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  1. Article ; Online: Mid- and long-term outcome after treatment with the Woven EndoBridge (WEB).

    Andersson, Tommy

    Acta neurochirurgica

    2023  Volume 165, Issue 8, Page(s) 2087–2088

    MeSH term(s) Humans ; Treatment Outcome ; Follow-Up Studies ; Intracranial Aneurysm/therapy ; Endovascular Procedures ; Embolization, Therapeutic ; Retrospective Studies
    Language English
    Publishing date 2023-06-27
    Publishing country Austria
    Document type Editorial
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-023-05669-5
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  2. Article ; Online: How are manual skills to reach excellence in microsurgery and endovascular technique best acquired, maintained, and developed with relation to unruptured aneurysm treatment: hybrid neurosurgeons or team approach?

    Andersson, Tommy

    Acta neurochirurgica

    2021  Volume 163, Issue 5, Page(s) 1525–1526

    MeSH term(s) Endovascular Procedures ; Humans ; Intracranial Aneurysm/surgery ; Medical Staff ; Microsurgery ; Neurosurgeons
    Language English
    Publishing date 2021-02-03
    Publishing country Austria
    Document type Editorial ; Comment
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-021-04747-w
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  3. Article ; Online: [No title information]

    Ullberg, Teresa / Andersson, Tommy

    Lakartidningen

    2023  Volume 120

    Title translation Reperfusionsbehandling vid akut stroke har lett till paradigmskifte.
    MeSH term(s) Humans ; Stroke/therapy ; Reperfusion
    Language Swedish
    Publishing date 2023-09-06
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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  4. Article ; Online: Procedural factors associated with successful recanalization in patients with acute ischemic stroke treated with endovascular thrombectomy-a nationwide register-based observational study.

    Wassélius, Johan / Hall, Emma / Ramgren, Birgitta / Andersson, Tommy / Ullberg, Teresa

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

    2024  , Page(s) 15910199241248268

    Abstract: Introduction: Several studies have addressed technical aspects of endovascular thrombectomy (EVT), but it is not well known how procedural factors contribute to technical success in routine healthcare. The aim was to explore factors associated with ... ...

    Abstract Introduction: Several studies have addressed technical aspects of endovascular thrombectomy (EVT), but it is not well known how procedural factors contribute to technical success in routine healthcare. The aim was to explore factors associated with technically successful EVT on nationwide scale.
    Methods: We did an observational register-based study assessing factors associated with technical success off anterior circulation EVT in Sweden. The main outcome was successful recanalization defined as modified treatment in cerebral ischemia score 2b-3. The association between baseline and treatment variables and successful recanalization were explored using Chi-square(d) test and univariable logistic regression. Multivariable logistic regression was used to define predictors of successful recanalization.
    Results: The study included 3211 patients treated during 2015 to 2020. Successful recanalization was achieved in 83.1% (2667) with a gradual improvement in technical outcome over the period. After adjustment for age and occlusion location, thet use of general anesthesia, balloon guide catheter (BGC) and an operator with an overall success rate of >85% were independent predictors of successful recanalization. An overall operator success rate of <80% or 80-85%, and an annual center volume lower than 50 were predicitors of recanalization failure.
    Conclusion: This study illustrates factors associated with procedural success in endovascular thrombectomy on a nationwide scale including the use of general anesthesia, BGC, annual center volumes >50 cases per year and the overall success rate of the individual operator. It highlights the potential benefit of systematic performance measurements, benchmarking, and continuous training to bring all centers and operators to the highest level of performance.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354913-3
    ISSN 2385-2011 ; 1591-0199 ; 1123-9344
    ISSN (online) 2385-2011
    ISSN 1591-0199 ; 1123-9344
    DOI 10.1177/15910199241248268
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  5. Article ; Online: Role of hyperpolarization-activated cyclic nucleotide-gated channel HCN2 in embryonic neural stem cell proliferation and differentiation.

    Nordström, Tommy / Andersson, Leif C / Åkerman, Karl E O

    Neurochemistry international

    2022  Volume 159, Page(s) 105387

    Abstract: Hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) are involved in spontaneous activity in many electrically active cell types such as cardiomyocytes and neurons. In this study, the role of HCN channels in proliferation and ... ...

