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Book: Imaging in arthritis

Østergaard, Mikkel / McQueen, Fiona M.

(Best practice & research : Clinical rheumatology ; 26,6)

2012

Author's details	Mikkel Østergaard ; Fiona M. McQueen
Series title	Best practice & research : Clinical rheumatology ; 26,6 Best practice & research Best practice & research ; Clinical rheumatology
Collection	Best practice & research Best practice & research ; Clinical rheumatology
Language	English
Size	S. 743 - 867 : Ill.
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book
HBZ-ID	HT017518452
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Rheumatology around the world: perspectives from Australia and New Zealand.

McQueen, Fiona M F

Arthritis research & therapy

2017 Volume 19, Issue 1, Page(s) 24

Abstract: Rheumatology continues to be an exciting and vibrant specialty for specialists practising in New Zealand and Australia. Clinicians follow treat-to-target regimens to manage peripheral and axial inflammatory arthritides using conventional and biological ... ...

Abstract	Rheumatology continues to be an exciting and vibrant specialty for specialists practising in New Zealand and Australia. Clinicians follow treat-to-target regimens to manage peripheral and axial inflammatory arthritides using conventional and biological agents, which have revolutionised management of rheumatic disease over the past two decades. However, optimal clinical practice has significant pharmacoeconomic implications which impact on health funding at a national level, and the advent of biosimilars is keenly awaited. The management of non-inflammatory rheumatic disease and the lack of effective disease-suppressing pharmacologic therapy for osteoarthritis continue to challenge clinicians. We are fortunate in having world-class rheumatology research in our region with basic scientists and clinical rheumatologists spearheading investigations, the ultimate aim of which is to improve the quality of life for our patients.
MeSH term(s)	Australia ; Female ; Humans ; Male ; New Zealand ; Rheumatic Diseases/therapy ; Rheumatology/methods ; Rheumatology/statistics & numerical data ; Rheumatology/trends
Language	English
Publishing date	2017-02-10
Publishing country	England
Document type	Editorial
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-017-1246-8
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Article ; Online: Contemporary imaging of rheumatoid arthritis: Clinical role of ultrasound and MRI.

Ranganath, Veena K / Hammer, Hilde B / McQueen, Fiona M

Best practice & research. Clinical rheumatology

2020 Volume 34, Issue 6, Page(s) 101593

Abstract: Magnetic resonance imaging (MRI) and musculoskeletal ultrasound (MSUS) are sensitive imaging modalities used by clinicians to assist in decision-making in the management of rheumatoid arthritis (RA). This review will examine the utility of MRI and MSUS ... ...

Abstract	Magnetic resonance imaging (MRI) and musculoskeletal ultrasound (MSUS) are sensitive imaging modalities used by clinicians to assist in decision-making in the management of rheumatoid arthritis (RA). This review will examine the utility of MRI and MSUS in diagnosing RA, predicting RA flares, tapering therapy, assessing remission, and examining difficult periarticular features. We will also outline the strengths and weaknesses of utilizing MRI and MSUS as outcome measures in the management of RA.
MeSH term(s)	Arthritis, Rheumatoid/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Ultrasonography
Language	English
Publishing date	2020-09-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2052323-3
ISSN	1532-1770 ; 1521-6942
ISSN (online)	1532-1770
ISSN	1521-6942
DOI	10.1016/j.berh.2020.101593
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Article ; Online: MRI in rheumatoid arthritis: a useful tool for the clinician?

McQueen, Fiona M

Postgraduate medical journal

2014 Volume 90, Issue 1064, Page(s) 332–339

Abstract: Over the last two decades, MRI has emerged as an important clinical tool to assist in the diagnosis and management of rheumatic disease. In rheumatoid arthritis (RA), MRI has improved our understanding of the pathological basis of disease and has ... ...

