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  1. Article ; Online: Encephalomyocarditis Virus Entry Unveiled.

    Cherry, Sara

    mBio

    2019  Volume 10, Issue 2

    Abstract: Picornaviruses are a widespread group of pathogens that can cause diverse pathologies. Pathogenesis is thought to be driven by the tissue-specific tropisms displayed by these viruses. For example, many picornaviruses can infect the heart and cause viral ... ...

    Abstract Picornaviruses are a widespread group of pathogens that can cause diverse pathologies. Pathogenesis is thought to be driven by the tissue-specific tropisms displayed by these viruses. For example, many picornaviruses can infect the heart and cause viral myocarditis. Encephalomyocarditis virus (EMCV) is a rodent pathogen that causes myocarditis in rodent models and has been used to model this biology. However, the receptor and entry requirements for this virus are poorly understood. L. E. Bazzone, M. King, C. R. MacKay, P. P. Kyawe, et al. (mBio 10:e02734-18, 2019, https://doi.org/10.1128/mBio.02734-18) tackled this problem using CRISPR knockout screening in human cells that are susceptible to EMCV and identified ADAM9 as an essential entry factor for EMCV in mouse and human cells. Since the extracellular domain but not the enzymatic activity or intracellular domain is required for infection, the data suggest that ADAM9 acts as an entry receptor or at an early step in the process, shedding light on the biology of EMCV infection and pathogenesis.
    MeSH term(s) ADAM Proteins ; Animals ; Disintegrins ; Encephalomyocarditis virus ; Humans ; Membrane Proteins ; Metalloproteases ; Mice ; Ribosomes
    Chemical Substances Disintegrins ; Membrane Proteins ; Metalloproteases (EC 3.4.-) ; ADAM Proteins (EC 3.4.24.-) ; ADAM9 protein, human (EC 3.4.24.-)
    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00305-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: From chemistry to fruit flies: An unpredictable series of fortunate conversations.

    Cherry, Sara

    PLoS pathogens

    2018  Volume 14, Issue 8, Page(s) e1007077

    MeSH term(s) Animals ; Drosophila ; Genetics ; Humans ; Virology
    Language English
    Publishing date 2018-08-09
    Publishing country United States
    Document type Journal Article ; Personal Narrative ; Portrait
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1007077
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  3. Book: Ethical Issues in Cardiovascular Medicine

    Zientek, David M / Cherry, Mark J

    (Routledge Annals of Bioethics)

    2022  

    Abstract: This book provides an exploration of the ethics of cardiology practice. It provides a variety of frameworks for analyzing ethical issues that arise in cardiovascular medicine. -- Cardiovascular medicine—the diagnosis and treatment of congenital and ... ...

    Author's details David M. Zientek is Clinical Assistant Professor at the Department of Internal Medicine, University of Texas at Austin Dell Medical School, USA. He has practiced general and interventional cardiology for 29 years and served as co-chair of the Ascension Seton Medical Center ethics committee for 17 years and a member of the American College of Cardiology Ethics and Disciplinary committee for 6 years. Mark J. Cherry is the Dr. Patricia A. Hayes Professor in Applied Ethics and Professor of Philosophy, St. Edwards University, USA. He is Editor of The Journal of Medicine and Philosophy, Senior Editor of Christian Bioethics, and Editor-in-Chief of HealthCare Ethics Committee (HEC) Forum. He is the author of Kidney for Sale by Owner: Human Organs, Transplantation, and the Market (2005/2015) and Sex, Family and the Culture Wars (2016)
    Series title Routledge Annals of Bioethics
    Abstract This book provides an exploration of the ethics of cardiology practice. It provides a variety of frameworks for analyzing ethical issues that arise in cardiovascular medicine. -- Cardiovascular medicine—the diagnosis and treatment of congenital and acquired diseases of the heart, major arteries, and veins—has seen rapid change in diagnosis, treatment, and the organization of practice in the last half of the twentieth and the beginning of the twenty first century. The complexity of these deve...
    Keywords Idiopathic Pulmonary Hypertension ; David M. Zientek ; Peripartum Cardiomyopathy ; Mark J. Cherry ; Left Ventricle Assist Devices ; Dawn Allain ; Idiopathic ; Sara Cherny ; LVADs ; James Smith ; Jr. ; Implantable Defibrillators ; Pamela Jordi ; Hypoplastic Left Heart Syndrome ; Dalia Feltman ; Total Artificial Hearts ; Keith M. Swetz ; Implantable Cardioverter Defibrillators ; Sara E. Wordingham ; Advanced Heart Failure ; Daniel Matlock ; PGD ; Behzad Pavri ; Pre-implantation Genetic Diagnosis ; Kayhan Parsi ; Ventricular Assist Device ; Alexandra Charrow ; TAVR ; James N. Kirkpatrick ; Advance Care Planning ; Mark A. Hoffman ; Atrial Septal Defect ; Joy Penticuff ; MCS ; Angela Clark ; Interim Analysis ; Ana S. Iltis ; Trisomy 18 ; Lynne Caples ; Moral Distress ; Emily Anderson ; LVAD Placement ; genetic disease ; Ventricular Septal Defect ; genetic testing ; Palliative Care ; genetic counselling ; SCN5A Variant ; cardiovascular disease ; Palliative Care Involvement ; pregnancy ; reproductive liberty ; congenital anomalies ; best interests standard for decision making ; left-ventricle assist devices ; palliative care heart transplant ; double-effect ; distributive justice ; euthanasia ; physician assisted suicide ; deactivating implantable cardiac devices ; noncompliance ; futility ; rationing ; nursing ethics ; Belmont Report
    Language English
    Size 270 p.
    Edition 1
    Publisher Taylor & Francis Ltd (Sales)
    Document type Book
    Note PDA Manuell_15
    Format 152 x 229 x 18
    ISBN 9781032139982 ; 1032139986
    Database PDA

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  4. Article ; Online: Gutcha: The microbiota drives tumor-induced mortality.

