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Article ; Online: Maldição de Ondina adquirida

Pedro Schestatsky / Luís Nelson T. Fernandes / Ângela Cristiane Silva

Clinical and Biomedical Research, Vol 22, Iss

2022 Volume 1

Abstract: Os autores relatam o caso de um homem de 55 anos, negro, hipertenso, diabético, tabagista, com história de acidente vascular encefálico e doença pulmonar obstrutiva crônica atendido na emergência do Hospital de Clínicas de Porto Alegre, com quadro ... ...

Abstract	Os autores relatam o caso de um homem de 55 anos, negro, hipertenso, diabético, tabagista, com história de acidente vascular encefálico e doença pulmonar obstrutiva crônica atendido na emergência do Hospital de Clínicas de Porto Alegre, com quadro sugestivo de síndrome vértebro-basilar. Na internação, o paciente teve vários episódios de apnéia prolongada, principalmente durante o sono, tendo sido freqüentemente “lembrado” de respirar. A ressonância magnética encefálica revelou área hiperintensa na porção lateral do tronco encefálico, principalmente na região bulbar, área correspondente às vias descendentes do controle da respiração autonômica. Foi traqueostomizado e submetido à ventilação mecânica assistida. Recebeu medroxiprogesterona, fluoxetina e acetazolamida. Após 64 dias de internação, recebeu alta hospitalar, respirando em ar ambiente, sem apnéias. Retornou à emergência no dia seguinte, com quadro de broncopneumonia aspirativa, evoluindo para choque séptico e óbito.
Keywords	Maldição de Ondina ; hipoventilação alveolar central ; insuficiência respiratória ; apnéia do sono ; Medicine ; R
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Hospital de Clinicas de Porto Alegre
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of transcranial direct current stimulation on the gut microbiome: A case report.

Artifon, Milena / Schestatsky, Pedro / Griebler, Nathália / Tossi, Gabriel Mayer / Beraldo, Lucas M / Pietta-Dias, Caroline

Brain stimulation

2020 Volume 13, Issue 5, Page(s) 1451–1452

Language	English
Publishing date	2020-08-06
Publishing country	United States
Document type	Letter
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2020.07.019
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Article ; Online: Definição, Diagnóstico e Tratamento da Dor Neuropática

Pedro Schestatsky

Clinical and Biomedical Research, Vol 28, Iss

2009 Volume 3

Abstract: A Dor Neuropática é definida como dor causada por lesão ou disfunção do sistema nervoso, como resultado da ativação anormal da via nociceptiva (fibras de pequeno calibre e trato espinotalâmico). As principais causas desta síndrome são: diabetes melito, ... ...

Abstract	A Dor Neuropática é definida como dor causada por lesão ou disfunção do sistema nervoso, como resultado da ativação anormal da via nociceptiva (fibras de pequeno calibre e trato espinotalâmico). As principais causas desta síndrome são: diabetes melito, neuralgia pós-herpética, neuralgia trigeminal, dor regional complexa, acidente vascular encefálico, esclerose múltipla, lesão medular, entre outros. Nos últimos anos, a Dor Neuropática vem recebendo especial atenção por dois motivos principais: 1) refratariedade terapêutica de várias síndromes dolorosas com componentes neuropáticos predominantes e 2) desenvolvimento de ferramentas diagnósticas para o reconhecimento deste tipo de dor. O presente artigo de revisão fornece informações relevantes para o entendimento e reconhecimento da Dor Neuropática, bem como quanto à abordagem terapêutica baseada em evidências.
Keywords	Dor Neuropática ; dor nociceptiva ; Medicine ; R
Language	English
Publishing date	2009-01-01T00:00:00Z
Publisher	Hospital de Clinicas de Porto Alegre
Document type	Article ; Online
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Article ; Online: Psychiatric profile and quality of life of subjects with excess weight treated with transcranial direct current stimulation combined with a hypocaloric diet.

