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  1. Article ; Online: Importance of C24:2 sulfatide.

    Thea, Rikke / Buschard, Karsten

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country Denmark
    Document type Letter
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.73: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Thesis: What causes type I diabetes?

    Buschard, Karsten

    lessons from animal models

    (Acta pathologica, microbiologica et immunologica Scandinavica : Supplementum ; 132)

    2011  

    Author's details Karsten Buschard
    Series title Acta pathologica, microbiologica et immunologica Scandinavica : Supplementum ; 132
    Acta pathologica, microbiologica et immunologica Scandinavica
    Acta pathologica, microbiologica et immunologica Scandinavica ; Supplementum
    Collection Acta pathologica, microbiologica et immunologica Scandinavica
    Acta pathologica, microbiologica et immunologica Scandinavica ; Supplementum
    Language English
    Size 19 S.
    Publisher Wiley-Blackwell
    Publishing place Oxford u.a.
    Publishing country Denmark
    Document type Book ; Thesis
    Thesis / German Habilitation thesis København, Univ., Diss., 2011
    HBZ-ID HT016888548
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 73 -Suppl.132- verfügbar in Königswinter Königswinter

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  3. Article: The etiology and pathogenesis of type 1 diabetes - A personal, non-systematic review of possible causes, and interventions.

    Buschard, Karsten

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 876470

    Abstract: In this review after a lifelong research career, my personal opinion on the development of type 1 diabetes (T1D) from its very start to clinical manifestation will be described. T1D is a disease of an increased intestinal permeability and a reduced ... ...

    Abstract In this review after a lifelong research career, my personal opinion on the development of type 1 diabetes (T1D) from its very start to clinical manifestation will be described. T1D is a disease of an increased intestinal permeability and a reduced pancreas volume. I am convinced that virus might be the initiator and that this virus could persist on strategically significant locations. Furthermore, intake of gluten is important both in foetal life and at later ages. Disturbances in sphingolipid metabolism may also be of crucial importance. During certain stages of T1D, T cells take over resulting in the ultimate destruction of beta cells, which manifests T1D as an autoimmune disease. Several preventive and early treatment strategies are mentioned. All together this review has more new theories than usually, and it might also be more speculative than ordinarily. But without new ideas and theories advancement is difficult, even though everything might not hold true during the continuous discovery of the etiology and pathogenesis of T1D.
    MeSH term(s) Causality ; Diabetes Mellitus, Type 1/etiology ; Diabetes Mellitus, Type 1/therapy ; Humans ; Insulin-Secreting Cells/metabolism ; T-Lymphocytes/metabolism
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.876470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Autoimmune vulnerability of beta versus alpha cells might be due to increased 2',5' synthetase.

    Buschard, Karsten / Haupt-Jorgensen, Martin

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2024  Volume 132, Issue 5, Page(s) 371–372

    MeSH term(s) Humans ; Interferons
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2024-02-12
    Publishing country Denmark
    Document type Letter
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.73: Show issues Location:
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  5. Article ; Online: Fenofibrate increases the amount of sulfatide which seems beneficial against Covid-19.

    Buschard, Karsten

    Medical hypotheses

    2020  Volume 143, Page(s) 110127

    Abstract: Fenofibrate, which is a PPAR-alfpha agonist, increases the level of sulfatide. In this letter we hypothesize on the background of various findings that this is beneficial against COVID-19. Fenofibrate has been used for decades against ... ...

    Abstract Fenofibrate, which is a PPAR-alfpha agonist, increases the level of sulfatide. In this letter we hypothesize on the background of various findings that this is beneficial against COVID-19. Fenofibrate has been used for decades against hypercholesterolemia and has no serious side effects. Therefore, a trial giving fenofibrate to patients with corona virus infection is recommended.
    MeSH term(s) Adult ; Aging/blood ; Betacoronavirus/physiology ; COVID-19 ; Child ; Coronavirus Infections/drug therapy ; Drug Repositioning ; Fenofibrate/pharmacology ; Fenofibrate/therapeutic use ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/complications ; Hypertension/blood ; Hypertension/complications ; Hypolipidemic Agents/pharmacology ; Hypolipidemic Agents/therapeutic use ; PPAR alpha/antagonists & inhibitors ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Sulfoglycosphingolipids/blood ; Virus Internalization
    Chemical Substances Hypolipidemic Agents ; PPAR alpha ; PPARA protein, human ; Sulfoglycosphingolipids ; Fenofibrate (U202363UOS)
    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  6. Article ; Online: Fenofibrate increases the amount of sulfatide which seems beneficial against Covid-19

    Buschard, Karsten

    Medical Hypotheses

    2020  Volume 143, Page(s) 110127

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110127
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  7. Article: Fenofibrate increases the amount of sulfatide which seems beneficial against Covid-19

    Buschard, Karsten

    Med Hypotheses

    Abstract: Fenofibrate, which is a PPAR-alfpha agonist, increases the level of sulfatide. In this letter we hypothesize on the background of various findings that this is beneficial against COVID-19. Fenofibrate has been used for decades against ... ...

    Abstract Fenofibrate, which is a PPAR-alfpha agonist, increases the level of sulfatide. In this letter we hypothesize on the background of various findings that this is beneficial against COVID-19. Fenofibrate has been used for decades against hypercholesterolemia and has no serious side effects. Therefore, a trial giving fenofibrate to patients with corona virus infection is recommended.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #663015
    Database COVID19

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  8. Article ; Online: Influence of sphingolipid enzymes on blood glucose levels, development of diabetes, and involvement of pericytes.

