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  1. Book: The astonishing hypothesis

    Crick, Francis

    the scientific search for the soul

    1994  

    Author's details Francis Crick
    Keywords Consciousness ; Neural Pathways ; Visual Perception
    Language English
    Size XIV, 317 S. : Ill., graph. Darst.
    Publisher Charles Scribner's sons u.a.
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT006262997
    ISBN 0-684-19431-7 ; 978-0-684-19431-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 2062 order for loan Magazin

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  2. Article ; Online: LdtC Is a Key l,d-Transpeptidase for Peptidoglycan Assembly in Mycobacterium smegmatis.

    Francis, Zanah K / Sanders, Akeisha N / Crick, Dean C / Mahapatra, Sebabrata / Islam, M Nurul / Pavelka, Martin S

    Journal of bacteriology

    2022  Volume 205, Issue 1, Page(s) e0042422

    Abstract: The peptidoglycan of mycobacteria has two types of direct cross-links, classical 4-3 cross-links that occur between diaminopimelate (DAP) and alanine residues, and nonclassical 3-3 cross-links that occur between DAP residues on adjacent peptides. The 3-3 ...

    Abstract The peptidoglycan of mycobacteria has two types of direct cross-links, classical 4-3 cross-links that occur between diaminopimelate (DAP) and alanine residues, and nonclassical 3-3 cross-links that occur between DAP residues on adjacent peptides. The 3-3 cross-links are synthesized by the concerted action of d,d-carboxypeptidases and l,d-transpeptidases (Ldts). Mycobacterial genomes encode several Ldt proteins that can be classified into six classes based upon sequence identity. As a group, the Ldt enzymes are resistant to most β-lactam antibiotics but are susceptible to carbapenem antibiotics, with the exception of LdtC, a class 5 enzyme. In previous work, we showed that loss of LdtC has the greatest effect on the carbapenem susceptibility phenotype of Mycobacterium smegmatis (also known as Mycolicibacterium smegmatis) compared to other
    MeSH term(s) Peptidyl Transferases/genetics ; Peptidyl Transferases/chemistry ; Peptidyl Transferases/metabolism ; Mycobacterium smegmatis/metabolism ; Peptidoglycan/metabolism ; Bacterial Proteins/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Mycobacterium ; Carbapenems ; Cell Wall/metabolism
    Chemical Substances Peptidyl Transferases (EC 2.3.2.12) ; Peptidoglycan ; Bacterial Proteins ; Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2022-12-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00424-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Ein irres Unternehmen

    Crick, Francis

    die Doppelhelix und das Abenteuer Molekularbiologie

    1990  

    Title translation What mad pursuit
    Author's details Francis Crick
    Keywords Molecular Biology / personal narratives ; DNA ; Doppelhelix ; Entdeckung
    Subject Wissenschaftliche Entdeckung ; Entdeckungen ; Watson-Crick-Spirale ; Doppelstrang
    Language German
    Size 242 S. : Ill.
    Edition [1. - 7. Tsd.]
    Publisher Piper
    Publishing place München u.a.
    Publishing country Germany
    Document type Book
    Note Aus dem Engl. übers.
    HBZ-ID HT003577067
    ISBN 3-492-03330-X ; 978-3-492-03330-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 B 209 order for loan Magazin

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  4. Article: What is the function of the claustrum?

    Crick, Francis C / Koch, Christof

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2005  Volume 360, Issue 1458, Page(s) 1271–1279

    Abstract: The claustrum is a thin, irregular, sheet-like neuronal structure hidden beneath the inner surface of the neocortex in the general region of the insula. Its function is enigmatic. Its anatomy is quite remarkable in that it receives input from almost all ... ...

    Abstract The claustrum is a thin, irregular, sheet-like neuronal structure hidden beneath the inner surface of the neocortex in the general region of the insula. Its function is enigmatic. Its anatomy is quite remarkable in that it receives input from almost all regions of cortex and projects back to almost all regions of cortex. We here briefly summarize what is known about the claustrum, speculate on its possible relationship to the processes that give rise to integrated conscious percepts, propose mechanisms that enable information to travel widely within the claustrum and discuss experiments to address these questions.
    MeSH term(s) Basal Ganglia/anatomy & histology ; Basal Ganglia/physiology ; Consciousness/physiology ; Humans ; Interneurons/cytology ; Models, Neurological
    Language English
    Publishing date 2005-06-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0962-8436 ; 0080-4622 ; 0264-3839
    ISSN (online) 1471-2970
    ISSN 0962-8436 ; 0080-4622 ; 0264-3839
    DOI 10.1098/rstb.2005.1661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A footnote on allostery.