Natividade, Gabriella Richter / de Araujo, Carina / Fitz, Raquel Crespo / Brietzke, Elisa / Schestatsky, Pedro / Gerchman, Fernando

Nutritional neuroscience

2019 Volume 24, Issue 12, Page(s) 919–926

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Anxiety/physiopathology ; Anxiety/therapy ; Caloric Restriction ; Depression/therapy ; Dorsolateral Prefrontal Cortex/physiopathology ; Double-Blind Method ; Female ; Humans ; Male ; Obesity/physiopathology ; Obesity/psychology ; Obesity/therapy ; Overweight/physiopathology ; Overweight/psychology ; Overweight/therapy ; Psychiatric Status Rating Scales ; Transcranial Direct Current Stimulation/adverse effects
Language	English
Publishing date	2019-11-22
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1447449-9
ISSN	1476-8305 ; 1028-415X
ISSN (online)	1476-8305
ISSN	1028-415X
DOI	10.1080/1028415X.2019.1693319
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Article ; Online: Recurrent aspiration pneumonia associated with giant aortic aneurysm

Leonardo Santos Hoff / Pedro Schestatsky

Clinical and Biomedical Research, Vol 34, Iss

2014 Volume 1

Abstract: A 83-year-old woman presented to the emergency department with fever, productive cough and dyspnea. She was previously diagnosed with dementia and systemic hypertension, and was heavy smoker for nearly 50 years. Her relatives reported that in the past ... ...

Abstract	A 83-year-old woman presented to the emergency department with fever, productive cough and dyspnea. She was previously diagnosed with dementia and systemic hypertension, and was heavy smoker for nearly 50 years. Her relatives reported that in the past four months she was admitted two times for aspiration pneumonia. Chest radiography showed right lower lobe consolidation and a large mediastinal mass (Panel A). A computed tomography angiography revealed a 10,2 cm descending aortic aneurysm compressing the esophagus (Panel B and C). Serologic VDRL test was negative. Esophageal clearance was moderately diminished above the level of the aortic arch, with antiperistaltic contractions, according to videofluoroscopic swallowing study; oropharyngeal dysphagia was also present. The patient was treated for aspiration pneumonia and assessed by cardiovascular surgeons, who decided for a conservative treatment due to the characteristics of the aneurysm and her clinical condition. She was discharged with an optimized treatment for systemic hypertension including beta-blockers, and appropriate diet for dysphagia.
Keywords	Aneurisma ; Pneumonia Aspirativa ; Disfagia ; Medicine ; R
Language	English
Publishing date	2014-04-01T00:00:00Z
Publisher	Hospital de Clinicas de Porto Alegre
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of transcranial direct current stimulation associated with hypocaloric diet on weight loss and metabolic profile in overweight or obesity: study protocol for a double-blind, randomized controlled clinical trial.

Araujo, Carina de / Fitz, Raquel Crespo / Nogara, Daniela Albugeri / Schestatsky, Pedro / Gerchman, Fernando

Trials

2018 Volume 19, Issue 1, Page(s) 386

Abstract: Background: Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the effects of a protocol combining ... ...

Abstract	Background: Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the effects of a protocol combining repetitive active transcranial direct current stimulation (tDCS) with a hypocaloric diet on weight loss and food consumption in overweight or obese adults. Methods/design: Overweight or obese adults between 20 and 50 years of age with stable weight over the last 4 months will be selected for a 4-week randomized clinical trial of fixed-dose tDCS (20 sessions; 5 consecutive weekdays/wk, 2 mA, 20 minutes) over the right dorsolateral prefrontal cortex associated with a weight loss diet. The subjects will be randomly assigned in a 1:1 ratio and stratified by sex to active tDCS + diet or sham tDCS + diet. The study will be conducted at the Endocrine and Metabolism Unit of the Hospital de Clínicas de Porto Alegre, Brazil. The primary outcome is weight loss. Energy and macronutrient consumption, as well as adherence to the diet, will be assessed using 3-day weighed dietary records. Changes in blood glucose and plasma insulin will be assessed, and participants will complete self-report questionnaires to assess changes in mood and food behavior. All analyses will be done on a per-protocol and intention-to-treat basis. Discussion: This study explores the potential role of tDCS as an adjunctive treatment with a hypocaloric diet for obesity management. Trial registration: ClinicalTrials.gov , NCT02683902 . Registered on 11 January 2016.
MeSH term(s)	Adult ; Basal Metabolism ; Blood Glucose/analysis ; Data Interpretation, Statistical ; Diet, Reducing ; Double-Blind Method ; Female ; Humans ; Insulin Resistance ; Male ; Middle Aged ; Obesity/therapy ; Overweight/therapy ; Randomized Controlled Trials as Topic ; Transcranial Direct Current Stimulation/methods ; Weight Loss ; Young Adult
Chemical Substances	Blood Glucose
Language	English
Publishing date	2018-07-16
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-018-2776-3
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Article ; Online: Simultaneous Median-Radial Nerve Electrical Stimulation Revisited: An Accurate Approach to Carpal Tunnel Syndrome Diagnosis and Severity.

