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  1. Article ; Online: [No title information]

    Chow, Ivy / Chan, Sara / Lin, Molly / Peters, Laurenna

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2023  Volume 195, Issue 49, Page(s) E1731–E1734

    Title translation Infection du cuir chevelu à
    MeSH term(s) Humans ; Mycobacterium abscessus ; Scalp ; Central America ; Skin Transplantation ; Hair
    Language French
    Publishing date 2023-12-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.230794-f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mycobacterium abscessus

    Chow, Ivy / Chan, Sara / Lin, Molly / Peters, Laurenna

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2023  Volume 195, Issue 42, Page(s) E1440–E1442

    MeSH term(s) Humans ; Mycobacterium abscessus ; Scalp ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/etiology ; Central America ; Hair ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-30
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.230794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Web Exclusive. Annals Graphic Medicine - Medicare Hearing Policy: A Path Forward.

    Lin, Frank / Sheehan, Molly / Reed, Nicholas / Sampson, Ian

    Annals of internal medicine

    2022  Volume 175, Issue 10, Page(s) W120–W135

    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/G21-0092
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  4. Article: Noninvasive PET imaging of tumor PD-L1 expression with

    Malih, Sara / Lin, Wilson / Tang, Zhongmin / DeLuca, Molly C / Engle, Jonathan W / Alirezapour, Behrouz / Cai, Weibo / Rasaee, Mohammad J

    American journal of nuclear medicine and molecular imaging

    2024  Volume 14, Issue 1, Page(s) 31–40

    Abstract: Breast cancer (BrCa) ranks as the most prevalent malignant neoplasm affecting women worldwide. The expression of programmed death-ligand 1 (PD-L1) in BrCa has recently emerged as a biomarker for immunotherapy response, but traditional ... ...

    Abstract Breast cancer (BrCa) ranks as the most prevalent malignant neoplasm affecting women worldwide. The expression of programmed death-ligand 1 (PD-L1) in BrCa has recently emerged as a biomarker for immunotherapy response, but traditional immunohistochemistry (IHC)-based methods are hindered by spatial and temporal heterogeneity. Noninvasive and quantitative PD-L1 imaging using appropriate radiotracers can serve to determine PD-L1 expression in tumors. This study aims to demonstrate the viability of PET imaging with
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623515-8
    ISSN 2160-8407
    ISSN 2160-8407
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  5. Article: Corneal dendritic cells in diabetes mellitus: A narrative review.

    Liu, Fengyi / Liu, Chang / Lee, Isabelle Xin Yu / Lin, Molly Tzu Yu / Liu, Yu-Chi

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1078660

    Abstract: Diabetes mellitus is a global public health problem with both macrovascular and microvascular complications, such as diabetic corneal neuropathy (DCN). ... ...

    Abstract Diabetes mellitus is a global public health problem with both macrovascular and microvascular complications, such as diabetic corneal neuropathy (DCN). Using
    MeSH term(s) Animals ; Humans ; Microscopy, Confocal ; Cornea/pathology ; Epithelium, Corneal/innervation ; Epithelium, Corneal/pathology ; Diabetic Neuropathies/pathology ; Dendritic Cells/metabolism ; Diabetes Mellitus/metabolism
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1078660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Separation of cyclotron-produced cobalt-55/58m from iron targets using cation exchange chromatography with non-aqueous solvents and extraction chromatography.

    Lin, Wilson / Aluicio-Sarduy, Eduardo / Barrett, Kendall E / Barnhart, Todd E / Mixdorf, Jason C / DeLuca, Molly C / Engle, Jonathan W

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2023  Volume 200, Page(s) 110980

    Abstract: Cobalt-55 and -58m form a theranostic pair that has relevant properties for cancer research. We report a cation exchange chromatography/extraction chromatography method that separates cyclotron- ... ...

    Abstract Cobalt-55 and -58m form a theranostic pair that has relevant properties for cancer research. We report a cation exchange chromatography/extraction chromatography method that separates cyclotron-produced
    Language English
    Publishing date 2023-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2023.110980
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  7. Article: Analysis of corneal nerve plexus in corneal confocal microscopy images.