    Buschard, Karsten / Josefsen, Knud / Krogvold, Lars / Gerling, Ivan / Dahl-Jørgensen, Knut / Pociot, Flemming

    Diabetes/metabolism research and reviews

    2024  Volume 40, Issue 3, Page(s) e3792

    Abstract: Aims: Sulfatide is a chaperone for insulin manufacturing in beta cells. Here we explore whether the blood glucose values normally could be associated with this sphingolipid and especially two of its building enzymes CERS2 and CERS6. Both T1D and T2D ... ...

    Abstract Aims: Sulfatide is a chaperone for insulin manufacturing in beta cells. Here we explore whether the blood glucose values normally could be associated with this sphingolipid and especially two of its building enzymes CERS2 and CERS6. Both T1D and T2D have low blood sulfatide levels, and insulin resistance on beta cells at clinical diagnosis. Furthermore, we examined islet pericytes for sulfatide, and beta-cell receptors for GLP-1, both of which are related to the insulin production.
    Materials and methods: We examined mRNA levels in islets from the DiViD and nPOD studies, performed genetic association analyses, and histologically investigated pericytes in the islets for sulfatide.
    Results: Polymorphisms of the gene encoding the CERS6 enzyme responsible for synthesising dihydroceramide, a precursor to sulfatide, are associated with random blood glucose values in non-diabetic persons. This fits well with our finding of sulfatide in pericytes in the islets, which regulates the capillary blood flow in the islets of Langerhans, which is important for oxygen supply to insulin production. In the islets of newly diagnosed T1D patients, we observed low levels of GLP-1 receptors; this may explain the insulin resistance in their beta cells and their low insulin production. In T2D patients, we identified associated polymorphisms in both CERS2 and CERS6.
    Conclusions: Here, we describe several polymorphisms in sulfatide enzymes related to blood glucose levels and HbA1c in non-diabetic individuals. Islet pericytes from such persons contain sulfatide. Furthermore, low insulin secretion in newly diagnosed T1D may be explained by beta-cell insulin resistance due to low levels of GLP-1 receptors.
    MeSH term(s) Humans ; Islets of Langerhans ; Blood Glucose ; Diabetes Mellitus, Type 1 ; Sphingolipids ; Insulin Resistance/genetics ; Pericytes ; Sulfoglycosphingolipids ; Insulin ; Insulin, Regular, Human ; Diabetes Mellitus, Type 2/genetics ; Glucagon-Like Peptide 1 ; Glucose
    Chemical Substances Blood Glucose ; Sphingolipids ; Sulfoglycosphingolipids ; Insulin ; Insulin, Regular, Human ; Glucagon-Like Peptide 1 (89750-14-1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.3792
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2119: Show issues Location:
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  9. Article ; Online: Failure to replicate the diabetes alleviating effect of a maternal gluten-free diet in non-obese diabetic mice.

    Mønsted, Mia Øgaard / Holm, Laurits Juulskov / Buschard, Karsten / Haupt-Jorgensen, Martin

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0289258

    Abstract: Type 1 diabetes (T1D) is an autoimmune disease with an unexplained rising incidence for which environmental factors like gluten may play a role. Previously, we showed that a gluten-free (GF) diet provided strictly in utero reduces the autoimmune diabetes ...

    Abstract Type 1 diabetes (T1D) is an autoimmune disease with an unexplained rising incidence for which environmental factors like gluten may play a role. Previously, we showed that a gluten-free (GF) diet provided strictly in utero reduces the autoimmune diabetes incidence in Non-Obese Diabetic (NOD) mice compared to a gluten-containing standard (STD) diet. The current study was initiated to elucidate possible mechanisms behind the diabetes-alleviating effect of the same diet intervention. NOD mice received either a GF Altromin diet or a STD Altromin diet during pregnancy. Female offspring from both groups were fed a STD diet throughout life and their diabetes incidence was recorded for 200 days. The following parameters were measured in 13-week-old female offspring: insulitis degree, glucose and insulin tolerance, and plasma insulin autoantibody titer. The diet intervention showed no reduction in autoimmune diabetes incidence, insulitis degree, glucose nor insulin tolerance and plasma insulin autoantibody titer. In conclusion, this study could not replicate the previously observed diabetes alleviative effects of a maternal gluten-free diet in NOD mouse offspring and could therefore not further elucidate potential mechanisms.
    MeSH term(s) Animals ; Female ; Mice ; Pregnancy ; Autoantibodies ; Diabetes Mellitus, Experimental/diet therapy ; Diabetes Mellitus, Type 1/diet therapy ; Diet, Gluten-Free ; Glucose ; Glutens ; Insulins ; Mice, Inbred NOD ; Maternal Nutritional Physiological Phenomena
    Chemical Substances Autoantibodies ; Glucose (IY9XDZ35W2) ; Glutens (8002-80-0) ; Insulins
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0289258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sulfatide and Longevity.

    Buschard, Karsten / Josefsen, Knud / Råstam, Lennart / Lindblad, Ulf / Daka, Bledar

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2022  Volume 77, Issue 9, Page(s) 1715–1716

    MeSH term(s) Longevity ; Sulfoglycosphingolipids
    Chemical Substances Sulfoglycosphingolipids
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glac126
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