Rodrigues, Thaís / Winckler, Pablo B / Félix-Torres, Vitor / Schestatsky, Pedro

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

2016 Volume 33, Issue 6, Page(s) 554–559

Abstract: Purpose: To assess the accuracy of an unusual test for CTS investigation and correlate it with clinical symptoms.: Methods: Initially, we applied a visual analog scale for CTS discomfort (CTS-VAS) and performed a standard electrophysiologic test for ... ...

Abstract	Purpose: To assess the accuracy of an unusual test for CTS investigation and correlate it with clinical symptoms. Methods: Initially, we applied a visual analog scale for CTS discomfort (CTS-VAS) and performed a standard electrophysiologic test for CTS diagnosis (median-ulnar velocity comparison). Posteriorly, a blinded neurophysiologist performed the orthodromic simultaneous median-radial nerve stimulation (SMRS) at the thumb, with recording of both action potentials over the lateral aspect of the wrist. Results: All hands (106) showed median-radial action potential splitting using the SMRS technique, in which was possible to measure the interpeak latencies (IPLs) between action potentials. The IPL and median nerve conduction velocity were different according to CTS intensity (Bonferroni; P < 0.001). There was significant correlation between IPL and median nerve conduction velocity (Spearman; r = -0.51; P < 0.01). In the same way, there was a significant correlation between IPL and median nerve conduction velocity with CTS-VAS (r = 0.6 and r = -0.3, respectively). The duration and unpleasantness of the SMRS procedure were lower when compared with standard approach (t Student < 0.001 for both comparisons). Twenty-nine symptomatic patients (39 hands) who did not fulfill criteria for CTS based on standard approach showed abnormal IPLs. Conclusions: The SMRS technique is a simple, sensitive, and tolerable approach for CTS diagnosis. Apart from that, the data from SMRS correlated better with clinical impact of CTS in comparison with the standard approach. Therefore, this method might be useful as adjunct to standard electrophysiologic approaches in clinical practice.
MeSH term(s)	Adult ; Aged ; Carpal Tunnel Syndrome/diagnosis ; Carpal Tunnel Syndrome/physiopathology ; Carpal Tunnel Syndrome/therapy ; Electric Stimulation Therapy/methods ; Female ; Humans ; Male ; Median Nerve/physiology ; Middle Aged ; Neural Conduction/physiology ; Radial Nerve/physiology ; Reaction Time/physiology ; Severity of Illness Index ; Statistics as Topic
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	605640-4
ISSN	1537-1603 ; 0736-0258
ISSN (online)	1537-1603
ISSN	0736-0258
DOI	10.1097/WNP.0000000000000290
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Article ; Online: How many coils do patients with aneurysmal subarachnoid hemorrhage need?

Schestatsky, Pedro / Picon, Paulo Dornelles

Stroke

2009 Volume 40, Issue 12, Page(s) e717; author reply e718

MeSH term(s)	Clinical Trials as Topic/standards ; Embolization, Therapeutic/economics ; Embolization, Therapeutic/instrumentation ; Embolization, Therapeutic/methods ; Evidence-Based Practice/standards ; Humans ; National Health Programs/economics ; Neurosurgery/economics ; Neurosurgery/standards ; Practice Guidelines as Topic/standards ; Prostheses and Implants/economics ; Prostheses and Implants/standards ; Subarachnoid Hemorrhage/economics ; Subarachnoid Hemorrhage/therapy
Language	English
Publishing date	2009-12
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.109.551903
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Article ; Online: Transcranial direct current stimulation effects on menopausal vasomotor symptoms.

Bianchi, Mônia Steigleder / Ferreira, Charles Francisco / Fregni, Felipe / Schestatsky, Pedro / Caumo, Wolnei / Wender, Maria Celeste Osório

Menopause (New York, N.Y.)

