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  1. Article: Homogeneous and isotropic cosmology in general teleparallel gravity.

    Heisenberg, Lavinia / Hohmann, Manuel / Kuhn, Simon

    The European physical journal. C, Particles and fields

    2023  Volume 83, Issue 4, Page(s) 315

    Abstract: We derive the most general homogeneous and isotropic teleparallel geometries, defined by a metric and a flat, affine connection. We find that there are five branches of connection solutions, which are connected via several limits, and can further be ... ...

    Abstract We derive the most general homogeneous and isotropic teleparallel geometries, defined by a metric and a flat, affine connection. We find that there are five branches of connection solutions, which are connected via several limits, and can further be restricted to the torsion-free and metric-compatible cases. We apply our results to several classes of general teleparallel gravity theories and derive their cosmological dynamics for all five branches. Our results show that for large subclasses of these theories the dynamics reduce to that of closely related metric or symmetric teleparallel gravity theories, while for other subclasses up to two new scalar degrees of freedom participate in the cosmological dynamics.
    Language English
    Publishing date 2023-04-21
    Publishing country France
    Document type Journal Article
    ZDB-ID 1459069-4
    ISSN 1434-6052 ; 1434-6044
    ISSN (online) 1434-6052
    ISSN 1434-6044
    DOI 10.1140/epjc/s10052-023-11462-6
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  2. Article ; Online: Nerve Blocks for Craniotomy.

    Stieger, Andrea / Romero, Carolina S / Andereggen, Lukas / Heisenberg, Daniel / Urman, Richard D / Luedi, Markus M

    Current pain and headache reports

    2024  

    Abstract: Purpose of review: Postcraniotomy headache (PCH) is a common adverse event and can lead to various complications and decreased quality of life.: Recent findings: To reduce postcraniotomy pain and associated complications, a multimodal pain therapy ... ...

    Abstract Purpose of review: Postcraniotomy headache (PCH) is a common adverse event and can lead to various complications and decreased quality of life.
    Recent findings: To reduce postcraniotomy pain and associated complications, a multimodal pain therapy including analgesics, analgesic adjuncts, and regional anesthesia is essential. The use of opioids should be minimized to facilitate prompt postoperative neurosurgical assessment. Here, we provide an update on the latest evidence regarding the role of scalp nerve blocks in the pain management of patients undergoing craniotomy procedure. Nerve blocks are effective in alleviating postoperative pain after craniotomy. Scalp blocks contribute to lower pain levels and less opioid consumption in the first 48 h following surgery. Moreover, there is a significant decrease in patients suffering from PONV among patients who receive scalp block.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055062-5
    ISSN 1534-3081 ; 1531-3433
    ISSN (online) 1534-3081
    ISSN 1531-3433
    DOI 10.1007/s11916-024-01236-4
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  3. Article: "Mind from Matter?" - Über Verhalten und Gehirn

    Heisenberg, Martin

    Neuroforum

    2018  Volume 24, Issue 2, Page(s) 121

    Language German
    Document type Article
    ZDB-ID 1238592-x
    ISSN 0947-0875
    Database Current Contents Medicine

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    Zs.A 4805: Show issues Location:
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  4. Article ; Online: Outcome learning, outcome expectations, and intentionality in Drosophila.

    Heisenberg, Martin

    Learning & memory (Cold Spring Harbor, N.Y.)

    2015  Volume 22, Issue 6, Page(s) 294–298

    Abstract: An animal generates behavioral actions because of the effects of these actions in the future. Occasionally, the animal may generate an action in response to a certain event or situation. If the outcome of the action is adaptive, the animal may keep this ... ...

    Abstract An animal generates behavioral actions because of the effects of these actions in the future. Occasionally, the animal may generate an action in response to a certain event or situation. If the outcome of the action is adaptive, the animal may keep this stimulus-response link in its behavioral repertoire, in case the event or situation occurs again. If a responsive action is innate but the outcome happens to be less adaptive than it had been before, the link may be loosened. This adjustment of outcome expectations involves a particular kind of learning, which will be called "outcome learning." The present article discusses several examples of outcome learning in Drosophila. Learning and memory are intensely studied in flies, but the focus is on classical conditioning. Outcome learning, a particular form of operant learning, is of special significance, because it modulates outcome expectations that are operational components of action selection and intentionality.
    MeSH term(s) Animals ; Behavior, Animal ; Conditioning, Operant ; Drosophila ; Intention ; Psychomotor Performance
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1204777-6
    ISSN 1549-5485 ; 1072-0502
    ISSN (online) 1549-5485
    ISSN 1072-0502
    DOI 10.1101/lm.037481.114
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    Zs.A 4107: Show issues Location:
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  5. Article ; Online: The beauty of the network in the brain and the origin of the mind in the control of behavior.