    Segrist, Elisha / Cherry, Sara

    Immunity

    2022  Volume 55, Issue 9, Page(s) 1581–1583

    Abstract: Tumors can cause wasting and mortality, but the connection between these outcomes is unclear. In this issue of Immunity, Chen and colleagues find the outcomes are separable as the tumor-altered gut microbiota activates renal immunity and alters ... ...

    Abstract Tumors can cause wasting and mortality, but the connection between these outcomes is unclear. In this issue of Immunity, Chen and colleagues find the outcomes are separable as the tumor-altered gut microbiota activates renal immunity and alters metabolism, leading to mortality independently of wasting.
    MeSH term(s) Gastrointestinal Microbiome ; Humans ; Microbiota ; Neoplasms
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.08.011
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  5. Article ; Online: From chemistry to fruit flies

    Sara Cherry

    PLoS Pathogens, Vol 14, Iss 8, p e

    An unpredictable series of fortunate conversations.

    2018  Volume 1007077

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2018-08-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model.

    Maio, Nunziata / Cherry, Sara / Schultz, David C / Hurst, Brett L / Linehan, W Marston / Rouault, Tracey A

    iScience

    2022  Volume 25, Issue 10, Page(s) 105074

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide outbreak, known ... inactivated the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 by causing the oxidative degradation ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide outbreak, known as coronavirus disease 2019 (COVID-19). Alongside vaccines, antiviral therapeutics is an important part of the healthcare response to COVID-19. We previously reported that TEMPOL, a small molecule stable nitroxide, inactivated the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 by causing the oxidative degradation of its iron-sulfur cofactors. Here, we demonstrate that TEMPOL is effective
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.105074
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  7. Article: Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states.

    Reffsin, Sam / Miller, Jesse / Ayyanathan, Kasirajan / Dunagin, Margaret C / Jain, Naveen / Schultz, David C / Cherry, Sara / Raj, Arjun

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... lung epithelial cells that are highly susceptible to infection with SARS-CoV-2. The transcriptional ...

    Abstract The ability of a virus to infect a cell type is at least in part determined by the presence of host factors required for the viral life cycle. However, even within cell types that express known factors needed for infection, not every cell is equally susceptible, suggesting that our knowledge of the full spectrum of factors that promote infection is incomplete. Profiling the most susceptible subsets of cells within a population may reveal additional factors that promote infection. However, because viral infection dramatically alters the state of the cell, new approaches are needed to reveal the state of these cells prior to infection with virus. Here, we used single-cell clone tracing to retrospectively identify and characterize lung epithelial cells that are highly susceptible to infection with SARS-CoV-2. The transcriptional state of these highly susceptible cells includes markers of retinoic acid signaling and epithelial differentiation. Loss of candidate factors identified by our approach revealed that many of these factors play roles in viral entry. Moreover, a subset of these factors exert control over the infectable cell state itself, regulating the expression of key factors associated with viral infection and entry. Analysis of patient samples revealed the heterogeneous expression of these factors across both cells and patients
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.06.547955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Protocol to assess RNA-RNA interactions in situ using an RNA-proximity ligation assay.

    Basavappa, Megha G / Henao-Mejia, Jorge / Cherry, Sara

    STAR protocols

    2022  Volume 3, Issue 4, Page(s) 101892

    Abstract: Here, we describe a protocol to assess RNA-RNA interactions in situ using an adapted proximity ligation assay (PLA). We detail steps to perform RNA-probe hybridization, in situ rolling circle amplification, and immunofluorescence confocal microscopy. ... ...

    Abstract Here, we describe a protocol to assess RNA-RNA interactions in situ using an adapted proximity ligation assay (PLA). We detail steps to perform RNA-probe hybridization, in situ rolling circle amplification, and immunofluorescence confocal microscopy. With these tools, it is possible to detect and characterize the intracellular localization of interacting RNA pairs using small cell numbers. This protocol provides a targeted approach to understanding RNA-RNA interactions in intact cells that can complement other established deep-sequencing-based approaches. For complete details on the use and execution of this protocol, please refer to Basavappa et al. (2022).
    MeSH term(s) RNA/genetics
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101892
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  9. Article ; Online: Editorial overview: Viruses in a changing world.

    Jurado, Kellie Ann / Cherry, Sara

    Current opinion in virology

    2020  Volume 40, Page(s) iii–iv

    MeSH term(s) Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/virology ; Humans ; Virus Diseases/epidemiology ; Virus Diseases/virology ; Virus Physiological Phenomena ; Viruses/genetics
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country Netherlands
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2020.07.017
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  10. Article ; Online: Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome.

    Cherry, Sara / Lynch, Kristen W

    Genes & development

    2020  Volume 34, Issue 15-16, Page(s) 1005–1016

    Abstract: Over the past decade there has been increased awareness of the potential role of alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing technology and analysis has led to a wave of discoveries in the last few years ... ...

    Abstract Over the past decade there has been increased awareness of the potential role of alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing technology and analysis has led to a wave of discoveries in the last few years regarding the causes and functional relevance of alternative splicing in cancer. Here we discuss the current understanding of the connections between splicing and cancer, with a focus on the most recent findings. We also discuss remaining questions and challenges that must be addressed in order to use our knowledge of splicing to guide the diagnosis and treatment of cancer.
    MeSH term(s) Alternative Splicing ; Humans ; Mutation ; Neoplasms/genetics ; RNA Splicing Factors/metabolism ; Transcriptome
    Chemical Substances RNA Splicing Factors
    Language English
    Publishing date 2020-05-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.338962.120
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