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Article: Functional and morphologic characterization of human T cells continuously grown in vitro. J. Immunol. 1977. 119: 131-138.

Ruscetti, Francis W / Morgan, Doris A / Gallo, Robert C

Journal of immunology (Baltimore, Md. : 1950)

2007 Volume 179, Issue 3, Page(s) 1415–1422

MeSH term(s)	Cell Proliferation ; Cells, Cultured ; History, 20th Century ; Humans ; Kinetics ; Lymphocyte Activation ; Lymphocyte Culture Test, Mixed/history ; Lymphokines/history ; Lymphokines/secretion ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/secretion
Chemical Substances	Lymphokines
Language	English
Publishing date	2007-08-01
Publishing country	United States
Document type	Biography ; Classical Article ; Historical Article ; Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

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Article ; Online: Re: Effect of reclassification on the incidence of benign and malignant renal tumors: T. A. Skolarus, M. F. Serrano, R. L. Grubb, III, M. D. Katz, T. L. Bullock, F. Gao, P. A. Humphrey and A. S. Kibel J Urol 2010; 183: 455-458.

Rossi, Giulio / Bruschi, Morgan

The Journal of urology

2010 Volume 184, Issue 2, Page(s) 804

MeSH term(s)	Humans ; Incidence ; Kidney Neoplasms/classification ; Kidney Neoplasms/epidemiology
Language	English
Publishing date	2010-08
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2010.04.002
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Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 331: Show issues

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Book ; Online ; E-Book: Pathology of the placenta

Khong, T. Yee / Mooney, Eoghan E. / Nikkels, Peter G. J. / Morgan, Terry K. / Gordijn, Sanne J.

a practical guide

2019

Author's details	T. Yee Khong, Eoghan E. Mooney, Peter G. J. Nikkels, Terry K. Morgan, Sanne J. Gordijn editors
Keywords	Pathology ; Obstetrics ; Epidemiology ; Pediatrics
Subject code	616.07
Language	English
Size	1 Online-Ressource (XVI, 395 Seiten), Illustrationen
Publisher	Springer International Publishing
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021323381
ISBN	978-3-319-97214-5 ; 9783319972138 ; 3-319-97214-6 ; 3319972138
DOI	10.1007/978-3-319-97214-5
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Biotic interactions in soil and dung shape parasite transmission in temperate ruminant systems: An integrative framework.

Boughton, Christopher J / Lancaster, Lesley T / Morgan, Eric R

Ecological applications : a publication of the Ecological Society of America

2024 Volume 34, Issue 3, Page(s) e2956

Abstract: Gastrointestinal helminth parasites undergo part of their life cycle outside their host, such that developmental stages interact with the soil and dung fauna. These interactions are capable of affecting parasite transmission on pastures yet are generally ...

Abstract	Gastrointestinal helminth parasites undergo part of their life cycle outside their host, such that developmental stages interact with the soil and dung fauna. These interactions are capable of affecting parasite transmission on pastures yet are generally ignored in current models, empirical studies and practical management. Dominant methods of parasite control, which rely on anthelmintic medications for livestock, are becoming increasingly ineffective due to the emergence of drug-resistant parasite populations. Furthermore, consumer and regulatory pressure on decreased chemical use in agriculture and the consequential disruption of biological processes in the dung through nontarget effects exacerbates issues with anthelmintic reliance. This presents a need for the application and enhancement of nature-based solutions and biocontrol methods. However, successfully harnessing these options relies on advanced understanding of the ecological system and interacting effects among biotic factors and with immature parasite stages. Here, we develop a framework linking three key groups of dung and soil fauna-fungi, earthworms, and dung beetles-with each other and developmental stages of helminths parasitic in farmed cattle, sheep, and goats in temperate grazing systems. We populate this framework from existing published studies and highlight the interplay between faunal groups and documented ecological outcomes. Of 1756 papers addressing abiotic drivers of populations of these organisms and helminth parasites, only 112 considered interactions between taxa and 36 presented data on interactions between more than two taxonomic groups. Results suggest that fungi reduce parasite abundance and earthworms may enhance fungal communities, while competition between dung taxa may reduce their individual effect on parasite transmission. Dung beetles were found to impact fungal populations and parasite transmission variably, possibly tied to the prevailing climate within a specific ecological context. By exploring combinations of biotic factors, we consider how interactions between species may be fundamental to the ecological consequences of biocontrol strategies and nontarget impacts of anthelmintics on dung and soil fauna and how pasture management alterations to promote invertebrates might help limit parasite transmission. With further development and parameterization the framework could be applied quantitatively to guide, prioritize, and interpret hypothesis-driven experiments and integrate biotic factors into established models of parasite transmission dynamics.
MeSH term(s)	Animals ; Cattle ; Sheep ; Parasites ; Soil/chemistry ; Feces ; Anthelmintics ; Coleoptera ; Ruminants
Chemical Substances	Soil ; Anthelmintics
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1074505-1
ISSN	1939-5582 ; 1051-0761
ISSN (online)	1939-5582
ISSN	1051-0761
DOI	10.1002/eap.2956
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Z 5240: Show issues