Abstract	Over the last two decades, MRI has emerged as an important clinical tool to assist in the diagnosis and management of rheumatic disease. In rheumatoid arthritis (RA), MRI has improved our understanding of the pathological basis of disease and has provided new information about imaging features that reflect joint inflammation and damage. Using MRI, we can now directly observe inflammation involving the synovial membrane and tenosynovium, plus joint damage including bone erosion and cartilage thinning. Inflammation of bone beneath the joint (osteitis) appears as bone oedema which is a feature unique to MRI and yields important diagnostic and prognostic information in patients with inflammatory arthritis. With the introduction of biologics to rheumatology clinical practice, sensitive tools are required to monitor disease activity and progression, so that the disease suppressing effect of these new agents can be measured. MRI fits the bill for this role as it can inform the clinician about the development of bone erosions well before plain radiography, and its ability to reveal cartilage damage is emerging. The use of MRI as a marker of outcome in clinical trials is being paralleled by its increasing role in the clinic. Both extremity and high field MRI have clinical applications in RA and need to be considered along with other advanced imaging techniques as useful tools to add to the clinician's armamentarium. This review will summarise recent advances in this field and will apply current knowledge to specific clinical scenarios relevant to modern rheumatology practice.
MeSH term(s)	Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/pathology ; Disease Progression ; Edema/pathology ; Female ; Humans ; Magnetic Resonance Imaging/trends ; Male ; Osteitis/pathology ; Prognosis ; Reproducibility of Results ; Severity of Illness Index ; Synovitis/pathology
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2014-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80325-x
ISSN	1469-0756 ; 0032-5473
ISSN (online)	1469-0756
ISSN	0032-5473
DOI	10.1136/postgradmedj-2013-132121
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Article ; Online: Gout in 2013. Imaging, genetics and therapy: gout research continues apace.

McQueen, Fiona M

Nature reviews. Rheumatology

2013 Volume 10, Issue 2, Page(s) 67–69

Abstract: In 2013, much progress has occurred in gout research. Imaging continues to help elucidate aspects of pathophysiology and now suggests that healing of erosions could occur when urate levels are reduced dramatically. New genetic loci associated with ... ...

Abstract	In 2013, much progress has occurred in gout research. Imaging continues to help elucidate aspects of pathophysiology and now suggests that healing of erosions could occur when urate levels are reduced dramatically. New genetic loci associated with hyperuricaemia have been identified and management strategies for prophylaxis of gout flares continue to evolve.
MeSH term(s)	Biomedical Research/trends ; Diagnostic Imaging/methods ; Genetic Predisposition to Disease/genetics ; Gout/diagnosis ; Gout/drug therapy ; Gout/genetics ; Gout Suppressants/therapeutic use ; Humans
Chemical Substances	Gout Suppressants
Language	English
Publishing date	2013-11-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2491532-4
ISSN	1759-4804 ; 1759-4790
ISSN (online)	1759-4804
ISSN	1759-4790
DOI	10.1038/nrrheum.2013.164
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Article ; Online: Imaging in early rheumatoid arthritis.

McQueen, Fiona M

Best practice & research. Clinical rheumatology

2013 Volume 27, Issue 4, Page(s) 499–522

Abstract: Imaging in early rheumatoid arthritis (RA) has undergone extraordinary change in recent years and new techniques are now available to help the clinician diagnose and manage patients much more effectively than previously. While established modalities such ...

Abstract	Imaging in early rheumatoid arthritis (RA) has undergone extraordinary change in recent years and new techniques are now available to help the clinician diagnose and manage patients much more effectively than previously. While established modalities such as plain radiography (X-Ray) remain important, especially for detection of erosions and determining the progression of joint damage, there are many instances where ultrasound (US), magnetic resonance imaging (MRI) and computed tomography (CT) scanning provide added information. MRI and US are now used regularly by clinicians to help diagnose RA in the pre-radiographic stage as they offer improved visualisation of joint erosions. They also have the potential to provide prognostic information as MRI bone oedema/osteitis is linked to the later development of erosions and power Doppler ultrasound (PDUS) joint positivity is also a predictor of joint damage. Nuclear imaging techniques such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) are also highly sensitive for detecting joint change in early RA and pre-RA but not yet used clinically mainly because of accessibility and radiation exposure. MRI, US, scintigraphy, SPECT and PET have all been shown to detect sub-clinical joint inflammation in patients in clinical remission, a state that is now the goal of most treat-to-target management strategies. Thus, imaging may be used to direct therapeutic decision making and MRI is also now being used in clinical trials to determine the impact of disease-suppressing therapy on the course of synovitis and osteitis. As is the case for all tests, it would be unwise to rely completely on any one imaging result, as false positives and negatives can occur for all modalities. Thus, the clinician needs to choose the most relevant and reliable imaging test, while also striving to minimise patient discomfort, radiation burden and economic impact.
MeSH term(s)	Arthritis, Rheumatoid/diagnosis ; Diagnostic Imaging/methods ; Disease Progression ; Humans ; Joints/pathology ; Prognosis
Language	English
Publishing date	2013-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2052323-3
ISSN	1532-1770 ; 1521-6942
ISSN (online)	1532-1770
ISSN	1521-6942
DOI	10.1016/j.berh.2013.09.005
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Article ; Online: Bone marrow edema and osteitis in rheumatoid arthritis: the imaging perspective.

