LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 31

Search options

  1. Article ; Online: Glucagon secretion and its association with glycaemic control and ketogenesis during sodium-glucose cotransporter 2 inhibition by ipragliflozin in people with type 1 diabetes: Results from the multicentre, open-label, prospective study.

    Nakamura, Yuta / Horie, Ichiro / Kitamura, Tadahiro / Kusunoki, Yoshiki / Nishida, Kenro / Yamamoto, Akane / Hirota, Yushi / Fukui, Tomoyasu / Maeda, Yasutaka / Minami, Masae / Matsui, Takanori / Kawakami, Atsushi / Abiru, Norio

    Diabetes, obesity & metabolism

    2024  Volume 26, Issue 5, Page(s) 1605–1614

    Abstract: Aim: Clinical trials showed the efficacy of sodium-glucose cotransporter 2 inhibitors for type 1 diabetes (T1D) by significant reductions in body weight and glycaemic variability, but elevated susceptibility to ketoacidosis via elevated glucagon ... ...

    Abstract Aim: Clinical trials showed the efficacy of sodium-glucose cotransporter 2 inhibitors for type 1 diabetes (T1D) by significant reductions in body weight and glycaemic variability, but elevated susceptibility to ketoacidosis via elevated glucagon secretion was a potential concern. The Suglat-AID evaluated glucagon responses and its associations with glycaemic control and ketogenesis before and after T1D treatment with the sodium-glucose cotransporter 2 inhibitor, ipragliflozin.
    Methods: Adults with T1D (n = 25) took 50-mg open-labelled ipragliflozin daily as adjunctive to insulin. Laboratory/clinical data including continuous glucose monitoring were collected until 12 weeks after the ipragliflozin initiation. The participants underwent a mixed-meal tolerance test (MMTT) twice [before (first MMTT) and 12 weeks after ipragliflozin treatment (second MMTT)] to evaluate responses of glucose, C-peptide, glucagon and β-hydroxybutyrate.
    Results: The area under the curve from fasting (0 min) to 120 min (AUC
    Conclusions: Ipragliflozin treatment for T1D increased postprandial glucagon secretion, which did not exacerbate postprandial hyperglycaemia but might protect against hypoglycaemia, leading to reduced glycaemic variability. The increased glucagon secretion might accelerate ketogenesis when adequate insulin is not supplied.
    MeSH term(s) Adult ; Humans ; 3-Hydroxybutyric Acid ; Blood Glucose ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/drug therapy ; Glucagon/metabolism ; Glucose ; Glucosides ; Glycemic Control ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/pharmacology ; Insulin/therapeutic use ; Prospective Studies ; Thiophenes
    Chemical Substances 3-Hydroxybutyric Acid (TZP1275679) ; Blood Glucose ; Glucagon (9007-92-5) ; Glucose (IY9XDZ35W2) ; Glucosides ; Hypoglycemic Agents ; Insulin ; ipragliflozin (3N2N8OOR7X) ; Thiophenes
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15458
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Novel Imaging of Hypoglycemia-induced Myocardial Abnormality by Cardiac Magnetic Resonance T1-mapping.

    Nakade, Taisuke / Sumida, Hitoshi / Katahira, Kazuhiro / Nishida, Kenro

    Internal medicine (Tokyo, Japan)

    2017  

    Language English
    Publishing date 2017-10-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.8889-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Short 5' Untranslated Region Enables Optimal Translation of Plant Virus Tricistronic RNA via Leaky Scanning.

    Fujimoto, Yuji / Keima, Takuya / Hashimoto, Masayoshi / Hagiwara-Komoda, Yuka / Hosoe, Naoi / Nishida, Shuko / Nijo, Takamichi / Oshima, Kenro / Verchot, Jeanmarie / Namba, Shigetou / Yamaji, Yasuyuki

    Journal of virology

    2022  Volume 96, Issue 7, Page(s) e0214421

    Abstract: Regardless of the general model of translation in eukaryotic cells, a number of studies suggested that many mRNAs encode multiple proteins. Leaky scanning, which supplies ribosomes to downstream open reading frames (ORFs) by readthrough of upstream ORFs, ...

    Abstract Regardless of the general model of translation in eukaryotic cells, a number of studies suggested that many mRNAs encode multiple proteins. Leaky scanning, which supplies ribosomes to downstream open reading frames (ORFs) by readthrough of upstream ORFs, has great potential to translate polycistronic mRNAs. However, the mRNA elements controlling leaky scanning and their biological relevance have rarely been elucidated, with exceptions such as the Kozak sequence. Here, we have analyzed the strategy of a plant RNA virus to translate three movement proteins from a single RNA molecule through leaky scanning. The
    MeSH term(s) 5' Untranslated Regions/genetics ; Open Reading Frames ; Plant Viruses/genetics ; Protein Biosynthesis/genetics ; RNA Viruses/genetics ; RNA, Messenger/genetics ; RNA, Viral/genetics ; RNA, Viral/metabolism
    Chemical Substances 5' Untranslated Regions ; RNA, Messenger ; RNA, Viral
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.02144-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Unique Evolution of Symbiobacterium thermophilum Suggested from Gene Content and Orthologous Protein Sequence Comparisons

    Kenro Oshima / Kenji Ueda / Teruhiko Beppu / Hiromi Nishida

    International Journal of Evolutionary Biology, Vol

    2011  Volume 2011

    Keywords Genetics ; QH426-470 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Genetics ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Evolutionary mechanisms of microbial genomes 2012.