    Crick, F H C / Wyman, Jeffries

    Journal of molecular biology

    2013  Volume 425, Issue 9, Page(s) 1500–1508

    Abstract: A manuscript on allostery signed by Francis Crick and Jeffries Wyman was sent by Crick to Jacques ...

    Abstract A manuscript on allostery signed by Francis Crick and Jeffries Wyman was sent by Crick to Jacques Monod in 1965. Monod transmitted a copy of the manuscript, upon which he had written several comments, to Jean-Pierre Changeux, then a post-doctoral fellow at the University of California Berkeley in the laboratory of Howard Schachman. Changeux provided a copy to Stuart Edelstein, a graduate student in the same laboratory. The manuscript was never submitted for publication, but Edelstein retained his copy since that time and has edited it for publication in the special issue on allostery. The text emphasized the interpretation of the properties of an allosteric oligomer by characterizing its equivalent monomer. The text also developed the concept of the allosteric range and included a simple equation for calculation of the Hill coefficient from the parameters of the Monod-Wyman-Changeux model.
    MeSH term(s) Allosteric Regulation ; History, 20th Century ; Ligands ; Models, Molecular ; Proteins/history
    Chemical Substances Ligands ; Proteins
    Language English
    Publishing date 2013-05-13
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2013.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Footnote on Allostery

    Crick, F.H.C / Wyman, Jeffries

    Journal of molecular biology. 2013 May 13, v. 425, no. 9

    2013  

    Abstract: A manuscript on allostery signed by Francis Crick and Jeffries Wyman was sent by Crick to Jacques ...

    Abstract A manuscript on allostery signed by Francis Crick and Jeffries Wyman was sent by Crick to Jacques Monod in 1965. Monod transmitted a copy of the manuscript, upon which he had written several comments, to Jean-Pierre Changeux, then a post-doctoral fellow at the University of California Berkeley in the laboratory of Howard Schachman. Changeux provided a copy to Stuart Edelstein, a graduate student in the same laboratory. The manuscript was never submitted for publication, but Edelstein retained his copy since that time and has edited it for publication in the special issue on allostery. The text emphasized the interpretation of the properties of an allosteric oligomer by characterizing its equivalent monomer. The text also developed the concept of the allosteric range and included a simple equation for calculation of the Hill coefficient from the parameters of the Monod-Wyman-Changeux model.
    Keywords equations ; models ; protein conformation ; proteins
    Language English
    Dates of publication 2013-0513
    Size p. 1500-1508.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2013.03.012
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  7. Article: A framework for consciousness.

    Crick, Francis / Koch, Christof

    Nature neuroscience

    2003  Volume 6, Issue 2, Page(s) 119–126

    Abstract: Here we summarize our present approach to the problem of consciousness. After an introduction outlining our general strategy, we describe what is meant by the term 'framework' and set it out under ten headings. This framework offers a coherent scheme for ...

    Abstract Here we summarize our present approach to the problem of consciousness. After an introduction outlining our general strategy, we describe what is meant by the term 'framework' and set it out under ten headings. This framework offers a coherent scheme for explaining the neural correlates of (visual) consciousness in terms of competing cellular assemblies. Most of the ideas we favor have been suggested before, but their combination is original. We also outline some general experimental approaches to the problem and, finally, acknowledge some relevant aspects of the brain that have been left out of the proposed framework.
    MeSH term(s) Action Potentials/physiology ; Animals ; Cerebral Cortex/cytology ; Cerebral Cortex/physiology ; Consciousness/physiology ; Humans ; Nerve Net/cytology ; Nerve Net/physiology ; Neural Pathways/cytology ; Neural Pathways/physiology ; Neurons/physiology ; Synaptic Transmission/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2003-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/nn0203-119
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    Zs.A 4891: Show issues Location:
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  8. Article ; Online: Consciousness and neurosurgery.

    Crick, Francis / Koch, Christof / Kreiman, Gabriel / Fried, Itzhak

    Neurosurgery

    2004  Volume 55, Issue 2, Page(s) 273–281; discussion 281–2

    Abstract: The neuronal basis of consciousness is the greatest challenge to the scientific worldview. Much relevant empirical work is carried out on the minimal neuronal mechanisms underlying any one specific conscious percept. Two broad approaches are popular ... ...