    Liu, Yu-Chi / Lin, Molly Tzu-Yu / Mehta, Jodhbir S

    Neural regeneration research

    2020  Volume 16, Issue 4, Page(s) 690–691

    Language English
    Publishing date 2020-10-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.289435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Neuropathic Corneal Pain after Coronavirus Disease 2019 (COVID-19) Infection.

    Wong, Natalie Shi Qi / Liu, Chang / Lin, Molly Tzu-Yu / Lee, Isabelle Xin Yu / Tong, Louis / Liu, Yu-Chi

    Diseases (Basel, Switzerland)

    2024  Volume 12, Issue 2

    Abstract: Introduction: This is a case report of a patient with neuropathic corneal pain after coronavirus disease 2019 (COVID-19) infection.: Methods: A previously healthy 27-year-old female presented with bilateral eye pain accompanied by increased light ... ...

    Abstract Introduction: This is a case report of a patient with neuropathic corneal pain after coronavirus disease 2019 (COVID-19) infection.
    Methods: A previously healthy 27-year-old female presented with bilateral eye pain accompanied by increased light sensitivity 5 months after COVID-19 infection. She was diagnosed with neuropathic corneal pain based on clear corneas without fluorescein staining, alongside the presence of microneuromas, dendritic cells, and activated stromal keratocytes identified bilaterally on in vivo confocal microscopy.
    Results: The patient's tear nerve growth factor, substance P, and calcitonin gene-related peptide levels were 5.9 pg/mL, 2978.7 pg/mL, and 1.1 ng/mL, respectively, for the right eye and 23.1 pg/mL, 4798.7 pg/mL, and 1.2 ng/mL, respectively, for the left eye, suggesting corneal neuroinflammatory status. After 6 weeks of topical 0.1% flurometholone treatment, decreased microneuroma size, less extensive dendritic cells, and reduced tear nerve growth factor and substance P levels were observed. The scores on the Ocular Pain Assessment Survey showed an improvement in burning sensation and light sensitivity, decreasing from 80% and 70% to 50% for both.
    Conclusions: Neuropathic corneal pain is a potential post-COVID-19 complication that warrants ophthalmologists' and neurologists' attention.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases12020037
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  9. Article ; Online: Neurometabolic alterations in children and adolescents with functional neurological disorder

    Molly Charney / Sheryl Foster / Vishwa Shukla / Wufan Zhao / Sam H. Jiang / Kasia Kozlowska / Alexander Lin

    NeuroImage: Clinical, Vol 41, Iss , Pp 103557- (2024)

    2024  

    Abstract: Objectives: In vivo magnetic resonance spectroscopy (MRS) was used to investigate neurometabolic homeostasis in children with functional neurological disorder (FND) in three regions of interest: supplementary motor area (SMA), anterior default mode ... ...