    Nishida, Hiromi / Kondo, Shinji / Nojiri, Hideaki / Noma, Ken-Ichi / Oshima, Kenro

    International journal of evolutionary biology

    2012  Volume 2012, Page(s) 872768

    Language English
    Publishing date 2012-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2587455-X
    ISSN 2090-052X ; 2090-052X
    ISSN (online) 2090-052X
    ISSN 2090-052X
    DOI 10.1155/2012/872768
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Detection of the genes evolving under Ureaplasma-specific selection.

    Oshima, Kenro / Nishida, Hiromi

    Journal of molecular evolution

    2008  Volume 66, Issue 5, Page(s) 529–532

    Abstract: Mycoplasmas are parasitic bacteria with small genomes. Since parasitic bacteria need to adapt themselves to their hosts, there is a possibility that some genes evolved under species-specific constraint. We assume that Ureaplasma parvum has candidate ... ...

    Abstract Mycoplasmas are parasitic bacteria with small genomes. Since parasitic bacteria need to adapt themselves to their hosts, there is a possibility that some genes evolved under species-specific constraint. We assume that Ureaplasma parvum has candidate genes that evolved in a species-specific manner in its genome. Here we examined synonymous-to-nonsynonymous substitution ratios (omega) of the 143 mycoplasma-orthologous genes of Ureaplasma and other mycoplasmas using branch models. As a result, the model allowing for Ureaplasma branch-specific omega in addition to omega of other mycoplasmas was significantly supported in 16 genes. First, the Ureaplasma-specific model was significantly supported in the genes encoding a transcription elongation factor and a transcription terminator factor, suggesting that transcription-related genes of Ureaplasma have evolved in a unique manner compared to those of other mycoplasmas. Second, the Ureaplasma-specific model was significantly supported in the gene encoding uracil-DNA glycosylase. In addition, the omega value of the gene in the Ureaplasma lineage was approximately 30-fold lower than those of other lineages, suggesting that uracil-DNA glycosylase of Ureaplasma evolved under stronger functional constraint than those of other mycoplasmas. Finally, three glycolytic genes of Ureaplasma were suggested to have evolved under relaxed selection. Among mycoplasmas, only Ureaplasma has urease and synthesizes ATPs via hydrolysis of urea. This raises the possibility that Ureaplasma does not need a glycolysis pathway for ATP synthesis. This unique energy-producing system may be related to the Ureaplasma-specific evolution of the glycolytic genes.
    MeSH term(s) Evolution, Molecular ; Genes, Bacterial/genetics ; Mycoplasma/genetics ; Selection, Genetic ; Ureaplasma/genetics
    Language English
    Publishing date 2008-04-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120148-7
    ISSN 1432-1432 ; 0022-2844
    ISSN (online) 1432-1432
    ISSN 0022-2844
    DOI 10.1007/s00239-008-9106-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1129: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Evolutionary mechanisms of microbial genomes.

    Nishida, Hiromi / Kondo, Shinji / Nojiri, Hideaki / Noma, Ken-Ichi / Oshima, Kenro

    International journal of evolutionary biology

    2011  Volume 2011, Page(s) 319479

    Language English
    Publishing date 2011-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2587455-X
    ISSN 2090-052X ; 2090-052X
    ISSN (online) 2090-052X
    ISSN 2090-052X
    DOI 10.4061/2011/319479
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Phylogenetic relationships among mycoplasmas based on the whole genomic information.

    Oshima, Kenro / Nishida, Hiromi

    Journal of molecular evolution

    2007  Volume 65, Issue 3, Page(s) 249–258

    Abstract: With the rapid increase in available bacterial whole-genome information, comparison of bacteria at the whole-genome level has proven to be highly useful in microbial phylogenetic research. Here we constructed a phylogenetic tree based on 15 whole genomes ...