2017 Volume 24, Issue 10, Page(s) 1122–1128

Abstract: Objective: To assess the effects of transcranial direct current stimulation (tDCS) compared with tDCS-sham on vasomotor symptoms of postmenopausal women.: Methods: Postmenopausal women (N = 30), aged between 45 and 68 years, with at least four ... ...

Abstract	Objective: To assess the effects of transcranial direct current stimulation (tDCS) compared with tDCS-sham on vasomotor symptoms of postmenopausal women. Methods: Postmenopausal women (N = 30), aged between 45 and 68 years, with at least four episodes of vasomotor symptoms per day, were recruited from a specialized outpatient clinic at a tertiary hospital in the south of Brazil and through a media call after inclusion and exclusion criteria were ensured. Active and tDCS-sham were administered over the motor cortex position (anode electrode) and contralateral supraorbital region (cathode electrode) for 10 consecutive days, except weekends. The number and intensity records of hot flashes were evaluated for 7 days before and along 30 days after the intervention. The Women's Health Questionnaire and the Hamilton Depression Rating Scale were applied to assess the quality of life and the depressive symptoms, respectively. Results: The frequencies of hot flashes per day happened in a similar way in both groups, with a reduction in the first 3 weeks after the intervention. There was a return in hot flash frequencies to baseline in the fourth week (week 0: 79.0 ± 6.2 and 75.8 ± 6.0, week 1: 61.6 ± 9.6 and 57.0 ± 7.8, week 2: 56.8 ± 8.9 and 55.9 ± 7.1, week 3: 56.8 ± 8.9 and 54.2 ± 7.2, week 4: 64.9 ± 10.7, 70.1 ± 8.9; tDCS-sham and tDCS groups, respectively). In the tDCS group, a trend towards a conversion of intensive hot flashes into mild ones was observed. Conclusions: Our results suggest that the tDCS technique showed small trends on postmenopausal vasomotor symptoms, justifying searches for more effective methods by which tDCS could reduce hot flashes.
MeSH term(s)	Brazil ; Depression/etiology ; Female ; Health Surveys ; Hot Flashes/complications ; Hot Flashes/psychology ; Hot Flashes/therapy ; Humans ; Middle Aged ; Pilot Projects ; Postmenopause ; Quality of Life ; Transcranial Direct Current Stimulation/methods
Language	English
Publishing date	2017-06-21
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000000905
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Article ; Online: Simultaneous EEG monitoring during transcranial direct current stimulation.

Schestatsky, Pedro / Morales-Quezada, Leon / Fregni, Felipe

Journal of visualized experiments : JoVE

2013 , Issue 76

Abstract: Transcranial direct current stimulation (tDCS) is a technique that delivers weak electric currents through the scalp. This constant electric current induces shifts in neuronal membrane excitability, resulting in secondary changes in cortical activity. ... ...

Abstract	Transcranial direct current stimulation (tDCS) is a technique that delivers weak electric currents through the scalp. This constant electric current induces shifts in neuronal membrane excitability, resulting in secondary changes in cortical activity. Although tDCS has most of its neuromodulatory effects on the underlying cortex, tDCS effects can also be observed in distant neural networks. Therefore, concomitant EEG monitoring of the effects of tDCS can provide valuable information on the mechanisms of tDCS. In addition, EEG findings can be an important surrogate marker for the effects of tDCS and thus can be used to optimize its parameters. This combined EEG-tDCS system can also be used for preventive treatment of neurological conditions characterized by abnormal peaks of cortical excitability, such as seizures. Such a system would be the basis of a non-invasive closed-loop device. In this article, we present a novel device that is capable of utilizing tDCS and EEG simultaneously. For that, we describe in a step-by-step fashion the main procedures of the application of this device using schematic figures, tables and video demonstrations. Additionally, we provide a literature review on clinical uses of tDCS and its cortical effects measured by EEG techniques.
MeSH term(s)	Electric Stimulation/instrumentation ; Electric Stimulation/methods ; Electroencephalography/instrumentation ; Electroencephalography/methods ; Humans ; Motor Cortex/physiology
Language	English
Publishing date	2013-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/50426
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