    Abstract Hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) are involved in spontaneous activity in many electrically active cell types such as cardiomyocytes and neurons. In this study, the role of HCN channels in proliferation and migration of Nestin and Sox2 expressing embryonic neural progenitor cells (NPC) originating from the subventricular zone (SVZ) was examined. Immunostaining and PCR data showed that the HCN2 subtype was highly expressed in these cells. Patch clamp recordings revealed a hyperpolarization-activated current, which was sensitive to inhibitors of HCN channels. Using the fluorescence dye bis-(1,3-dibutylbarbituric acid)-trimethineoxonol (DiBAC(4)(3)) we found that a prompt reduction of the extracellular K
    MeSH term(s) Cell Proliferation ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; Hypoxia ; Potassium Channels
    Chemical Substances Cyclic Nucleotide-Gated Cation Channels ; HCN2 protein, human ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; Potassium Channels
    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 283190-9
    ISSN 1872-9754 ; 0197-0186
    ISSN (online) 1872-9754
    ISSN 0197-0186
    DOI 10.1016/j.neuint.2022.105387
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  6. Book ; Thesis: Causes and consequences of persistent neuronal paramyxovirus infections

    Andersson, Tommy

    1994  

    Author's details av Tommy Andersson
    Language English
    Size Getr. Zählung : Ill., graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Stockholm, Karolinska Inst., Diss., 1994
    HBZ-ID HT006398843
    ISBN 91-628-1232-7 ; 978-91-628-1232-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    94 E 1919 order for loan Magazin

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  7. Article ; Online: Emergency department reorganisation introducing increased autonomy: A mixed effects approach to evaluate the effects of a national policy.

    Tipsmark, Line Stjernholm / Obel, Børge / Andersson, Tommy / Søgaard, Rikke

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0283325

    Abstract: Background: In 2007, a Danish national policy to future-proof emergency department (ED) performance was launched. The policy included several recommendations for the management and organisation of care that essentially introduced greater ED autonomy. In ...

    Abstract Background: In 2007, a Danish national policy to future-proof emergency department (ED) performance was launched. The policy included several recommendations for the management and organisation of care that essentially introduced greater ED autonomy. In this study, we evaluate the effects of increased ED autonomy on readmission, mortality and episode costs for two large patient groups.
    Method: A non-randomised stepped wedge study-design where all EDs gradually implemented the policy at different steps during the study period (2008-2016). The timing and extent of policy implementation was determined from a retrospective cross-sectional survey of all 21 Danish EDs. This was linked to all episodes of hip fracture (n = 79,697) and erysipelas (n = 39,900) identified in the Nation Patient Registry and with episode-level outcomes. Mixed effect models were specified for the outcomes of 30-day readmission, 30-day mortality and episode costs, and adjusted for relevant ED- and episode-level heterogeneity.
    Results: Increased ED autonomy was associated with more readmissions (p<0.05) and higher episode costs (p<0.001) in hip fracture episodes. In erysipelas episodes, no general associations were found. When restricted to night-time admissions, increased ED autonomy was associated with poorer outcomes for erysipelas episodes and increased episode costs for both patient groups.
    Conclusion: The intended policy effects were not found for these two patient groups; in fact, reorganisation appeared to have harmed hip fracture patients and increased episode costs. Uncertainty remains regarding the longer-term consequences.
    MeSH term(s) Humans ; Retrospective Studies ; Cross-Sectional Studies ; Erysipelas ; Patient Readmission ; Policy ; Hip Fractures ; Emergency Service, Hospital
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283325
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  8. Article ; Online: Emergency department reorganisation introducing increased autonomy

    Line Stjernholm Tipsmark / Børge Obel / Tommy Andersson / Rikke Søgaard

    PLoS ONE, Vol 18, Iss

    A mixed effects approach to evaluate the effects of a national policy

    2023  Volume 3

    Abstract: Background In 2007, a Danish national policy to future-proof emergency department (ED) performance was launched. The policy included several recommendations for the management and organisation of care that essentially introduced greater ED autonomy. In ... ...