    Abstract With the rapid increase in available bacterial whole-genome information, comparison of bacteria at the whole-genome level has proven to be highly useful in microbial phylogenetic research. Here we constructed a phylogenetic tree based on 15 whole genomes of Mycoplasma and the related bacteria. First, 143 orthologous gene families that are shared by all of the 15 bacteria were selected and 143 multiple alignments were generated. Next, a concatenated multiple alignment inferred from the 143 multiple alignments was generated. A total of 43,370 amino acid sites were considered in the neighbor-joining analysis. The phylogenetic tree based on the whole-genomic information indicated that the 15 bacteria were divided into four major groups with 100% bootstrap support, i.e., the M. hyopneumoniae (Mhy) group, the M. mycoides (Mmy) group, the M. pneumoniae (Mpn) group, and the Bacillus-Phytoplasma (BP) group. In the phylogenetic tree, the Mhy group was more closely related to the Mpn group than the Mmy group. The relationships among the Mhy, Mmy, Mpn, and BP groups were supported with 100% in bootstrap analysis. The phylogenetic tree based on the whole-genome comparison is different from the 16S rRNA tree. Thirty-nine of the 143 phylogenetic trees had the same type of the topology based on the whole-genome comparison. However, we could not identify a gene family contributing or solely belonging to the topology of the 39 proteins. In this study, we showed that some proteins, such as RpoA, RpoB, RpoC, and RpoD, are not suitable for evolutionary studies on relationships among major groups of mycoplasmas. We also showed that glycolysis-related genes of Ureaplasma have a higher substitution rate than the other bacteria. The phylogenetic approaches at the whole-genome level are very important and will be essential for microbial evolutionary studies.
    MeSH term(s) Genes, Bacterial ; Genetic Variation ; Genome, Bacterial ; Mycoplasma/genetics ; Phylogeny ; Phytoplasma/genetics
    Language English
    Publishing date 2007-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120148-7
    ISSN 1432-1432 ; 0022-2844
    ISSN (online) 1432-1432
    ISSN 0022-2844
    DOI 10.1007/s00239-007-9010-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1129: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Evolutionary Mechanisms of Microbial Genomes 2012

    Hiromi Nishida / Shinji Kondo / Hideaki Nojiri / Ken-ichi Noma / Kenro Oshima

    International Journal of Evolutionary Biology, Vol

    2012  Volume 2012

    Keywords Genetics ; QH426-470 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Genetics ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Comparison of the efficacy and safety of once-daily insulin degludec/insulin aspart (IDegAsp) and long-acting second-generation basal insulin (insulin degludec and insulin glargine 300 units/mL) in insulin-naïve Japanese adults with type 2 diabetes: a pilot, randomized, controlled study.

    Shimoda, Seiya / Sakamoto, Wakana / Hokamura, Ayaka / Matsuo, Yasuto / Sekigami, Taiji / Ichimori, Shinji / Iwashita, Shinsuke / Ishii, Norio / Otsu, Kae / Yoshimura, Ryohei / Nishiyama, Toshihiko / Sakaguchi, Masaji / Nishida, Kenro / Araki, Eiichi

    Endocrine journal

    2019  Volume 66, Issue 8, Page(s) 745–752

    Abstract: To examine the efficacy and safety of once-daily insulin degludec/insulin aspart (IDegAsp) or once-daily second-generation basal insulin analogs (insulin degludec and insulin glargine 300 units/mL) in insulin-naïve Japanese adults with type 2 diabetes in ...

    Abstract To examine the efficacy and safety of once-daily insulin degludec/insulin aspart (IDegAsp) or once-daily second-generation basal insulin analogs (insulin degludec and insulin glargine 300 units/mL) in insulin-naïve Japanese adults with type 2 diabetes in routine clinical practice. A 12-week multicenter, open-label, randomized, pilot study was performed in 52 subjects with type 2 diabetes treated with oral antidiabetic drugs (OADs). Subjects were randomized to once-daily IDegAsp (n = 26) or basal insulin (n = 26). The primary endpoint was percent change in HbA1c from baseline to week 12. Furthermore, it was analyzed post hoc in subgroups stratified by baseline HbA1c. During a follow-up period, percent change in HbA1c was not significantly different between the two groups (p = 0.161). Daily insulin doses and frequency of overall hypoglycemia were also similar in the two groups. In post hoc analyses, once-daily basal insulin was more effective than IDegAsp in subjects with HbA1c more than or equal to 8.5% (p < 0.05); however, in subjects with HbA1c less than 8.5%, once-daily IDegAsp showed a significant improvement in percent change in HbA1c at week 12, compared with basal insulin (p < 0.01). Although there was no apparent difference in the HbA1c-lowering effects between two groups, when compared in subjects with HbA1c less than 8.5%, once-daily IDegAsp showed a significant effect in comparison with once-daily basal insulin. These findings suggest that the baseline HbA1c level might provide the important information for choosing IDegAsp or basal insulin in patients insufficiently controlled with OADs. This trial was registered with UMIN (no. UMIN000035431).
    MeSH term(s) Administration, Oral ; Adult ; Aged ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Delayed-Action Preparations ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Combinations ; Female ; Glycated Hemoglobin A/drug effects ; Glycated Hemoglobin A/metabolism ; Humans ; Insulin Glargine/administration & dosage ; Insulin Glargine/adverse effects ; Insulin, Long-Acting/administration & dosage ; Insulin, Long-Acting/adverse effects ; Japan ; Male ; Middle Aged ; Pilot Projects
    Chemical Substances Blood Glucose ; Delayed-Action Preparations ; Drug Combinations ; Glycated Hemoglobin A ; Insulin, Long-Acting ; insulin degludec, insulin aspart drug combination ; Insulin Glargine (2ZM8CX04RZ) ; insulin degludec (54Q18076QB)
    Language English
    Publishing date 2019-07-12
    Publishing country Japan
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ19-0179
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top