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  1. Article: Updates on pharmacological treatment for Alzheimer's disease: response to Letter to the Editors.

    Tipton, Philip W

    Neurologia i neurochirurgia polska

    2023  Volume 58, Issue 1, Page(s) 142–143

    MeSH term(s) Humans ; Alzheimer Disease/drug therapy
    Language English
    Publishing date 2023-12-19
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 415519-1
    ISSN 1897-4260 ; 0028-3843
    ISSN (online) 1897-4260
    ISSN 0028-3843
    DOI 10.5603/pjnns.98249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Updates on pharmacological treatment for Alzheimer's disease.

    Tipton, Philip W

    Neurologia i neurochirurgia polska

    2023  

    Abstract: Alzheimer's disease (AD) is the most common cause of dementia, and its rising prevalence is constantly increasing the global health burden. There are currently no curative therapies for AD, and current treatment options provide only modest clinical ... ...

    Abstract Alzheimer's disease (AD) is the most common cause of dementia, and its rising prevalence is constantly increasing the global health burden. There are currently no curative therapies for AD, and current treatment options provide only modest clinical benefit. Despite numerous clinical trials, there have been no major additions to the AD treatment armamentarium this century. The prevailing pathomechanistic hypothesis for AD begins with abnormal accumulation of amyloid β (Aβ) leading to plaque development, and disease-modifying candidate therapies have largely aimed to disrupt this process. Numerous clinical trials of monoclonal antibodies directed at various stages of Aβ plaque development have yielded mostly negative results; however, recent results suggest that a breakthrough may be on the horizon. The past two years have yielded positive results for three monoclonal antibodies (aducanumab, lecanemab, and donanemab) although questions remain regarding their clinical effectiveness. Additional clarity is needed to determine whether the clinical benefits are great enough to offset the treatment risks and the resource implications for healthcare systems. This review provides a foundational context and update on recent disease-modifying therapies for AD that have reached Phase III clinical trials. Up-to-date information on these therapies will help clinicians better inform their clinical decision-making and the counselling they can offer patients and their carers.
    Language English
    Publishing date 2023-08-22
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 415519-1
    ISSN 1897-4260 ; 0028-3843
    ISSN (online) 1897-4260
    ISSN 0028-3843
    DOI 10.5603/pjnns.96286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Dissecting parkinsonism: cognitive and gait disturbances.

    Tipton, Philip W

    Neurologia i neurochirurgia polska

    2021  Volume 55, Issue 6, Page(s) 513–524

    Abstract: Parkinsonism is usually designated a movement disorder. However, cognitive impairment comprises a major part of many parkinsonian syndromes, and inversely correlates with quality of life. Parkinsonian features are largely attributed to subcortical ... ...

    Abstract Parkinsonism is usually designated a movement disorder. However, cognitive impairment comprises a major part of many parkinsonian syndromes, and inversely correlates with quality of life. Parkinsonian features are largely attributed to subcortical dopaminergic dysfunction, although other brain regions and neurotransmitters also contribute. This is illustrated by phenotypic differences among different parkinsonian syndromes. Slowed processing speed and executive dysfunction are generally expected in parkinsonian patients, but additional cognitive features can suggest specific pathological substrates, e.g. apraxia in corticobasal degeneration. Similarly, motor symptoms generally include combinations of bradykinesia, rigidity, rest tremor, and postural instability, although nuanced differences and associated clinical features often help differentiate between parkinsonian syndromes. Human gait requires complex synchronisation at every level of the nervous system, yet occurs with minimal conscious effort on behalf of the walker. Deviations from the normal gait pattern can result from otherwise unnoticeable insults to the body, both intrinsic and extrinsic to the nervous system. Gait is almost always abnormal in parkinsonism, ranging from subtle arm swing asymmetry to discrete episodes of gait freezing. Moreover, one's cognitive state can directly affect one's quality of gait. The notion that a gait profile could in fact be a disease-specific biomarker is an area of great research interest. This review focuses on the manifestations of, and correlations between, cognitive and gait impairment in common parkinsonian conditions, and provides guidance for a clinical approach to assessing them.
    MeSH term(s) Cognition ; Corticobasal Degeneration ; Gait ; Humans ; Parkinsonian Disorders/complications ; Quality of Life
    Language English
    Publishing date 2021-11-24
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 415519-1
    ISSN 1897-4260 ; 0028-3843
    ISSN (online) 1897-4260
    ISSN 0028-3843
    DOI 10.5603/PJNNS.a2021.0084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Does deep brain stimulation stimulate metabolism?

    Tipton, Philip W / Middlebrooks, Erik H

    Neurologia i neurochirurgia polska

    2022  Volume 56, Issue 5, Page(s) 385–388

    MeSH term(s) Humans ; Deep Brain Stimulation ; Brain
    Language English
    Publishing date 2022-09-15
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 415519-1
    ISSN 1897-4260 ; 0028-3843
    ISSN (online) 1897-4260
    ISSN 0028-3843
    DOI 10.5603/PJNNS.a2022.0061
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  5. Article ; Online: A Man with Rapid Speech and Handwriting.

    Bhansali, Sakhi / Tipton, Philip W / van Gerpen, Jay

    Movement disorders clinical practice

    2023  Volume 10, Issue 8, Page(s) 1217–1218

    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Sexual dysfunction in Huntington's Disease: what do we really know?