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Article: Inferring the age and sex of ancient potters from fingerprint ridge densities: A data-driven, Bayesian mixture modelling approach.

Burchill, Andrew T / Sanders, Akiva / Morgan, Thomas J H

MethodsX

2023 Volume 11, Page(s) 102292

Abstract: The density of epidermal ridges in a fingerprint varies predictably by age and sex. Archaeologists are therefore interested in using recovered fingerprints to learn about the ancient people who produced them. Recent studies focus on estimating the age ... ...

Abstract	The density of epidermal ridges in a fingerprint varies predictably by age and sex. Archaeologists are therefore interested in using recovered fingerprints to learn about the ancient people who produced them. Recent studies focus on estimating the age and sex of individuals by measuring their fingerprints with one of two similar metrics: mean ridge breadth (MRB) or ridge density (RD). Yet these attempts face several critical problems: expected values for adult females and adolescent males are inherently indistinguishable, and inter-assemblage variation caused by biological and technological differences cannot be easily estimated. Each of these factors greatly decreases the accuracy of predictions based on individual prints, and together they condemn this strategy to relative uselessness. However, information in fingerprints from across an assemblage can be pooled to generate a more accurate depiction of potter demographics. We present a new approach to epidermal ridge density analysis using Bayesian mixture models with the following key benefits:•Age and sex are estimated more accurately than existing methods by incorporating a data-driven understanding of how demographics and ridge density covary.•Uncertainty in demographic estimates is automatically quantified and included in output.•The Bayesian framework can be easily adapted to fit the unique needs of different researchers.
Language	English
Publishing date	2023-07-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2830212-6
ISSN	2215-0161
ISSN	2215-0161
DOI	10.1016/j.mex.2023.102292
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Article: Tranexamic Acid in Tumescence for Cervicofacial Rhytidectomies.

Trimas, Gracen E / Frost, Morgan D T / Trimas, Scott J

Plastic and reconstructive surgery. Global open

2024 Volume 12, Issue 1, Page(s) e5540

Abstract: Background: Cervicofacial rhytidectomies are one of the most common procedures in the United States. There are many different methods and techniques involved, but all aim to minimize blood loss and procedure time. In our study, we investigated the ... ...

Abstract	Background: Cervicofacial rhytidectomies are one of the most common procedures in the United States. There are many different methods and techniques involved, but all aim to minimize blood loss and procedure time. In our study, we investigated the addition of tranexamic acid (TXA) to tumescent anesthesia during rhytidectomy procedures. Our objective was to analyze the difference in mean procedure time and estimated blood loss in patients undergoing both general and other anesthesia types, with and without the addition of TXA, while maintaining patient safety. Methods: Seventy-four patients underwent a standard superficial musculoaponeurotic system plication technique rhytidectomy, with 60 patients undergoing general anesthesia and the remaining 14 undergoing other anesthesia types. Forty patients were treated without TXA, whereas the remaining 34 were treated with TXA. Results: Although the difference was not statistically significant, the addition of TXA resulted in a lower procedure time and estimated blood loss. Within anesthesia type, there was also a slight difference that TXA decreased blood loss and procedure time. We did find that general anesthesia type does significantly impact procedure time and estimated blood loss, when compared with other anesthesia types, independent of TXA use. Conclusion: The use of tumescent TXA may allow for a faster procedure with less blood loss, although further studies with a larger sample size are needed.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000005540
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Zs.A 7091: Show issues

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Article ; Online: To speak may draw on epigenetic writing and reading: Unravelling the complexity of speech and language outcomes across chromatin-related neurodevelopmental disorders.

