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Article ; Online: What can we learn from COVID-19 vaccine R&D in China? A discussion from a public policy perspective.

Hu, Yinglian / Chen, Simiao

2021 Volume 28, Issue 4

MeSH term(s)	Biomedical Research ; COVID-19/prevention & control ; COVID-19 Vaccines ; China ; Humans ; Public Policy
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-02-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taab026
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Article ; Online: Comparative Efficacy of P-CAB vs Proton Pump Inhibitors for Grade C/D Esophagitis: A Systematic Review and Network Meta-analysis.

Zhuang, Qianjun / Chen, Songfeng / Zhou, Xuyu / Jia, Xingyu / Zhang, Mengyu / Tan, Niandi / Chen, Fangfei / Zhang, Zhanye / Hu, Junnan / Xiao, Yinglian

The American journal of gastroenterology

2024 Volume 119, Issue 5, Page(s) 803–813

Abstract: Introduction: Los Angeles grade C/D esophagitis is a severe manifestation of gastroesophageal reflux disease that require active treatment and close follow-up. Potassium competitive acid blockers (P-CAB) are promising alternatives to proton pump ... ...

Abstract	Introduction: Los Angeles grade C/D esophagitis is a severe manifestation of gastroesophageal reflux disease that require active treatment and close follow-up. Potassium competitive acid blockers (P-CAB) are promising alternatives to proton pump inhibitors (PPI). We aimed to compare the efficacy and safety of P-CAB and PPI in healing grade C/D esophagitis to aid clinical decision-making. Methods: A systematic literature search was performed using PubMed, MEDLINE, and Cochrane Central Register of Controlled Trials. Randomized controlled trials were eligible for inclusion if efficacy of P-CAB and PPI in healing grade C/D esophagitis was reported. Pooled risk ratios and risk difference with 95% credible intervals were used to summarize estimated effect of each comparison. The benefit of treatments was ranked using the surface under the cumulative probability ranking score. Results: Of 5,876 articles identified in the database, 24 studies were eligible. Studies included incorporated 3 P-CAB (vonoprazan, tegoprazan, and keverprazan) and 6 PPI (lansoprazole, esomeprazole, omeprazole, rabeprazole extended-release (ER), pantoprazole, and dexlansoprazole). Based on the failure to achieve mucosal healing, 20 mg of vonoprazan q.d. ranked the first among PPI in initial and maintained healing of grade C/D esophagitis (surface under the cumulative probability ranking score = 0.89 and 0.87, respectively). Vonoprazan had similar risk of incurring adverse events, severe adverse events, and withdrawal to drug when compared with PPI. For those who attempted lower maintenance treatment dose, 10 mg of vonoprazan q.d. was a reasonable choice, considering its moderate efficacy and safety. Discussion: Vonoprazan has considerable efficacy in initial and maintained healing of grade C/D esophagitis compared with PPI, with moderate short-term and long-term safety.
MeSH term(s)	Humans ; Proton Pump Inhibitors/therapeutic use ; Network Meta-Analysis ; Esophagitis/drug therapy ; Gastroesophageal Reflux/drug therapy ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Esophagitis, Peptic/drug therapy ; Pyrroles ; Sulfonamides
Chemical Substances	Proton Pump Inhibitors ; 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Pyrroles ; Sulfonamides
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article ; Systematic Review ; Meta-Analysis ; Comparative Study
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000002714
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Article: The molecular pathogenesis of achalasia: a paired lower esophageal sphincter muscle and serum 4D label-free proteomic study.

Chen, Songfeng / Xing, Xiangbin / Hou, Xun / Zhuang, Qianjun / Tan, Niandi / Cui, Yi / Wang, Jinhui / Zhang, Mengyu / Hu, Shixian / Xiao, Yinglian

Gastroenterology report

2023 Volume 11, Page(s) goad031

Abstract: Background: Achalasia is a primary esophageal motility disorder with potential molecular pathogenesis remaining uncertain. This study aimed to identify the differentially expressed proteins and potential pathways among achalasia subtypes and controls to ...

