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Article: Hypofractionated Radiotherapy as a Standalone Treatment Modality for Locally Advanced Type B2 Thymoma in an Octogenarian Patient: 45 Gy in 15 Fractions.

Katano, Atsuto / Kasuga, Yuki / Ohira, Shingo / Minamitani, Masanari / Yamashita, Hideomi

2024 Volume 16, Issue 1, Page(s) e51528

Abstract: Thymic epithelial tumors (TETs), particularly type B2 thymomas, are rare neoplasms primarily found in the anterior mediastinum. The current therapeutic approach includes surgery, chemotherapy, and radiotherapy, but there is limited research on ... ...

Abstract	Thymic epithelial tumors (TETs), particularly type B2 thymomas, are rare neoplasms primarily found in the anterior mediastinum. The current therapeutic approach includes surgery, chemotherapy, and radiotherapy, but there is limited research on radiotherapy as a standalone treatment. This case report aims to elucidate the clinical outcomes of hypofractionated radiotherapy as a standalone treatment for locally advanced type B2 thymoma, offering insights into its potential efficacy and role in clinical practice.
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.51528
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Article ; Online: Age-related differences in kinetics during double- and single-leg jumps in boys.

Hioki, Yusuke / Furuhashi, Yuki / Kasuga, Kohsyo / Hayashi, Ryohei

The Journal of sports medicine and physical fitness

2023 Volume 63, Issue 4, Page(s) 550–557

Abstract: Background: Plyometric training, such as single-leg jumps, may be one of the most effective ways to improve a child's jumping and sprinting ability. However, few studies on age-related changes in single-legged jumping ability seem to exist. Therefore, ... ...

Abstract	Background: Plyometric training, such as single-leg jumps, may be one of the most effective ways to improve a child's jumping and sprinting ability. However, few studies on age-related changes in single-legged jumping ability seem to exist. Therefore, the aim of this study was to examine age-related changes in double- and single-leg jump performance. Methods: A total of 143 untrained boys aged 7-15 years performed double-leg counter-movement jump (CMJ) and rebound jump (RJ) and single-leg CMJ (SCMJ) and RJ (SRJ). Jump height (JH), peak vertical ground reaction force (PvGRF), and relative vertical ground reaction force (RvGRF) during CMJ and SCMJ, and RJ-Index, JH, ground contact time (CT), PvGRF, and RvGRF during RJ and SRJ were recorded, and one-way analysis of variance was used to examine differences between age group. Results: JH, PvGRF, and RvGRF of CMJ and SCMJ increased with age with a similar trend (P<0.001). RJ-Index, JH, and PvGRF of RJ and SRJ also increased with age (P<0.001). CT of RJ did not change with age, but SRJ became longer with age (P<0.001). The RvGRF of RJ increased with age (P<0.001), but the RvGRF of SRJ did not change. Conclusions: These results suggest that age-related changes in CMJ among boys aged 7-15 years have similar trends for double- and single-leg jumps. However, age-related changes of RJ differed between double- and single-leg jumps, suggesting that differences in adaptation of relative force exertion may occur.
MeSH term(s)	Male ; Child ; Humans ; Leg ; Plyometric Exercise/methods ; Movement ; Kinetics ; Adaptation, Physiological
Language	English
Publishing date	2023-01-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	410823-1
ISSN	1827-1928 ; 0022-4707
ISSN (online)	1827-1928
ISSN	0022-4707
DOI	10.23736/S0022-4707.22.14569-X
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Article ; Online: A new grading assessment of eosinophilic esophagitis using red dichromatic imaging: A pilot study.

Kuribayashi, Shiko / Hosaka, Hiroko / Tomaru, Shota / Sato, Keigo / Itoi, Yuki / Hashimoto, Yu / Kasuga, Kengo / Tanaka, Hirohio / Takeuchi, Yoji / Uraoka, Toshio

Gastrointestinal endoscopy

2024

Abstract: Background and aims: The endoscopic reference score (EREFS) using white light imaging (WLI) is used for evaluating the severity of findings objectively in patients with eosinophilic esophagitis (EoE). A novel image-enhanced endoscopy, red dichromatic ... ...

