LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 221

Search options

  1. Article ; Online: Unraveling the Role of Immune Checkpoints in Leishmaniasis.

    de Freitas E Silva, Rafael / von Stebut, Esther

    Frontiers in immunology

    2021  Volume 12, Page(s) 620144

    Abstract: Leishmaniasis are Neglected Tropical Diseases affecting millions of people every year in at least 98 countries and is one of the major unsolved world health issues. ...

    Abstract Leishmaniasis are Neglected Tropical Diseases affecting millions of people every year in at least 98 countries and is one of the major unsolved world health issues.
    MeSH term(s) Animals ; Biomarkers ; Disease Models, Animal ; Disease Susceptibility ; Host-Parasite Interactions/genetics ; Host-Parasite Interactions/immunology ; Humans ; Immune Checkpoint Proteins/genetics ; Immune Checkpoint Proteins/metabolism ; Leishmania/immunology ; Leishmaniasis/diagnosis ; Leishmaniasis/etiology ; Leishmaniasis/metabolism ; Leishmaniasis/therapy ; Symptom Assessment ; Translational Medical Research
    Chemical Substances Biomarkers ; Immune Checkpoint Proteins
    Language English
    Publishing date 2021-03-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.620144
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: What are the factors influencing the COVID-19 outbreak in Latin America?

    de Freitas E Silva, Rafael / Pitzurra, Raffaela

    Travel medicine and infectious disease

    2020  Volume 35, Page(s) 101667

    MeSH term(s) Betacoronavirus ; Brazil ; COVID-19 ; Coronavirus Infections ; Humans ; Latin America ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-11
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101667
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Central and Effector Memory Human CD4+ and CD8+ T Cells during Cutaneous Leishmaniasis and after In Vitro Stimulation with Leishmania (Viannia) braziliensis Epitopes

    de Oliveira, Beatriz Coutinho / da Silva, Ailton Alvaro / de Andrade Cavalcante, Marton Kaique / de Brito, Maria Edileuza Felinto / de Castro, Maria Carolina Accioly Brelaz / de Medeiros, Vanessa Lucília Silveira / de Freitas E Silva, Rafael / Pereira, Valéria Rêgo Alves

    Vaccines

    2023  Volume 11, Issue 1

    Abstract: Cutaneous Leishmaniasis (CL) is a Neglected Tropical Disease characterized by skin ulcers caused ... ...

    Abstract Cutaneous Leishmaniasis (CL) is a Neglected Tropical Disease characterized by skin ulcers caused by
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11010158
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Opinion Article: NK Cells in Cutaneous Leishmaniasis: Protection or Damage?

    Cavalcante, Marton Kaique de Andrade / de Freitas E Silva, Rafael / Pereira, Valéria Rêgo Alves / Brelaz-de-Castro, Maria Carolina Accioly

    Frontiers in immunology

    2022  Volume 13, Page(s) 933490

    MeSH term(s) Humans ; Killer Cells, Natural ; Leishmaniasis, Cutaneous
    Language English
    Publishing date 2022-07-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.933490
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Sirtuins: Key pieces in the host response to pathogens' puzzle.

    Silva, Rafael de Freitas E / Bassi, Gabriela / Câmara, Niels Olsen Saraiva / Moretti, Nilmar Silvio

    Molecular immunology

    2023  Volume 160, Page(s) 150–160

    Abstract: Global warming is changing the distribution of different pathogens around the globe, and humans are more susceptible to new or re-emerging infections. The human response to microbes is complex and involves different mechanisms of the immune system. ... ...

    Abstract Global warming is changing the distribution of different pathogens around the globe, and humans are more susceptible to new or re-emerging infections. The human response to microbes is complex and involves different mechanisms of the immune system. Regulation of gene expression of immunity genes and of metabolism of immune cells are essential in this process. Both mechanisms could be regulated by protein lysine acetylation that will control chromatin structure affecting gene expression or key enzyme activity involved in cellular processes. Protein acetylation is crucial for the immunity and involves two families of enzymes: lysine acetyltransferases (KATs), which will promote protein acetylation, and lysine deacetylases (KDACs) that will reduce this modification. Lysine deacetylases are divided into Zinc-dependent or HDACs and NAD
    MeSH term(s) Animals ; Humans ; Lysine/metabolism ; Sirtuins/metabolism ; Protein Processing, Post-Translational ; Acetylation ; Mammals
    Chemical Substances Lysine (K3Z4F929H6) ; Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2023.06.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Sirtuins: Key pieces in the host response to pathogens’ puzzle

