderophore catabolism, rather than prematurely released biosynthetic intermediates. In E. coli, iron acquisition from iron(III)-Ent complexes requires intracellular esterases that hydrolyze the siderophore. Although UPEC are equipped to consume the products of completely hydrolyzed Ent, we find that Ent and its derivatives may be incompletely hydrolyzed to yield products with retained siderophore activity. These results are consistent with catabolic inefficiency as means to obtain more than one iron ion per siderophore molecule. This is compatible with an evolved UPEC strategy to maximize the nutritional returns from metabolic investments in siderophore biosynthesis.
    MeSH term(s) Enterobactin/metabolism ; Ferric Compounds/metabolism ; Iron/metabolism ; Siderophores/metabolism ; Uropathogenic Escherichia coli/metabolism
    Chemical Substances Enterobactin (28384-96-5) ; Ferric Compounds ; Iron (E1UOL152H7) ; Siderophores
    Language English
    Publishing date 2023-12-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105554
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