Abstract	Background and aims: The endoscopic reference score (EREFS) using white light imaging (WLI) is used for evaluating the severity of findings objectively in patients with eosinophilic esophagitis (EoE). A novel image-enhanced endoscopy, red dichromatic imaging (RDI) can visualize deeper vessels in the gastrointestinal tract, which could assess edema more precise than WLI. Methods: A total of 21 consecutive patients with EoE were prospectively evaluated. Patients were categorized by three grades based on the visibility of vessels with RDI. Clinical features, such as peak eosinophil counts (PEC) and presence of symptoms, were reviewed. Results: There were 10 patients with RDI Grade 0/1, and 11 patients with RDI Grade 2. PEC and the prevalence of heartburn were significantly higher in patients with RDI Grade 2 than in patients with RDI Grade 0/1. Conclusions: The severity of eosinophilic infiltration could be predicted more precisely using RDI than by evaluating with WLI.
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2024.02.007
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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Relationship between peak aortic jet velocity and progression of aortic stenosis in patients undergoing hemodialysis.

Kurasawa, Shimon / Imaizumi, Takahiro / Kondo, Toru / Hishida, Manabu / Okazaki, Masaki / Nishibori, Nobuhiro / Takeda, Yuki / Kasuga, Hirotake / Maruyama, Shoichi

International journal of cardiology

2024 Volume 402, Page(s) 131822

Abstract: Background: The natural history of aortic stenosis (AS) progression, especially before severe AS development, is not well documented. We aimed to investigate the time course of peak aortic jet velocity (Vmax) and AS progression risk according to ... ...

Abstract	Background: The natural history of aortic stenosis (AS) progression, especially before severe AS development, is not well documented. We aimed to investigate the time course of peak aortic jet velocity (Vmax) and AS progression risk according to baseline Vmax, particularly whether there is a Vmax threshold. Methods: In a retrospective multicenter cohort study of patients on hemodialysis with aortic valve calcification, we investigated the time series of Vmax and the relationship between the baseline Vmax and progression to severe AS by analyzing longitudinal echocardiographic data. Results: Among 758 included patients (mean age, 71 years; 65% male), patients with Vmax <1.5, 1.5-1.9, 2.0-2.4, 2.5-2.9, and 3.0-3.9 m/s were 395 (52%), 216 (29%), 85 (11%), 39 (5.1%), and 23 (3.0%), respectively. The Vmax slope was gradual (mean 0.05-0.07 m/s/year) at Vmax <2 m/s, but steeper (mean 0.13-0.21 m/s/year) at Vmax ≥2 m/s. During a median 3.2-year follow-up, 52 (6.9%) patients developed severe AS. While patients with Vmax <2 m/s rarely developed severe AS, the risk of those with Vmax ≥2 m/s increased remarkably with an increasing baseline Vmax; the adjusted incidence rates in patients with Vmax <1.5, 1.5-1.9, 2.0-2.4, 2.5-2.9, and 3.0-3.9 m/s were 0.59, 0.57, 4.25, 13.8, and 56.1 per 100 person-years, respectively; the adjusted hazard ratio per 0.2 m/s increase in the baseline Vmax was 1.49 (95% confidence interval: 1.32-1.68) when Vmax ≥2 m/s. Conclusions: The risk of progression to severe AS increased with the baseline Vmax primarily at ≥2 m/s; a Vmax threshold of 2 m/s was observed.
MeSH term(s)	Humans ; Male ; Aged ; Female ; Cohort Studies ; Retrospective Studies ; Severity of Illness Index ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/epidemiology ; Aortic Valve/diagnostic imaging ; Renal Dialysis/adverse effects
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2024.131822
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Zs.A 1673: Show issues

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Article ; Online: An HIV-infected patient with acute retinal necrosis as immune reconstitution inflammatory syndrome due to varicella-zoster virus.

Hosoda, Tomohiro / Uehara, Yuki / Kasuga, Toshimitsu / Naito, Toshio

AIDS (London, England)

2020 Volume 34, Issue 5, Page(s) 795–796

MeSH term(s)	Acyclovir/administration & dosage ; Administration, Intravenous ; Adult ; Cataract Extraction ; Combined Modality Therapy ; Ganciclovir/administration & dosage ; HIV Infections/complications ; Herpesvirus 3, Human/genetics ; Herpesvirus 3, Human/isolation & purification ; Humans ; Immune Reconstitution Inflammatory Syndrome/diagnosis ; Intravitreal Injections ; Lens Implantation, Intraocular ; Male ; Polymerase Chain Reaction ; Prednisolone/administration & dosage ; Retinal Detachment/prevention & control ; Retinal Necrosis Syndrome, Acute/diagnosis ; Retinal Necrosis Syndrome, Acute/therapy ; Treatment Outcome ; Valacyclovir/administration & dosage
Chemical Substances	Prednisolone (9PHQ9Y1OLM) ; Valacyclovir (MZ1IW7Q79D) ; Ganciclovir (P9G3CKZ4P5) ; Acyclovir (X4HES1O11F)
Language	English
Publishing date	2020-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000002477
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Zs.A 2228: Show issues

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Article ; Online: The relationship between manometric subtype and symptom details in achalasia.