St John, Miya / Tripathi, Tanya / Morgan, Angela T / Amor, David J

Neuroscience and biobehavioral reviews

2023 Volume 152, Page(s) 105293

Abstract: Speech and language development are complex neurodevelopmental processes that are incompletely understood, yet current evidence suggests that speech and language disorders are prominent in those with disorders of chromatin regulation. This review aimed ... ...

Abstract	Speech and language development are complex neurodevelopmental processes that are incompletely understood, yet current evidence suggests that speech and language disorders are prominent in those with disorders of chromatin regulation. This review aimed to unravel what is known about speech and language outcomes for individuals with chromatin-related neurodevelopmental disorders. A systematic literature search following PRISMA guidelines was conducted on 70 chromatin genes, to identify reports of speech/language outcomes across studies, including clinical reports, formal subjective measures, and standardised/objective measures. 3932 studies were identified and screened and 112 were systematically reviewed. Communication impairment was core across chromatin disorders, and specifically, chromatin writers and readers appear to play an important role in motor speech development. Identification of these relationships is important because chromatin disorders show promise as therapeutic targets due to the capacity for epigenetic modification. Further research is required using standardised and formal assessments to understand the nuanced speech/language profiles associated with variants in each gene, and the influence of chromatin dysregulation on the neurobiology of speech and language development.
MeSH term(s)	Humans ; Chromatin/genetics ; Communication Disorders ; Reading ; Speech ; Writing
Chemical Substances	Chromatin
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2023.105293
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Zs.A 1371: Show issues

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Article ; Online: Clinical decision support for gastrointestinal panel testing.

Saif, Nadia T / Dooley, Cara / Baghdadi, Jonathan D / Morgan, Daniel J / Coffey, K C

Antimicrobial stewardship & healthcare epidemiology : ASHE

2024 Volume 4, Issue 1, Page(s) e22

Abstract: Objective: This study aimed to assess the impact of clinical decision support (CDS) to improve ordering of multiplex gastrointestinal polymerase chain reaction (PCR) testing panel ("GI panel").: Design: Single-center, retrospective, before-after ... ...

Abstract	Objective: This study aimed to assess the impact of clinical decision support (CDS) to improve ordering of multiplex gastrointestinal polymerase chain reaction (PCR) testing panel ("GI panel"). Design: Single-center, retrospective, before-after study. Setting: Tertiary care Veteran's Affairs (VA) Medical Center provides inpatient, outpatient, and residential care. Patients: All patients tested with a GI panel between June 22, 2022 and April 20, 2023. Intervention: We designed a CDS questionnaire in the electronic medical record (EMR) to guide appropriate ordering of the GI panel. A "soft stop" reminder at the point of ordering prompted providers to confirm five appropriateness criteria: 1) documented diarrhea, 2) no recent receipt of laxatives, 3) Results: Compared to the pre-implementation period ( Conclusions: Implementation of CDS in the EMR decreased testing and inappropriate ordering based on use of laxatives or undocumented diarrhea. However, inappropriate ordering of tests overall remained high post-intervention, signaling the need for continued diagnostic stewardship efforts.
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ISSN	2732-494X
ISSN (online)	2732-494X
DOI	10.1017/ash.2024.15
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Article ; Online: The value of genomic testing in severe childhood speech disorders.

Meng, Yan / Best, Stephanie / Amor, David J / Braden, Ruth / Morgan, Angela T / Goranitis, Ilias

European journal of human genetics : EJHG

2024 Volume 32, Issue 4, Page(s) 440–447

Abstract: With increasing gene discoveries for severe speech disorders, genomic testing can alter the diagnostic and clinical paradigms, enabling better life outcomes for children and their families. However, evidence on the value of the outcomes generated is ... ...

