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Article ; Online: First live birth after uterine transposition: giving life to uterine-focused fertility preservation.

Gornet, Megan / Kao, Lynn / Christianson, Mindy S / Rehmer, Jenna

2023 Volume 120, Issue 1, Page(s) 194–195

MeSH term(s)	Pregnancy ; Female ; Humans ; Fertility Preservation ; Live Birth ; Uterus/surgery ; Ovary
Language	English
Publishing date	2023-05-06
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2023.05.002
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Article: Que doivent savoir les chirurgiens à propos des troubles digestifs et des anomalies paracliniques induits par le COVID 19 ?

Gornet, J-M / Tran Minh, M L / Leleu, F / Hassid, D

Journal de chirurgie viscerale

2020 Volume 157, Issue 3, Page(s) S52–S59

Abstract: The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. However, digestive symptoms have also been reportedAt first considered as infrequent, they in fact seem to affect more than half of ... ...

Title translation	What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19?
Abstract	The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. However, digestive symptoms have also been reportedAt first considered as infrequent, they in fact seem to affect more than half of patients. The symptoms are mainly manifested by anorexia, diarrhea, nausea and/or vomiting and abdominal pain. Even though prognosis is associated with lung injury, digestive symptoms seem significantly more frequent in patients presenting with severe COVID-19 infection. Digestive forms, which may be isolated or which can precede pulmonary symptoms, have indeed been reported, with diarrhea as a leading clinical sign. The main biological abnormalities that can suggest COVID-19 infection at an early stage are lymphopenia, elevated CRP and heightened ASAT transaminases. Thoraco-abdominal scan seems useful as a means of on the one hand ruling out digestive pathology unrelated to coronavirus and on the other hand searching for pulmonary images suggestive of COVID-19 infection. No data exist on the interest of digestive endoscopy in cases of persistent digestive symptoms. Moreover, the endoscopists may themselves be at significant risk of contamination. Fecal-oral transmission of the infection is possible, especially insofar as viral shedding in stools seems frequent and of longer duration than at the ENT level, including in patients with negative throat swab and without digestive symptoms. In some doubtful cases, virologic assessment of stool samples can yield definitive diagnosis. In the event of prolonged viral shedding in stools, a patient's persistent contagiousness is conceivable but not conclusively established. Upcoming serology should enable identification of the patients having been infected by the COVID-19 epidemic, particularly among previously undetected pauci-symptomatic members of a health care staff. Resumption of medico-surgical activity should be guided by dedicated strategy preceding deconfinement.
Keywords	covid19
Language	French
Publishing date	2020-04-27
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	2541648-0
ISSN	1878-786X ; 0021-7697
ISSN	1878-786X ; 0021-7697
DOI	10.1016/j.jchirv.2020.04.013
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Article ; Online: What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19?

Gornet, J-M / Tran Minh, M L / Leleu, F / Hassid, D

Journal of visceral surgery

2020 Volume 157, Issue 3S1, Page(s) S51–S57

Abstract: The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. However, digestive symptoms have also been reported. At first considered as infrequent, they in fact seem to affect more than half of ... ...