    Silva, Rafael de Freitas e / Bassi, Gabriela / Câmara, Niels Olsen Saraiva / Moretti, Nilmar Silvio

    Molecular Immunology. 2023 Aug., v. 160 p.150-160

    2023  

    Abstract: Global warming is changing the distribution of different pathogens around the globe, and humans are more susceptible to new or re-emerging infections. The human response to microbes is complex and involves different mechanisms of the immune system. ... ...

    Abstract Global warming is changing the distribution of different pathogens around the globe, and humans are more susceptible to new or re-emerging infections. The human response to microbes is complex and involves different mechanisms of the immune system. Regulation of gene expression of immunity genes and of metabolism of immune cells are essential in this process. Both mechanisms could be regulated by protein lysine acetylation that will control chromatin structure affecting gene expression or key enzyme activity involved in cellular processes. Protein acetylation is crucial for the immunity and involves two families of enzymes: lysine acetyltransferases (KATs), which will promote protein acetylation, and lysine deacetylases (KDACs) that will reduce this modification. Lysine deacetylases are divided into Zinc-dependent or HDACs and NAD⁺ -dependent, or Sirtuins. These enzymes are in the nucleus, cytosol, and mitochondria of mammalian cells affecting different cellular pathways, such as metabolism, gene expression, DNA repair, cell proliferation, and apoptosis, opening the opportunity to explore these proteins as drug targets in different diseases, including cancer and neurodegenerative illness. Although widely explored in chronic diseases, very little is known about the role of Sirtuins during host response against microbes’ infection. In this review we aim to explore the most recent literature evidencing a role for these enzymes during host responses to viruses, bacterial and protozoan infections, pointing out how these proteins can be manipulated by these pathogens to progress in the infection. Moreover, we will uncover the potential of host KDACs as therapeutic targets to prevent infections by activating effector immune functions.
    Keywords DNA repair ; Protozoa ; acetylation ; apoptosis ; cell proliferation ; chromatin ; cytosol ; drugs ; enzyme activity ; gene expression ; gene expression regulation ; humans ; immune system ; immunity ; lysine ; lysine N-acetyltransferase ; metabolism ; mitochondria ; sirtuins ; therapeutics ; Infection ; Virus ; Bacteria ; Protozoan ; Immune response
    Language English
    Dates of publication 2023-08
    Size p. 150-160.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2023.06.010
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Trypanosoma cruzi killing and immune response boosting by novel phenoxyhydrazine-thiazole against Chagas disease.

    Cristovão-Silva, Ana Catarina / Brelaz-de-Castro, Maria Carolina Accioly / Dionisio da Silva, Elis / Leite, Ana Cristina Lima / Santiago, Lizandra Beatriz Amorim Alves / Conceição, Juliana Maria da / da Silva Tiburcio, Robert / de Santana, Davi Pereira / Bedor, Danilo Cesar Galindo / de Carvalho, Breno Ítalo Valença / Ferreira, Luiz Felipe Gomes Rebello / de Freitas E Silva, Rafael / Alves Pereira, Valéria Rêgo / Hernandes, Marcelo Zaldini

    Experimental parasitology

    2024  Volume 261, Page(s) 108749

    Abstract: Trypanosoma cruzi (T. cruzi) causes Chagas, which is a neglected tropical disease (NTD). WHO estimates that 6 to 7 million people are infected worldwide. Current treatment is done with benznidazole (BZN), which is very toxic and effective only in the ... ...