    Heisenberg, M

    Journal of neurogenetics

    2014  Volume 28, Issue 3-4, Page(s) 389–399

    Abstract: Behavior is not adequately described as a stimulus-response process. It is initiated by the animal and is generated because of its expected outcome in the future. The outcome can be good or bad for the animal. The brain is in charge of the selection ... ...

    Abstract Behavior is not adequately described as a stimulus-response process. It is initiated by the animal and is generated because of its expected outcome in the future. The outcome can be good or bad for the animal. The brain is in charge of the selection process. This is the basic function of the brain. Taking Drosophila as a study case, this paper discusses initiating activity, several examples of outcome expectations, trying out (the internal search for a suitable behavior), chaining of actions, and the functional roles of chance in action selection. It takes mental processes and states such as goals, intentions, feelings, memories, cognition, and attention as higher levels of behavioral control that have their origin in biological evolution.
    MeSH term(s) Animals ; Behavior, Animal/physiology ; Brain/physiology ; Cognition/physiology ; Drosophila/physiology ; Nerve Net/physiology
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605543-6
    ISSN 1563-5260 ; 0167-7063
    ISSN (online) 1563-5260
    ISSN 0167-7063
    DOI 10.3109/01677063.2014.912279
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  6. Article ; Online: Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts.

    Arslan, Feyza Nur / Hannezo, Édouard / Merrin, Jack / Loose, Martin / Heisenberg, Carl-Philipp

    Current biology : CB

    2023  Volume 34, Issue 1, Page(s) 171–182.e8

    Abstract: Metazoan development relies on the formation and remodeling of cell-cell contacts. Dynamic reorganization of adhesion receptors and the actomyosin cell cortex in space and time plays a central role in cell-cell contact formation and maturation. ... ...

    Abstract Metazoan development relies on the formation and remodeling of cell-cell contacts. Dynamic reorganization of adhesion receptors and the actomyosin cell cortex in space and time plays a central role in cell-cell contact formation and maturation. Nevertheless, how this process is mechanistically achieved when new contacts are formed remains unclear. Here, by building a biomimetic assay composed of progenitor cells adhering to supported lipid bilayers functionalized with E-cadherin ectodomains, we show that cortical F-actin flows, driven by the depletion of myosin-2 at the cell contact center, mediate the dynamic reorganization of adhesion receptors and cell cortex at the contact. E-cadherin-dependent downregulation of the small GTPase RhoA at the forming contact leads to both a depletion of myosin-2 and a decrease of F-actin at the contact center. At the contact rim, in contrast, myosin-2 becomes enriched by the retraction of bleb-like protrusions, resulting in a cortical tension gradient from the contact rim to its center. This tension gradient, in turn, triggers centrifugal F-actin flows, leading to further accumulation of F-actin at the contact rim and the progressive redistribution of E-cadherin from the contact center to the rim. Eventually, this combination of actomyosin downregulation and flows at the contact determines the characteristic molecular organization, with E-cadherin and F-actin accumulating at the contact rim, where they are needed to mechanically link the contractile cortices of the adhering cells.
    MeSH term(s) Animals ; Actins/metabolism ; Cell Adhesion/physiology ; Actomyosin/metabolism ; Cadherins/genetics ; Cadherins/metabolism ; Cytoskeletal Proteins ; Myosins
    Chemical Substances Actins ; Actomyosin (9013-26-7) ; Cadherins ; Cytoskeletal Proteins ; Myosins (EC 3.6.4.1)
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.11.067
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  7. Article ; Online: 'Humans and other animals'-on the scope of brain science.