Hosaka, Hiroko / Kuribayashi, Shiko / Kawamura, Osamu / Itoi, Yuki / Sato, Keigo / Hashimoto, Yu / Kasuga, Kengo / Tanaka, Hirohito / Kusano, Motoyasu / Uraoka, Toshio

Esophagus : official journal of the Japan Esophageal Society

2023 Volume 20, Issue 4, Page(s) 761–768

Abstract: Background: Although dysphagia and chest pain are the two most common symptoms in patients with achalasia, the mechanism of evoking symptoms is still unknown. The aim of this study was to reveal the relationship between symptoms and the subtypes of ... ...

Abstract	Background: Although dysphagia and chest pain are the two most common symptoms in patients with achalasia, the mechanism of evoking symptoms is still unknown. The aim of this study was to reveal the relationship between symptoms and the subtypes of achalasia defined by the Chicago classification. Methods: A total of 71consecutive patients with newly diagnosed achalasia were enrolled between March 2009 and December 2017. Esophageal motility was assessed by high-resolution manometry (HRM) with the Chicago classification v 3.0. and esophagograms. Their symptoms were evaluated with structured self-reported questionnaires focused on dysphagia and chest pain. Symptom profiles and radiographic findings according to the manometric subtypes were investigated. Results: Among the total 71 patients, 69 patients (97%) had dysphagia and 39 patients (54%) had chest pain. Regarding dysphagia, type II patients reported dysphagia in the throat the most, while types I and III patients mostly felt it in the epigastrium. Type II patients often felt dysphagia at the time of swallowing (41%), but this was reported in only 8.7% of Type I and 33% of Type III patients (p = 0.02). Concerning chest pain, Type I patients rarely had pain during meals (14%), but more often while sleeping (43%) and in early morning (43%), while type III patients often had pain during meals (67%). Type III patients reported that solid food caused pain more often than other types (I/II/III 0/10/33%, p = 0.09). Conclusions: Detailed symptoms of achalasia, such as its site and timing, varied by subtypes. The status of the esophageal body might induce those differences in symptoms.
MeSH term(s)	Humans ; Esophageal Achalasia/complications ; Esophageal Achalasia/diagnosis ; Deglutition Disorders/etiology ; Retrospective Studies ; Chest Pain/etiology ; Manometry
Language	English
Publishing date	2023-04-24
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2133367-1
ISSN	1612-9067 ; 1612-9059
ISSN (online)	1612-9067
ISSN	1612-9059
DOI	10.1007/s10388-023-01008-w
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Article ; Online: Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.

Adachi, Yuta / Kimura, Ryo / Hirade, Kentaro / Yanase, Shogo / Nishioka, Yuki / Kasuga, Natsumi / Yamaguchi, Rui / Ebi, Hiromichi

Nature cancer

2023 Volume 4, Issue 6, Page(s) 829–843

Abstract: Tumor cells evade targeted drugs by rewiring their genetic and epigenetic networks. Here, we identified that inhibition of MAPK signaling rapidly induces an epithelial-to-mesenchymal transition program by promoting re-localization of an apical-basal ... ...

Abstract	Tumor cells evade targeted drugs by rewiring their genetic and epigenetic networks. Here, we identified that inhibition of MAPK signaling rapidly induces an epithelial-to-mesenchymal transition program by promoting re-localization of an apical-basal polarity protein, Scribble, in oncogene-addicted lung cancer models. Mis-localization of Scribble suppressed Hippo-YAP signaling, leading to YAP nuclear translocation. Furthermore, we discovered that a RAS superfamily protein MRAS is a direct target of YAP. Treatment with KRAS G12C inhibitors induced MRAS expression, which formed a complex with SHOC2, precipitating feedback activation of MAPK signaling. Abrogation of YAP activation or MRAS induction enhanced the efficacy of KRAS G12C inhibitor treatment in vivo. These results highlight a role for protein localization in the induction of a non-genetic mechanism of resistance to targeted therapies in lung cancer. Furthermore, we demonstrate that induced MRAS expression is a key mechanism of adaptive resistance following KRAS G12C inhibitor treatment.
MeSH term(s)	Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Mutation ; Feedback ; Signal Transduction ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/therapeutic use ; ras Proteins/genetics ; ras Proteins/therapeutic use
Chemical Substances	Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; SHOC2 protein, human ; Intracellular Signaling Peptides and Proteins ; KRAS protein, human ; MRAS protein, human ; ras Proteins (EC 3.6.5.2)
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-023-00575-2
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Article ; Online: Number of calcified aortic valve leaflets: natural history and prognostic value in patients undergoing haemodialysis.