    Abstract The neuronal basis of consciousness is the greatest challenge to the scientific worldview. Much relevant empirical work is carried out on the minimal neuronal mechanisms underlying any one specific conscious percept. Two broad approaches are popular among brain scientists: electrophysiological recordings from individual neurons in the cortex of behaving monkeys or behavior combined with functional brain imaging in humans. However, many aspects of consciousness are problematic or remain off-limits to the former approach, while the latter one lacks sufficient spatial and temporal resolution to monitor individual neurons that are key to perception, thought, memory, and action. It is here that neurosurgeons, probing the living human brain on a daily basis, can play a decisive role. This article explores the contributions of neurosurgeons to this quest and outlines some of the results that have already been achieved.
    MeSH term(s) Animals ; Arousal/physiology ; Attention/physiology ; Awareness/physiology ; Brain Mapping ; Cerebral Cortex/physiopathology ; Consciousness/physiology ; Electric Stimulation ; Electroencephalography ; Entorhinal Cortex/physiopathology ; Haplorhini ; Humans ; Imagination/physiology ; Neurons/physiology ; Neurosurgery ; Physician's Role ; Temporal Lobe/physiology ; Visual Cortex/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2004-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/01.neu.0000129279.26534.76
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1424: Show issues Location:
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    Zs.MO 539: Show issues

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  9. Book: Bewusstsein

    Koch, Christof / Crick, Francis / Niehaus, Monika / Wissmann, Jorunn

    ein neurobiologisches Rätsel

    2005  

    Abstract: Das Bewusstsein ist eines der letzten großen ungelösten Rätsel der Wissenschaft - und sicherlich das größte der Biologie. Wir können den salzigen Geschmack von Kartoffel-Chips spüren, den unverkennbaren Geruch von Hunden wahrnehmen, wenn sie im Regen ... ...

    Title translation The quest for consciousness <dt.>
    Author's details Christof Koch. Mit einem Vorw. von Francis Crick. Aus dem Amerikan. übers. von Monika Niehaus-Osterloh und Jorunn Wissmann
    Abstract Das Bewusstsein ist eines der letzten großen ungelösten Rätsel der Wissenschaft - und sicherlich das größte der Biologie. Wir können den salzigen Geschmack von Kartoffel-Chips spüren, den unverkennbaren Geruch von Hunden wahrnehmen, wenn sie im Regen waren, und kennen das besondere Gefühl, wenn man nur an den Fingerkuppen hängend viele Meter über dem sicheren Boden in einer Felswand klettert. Wie können diese Eindrücke aus den Neuronen und den mit ihnen assoziierten Synapsen und molekularen Prozessen entstehen? Ausgehend von umfangreichen anatomischen, physiologischen, klinischen, psychologischen und philosophischen Ansätzen und Daten umreißt dieses anspruchsvolle Sachbuch die wissenschaftliche Grundlage von Bewusstsein, zeigt die Grenzen unseres Wissens auf und beschreibt Versuche, die durchgeführt werden müssen, um dieses Rätsel erfolgreich abzuschließen
    Keywords Neurobiologie ; Gehirn ; Bewusstsein
    Language German
    Size XVII, 448 S., Ill., 25 cm
    Edition 1. Aufl.
    Publisher Elsevier, Spektrum Akad. Verl
    Publishing place München
    Document type Book
    Note Literaturverz. S. [385] - 435
    ISBN 3827415780 ; 9783827415783
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book: Abhandlungen zur Molekulargenetik

    Crick, Francis H. C / Geißler, Erhard / Holley, Robert W / Watson, James D

    (1944 - 1967)

    (Ostwalds Klassiker der exakten Wissenschaften ; 254)

    1996  

    Author's details Francis H. C. Crick .... Hrsg., eingeleitet und kommentiert von E. Geissler
    Series title Ostwalds Klassiker der exakten Wissenschaften ; 254
    Keywords Molekulargenetik
    Language German
    Size 188 S, Ill., graph. Darst, 19 cm
    Edition 2. Aufl
    Publisher Deutsch
    Publishing place Thun u.a.
    Document type Book
    Note Literaturangaben S. 187 - 188
    ISBN 3817132549 ; 9783817132546
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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