Abstract	Background: Achalasia is a primary esophageal motility disorder with potential molecular pathogenesis remaining uncertain. This study aimed to identify the differentially expressed proteins and potential pathways among achalasia subtypes and controls to further reveal the molecular pathogenesis of achalasia. Methods: Paired lower esophageal sphincter (LES) muscle and serum samples from 24 achalasia patients were collected. We also collected 10 normal serum samples from healthy controls and 10 normal LES muscle samples from esophageal cancer patients. The 4D label-free proteomic analysis was performed to identify the potential proteins and pathways involved in achalasia. Results: Analysis of Similarities showed distinct proteomic patterns of serum and muscle samples between achalasia patients and controls (both Conclusions: This first 4D label-free proteomic study of achalasia indicated that there were specific protein alterations in both the serum and muscle of achalasia, involving immunity, inflammation, infection, and neurodegeneration pathways. Distinct protein clusters between types I, II, and III revealed the potential molecular pathways associated with different disease stages. Analysis of proteins changed in both muscle and serum samples highlighted the importance of further studies on LES muscle and revealed potential autoantibodies.
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2710871-5
ISSN	2052-0034
ISSN	2052-0034
DOI	10.1093/gastro/goad031
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Article: Comparison of the disinfection effect of iodophor at two different temperatures on the skin of surgical field and its influence on blood pressure and heart rate of patients.

Hu, Shuangshuang / Lu, Weihua / Di, Yinglian / Geng, Fan / Cheng, Wenling / Jin, Yongmei

American journal of translational research

2022 Volume 14, Issue 2, Page(s) 1339–1346

Abstract: Objective: To compare the disinfection effect of iodophor at two different temperatures on the skin of surgical field and its influence on blood pressure and heart rate of patients.: Methods: The clinical data of 150 patients who underwent surgery in ...

Abstract	Objective: To compare the disinfection effect of iodophor at two different temperatures on the skin of surgical field and its influence on blood pressure and heart rate of patients. Methods: The clinical data of 150 patients who underwent surgery in the Seventh People's Hospital of Shanghai University of TCM were collected and divided into two groups based on different disinfection temperatures; the observation group (constant 36°C) and the control group ((24±2)°C), with 75 patients in each. The postoperative disinfection effects of the two groups were evaluated including the disinfection effect, blood pressure, heart rate, body temperature, cold sensation, gastrointestinal reactions, stress response, incidence of complications in the perioperative period, incision healing and satisfaction rate. Results: The disinfection efficacy of the observation group was 96.00%, which was higher than that of the control group (81.33%, P<0.01); the blood pressure and heart rate of patients in the observation group after disinfection were lower than those in the control group (P<0.001); the body temperature was higher than that of the control group (P<0.001); the cold sensation was weaker and gastrointestinal adverse reactions were less than those of the control group (P<0.05); the MDA, GSH-PX and SOD levels after disinfection in the observation group were lower than those of the control group (P<0.001); the incidence rate of complications in the observation group was lower than that of the control group (P<0.05) and the incision healing rate was higher than that of the control group (P<0.05). Patients in observation group were more satisfied with disinfection method, disinfection effect, prevention of complications, postoperative recovery and disinfection times than patients in the control group (P<0.01). Conclusion: Iodophor at constant temperature is more effective in skin disinfection of the surgical field, with little influence on blood pressure, heart rate and body temperature. This helps to reduce the cold sensation of skin, the incidence rate of gastrointestinal adverse reactions and complications, promote incision healing and improve the satisfaction rate of the surgery. It is worthy of wide application and promotion.
Language	English
Publishing date	2022-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Honokiol Inhibits the Inflammatory Response and Lipid Metabolism Disorder by Inhibiting p38α in Alcoholic Liver Disease.

Yang, Chenchen / Zhao, Yinglian / Luo, Zhipan / Hu, Ying / Wang, Shuxian / Hu, Shuang / Yao, Yan / Pan, Linxin / Shen, Chuanpu / Xu, Tao

Planta medica

2022 Volume 89, Issue 3, Page(s) 273–285

Abstract: Alcoholic liver disease is one of the leading causes of liver-related morbidity and mortality worldwide, but effective treatments are still lacking. Honokiol, a lignin-type natural compound isolated from the leaves and bark of Magnolia plants, has been ... ...