    Abstract Objectives: In vivo magnetic resonance spectroscopy (MRS) was used to investigate neurometabolic homeostasis in children with functional neurological disorder (FND) in three regions of interest: supplementary motor area (SMA), anterior default mode network (aDMN), and posterior default mode network (dDMN). Metabolites assessed included N-acetyl aspartate (NAA), a marker of neuron function; myo-inositol (mI), a glial-cell marker; choline (Cho), a membrane marker; glutamate plus glutamine (Glx), a marker of excitatory neurotransmission; γ-aminobutyric acid (GABA), a marker of inhibitor neurotransmission; and creatine (Cr), an energy marker. The relationship between excitatory (glutamate and glutamine) and inhibitory (GABA) neurotransmitter (E/I) balance was also examined. Methods: MRS data were acquired for 32 children with mixed FND (25 girls, 7 boys, aged 10.00 to 16.08 years) and 41 healthy controls of similar age using both short echo point-resolved spectroscopy (PRESS) and Mescher-Garwood point-resolved spectroscopy (MEGAPRESS) sequences in the three regions of interest. Results: In the SMA, children with FND had lower NAA/Cr, mI/Cr (trend level), and GABA/Cr ratios. In the aDMN, no group differences in metabolite ratios were found. In the pDMN, children with FND had lower NAA/Cr and mI/Cr (trend level) ratios. While no group differences in E/I balance were found (FND vs. controls), E/I balance in the aDMN was lower in children with functional seizures—a subgroup within the FND group. Pearson correlations found that increased arousal (indexed by higher heart rate) was associated with lower mI/Cr in the SMA and pDMN. Conclusions: Our findings of multiple differences in neurometabolites in children with FND suggest dysfunction on multiple levels of the biological system: the neuron (lower NAA), the glial cell (lower mI), and inhibitory neurotransmission (lower GABA), as well as dysfunction in energy regulation in the subgroup with functional seizures.
    Keywords Functional neurological disorder ; Functional seizures ; Magnetic resonance spectroscopy ; Excitatory/inhibitory neurotransmitters ; MEGAPRESS ; Neurometabolite ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 571
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Impact of corrected refractive power on the corneal denervation and ocular surface in small-incision lenticule extraction and LASIK.

    Liu, Chang / Lin, Molly Tzu-Yu / Lee, Isabelle Xin Yu / Mehta, Jodhbir S / Liu, Yu-Chi

    Journal of cataract and refractive surgery

    2023  Volume 49, Issue 11, Page(s) 1106–1113

    Abstract: Purpose: To evaluate the impact of corrected refractive power on the corneal denervation and ocular surface in small-incision lenticule extraction (SMILE) and laser in situ keratomileusis (LASIK).: Setting: Singapore National Eye Center, Singapore.!## ...

    Abstract Purpose: To evaluate the impact of corrected refractive power on the corneal denervation and ocular surface in small-incision lenticule extraction (SMILE) and laser in situ keratomileusis (LASIK).
    Setting: Singapore National Eye Center, Singapore.
    Design: Prospective study.
    Methods: 88 eyes undergoing SMILE or LASIK were divided into low-moderate (manifest refractive spherical equivalent [MRSE] <-6.0 diopters [D]) and high myopic (MRSE ≥-6.0 D) groups. In vivo confocal microscopy and clinical assessments were performed preoperatively and at 1 month, 3 months, 6 months, and 12 months postoperatively.
    Results: In SMILE, high myopic treatment presented with significantly greater reduction in the corneal nerve fiber area (CNFA) and nerve fiber fractal dimension (CFracDim) compared with low-moderate myopic treatment (both P < .05). There was a significant and negative correlation between the corrected MRSE and the reduction in corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length, CNFA, and CFracDim after SMILE (r = -0.38 to -0.66, all P < .05). In LASIK, a significant correlation between the MRSE and the changes in CNBD, corneal nerve fiber total branch density, CNFA (r = -0.37 to -0.41), and corneal nerve fiber width (r = 0.43) was observed (all P < .05). Compared with SMILE, LASIK had greater reduction in CNBD and CNFA for every diopter increase in the corrected MRSE. High myopic SMILE, compared with low-moderate myopic SMILE, resulted in significantly lower tear break-up time at 1 and 6 months (both P < .05). The changes in CNFA and CFracDim were significantly associated with Schirmer test values (both P < .001).
    Conclusions: Postoperative corneal denervation was related to corrected refractive power in both SMILE and LASIK. With the same refractive correction, LASIK led to more prominent corneal denervation.
    MeSH term(s) Humans ; Keratomileusis, Laser In Situ/methods ; Corneal Stroma/surgery ; Prospective Studies ; Visual Acuity ; Lasers, Excimer/therapeutic use ; Refraction, Ocular ; Myopia/surgery ; Denervation
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632744-8
    ISSN 1873-4502 ; 0886-3350
    ISSN (online) 1873-4502
    ISSN 0886-3350
    DOI 10.1097/j.jcrs.0000000000001278
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