McQueen, Fiona M

Arthritis research & therapy

2012 Volume 14, Issue 5, Page(s) 224

Abstract: Magnetic resonance imaging bone marrow edema is an imaging feature that has been described in many conditions, including osteomyelitis, overuse syndromes, avascular necrosis, trauma, and inflammatory arthritides. In rheumatoid arthritis (RA), bone edema ... ...

Abstract	Magnetic resonance imaging bone marrow edema is an imaging feature that has been described in many conditions, including osteomyelitis, overuse syndromes, avascular necrosis, trauma, and inflammatory arthritides. In rheumatoid arthritis (RA), bone edema has special significance as it has been shown to be a common and widespread lesion that is often apparent at the hands and wrists but has also been described elsewhere, including the feet. It may occur in early or late disease and has been shown in several large cohort studies to have major negative implications for prognosis. It is the strongest predictor of erosive progression yet to be identified and characteristically occurs in those patients with the most aggressive and potentially disabling disease. In patients with undifferentiated arthritis, bone edema also predicts progression to criteria-positive RA, both independently and to a greater extent when combined with anti-cyclic citrullinated peptide status or rheumatoid factor positivity. Its histological correlate in the late stages of RA has been shown to be osteitis, in which the bone marrow beneath the joint is invaded by an inflammatory and vascular lymphoplasmacytic infiltrate. This lies adjacent to trabecular bone, where increased numbers of osteoclasts have been observed within resorption lacunae, suggesting a mechanistic link between inflammation and erosive bone damage. This could lead to erosion both of the overlying cortex, leading to classic radiographic rheumatoid erosions, and of local trabecular bone, possibly contributing to periarticular osteopenia and cyst formation. In addition to synovitis, osteitis is now regarded as a major rheumatoid lesion that is responsive to therapeutic intervention.
MeSH term(s)	Arthritis, Rheumatoid/diagnosis ; Bone Marrow Diseases/diagnosis ; Diagnostic Imaging/methods ; Diagnostic Imaging/trends ; Disease Progression ; Edema/diagnosis ; Humans ; Magnetic Resonance Imaging ; Osteitis/diagnosis ; Radiography ; Ultrasonography
Language	English
Publishing date	2012-09-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/ar4035
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Article ; Online: The psychological impact of paediatric burn injuries: a systematic review.

Woolard, Alix / Hill, Nicole T M / McQueen, Matthew / Martin, Lisa / Milroy, Helen / Wood, Fiona M / Bullman, Indijah / Lin, Ashleigh

BMC public health

2021 Volume 21, Issue 1, Page(s) 2281

Abstract: Objective: To review and synthesise qualitative literature regarding the psychological outcomes following paediatric burn injuries, and to determine if children and adolescents who experience a burn injury have elevated risk of psychopathology following ...

Abstract	Objective: To review and synthesise qualitative literature regarding the psychological outcomes following paediatric burn injuries, and to determine if children and adolescents who experience a burn injury have elevated risk of psychopathology following the injury. Design: Systematic review of quantitative and qualitative studies. Data sources: Informit health, Medline, Embase, and PsycINFO were searched from January 2010 to December 2020. Data extraction and synthesis: Two reviewers screened articles, and one reviewer extracted data (with cross-checking from another reviewer) from the included studies and assessed quality using an established tool. Narrative synthesis was used to synthesise the findings from the quantitative studies, and thematic synthesis was used to synthesise the findings of included qualitative studies. Results: Searches yielded 1240 unique titles, with 130 retained for full-text screening. Forty-five studies from 17 countries were included. The psychological outcomes included in the studies were mental health diagnoses, medication for mental illness, depression, anxiety, stress, fear, post-traumatic stress, post-traumatic growth, emotional issues, self-harm, self-esteem, self-concept, stigmatisation, quality of life, level of disability, resilience, coping, and suicidality. Conclusions: Our findings highlight paediatric burn patients as a particularly vulnerable population following a burn injury. Studies suggest elevated anxiety and traumatic stress symptoms, and higher rates of psychopathology in the long-term. Further research is recommended to determine the psychological outcomes in the other mental health domains highlighted in this review, as findings were mixed. Clinical care teams responsible for the aftercare of burn patients should involve psychological support for the children and families to improve outcomes.
MeSH term(s)	Adolescent ; Anxiety ; Anxiety Disorders ; Burns/therapy ; Child ; Humans ; Mental Health ; Quality of Life
Language	English
Publishing date	2021-12-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-021-12296-1
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Article ; Online: Qualitative study: the experience and impact of living with Behcet's syndrome.