Abstract	The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. However, digestive symptoms have also been reported. At first considered as infrequent, they in fact seem to affect more than half of patients. The symptoms mainly include anorexia, diarrhea, nausea and/or vomiting and abdominal pain. Even though prognosis is associated with lung injury, digestive symptoms seem significantly more frequent in patients presenting with severe COVID-19 infection. Digestive presentations, which may be isolated or which can precede pulmonary symptoms, have indeed been reported, with diarrhea as a leading clinical sign. The main biological abnormalities that can suggest COVID-19 infection at an early stage are lymphopenia, elevated CRP and heightened ASAT transaminases. Thoraco-abdominal scan seems useful as a means of on the one hand ruling out digestive pathology not connected with coronavirus and on the other hand searching for pulmonary images consistent with COVID-19 infection. No data exist on the value of digestive endoscopy in cases of persistent digestive symptoms. Moreover, the endoscopists may themselves be at significant risk of contamination. Fecal-oral transmission of the infection is possible, especially insofar as viral shedding in stools seems frequent and of longer duration than at the ENT level, including in patients with negative throat swab and without digestive symptoms. In some doubtful cases, virologic assessment of stool samples can yield definitive diagnosis. In the event of prolonged viral shedding in stools, a patient's persistent contagiousness is conceivable but not conclusively established. Upcoming serology should enable identification of the patients having been infected by the COVID-19 epidemic, particularly among previously undetected pauci-symptomatic members of a health care staff. Resumption of medico-surgical activity should be the object of a dedicated strategy preceding deconfinement.
MeSH term(s)	COVID-19 ; Coronavirus Infections/complications ; Digestive System Diseases/etiology ; Digestive System Diseases/surgery ; Digestive System Surgical Procedures ; Humans ; Pandemics ; Pneumonia, Viral/complications
Keywords	covid19
Language	English
Publishing date	2020-04-24
Publishing country	France
Document type	Journal Article ; Review
ISSN	1878-7886
ISSN (online)	1878-7886
DOI	10.1016/j.jviscsurg.2020.04.017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of the relevance of the growth modulation index (GMI) from the FFCD 0307 randomized phase III trial comparing the sequence of two chemotherapeutic regimens.

du Rusquec, P / Guimbaud, R / Le Malicot, K / Gornet, J-M / Nguyen, S / Lecomte, T / Khemissa-Akouz, F / Perrier, H / Bouché, O / Paoletti, X / Le Tourneau, C

ESMO open

2023 Volume 8, Issue 4, Page(s) 101616

Abstract: Background: Precision medicine trials disrupted the paradigm of randomized controlled trials in large populations. Patient selection may be based on molecular alterations rather than on primary tumor location. In small patient populations, the growth ... ...

Abstract	Background: Precision medicine trials disrupted the paradigm of randomized controlled trials in large populations. Patient selection may be based on molecular alterations rather than on primary tumor location. In small patient populations, the growth modulation index (GMI) has been developed to evaluate treatment efficacy by using each patient as its own control. The FFCD 0307 randomized phase III trial compared two sequences of chemotherapy in advanced gastric cancer, which represents a unique opportunity to evaluate the relevance of the GMI. Patients and methods: In the FFCD 0307 trial, patients with advanced gastric cancer were randomized between two chemotherapy sequences [ECX followed by FOLFIRI at disease progression (arm A) versus FOLFIRI followed by ECX (arm B)]. GMI was defined as the ratio of the progression-free survival on second treatment (PFS2) to the time to progression on first treatment (TTP1). Sequence benefit was defined as a GMI exceeding 1.3 (GMI-high). GMI was correlated with overall survival (OS). OS1 and OS2 were measured from first randomization and second-line failure to death. Results: Four hundred and sixteen patients were randomized (209 in arm A, 207 in arm B). One hundred and seventy-five patients (42%) received the two sequences and were assessable for GMI (97 in arm A, 79 in arm B). The median GMI was higher in arm A than in arm B (0.62 versus 0.47, P = 0.04). Patients with a high GMI had a longer OS1 (median 14.9 versus 11.5 months, NS). Median OS2 was doubled in the GMI-high group (3.4 versus 1.6 months, NS). Conclusion: GMI analyses suggest that ECX followed by FOLFIRI might represent a better therapeutic strategy than FOLFIRI followed by ECX. High GMI was associated with prolonged survival.
MeSH term(s)	Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Leucovorin/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Treatment Outcome ; Randomized Controlled Trials as Topic
Chemical Substances	Fluorouracil (U3P01618RT) ; Leucovorin (Q573I9DVLP)
Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Clinical Trial, Phase III ; Journal Article
ISSN	2059-7029
ISSN (online)	2059-7029
DOI	10.1016/j.esmoop.2023.101616
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Book ; Online: Stochastic Multi-armed Bandits with Non-stationary Rewards Generated by a Linear Dynamical System

Gornet, Jonathan / Hosseinzadeh, Mehdi / Sinopoli, Bruno

2022

Abstract: The stochastic multi-armed bandit has provided a framework for studying decision-making in unknown environments. We propose a variant of the stochastic multi-armed bandit where the rewards are sampled from a stochastic linear dynamical system. The ... ...