    Tipton, Philip W

    Neurologia i neurochirurgia polska

    2020  Volume 54, Issue 4, Page(s) 291–293

    Abstract: Introduction: In this edition, Szymuś et al. conducted a systematic review revealing sexual dysfunction to be more prevalent in patients with Huntington's Disease compared to controls.: Clinical reflections: Sexual dysfunction in HD (SDHD) is common ... ...

    Abstract Introduction: In this edition, Szymuś et al. conducted a systematic review revealing sexual dysfunction to be more prevalent in patients with Huntington's Disease compared to controls.
    Clinical reflections: Sexual dysfunction in HD (SDHD) is common and significantly affects patient quality of life. Commonly used HD rating scales and treatment guidelines do not explicitly address SDHD, and research studies are limited by size and methodology.
    Clinical implications: It is important that validated sexual dysfunction screening tools be utilised in clinical and research settings.
    MeSH term(s) Humans ; Huntington Disease ; Quality of Life ; Sexual Dysfunction, Physiological
    Language English
    Publishing date 2020-09-01
    Publishing country Poland
    Document type Journal Article ; Systematic Review
    ZDB-ID 415519-1
    ISSN 1897-4260 ; 0028-3843
    ISSN (online) 1897-4260
    ISSN 0028-3843
    DOI 10.5603/PJNNS.2020.0034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Searching for tics.

    Tipton, Philip W

    Neurologia i neurochirurgia polska

    2019  Volume 53, Issue 5, Page(s) 315–316

    Abstract: Introduction: In the current edition, Szejko and colleagues describe a subset of patients with Gilles de la Tourette syndrome (GTS) who had dystonic tics (DTs), which occurred more frequently in those with a greater number of tics and likely contribute ... ...

    Abstract Introduction: In the current edition, Szejko and colleagues describe a subset of patients with Gilles de la Tourette syndrome (GTS) who had dystonic tics (DTs), which occurred more frequently in those with a greater number of tics and likely contribute to impairment. Clinical Reflections: DTs manifest as an abnormal posture that may be difficult to distinguish from other movements, such as dystonia and other tic types. Electromyography is an invaluable tool that can aid clinicians in making this important distinction.
    Clinical implications: Accurately diagnosing these movements can significantly impact treatment decisions and contribute to more homogenous research populations.
    MeSH term(s) Dystonia ; Humans ; Tics ; Tourette Syndrome
    Language English
    Publishing date 2019-10-28
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 415519-1
    ISSN 1897-4260 ; 0028-3843
    ISSN (online) 1897-4260
    ISSN 0028-3843
    DOI 10.5603/PJNNS.a2019.0050
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  8. Article ; Online: Reply to: "The First Allogeneic Hematopoietic Stem Cell Transplantation in a Polish Patient with Adult-Onset Leukoencephalopathy with Spheroids and Pigmented Glia".

    Tipton, Philip W / Wierenga, Klaas J / Wszolek, Zbigniew K

    Movement disorders : official journal of the Movement Disorder Society

    2022  Volume 37, Issue 7, Page(s) 1572–1573

    MeSH term(s) Adult ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukoencephalopathies/complications ; Mutation ; Neuroglia ; Poland
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29065
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  9. Article: Neuropsychological profile of CSF1R-related leukoencephalopathy.

    Rush, Beth K / Tipton, Philip W / Strongosky, Audrey / Wszolek, Zbigniew K

    Frontiers in neurology

    2023  Volume 14, Page(s) 1155387

    Abstract: Introduction: The neuropsychological profile of CSF1R-related leukoencephalopathy (CRL) is undefined. This study defines the profile, contrasts it with that of other dementia syndromes, and highlights measures sensitive to cognitive impairment.: ... ...

    Abstract Introduction: The neuropsychological profile of CSF1R-related leukoencephalopathy (CRL) is undefined. This study defines the profile, contrasts it with that of other dementia syndromes, and highlights measures sensitive to cognitive impairment.
    Methods: We administered a standardized battery of neuropsychological tests to five consecutive CRL cases.
    Results: The neuropsychological profile of CRL reflects impaired general cognitive function, processing speed, executive function, speeded visual problem solving, verbal fluency, and self-reported depression and anxiety. Confrontation naming and memory are preserved. Within cognitive domains, certain measures more frequently identified impairment than others.
    Discussion: CRL impairs general cognitive function, processing speed, executive function. Language and visual problem solving may be impaired if processing speed is required. Confrontation naming and memory are uniquely preserved, contrasting CRL to other dementia syndromes. Cognitive screens excluding processing speed and executive function may not detect CRL cognitive manifestations. Findings sharply define cognitive impairment of CRL and inform cognitive test selection.
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1155387
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  10. Article: Response to "Does amantadine have a protective effect against COVID-19?"

    Tipton, Philip W / Wszolek, Zbigniew K

    Neurologia i neurochirurgia polska

    2020  Volume 54, Issue 3, Page(s) 286–287

    MeSH term(s) Amantadine ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Amantadine (BF4C9Z1J53)
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country Poland
    Document type Journal Article ; Comment
    ZDB-ID 415519-1
    ISSN 1897-4260 ; 0028-3843
    ISSN (online) 1897-4260
    ISSN 0028-3843
    DOI 10.5603/PJNNS.a2020.0048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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