    Heisenberg, M

    Journal of neurogenetics

    2012  Volume 26, Issue 3-4, Page(s) 267–270

    Abstract: Abstract: This essay is dedicated to Obaid on the occasion of his 80th birthday. We both worked on the behavior of Drosophila and on what underlies behavior in the fly brain. Is that the fly's mind? The essay is about some limitations of brain science. ... ...

    Abstract Abstract: This essay is dedicated to Obaid on the occasion of his 80th birthday. We both worked on the behavior of Drosophila and on what underlies behavior in the fly brain. Is that the fly's mind? The essay is about some limitations of brain science. It is just a little piece of writing. It is meant to honor Obaid for his contributions to Drosophila neurogenetics in 40 years and to science in India. I hope he takes it instead of a bowl of flowers-adding to the praise.
    MeSH term(s) Animals ; Biological Evolution ; Brain/physiology ; Consciousness ; History, 19th Century ; Humans ; Neurosciences/history ; Psychophysiology
    Language English
    Publishing date 2012-09
    Publishing country England
    Document type Historical Article ; Journal Article ; Portraits
    ZDB-ID 605543-6
    ISSN 1563-5260 ; 0167-7063
    ISSN (online) 1563-5260
    ISSN 0167-7063
    DOI 10.3109/01677063.2012.687796
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  8. Article ; Online: Erich Buchner.

    Heisenberg, Martin

    Journal of neurogenetics

    2010  Volume 24, Issue 3, Page(s) 93–94

    MeSH term(s) Animals ; Drosophila melanogaster/cytology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/physiology ; Germany ; History, 20th Century ; History, 21st Century ; Molecular Biology/history ; Neurobiology/history
    Language English
    Publishing date 2010-09
    Publishing country England
    Document type Biography ; Historical Article
    ZDB-ID 605543-6
    ISSN 1563-5260 ; 0167-7063
    ISSN (online) 1563-5260
    ISSN 0167-7063
    DOI 10.3109/01677063.2010.499979
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  9. Article: Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization.

    Caballero-Mancebo, Silvia / Shinde, Rushikesh / Bolger-Munro, Madison / Peruzzo, Matilda / Szep, Gregory / Steccari, Irene / Labrousse-Arias, David / Zheden, Vanessa / Merrin, Jack / Callan-Jones, Andrew / Voituriez, Raphaël / Heisenberg, Carl-Philipp

    Nature physics

    2024  Volume 20, Issue 2, Page(s) 310–321

    Abstract: Contraction and flow of the actin cell cortex have emerged as a common principle by which cells reorganize their cytoplasm and take shape. However, how these cortical flows interact with adjacent cytoplasmic components, changing their form and ... ...

    Abstract Contraction and flow of the actin cell cortex have emerged as a common principle by which cells reorganize their cytoplasm and take shape. However, how these cortical flows interact with adjacent cytoplasmic components, changing their form and localization, and how this affects cytoplasmic organization and cell shape remains unclear. Here we show that in ascidian oocytes, the cooperative activities of cortical actomyosin flows and deformation of the adjacent mitochondria-rich myoplasm drive oocyte cytoplasmic reorganization and shape changes following fertilization. We show that vegetal-directed cortical actomyosin flows, established upon oocyte fertilization, lead to both the accumulation of cortical actin at the vegetal pole of the zygote and compression and local buckling of the adjacent elastic solid-like myoplasm layer due to friction forces generated at their interface. Once cortical flows have ceased, the multiple myoplasm buckles resolve into one larger buckle, which again drives the formation of the contraction pole-a protuberance of the zygote's vegetal pole where maternal mRNAs accumulate. Thus, our findings reveal a mechanism where cortical actomyosin network flows determine cytoplasmic reorganization and cell shape by deforming adjacent cytoplasmic components through friction forces.
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2206346-8
    ISSN 1745-2481 ; 1745-2473
    ISSN (online) 1745-2481
    ISSN 1745-2473
    DOI 10.1038/s41567-023-02302-1
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  10. Article ; Online: Is free will an illusion?

    Heisenberg, Martin

    Nature

    2009  Volume 459, Issue 7244, Page(s) 164–165

    MeSH term(s) Animals ; Behavior/physiology ; Behavior, Animal/physiology ; Decision Making/physiology ; Humans ; Models, Neurological ; Personal Autonomy
    Language English
    Publishing date 2009-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/459164a
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