Abstract	The stochastic multi-armed bandit has provided a framework for studying decision-making in unknown environments. We propose a variant of the stochastic multi-armed bandit where the rewards are sampled from a stochastic linear dynamical system. The proposed strategy for this stochastic multi-armed bandit variant is to learn a model of the dynamical system while choosing the optimal action based on the learned model. Motivated by mathematical finance areas such as Intertemporal Capital Asset Pricing Model proposed by Merton and Stochastic Portfolio Theory proposed by Fernholz that both model asset returns with stochastic differential equations, this strategy is applied to quantitative finance as a high-frequency trading strategy, where the goal is to maximize returns within a time period.
Keywords	Computer Science - Machine Learning ; Electrical Engineering and Systems Science - Systems and Control
Subject code	006
Publishing date	2022-04-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Que doivent savoir les chirurgiens à propos des troubles digestifs et des anomalies paracliniques induits par le COVID 19 ?

Gornet, J.-M. / Tran Minh, M.L. / Leleu, F. / Hassid, D.

Journal de Chirurgie Viscérale

2020 Volume 157, Issue 3, Page(s) S52–S59

Keywords	Surgery ; covid19
Language	French
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2541648-0
ISSN	1878-786X ; 0021-7697
ISSN	1878-786X ; 0021-7697
DOI	10.1016/j.jchirv.2020.04.013
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Infliximab desensitization in patients with inflammatory bowel diseases: a safe therapeutic alternative.

Hammoudi, Nassim / Hassid, Déborah / Bonnet, Joëlle / Tran Minh, My-Linh / Baudry, Clotilde / Vauthier, Anne / Chedouba, Leila / Houzé, Pascal / Lourenco, Nelson / Aparicio, Thomas / Gornet, Jean-Marc / Allez, Matthieu

Scandinavian journal of gastroenterology

2024 Volume 59, Issue 5, Page(s) 553–560

Abstract: Background: Hypersensitivity reactions (HSR) to the administration of infliximab (IFX) in Inflammatory Bowel Diseases (IBD) patients are not rare and usually lead to drug discontinuation. We report data on safety and effectiveness of desensitization to ... ...

Abstract	Background: Hypersensitivity reactions (HSR) to the administration of infliximab (IFX) in Inflammatory Bowel Diseases (IBD) patients are not rare and usually lead to drug discontinuation. We report data on safety and effectiveness of desensitization to IFX in patients with previous HSR. Methods: We conducted a retrospective monocentric observational study. Patients for whom a desensitization protocol to IFX was realized after a previous HSR were included. Anti-drug antibodies (ADA) and IFX trough levels at both inclusion and six months after desensitization were collected. Clinical outcomes, including recurrence of HSR were evaluated. Results: From 2005 to 2020, 27 patients (Crohn's Disease: 26 (96%) were included). Desensitization after HSR was performed after a median time of 10.4 months (2.9-33.1). Nineteen (70%) patients received immunosuppressants at time of desensitization. Eight (30%) patients presented HSR at first ( Conclusion: IFX desensitization in patients with IBD is a safe therapeutic alternative and represents a potential option for patients refractory to multiple biologics.
MeSH term(s)	Humans ; Infliximab/therapeutic use ; Infliximab/administration & dosage ; Infliximab/immunology ; Infliximab/adverse effects ; Female ; Male ; Retrospective Studies ; Adult ; Desensitization, Immunologic/methods ; Drug Hypersensitivity/immunology ; Drug Hypersensitivity/etiology ; Middle Aged ; Gastrointestinal Agents/therapeutic use ; Gastrointestinal Agents/adverse effects ; Gastrointestinal Agents/immunology ; Gastrointestinal Agents/administration & dosage ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/immunology ; Crohn Disease/drug therapy ; Crohn Disease/immunology ; Treatment Outcome ; Young Adult
Chemical Substances	Infliximab (B72HH48FLU) ; Gastrointestinal Agents
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2024.2316765
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Article ; Online: What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19?

Gornet, J.-M. / Tran Minh, M.L. / Leleu, F. / Hassid, D.

Journal of Visceral Surgery

2020 Volume 157, Issue 3, Page(s) S51–S57

Keywords	General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	1878-7886
DOI	10.1016/j.jviscsurg.2020.04.017
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prognosis and molecular characteristics of IBD-associated colorectal cancer: Experience from a French tertiary-care center.