Abstract	Alcoholic liver disease is one of the leading causes of liver-related morbidity and mortality worldwide, but effective treatments are still lacking. Honokiol, a lignin-type natural compound isolated from the leaves and bark of Magnolia plants, has been widely studied for its beneficial effects on several chronic diseases. Accumulating studies have revealed that honokiol displays a potential therapeutic effect on alcoholic liver disease. In this study, the protective activity of honokiol on alcoholic liver disease was confirmed due to its significant inhibitory activity on the expression levels of inflammatory cytokines (such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1
MeSH term(s)	Mice ; Animals ; Interleukin-1beta/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Lipid Metabolism ; Interleukin-6/metabolism ; NF-kappa B/metabolism ; PPAR alpha/metabolism ; Liver Diseases, Alcoholic/drug therapy ; Liver Diseases, Alcoholic/metabolism ; Liver ; Lignans/pharmacology ; Lignans/therapeutic use ; Cytokines/metabolism ; Lipid Metabolism Disorders/metabolism ; Sterols/metabolism ; Sterols/pharmacology
Chemical Substances	honokiol (11513CCO0N) ; Interleukin-1beta ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; NF-kappa B ; PPAR alpha ; Lignans ; Cytokines ; Sterols
Language	English
Publishing date	2022-06-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/a-1878-3991
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A composite chitosan derivative nanoparticle to stabilize a W1/O/W2 emulsion: Preparation and characterization

Fu, Juanjuan / Zhu, Yinglian / Cheng, Fansheng / Zhang, Shuangling / Xiu, Tiantian / Hu, Yue / Yang, Shuo

Carbohydrate polymers. 2021 Mar. 15, v. 256

2021

Abstract: For preparing stable water-in-oil-in-water emulsion, the role of nanoparticles in stabilizing the interface is very important. In this study, chitosan hydrochloride-carboxymethyl chitosan (CHC-CMC) nanoparticles were prepared considering electrostatic ... ...

Abstract	For preparing stable water-in-oil-in-water emulsion, the role of nanoparticles in stabilizing the interface is very important. In this study, chitosan hydrochloride-carboxymethyl chitosan (CHC-CMC) nanoparticles were prepared considering electrostatic interactions; then the emulsion was prepared and the stability characteristics in presence of NaCl (0–200 mmol/L) and 30 d storage were studied. CHC-CMC nanoparticles (261 nm) were obtained when the CHC: CMC ratio was 1:2. CHC-CMC formation was verified by FT-IR when a new peak appeared at 1580 cm⁻¹; W₂ contained 2 wt % CHC-CMC and W₁ contained 1 wt % sodium alginate, the creaming index (81.6 %) was higher for the emulsions than Tween 80 (67.4 %) after 30 d. Confocal laser scanning microscopy confirmed the double microstructures, in contrast to the collapse with Tween 80, because the CHC-CMC nanoparticles were densely adsorbing on the oil-water interface. This indicates that CHC-CMC has a stronger ability to stabilize W₁/O/W₂ emulsion than Tween 80.
Keywords	chitosan ; emulsions ; oil-water interface ; polysorbates ; sodium alginate
Language	English
Dates of publication	2021-0315
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.117533
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A composite chitosan derivative nanoparticle to stabilize a W

Fu, Juanjuan / Zhu, Yinglian / Cheng, Fansheng / Zhang, Shuangling / Xiu, Tiantian / Hu, Yue / Yang, Shuo