Tai, Vicky / Lindsay, Karen / Sims, Joanne L / McQueen, Fiona M

The New Zealand medical journal

2017 Volume 130, Issue 1462, Page(s) 27–36

Abstract: Aim: Behcet's syndrome is a rare chronic multisystemic vasculitis of unknown aetiology, is unpredictable and can cause life-threatening complications. This qualitative study aims to explore the experiences of patients living with Behcet's syndrome in ... ...

Abstract	Aim: Behcet's syndrome is a rare chronic multisystemic vasculitis of unknown aetiology, is unpredictable and can cause life-threatening complications. This qualitative study aims to explore the experiences of patients living with Behcet's syndrome in New Zealand. Methods: Eight English-speaking patients participated in in-depth semi-structured interviews about their experiences of living with Behcet's syndrome. Interviews were recorded and transcribed. Data were analysed using a general inductive thematic approach. Results: Five themes related to the experience of Behcet's syndrome emerged from the interviews: diagnosis (diagnostic challenge and closure), impact of disease (pain, fatigue, reduced vision, fear and uncertainty), loneliness and isolation (lack of support and information, invisible illness), acquiring resilience (coping, gaining sense of control, support group) and ongoing interactions with health system (specialist care, primary care, need for multidisciplinary care, doctor-patient relationship). Conclusions: Behcet's syndrome patients experience difficulties in obtaining a timely and correct diagnosis and contend numerous physical and emotional challenges, often experiencing loneliness and isolation. Establishing trusting doctor-patient relationships, allowing timely access to specialist care and recruiting psychosocial supports will help patients better cope with their illness. Diagnosis and management of Behcet's syndrome requires close collaboration and communication among specialists and general practitioners and improved education on Behcet's syndrome.
MeSH term(s)	Adaptation, Psychological ; Adult ; Aged ; Behcet Syndrome/diagnosis ; Behcet Syndrome/physiopathology ; Behcet Syndrome/psychology ; Fatigue/etiology ; Fear ; Female ; Humans ; Interdisciplinary Communication ; Interviews as Topic ; Male ; Middle Aged ; New Zealand ; Pain/etiology ; Physician-Patient Relations ; Qualitative Research ; Social Isolation ; Vision, Low/etiology ; Young Adult
Language	English
Publishing date	2017-09-22
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	390590-1
ISSN	1175-8716 ; 0028-8446 ; 0110-7704
ISSN (online)	1175-8716
ISSN	0028-8446 ; 0110-7704
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Article ; Online: The MRI view of synovitis and tenosynovitis in inflammatory arthritis: implications for diagnosis and management.

McQueen, Fiona M

Annals of the New York Academy of Sciences

2009 Volume 1154, Page(s) 21–34

Abstract: MRI scanning is the current gold standard modality for imaging synovitis and tenosynovitis in patients with inflammatory arthritis. Inflamed synovial membrane within the joints and investing tendon sheaths appears thickened on T1-weighted sequences and ... ...

Abstract	MRI scanning is the current gold standard modality for imaging synovitis and tenosynovitis in patients with inflammatory arthritis. Inflamed synovial membrane within the joints and investing tendon sheaths appears thickened on T1-weighted sequences and enhances postcontrast. On T2-weighted sequences, synovitis and synovial effusions typically show a high signal. Studies have shown correlations between the degree of inflammation and vascularity of synovium obtained at biopsy and postcontrast enhancement on matching dynamic MRI scans. Scoring systems have been devised that are based on quantifying synovial membrane thickening and signal intensity on static postcontrast scans and have been validated in multireader settings. Moderate to high reliability has been demonstrated with trained readers and quantification of synovitis in this way is being used increasingly as an outcome measure in clinical trials to assess response to therapy. MRI-observed synovitis is almost invariable in those with active rheumatoid arthritis, but recent studies have also demonstrated its presence in patients in clinical remission, emphasizing the sensitivity of this technique and the importance of subclinical joint inflammation. MRI-observed synovitis has been validated against other imaging modalities, including power Doppler ultrasound, and has also been investigated in normal subjects (where mild enhancement can rarely occur). Studies over 1-2 years have suggested that MRI synovial membrane volume and postcontrast enhancement on dynamic imaging can predict the development of erosions. In the long term, an overall score of inflammation incorporating synovitis, tenosynovitis, and bone edema may be a more useful MRI predictor of aggressive erosive disease.
MeSH term(s)	Animals ; Arthritis/complications ; Humans ; Inflammation/complications ; Magnetic Resonance Imaging ; Sensitivity and Specificity ; Synovitis/complications ; Synovitis/diagnosis ; Synovitis/pathology ; Synovitis/therapy ; Tenosynovitis/complications ; Tenosynovitis/diagnosis ; Tenosynovitis/therapy
Language	English
Publishing date	2009-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1111/j.1749-6632.2009.04382.x
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