Hammoudi, N / Lehmann-Che, J / Lambert, J / Amoyel, M / Maggiori, L / Salfati, D / Tran Minh, M L / Baudry, C / Asesio, N / Poirot, B / Lourenco, N / Corte, H / Allez, M / Aparicio, T / Gornet, J M

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2023 Volume 55, Issue 9, Page(s) 1280–1287

Abstract: Background: Little is known about the prognosis of colorectal cancer associated with inflammatory bowel disease (CRC-IBD) in a real-world cohort in France.: Methods: We conducted a retrospective observational study including all patients presenting ... ...

Abstract	Background: Little is known about the prognosis of colorectal cancer associated with inflammatory bowel disease (CRC-IBD) in a real-world cohort in France. Methods: We conducted a retrospective observational study including all patients presenting CRC-IBD in a French tertiary center. Results: Among 6510 patients, the rate of CRC was 0.8% with a median delay of 19.5 years after IBD diagnosis (median age 46 years, ulcerative colitis 59%, initially localized tumor 69%). There was a previous exposure to immunosuppressants (IS) in 57% and anti-TNF in 29% of the cases. A RAS mutation was observed in only 13% of metastatic patients. OS of the whole cohort was 45 months. OS and PFS of synchronous metastatic patients was 20.4 months and 8.5 months respectively. Among the patients with localized tumor those previously exposed to IS had a better PFS (39 months vs 23 months; p = 0.05) and OS (74 vs 44 months; p = 0.03). The IBD relapse rate was 4%. No unexpected chemotherapy side-effect was observed CONCLUSIONS: OS of CRC-IBD is poor in metastatic patients although IBD is not associated with under-exposure or increased toxicity to chemotherapy. Previous IS exposure may be associated with a better prognosis.
MeSH term(s)	Humans ; Middle Aged ; Crohn Disease/complications ; Tumor Necrosis Factor Inhibitors ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/complications ; Risk Factors ; Neoplasm Recurrence, Local ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/pathology ; Prognosis ; Immunosuppressive Agents
Chemical Substances	Tumor Necrosis Factor Inhibitors ; Immunosuppressive Agents
Language	English
Publishing date	2023-03-04
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2023.02.011
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Article: What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19?

Gornet, J-M / Tran Minh, M L / Leleu, F / Hassid, D

J Visc Surg

Abstract: The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. However, digestive symptoms have also been reported. At first considered as infrequent, they in fact seem to affect more than half of ... ...

Abstract	The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. However, digestive symptoms have also been reported. At first considered as infrequent, they in fact seem to affect more than half of patients. The symptoms mainly include anorexia, diarrhea, nausea and/or vomiting and abdominal pain. Even though prognosis is associated with lung injury, digestive symptoms seem significantly more frequent in patients presenting with severe COVID-19 infection. Digestive presentations, which may be isolated or which can precede pulmonary symptoms, have indeed been reported, with diarrhea as a leading clinical sign. The main biological abnormalities that can suggest COVID-19 infection at an early stage are lymphopenia, elevated CRP and heightened ASAT transaminases. Thoraco-abdominal scan seems useful as a means of on the one hand ruling out digestive pathology not connected with coronavirus and on the other hand searching for pulmonary images consistent with COVID-19 infection. No data exist on the value of digestive endoscopy in cases of persistent digestive symptoms. Moreover, the endoscopists may themselves be at significant risk of contamination. Fecal-oral transmission of the infection is possible, especially insofar as viral shedding in stools seems frequent and of longer duration than at the ENT level, including in patients with negative throat swab and without digestive symptoms. In some doubtful cases, virologic assessment of stool samples can yield definitive diagnosis. In the event of prolonged viral shedding in stools, a patient's persistent contagiousness is conceivable but not conclusively established. Upcoming serology should enable identification of the patients having been infected by the COVID-19 epidemic, particularly among previously undetected pauci-symptomatic members of a health care staff. Resumption of medico-surgical activity should be the object of a dedicated strategy preceding deconfinement.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #116695
Database	COVID19

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