    Abstract Background In 2007, a Danish national policy to future-proof emergency department (ED) performance was launched. The policy included several recommendations for the management and organisation of care that essentially introduced greater ED autonomy. In this study, we evaluate the effects of increased ED autonomy on readmission, mortality and episode costs for two large patient groups. Method A non-randomised stepped wedge study-design where all EDs gradually implemented the policy at different steps during the study period (2008–2016). The timing and extent of policy implementation was determined from a retrospective cross-sectional survey of all 21 Danish EDs. This was linked to all episodes of hip fracture (n = 79,697) and erysipelas (n = 39,900) identified in the Nation Patient Registry and with episode-level outcomes. Mixed effect models were specified for the outcomes of 30-day readmission, 30-day mortality and episode costs, and adjusted for relevant ED- and episode-level heterogeneity. Results Increased ED autonomy was associated with more readmissions (p<0.05) and higher episode costs (p<0.001) in hip fracture episodes. In erysipelas episodes, no general associations were found. When restricted to night-time admissions, increased ED autonomy was associated with poorer outcomes for erysipelas episodes and increased episode costs for both patient groups. Conclusion The intended policy effects were not found for these two patient groups; in fact, reorganisation appeared to have harmed hip fracture patients and increased episode costs. Uncertainty remains regarding the longer-term consequences.
    Keywords Medicine ; R ; Science ; Q
    Subject code 300
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Emergency department reorganisation introducing increased autonomy

    Line Stjernholm Tipsmark / Børge Obel / Tommy Andersson / Rikke Søgaard

    PLoS ONE, Vol 18, Iss 3, p e

    A mixed effects approach to evaluate the effects of a national policy.

    2023  Volume 0283325

    Abstract: Background In 2007, a Danish national policy to future-proof emergency department (ED) performance was launched. The policy included several recommendations for the management and organisation of care that essentially introduced greater ED autonomy. In ... ...

    Abstract Background In 2007, a Danish national policy to future-proof emergency department (ED) performance was launched. The policy included several recommendations for the management and organisation of care that essentially introduced greater ED autonomy. In this study, we evaluate the effects of increased ED autonomy on readmission, mortality and episode costs for two large patient groups. Method A non-randomised stepped wedge study-design where all EDs gradually implemented the policy at different steps during the study period (2008-2016). The timing and extent of policy implementation was determined from a retrospective cross-sectional survey of all 21 Danish EDs. This was linked to all episodes of hip fracture (n = 79,697) and erysipelas (n = 39,900) identified in the Nation Patient Registry and with episode-level outcomes. Mixed effect models were specified for the outcomes of 30-day readmission, 30-day mortality and episode costs, and adjusted for relevant ED- and episode-level heterogeneity. Results Increased ED autonomy was associated with more readmissions (p<0.05) and higher episode costs (p<0.001) in hip fracture episodes. In erysipelas episodes, no general associations were found. When restricted to night-time admissions, increased ED autonomy was associated with poorer outcomes for erysipelas episodes and increased episode costs for both patient groups. Conclusion The intended policy effects were not found for these two patient groups; in fact, reorganisation appeared to have harmed hip fracture patients and increased episode costs. Uncertainty remains regarding the longer-term consequences.
    Keywords Medicine ; R ; Science ; Q
    Subject code 300
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.

    Andersson, Tommy B

    Basic & clinical pharmacology & toxicology

    2017  Volume 121, Issue 4, Page(s) 234–238

    Abstract: The pharmaceutical industry urgently needs reliable pre-clinical models to evaluate the efficacy and safety of new chemical entities before they enter the clinical trials. Development of in vitro model systems that emulate the functions of the human ... ...

    Abstract The pharmaceutical industry urgently needs reliable pre-clinical models to evaluate the efficacy and safety of new chemical entities before they enter the clinical trials. Development of in vitro model systems that emulate the functions of the human liver organ has been an elusive task. Cell lines exhibit a low drug-metabolizing capacity and primary liver cells rapidly dedifferentiate in culture, which restrict their usefulness substantially. Recently, the development of hepatocyte spheroid cultures has shown promising results. The proteome and transcriptome in the spheroids were similar to the liver tissue, and hepatotoxicity of selected substances was detected at in vivo-relevant concentrations.
    Language English
    Publishing date 2017-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.12804
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