Carbohydrate polymers

2020 Volume 256, Page(s) 117533

Abstract	For preparing stable water-in-oil-in-water emulsion, the role of nanoparticles in stabilizing the interface is very important. In this study, chitosan hydrochloride-carboxymethyl chitosan (CHC-CMC) nanoparticles were prepared considering electrostatic interactions; then the emulsion was prepared and the stability characteristics in presence of NaCl (0-200 mmol/L) and 30 d storage were studied. CHC-CMC nanoparticles (261 nm) were obtained when the CHC: CMC ratio was 1:2. CHC-CMC formation was verified by FT-IR when a new peak appeared at 1580 cm
MeSH term(s)	Alginates/chemistry ; Chitosan/analogs & derivatives ; Chitosan/chemistry ; Emulsions ; Ions ; Microscopy ; Microscopy, Confocal ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Nanoparticles/chemistry ; Nanotechnology/methods ; Polysorbates/chemistry ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Alginates ; Emulsions ; Ions ; Polysorbates ; carboxymethyl-chitosan ; Chitosan (9012-76-4)
Language	English
Publishing date	2020-12-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.117533
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Clinical outcomes of asymptomatic low-grade esophagitis: results from a multicenter Chinese cohort.

Chen, Songfeng / Xiang, Xuelian / Zhang, Xiaohao / Zhuang, Qianjun / Tan, Niandi / Hou, Xun / Zhang, Mengyu / Hu, Junnan / Duan, Chaofan / Cui, Yi / Wang, Jinhui / Xing, Xiangbin / Zhang, Nina / Xiao, Yinglian

Gastroenterology report

2022 Volume 10, Page(s) goac057

Abstract: Background: Asymptomatic low-grade (Los Angeles Classification Grades A and B) esophagitis is common in clinical practice with unclear clinical outcomes. This study aimed to explore the clinical outcomes of asymptomatic low-grade esophagitis.: Methods! ...

Abstract	Background: Asymptomatic low-grade (Los Angeles Classification Grades A and B) esophagitis is common in clinical practice with unclear clinical outcomes. This study aimed to explore the clinical outcomes of asymptomatic low-grade esophagitis. Methods: This was a multicenter cohort study conducted by three academic hospitals in China. Asymptomatic low-grade esophagitis patients between January 2015 and December 2019 were included. Mucosal healing condition 1 year after initial diagnosis, symptom outcomes, and proton-pump inhibitor (PPI) use within 1 year after initial diagnosis were studied and compared. Results: A total of 248 asymptomatic low-grade esophagitis patients were included. Esophagitis disappeared in 76.2% of patients 1 year after initial diagnosis. In terms of symptom outcomes, 89.9% of patients did not present gastroesophageal reflux disease (GERD) symptoms within 1 year after initial diagnosis. No significant difference was found in the proportion of patients who presented GERD symptoms and in the proportion of patients with persistent esophagitis between the PPI group and the non-PPI group (all Conclusions: This study demonstrated that asymptomatic low-grade esophagitis had relatively benign clinical outcomes. Patients with initial Grade B esophagitis and patients with follow-up GERD symptoms were more likely to be those who are in genuine need of further follow-up and treatments.
Language	English
Publishing date	2022-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2710871-5
ISSN	2052-0034
ISSN	2052-0034
DOI	10.1093/gastro/goac057
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Article: Honokiol Inhibits the Inflammatory Response and Lipid Metabolism Disorder by Inhibiting p38α in Alcoholic Liver Disease

Yang, Chenchen / Zhao, Yinglian / Luo, Zhipan / Hu, Ying / Wang, Shuxian / Hu, Shuang / Yao, Yan / Pan, Linxin / Shen, Chuanpu / Xu, Tao

