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  1. Article: View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences.

    Froldi, Guglielmina

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 4

    Abstract: Metformin is a synthetic biguanide used as an antidiabetic drug in type 2 diabetes mellitus, achieved by studying the bioactive metabolites ... ...

    Abstract Metformin is a synthetic biguanide used as an antidiabetic drug in type 2 diabetes mellitus, achieved by studying the bioactive metabolites of
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17040478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Use of Medicinal Plants in Blood Vessel Diseases: The Influence of Gender.

    Froldi, Guglielmina

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Data available in the literature on the use of herbal products to treat inflammation-related vascular diseases were considered in this study, while also assessing the influence of gender. To this end, the articles published in PubMed over the past 10 ... ...

    Abstract Data available in the literature on the use of herbal products to treat inflammation-related vascular diseases were considered in this study, while also assessing the influence of gender. To this end, the articles published in PubMed over the past 10 years that described the use of plant extracts in randomized clinical trials studying the effectiveness in vascular pathologies were analyzed. The difference in efficacy of plant-derived preparations in female and male subjects was always considered when reporting. The safety profiles of the selected plants were described, reporting unwanted effects in humans and also by searching the WHO database (VigiBase
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13040866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: What could be the better choice between ACE inhibitors and AT1R antagonists in coronavirus disease 2019 (COVID-19) patients?

    Froldi, Guglielmina

    Journal of medical virology

    2020  Volume 92, Issue 11, Page(s) 2302–2303

    MeSH term(s) Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; COVID-19/drug therapy ; Humans ; Mice
    Chemical Substances Angiotensin II Type 1 Receptor Blockers ; Angiotensin-Converting Enzyme Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25974
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  5. Article ; Online: What could be the better choice between ACE inhibitors and AT1R antagonists in coronavirus disease 2019 (COVID‐19) patients?

    Froldi, Guglielmina

    Journal of Medical Virology

    2020  Volume 92, Issue 11, Page(s) 2302–2303

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25974
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  6. Article ; Online: Selected Plant-Derived Polyphenols as Potential Therapeutic Agents for Peripheral Artery Disease: Molecular Mechanisms, Efficacy and Safety.

    Froldi, Guglielmina / Ragazzi, Eugenio

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 20

    Abstract: Vascular diseases, such as peripheral artery disease (PAD), are associated with diabetes mellitus and a higher risk of cardiovascular disease and even death. Surgical revascularization and pharmacological treatments (mainly antiplatelet, lipid-lowering ... ...

    Abstract Vascular diseases, such as peripheral artery disease (PAD), are associated with diabetes mellitus and a higher risk of cardiovascular disease and even death. Surgical revascularization and pharmacological treatments (mainly antiplatelet, lipid-lowering drugs, and antidiabetic agents) have some effectiveness, but the response and efficacy of therapy are overly dependent on the patient's conditions. Thus, the demand for new cures exists. In this regard, new studies on natural polyphenols that act on key points involved in the pathogenesis of vascular diseases and, thus, on PAD are of great urgency. The purpose of this review is to take into account the mechanisms that lead to endothelium dysfunction, such as the glycoxidation process and the production of advanced glycation end-products (AGEs) that result in protein misfolding, and to suggest plant-derived polyphenols that could be useful in PAD. Thus, five polyphenols are considered, baicalein, curcumin, mangiferin, quercetin and resveratrol, reviewing the literature in PubMed. The key molecular mechanisms and preclinical and clinical studies of each selected compound are examined. Furthermore, the safety profiles of the polyphenols are outlined, together with the unwanted effects reported in humans, also by searching the WHO database (VigiBase).
    MeSH term(s) Humans ; Polyphenols/pharmacology ; Polyphenols/therapeutic use ; Resveratrol ; Quercetin/pharmacology ; Curcumin/pharmacology ; Peripheral Arterial Disease/drug therapy ; Hypoglycemic Agents ; Lipids
    Chemical Substances Polyphenols ; Resveratrol (Q369O8926L) ; Quercetin (9IKM0I5T1E) ; Curcumin (IT942ZTH98) ; Hypoglycemic Agents ; Lipids
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27207110
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article ; Online: What could be the better choice between ACE inhibitors and AT1R antagonists in coronavirus disease 2019 (COVID-19) patients?