    Abstract Trypanosoma cruzi (T. cruzi) causes Chagas, which is a neglected tropical disease (NTD). WHO estimates that 6 to 7 million people are infected worldwide. Current treatment is done with benznidazole (BZN), which is very toxic and effective only in the acute phase of the disease. In this work, we designed, synthesized, and characterized thirteen new phenoxyhydrazine-thiazole compounds and applied molecular docking and in vitro methods to investigate cell cytotoxicity, trypanocide activity, nitric oxide (NO) production, cell death, and immunomodulation. We observed a higher predicted affinity of the compounds for the squalene synthase and 14-alpha demethylase enzymes of T. cruzi. Moreover, the compounds displayed a higher predicted affinity for human TLR2 and TLR4, were mildly toxic in vitro for most mammalian cell types tested, and LIZ531 (IC50 2.8 μM) was highly toxic for epimastigotes, LIZ311 (IC50 8.6 μM) for trypomastigotes, and LIZ331 (IC50 1.9 μM) for amastigotes. We observed that LIZ311 (IC50 2.5 μM), LIZ431 (IC50 4.1 μM) and LIZ531 (IC50 5 μM) induced 200 μg/mL of NO and JM14 induced NO production in three different concentrations tested. The compound LIZ331 induced the production of TNF and IL-6. LIZ311 induced the secretion of TNF, IFNγ, IL-2, IL-4, IL-10, and IL-17, cell death by apoptosis, decreased acidic compartment formation, and induced changes in the mitochondrial membrane potential. Taken together, LIZ311 is a promising anti-T. cruzi compound is not toxic to mammalian cells and has increased antiparasitic activity and immunomodulatory properties.
    Language English
    Publishing date 2024-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391089-1
    ISSN 1090-2449 ; 0014-4894
    ISSN (online) 1090-2449
    ISSN 0014-4894
    DOI 10.1016/j.exppara.2024.108749
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Chemokine receptors on human regulatory T cells during cutaneous leishmaniasis.

    Brelaz de Castro, Maria Carolina Accioly / de Freitas E Silva, Rafael / de Andrade Cavalcante, Marton Kaique / Silva, Larissa Layne Soares Bezerra / Santos Dos Gomes, Fabiana Oliveira / de Brito, Maria Edileuza Felinto / Pereira, Valéria Rêgo Alves

    Parasite immunology

    2023  Volume 45, Issue 3, Page(s) e12966

    Abstract: The aim of this work was to define the population of regulatory T cells (Tregs) which are circulating in the blood of Leishmania infected individuals clinically displaying a lesion (active disease-AD) and sub-clinical (SC) ones. We have individually ... ...

    Abstract The aim of this work was to define the population of regulatory T cells (Tregs) which are circulating in the blood of Leishmania infected individuals clinically displaying a lesion (active disease-AD) and sub-clinical (SC) ones. We have individually collected blood samples, processed the PBMC and stained with fluorochrome-conjugated antibodies against CD3, CD4, Foxp3, CD25, CTLA-4, Ki-67, CCR4, CCR5, and CCR7. Cells were analyzed by flow cytometry. Our results suggest that CD25 and CTLA-4 are upregulated in Tregs of AD patients when compared to SC and uninfected (UN) controls. Moreover, Tregs proliferate upon infection based on Ki-67 nuclear antigen staining. Finally, we have observed that these Tregs of SC and AD patients upregulate CCR4, but not CCR5 and CCR7. There is an increase in the number of circulating Tregs in the blood of Leishmania infected individuals. These cells are potentially more suppressive based on the increased upregulation of CD25 and CTLA-4 during clinical infection (AD) when compared to SC infection. Tregs of both SC and AD cohorts are proliferating and express CCR4, which potentially guide them to the skin, but do not upregulate CCR5 and CCR7.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; CTLA-4 Antigen ; Leukocytes, Mononuclear ; Receptors, CCR7 ; Ki-67 Antigen ; Leishmaniasis, Cutaneous ; Leishmania ; Forkhead Transcription Factors
    Chemical Substances CTLA-4 Antigen ; Receptors, CCR7 ; Ki-67 Antigen ; Forkhead Transcription Factors
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424444-8
    ISSN 1365-3024 ; 0141-9838
    ISSN (online) 1365-3024
    ISSN 0141-9838
    DOI 10.1111/pim.12966
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1509: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: What are the factors influencing the COVID-19 outbreak in Latin America?

    de Freitas e Silva, Rafael / Pitzurra, Raffaela

    Travel Medicine and Infectious Disease

    2020  Volume 35, Page(s) 101667

    Keywords Public Health, Environmental and Occupational Health ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101667
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top