Abstract	With increasing gene discoveries for severe speech disorders, genomic testing can alter the diagnostic and clinical paradigms, enabling better life outcomes for children and their families. However, evidence on the value of the outcomes generated is lacking, impeding optimal translation into health care. This study aims to estimate the value and uptake of genomic testing for severe childhood speech disorders. A discrete choice experiment was undertaken to elicit preferences for genomic testing from the perspective of the Australian public (n = 951) and parents of children experiencing severe speech disorder (n = 56). Choice attributes associated with genomic testing were identified through focus groups. A Bayesian D-efficient design was used to develop choice scenarios and choice data were analyzed using a panel error component mixed logit model and a latent class model. Statistically significant preferences were identified across all seven attributes. The mean monetary value of the benefits of genomic testing relative to standard diagnostic care in Australia was estimated at AU$7489 (US$5021) and AU$4452 (US$2985) from the perspectives of the Australian public and families with lived experience of severe speech disorders, with a corresponding test uptake of 94.2% and 99.6%. To ensure fair prioritization of genomics, decision-makers need to consider the wide range of risks and benefits associated with genomic information.
MeSH term(s)	Child ; Humans ; Choice Behavior ; Australia ; Bayes Theorem ; Genetic Testing ; Speech Disorders/diagnosis ; Speech Disorders/genetics ; Surveys and Questionnaires ; Patient Preference
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-024-01534-w
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Zs.A 3589: Show issues

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Article ; Online: Genetic architecture of childhood speech disorder: a review.

Morgan, Angela T / Amor, David J / St John, Miya D / Scheffer, Ingrid E / Hildebrand, Michael S

Molecular psychiatry

2024

Abstract: Severe speech disorders lead to poor literacy, reduced academic attainment and negative psychosocial outcomes. As early as the 1950s, the familial nature of speech disorders was recognized, implying a genetic basis; but the molecular genetic basis ... ...

Abstract	Severe speech disorders lead to poor literacy, reduced academic attainment and negative psychosocial outcomes. As early as the 1950s, the familial nature of speech disorders was recognized, implying a genetic basis; but the molecular genetic basis remained unknown. In 2001, investigation of a large three generational family with severe speech disorder, known as childhood apraxia of speech (CAS), revealed the first causative gene; FOXP2. A long hiatus then followed for CAS candidate genes, but in the past three years, genetic analysis of cohorts ascertained for CAS have revealed over 30 causative genes. A total of 36 pathogenic variants have been identified from 122 cases across 3 cohorts in this nascent field. All genes identified have been in coding regions to date, with no apparent benefit at this stage for WGS over WES in identifying monogenic conditions associated with CAS. Hence current findings suggest a remarkable one in three children have a genetic variant that explains their CAS, with significant genetic heterogeneity emerging. Around half of the candidate genes identified are currently supported by medium (6 genes) to strong (9 genes) evidence supporting the association between the gene and CAS. Despite genetic heterogeneity; many implicated proteins functionally converge on pathways involved in chromatin modification or transcriptional regulation, opening the door to precision diagnosis and therapies. Most of the new candidate genes for CAS are associated with previously described neurodevelopmental conditions that include intellectual disability, autism and epilepsy; broadening the phenotypic spectrum to a distinctly milder presentation defined by primary speech disorder in the setting of normal intellect. Insights into the genetic bases of CAS, a severe, rare speech disorder, are yet to translate to understanding the heritability of more common, typically milder forms of speech or language impairment such as stuttering or phonological disorder. These disorders likely follow complex inheritance with polygenic contributions in many cases, rather than the monogenic patterns that underly one-third of patients with CAS. Clinical genetic testing for should now be implemented for individuals with CAS, given its high diagnostic rate, which parallels many other neurodevelopmental disorders where this testing is already standard of care. The shared mechanisms implicated by gene discovery for CAS highlight potential new targets for future precision therapies.
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-024-02409-8
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