    Froldi, Guglielmina

    2020  

    Abstract: Angiotensin-converting enzyme 2 (ACE2) removes a single residue from Ang I to yield Ang (1-9) and cleaves a single residue from Ang II to generate Ang (1-7). Thus ACE2 counterbalances ACE function decreasing Ang II levels1 . Consequently, this enzyme has ...

    Abstract Angiotensin-converting enzyme 2 (ACE2) removes a single residue from Ang I to yield Ang (1-9) and cleaves a single residue from Ang II to generate Ang (1-7). Thus ACE2 counterbalances ACE function decreasing Ang II levels1 . Consequently, this enzyme has a protective role against excessively high blood pressure values and high level of renin-angiotensin system (RAS) activation2 . This article is protected by copyright. All rights reserved.
    Keywords ACE inhibitors ; Sartans ; COVID-19 ; covid19
    Language English
    Publisher Wiley
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Luteolin and Vernodalol as Bioactive Compounds of Leaf and Root

    Djeujo, Francine Medjiofack / Stablum, Valentina / Pangrazzi, Elisa / Ragazzi, Eugenio / Froldi, Guglielmina

    Pharmaceutics

    2023  Volume 15, Issue 5

    Abstract: The aqueous decoctions ... ...

    Abstract The aqueous decoctions of
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15051541
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  9. Article ; Online: Endothelial dysfunction in Coronavirus disease 2019 (COVID-19): Gender and age influences.

    Froldi, Guglielmina / Dorigo, Paola

    Medical hypotheses

    2020  Volume 144, Page(s) 110015

    Abstract: Several risk factors are associated with a worse outcome for COVID-19 patients; the most recognized are demographic characteristics such as older age and male gender, and pre-existing cardiovascular conditions. About the latter, hypertension and coronary ...

    Abstract Several risk factors are associated with a worse outcome for COVID-19 patients; the most recognized are demographic characteristics such as older age and male gender, and pre-existing cardiovascular conditions. About the latter, hypertension and coronary heart disease are among the most common comorbidities recorded in infected patients, together with type 2 diabetes mellitus (T2DM). Data from Istituto Superiore di Sanità (ISS, Italy) show that more than 68.3% of patients had hypertension, 28.2% ischemic heart disease, 22.5% atrial fibrillation, while 30.1% T2DM. Several authors suggested that cardiovascular diseases and diabetes mellitus are linked to endothelial dysfunction, and all of them are strictly related to aging. Considering the impact of the gender on the COVID-19 epidemic, even if confirmed cases from each nation are changing every day, epidemiological data clearly evidence that in men the infection causes worse outcomes compared to women. In Italy, up to 21 May, in the age range of 60-89 years, male deaths were 63.9% of total cases. The reason behind this difference between genders appears not clear; however, the diversity in sex-hormones and styles of life are believed to play a role in the patient's susceptibility to severe SARS-CoV-2 outcomes. It is known that the activation of endothelial estrogen receptors increases NO and decreases ROS, protecting the vascular system from angiotensin II-mediated vasoconstriction, inflammation, and ROS production. During the pandemic, joining forces is vital; thus, as people help doctors by limiting their displacements out of their houses avoiding hence the spread of the infection, doctors help patients to overcome severe SARS-CoV-2 infections by using multiple pharmacological approaches. In this context, the preservation of endothelial function and the mitigation of vascular inflammation are prominent targets, essential to reduce severe outcomes also in male older patients.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Aging ; COVID-19/epidemiology ; COVID-19/physiopathology ; Comorbidity ; Coronary Disease/physiopathology ; Endothelium, Vascular/physiopathology ; Female ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Pandemics ; Risk Factors ; Sex Factors ; Treatment Outcome ; Vascular Diseases/epidemiology ; Vascular Diseases/physiopathology
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Endothelial dysfunction in Coronavirus disease 2019 (COVID-19)

    Froldi, Guglielmina / Dorigo, Paola

    Medical Hypotheses

    Gender and age influences

    2020  Volume 144, Page(s) 110015

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110015
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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