Kurasawa, Shimon / Okazaki, Masaki / Imaizumi, Takahiro / Kondo, Toru / Hishida, Manabu / Nishibori, Nobuhiro / Takeda, Yuki / Kasuga, Hirotake / Maruyama, Shoichi

European heart journal. Cardiovascular Imaging

2023 Volume 24, Issue 7, Page(s) 909–920

Abstract: Aims: Aortic valve calcification in aortic sclerosis, a precursor of aortic stenosis (AS), is not always present in all three leaflets; how calcification develops in each leaflet is unknown. We aimed to investigate the natural history of calcification ... ...

Abstract	Aims: Aortic valve calcification in aortic sclerosis, a precursor of aortic stenosis (AS), is not always present in all three leaflets; how calcification develops in each leaflet is unknown. We aimed to investigate the natural history of calcification development in each aortic valve leaflet and the prognostic value of the number of calcified leaflets. Methods and results: In a retrospective multicentre cohort study of patients undergoing haemodialysis without AS, we observed calcification development in each aortic valve leaflet using echocardiography. We investigated the association between the number of calcified leaflets and AS development and mortality using time-to-event analysis. Among the 1507 patients (mean age, 66 years; 66% male) included in the longitudinal echocardiography analysis, 709 (47%) had aortic sclerosis at baseline: one-leaflet calcified, 370 (52%); two-leaflet calcified, 215 (30%); and three-leaflet calcified, 124 (17%). The median time for one calcified leaflet increase was 3-4 years, and 251 (17%) patients developed AS during a median 3.2-year follow-up. The increased number of calcified aortic valve leaflets was associated with developing AS; compared with that of one-leaflet calcified, the adjusted hazard ratios (aHRs) [95% confidence intervals (CIs)] of two- and three-leaflet calcified were 2.12 (1.49-3.00) and 4.43 (3.01-6.52), respectively; the aHR (95% CI) per one calcified leaflet increase was 2.24 (1.96-2.55). It was also associated with all-cause mortality; the aHR (95% CI) per one calcified leaflet increase was 1.18 (1.08-1.27). Conclusion: The number of calcified aortic valve leaflets strongly predicted AS development and even mortality in patients undergoing haemodialysis, suggesting the usefulness of assessing calcification for each valve leaflet separately using echocardiography.
MeSH term(s)	Humans ; Male ; Aged ; Female ; Aortic Valve/diagnostic imaging ; Aortic Valve/pathology ; Cohort Studies ; Prognosis ; Sclerosis/pathology ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/pathology ; Aortic Diseases/pathology ; Renal Dialysis
Language	English
Publishing date	2023-02-23
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jead020
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Article ; Online: Unravelling the dissolution mechanism of polyphosphate glasses by

Avila Salazar, Dahiana A / Bellstedt, Peter / Miura, Atsuhiro / Oi, Yuki / Kasuga, Toshihiro / Brauer, Delia S

Dalton transactions (Cambridge, England : 2003)

2021 Volume 50, Issue 11, Page(s) 3966–3978

Abstract: Phosphate glass dissolution can be tailored via compositional and subsequent structural changes, which is of interest for biomedical applications such as therapeutic ion delivery. Here, solid- ... ...

Abstract	Phosphate glass dissolution can be tailored via compositional and subsequent structural changes, which is of interest for biomedical applications such as therapeutic ion delivery. Here, solid-state
Language	English
Publishing date	2021-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d0dt03381b
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Article ; Online: Early Rectal Cancer With Submucosal Infiltration: When to Avoid Cold Snare Polypectomy for <1 cm Lesions?

Xing, Yujin / Hosaka, Hiroko / Tanaka, Hirohito / Kasuga, Kengo / Nakata, Ko / Itoi, Yuki / Hashimoto, Yu / Kuribayashi, Shiko / Uraoka, Toshio

The American journal of gastroenterology

2022 Volume 117, Issue 11, Page(s) 1733

MeSH term(s)	Humans ; Colonic Polyps/surgery ; Colonic Polyps/pathology ; Colonoscopy ; Intestinal Polyps/surgery ; Intestinal Polyps/pathology ; Colorectal Neoplasms ; Rectal Neoplasms/surgery
Language	English
Publishing date	2022-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000001902
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