Planta Medica

2022 Volume 89, Issue 03, Page(s) 273–285

Abstract	Alcoholic liver disease is one of the leading causes of liver-related morbidity and mortality worldwide, but effective treatments are still lacking. Honokiol, a lignin-type natural compound isolated from the leaves and bark of Magnolia plants, has been widely studied for its beneficial effects on several chronic diseases. Accumulating studies have revealed that honokiol displays a potential therapeutic effect on alcoholic liver disease. In this study, the protective activity of honokiol on alcoholic liver disease was confirmed due to its significant inhibitory activity on the expression levels of inflammatory cytokines (such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1 β ) in EtOH-fed mice and in EtOH-induced AML-12 cells. Meanwhile, the expression of the lipid metabolic parameter sterol regulatory element-binding protein-1c was also reduced. However, peroxisome proliferator-activated receptor α was increased in animal and cell experiments, which indicates that the activity of honokiol was related to its regulated activity on lipid metabolism. The result showed that honokiol significantly inhibited the expression level of p38 α in vivo and in vitro. Blocking p38 α inhibited the expression levels of tumor necrosis factor-alpha, interleukin-6, interleukin-1 β, and sterol regulatory element-binding protein-1c but promoted the expression level of peroxisome proliferator-activated receptor α compared with the honokiol-treated group. Moreover, the forced expression level of p38 α further produced the opposite effect on inflammatory cytokines and lipid metabolism indicators. Furthermore, p38 α has been related to the activation of the nuclear factor kappa B signaling pathway. In our study, honokiol significantly inhibited the activation of the nuclear factor kappa B signaling pathway mediated by p38 α. In conclusion, the results suggest that honokiol might be an effective regulator of p38 α by downregulating the nuclear factor kappa B signaling pathway, thereby reducing the inflammatory response and lipid metabolism disorder in alcoholic liver disease.
Keywords	honokiol ; alcoholic liver disease ; p38 ; inflammation ; lipid metabolism ; NF- ; B ; Magnolia officinalis ; Magnoliaceae
Language	English
Publishing date	2022-06-17
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/a-1878-3991
Database	Thieme publisher's database

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Article ; Online: Zhizhu Kuanzhong Capsule in treating patients with functional dyspepsia postprandial distress syndrome

Mengli Xiao / Linda L. D. Zhong / Wai Ching Lam / Yingpan Zhao / Kok-Ann Gwee / Gerald Holtmann / Jan Tack / Hidekazu Suzuki / Min-Hu Chen / Yinglian Xiao / Xiaohua Hou / Jinsong Liu / Yang Li / Xu-Dong Tang / Fang Lu

Trials, Vol 23, Iss 1, Pp 1-

study protocol for a multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial

2022 Volume 10

Abstract: Abstract Background Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders. Based on the various symptoms present in patients with functional dyspepsia postprandial distress syndrome (FD-PDS), routine agents such as ... ...

Abstract	Abstract Background Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders. Based on the various symptoms present in patients with functional dyspepsia postprandial distress syndrome (FD-PDS), routine agents such as acid suppressants, prokinetic drugs, and centrally acting drugs, offer limited treatment choices with potential side effects. As a preliminary clinical trial showed that the marketed product Zhizhu Kuanzhong Capsule (ZZKZ) can improve symptoms in FD-PDS patients, our study aims to provide further evidence on the clinical efficacy and safety of ZZKZ in the treatment of patients with FD-PDS. Methods In this multicenter, randomized, patient- and investigator-blinded, placebo-controlled, parallel-group clinical trial, we will recruit patients with FD-PDS from 18 hospitals in China and Australia. The trial will enroll patients with FD-PDS based on the Rome IV diagnostic criteria. A total of 480 eligible patients will be randomized 1:1 into either ZZKZ or placebo group with 8 weeks of treatment and 4 weeks of follow-up. The primary endpoint will be measured by a self-rated Visual Analogue Score (VAS) for the degree of discomfort with both symptoms of postprandial fullness and early satiation, recorded once a day and 7 days a week. The primary analysis will aim to compare the response rate for FD-PDS VAS score between the groups before and after 8 weeks of treatment with an alpha level of 0.05 (2-sided). Discussion This trial aims to strengthen the evidence for the efficacy and safety of ZZKZ, a marketed product, in treating FD-PDS. Compared to the previous clinical trial that targeted FD-PDS, this trial will have an 8-week double-blind treatment period to investigate the effect of long-term mediation through comparison with the placebo group. Trial registration ClinicalTrials.gov NCT03825692 . Registered on 28 January 2019
Keywords	Zhizhu Kuanzhong ; Functional dyspepsia ; Postprandial distress syndrome ; Randomized controlled trial ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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