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Article ; Online: Rodilla flotante y sus complicaciones

José A. Velutini-Kochen / Ricardo Velutini-Becker / Alejandro G. Gallegos-Tejeda

Anales Médicos, Vol 68, Iss

2023 Volume 2

Abstract: La fractura ipsilateral de fémur y tibia es una lesión rara que suele asociarse a un traumatismo de alta energía; a dicha asociación se le nombra rodilla flotante. En esta lesión, las complicaciones suelen ser frecuentes, como la infección, la embolia ... ...

Abstract	La fractura ipsilateral de fémur y tibia es una lesión rara que suele asociarse a un traumatismo de alta energía; a dicha asociación se le nombra rodilla flotante. En esta lesión, las complicaciones suelen ser frecuentes, como la infección, la embolia grasa, la mala unión, la no unión, la rigidez articular y el dolor residual, por mencionar las más comunes. Presentamos el caso de un paciente que, luego de un accidente en motocicleta, desarrolló una rodilla flotante en el miembro pélvico izquierdo. Fue atendido inicialmente en otro hospital de traumatología, donde le colocaron fijadores externos, retirados cuatro meses después, y, posteriormente, le realizaron una fijación definitiva con clavos centromedulares en fémur y tibia que, igualmente, se extrajeron cinco meses después por la no unión de ambas fracturas. Se retomó el manejo del caso a partir de ese momento, realizando un tratamiento combinado con desbridamiento, aplicación de injerto autólogo y osteosíntesis tanto en el fémur con clavos de Ender, protegida con una placa anatómica, como en la tibia, con una placa de comprensión dinámica. Una vez consolidadas las facturas, el paciente desarrolló una gonartrosis que obligó a colocar dos implantes unicondilares. El paciente, tras nueve años de evolución, tiene arcos de movimiento funcionales, no tiene dolor y puede realizar todo tipo de actividad física.
Keywords	Rodilla flotante. Unicondilar. Artroplastía de rodilla ; Medicine ; R
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Publicaciones Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rodilla flotante y sus complicaciones

JosÃ© A. Velutini-Kochen / Ricardo Velutini-Becker / Alejandro G. Gallegos-Tejeda

Gaceta Médica de México, Vol 68, Iss

2023 Volume 2

Abstract	La fractura ipsilateral de fémur y tibia es una lesión rara que suele asociarse a un traumatismo de alta energía; a dicha asociación se le nombra rodilla flotante. En esta lesión, las complicaciones suelen ser frecuentes, como la infección, la embolia grasa, la mala unión, la no unión, la rigidez articular y el dolor residual, por mencionar las más comunes. Presentamos el caso de un paciente que, luego de un accidente en motocicleta, desarrolló una rodilla flotante en el miembro pélvico izquierdo. Fue atendido inicialmente en otro hospital de traumatología, donde le colocaron fijadores externos, retirados cuatro meses después, y, posteriormente, le realizaron una fijación definitiva con clavos centromedulares en fémur y tibia que, igualmente, se extrajeron cinco meses después por la no unión de ambas fracturas. Se retomó el manejo del caso a partir de ese momento, realizando un tratamiento combinado con desbridamiento, aplicación de injerto autólogo y osteosíntesis tanto en el fémur con clavos de Ender, protegida con una placa anatómica, como en la tibia, con una placa de comprensión dinámica. Una vez consolidadas las facturas, el paciente desarrolló una gonartrosis que obligó a colocar dos implantes unicondilares. El paciente, tras nueve años de evolución, tiene arcos de movimiento funcionales, no tiene dolor y puede realizar todo tipo de actividad física.
Keywords	Rodilla flotante. Unicondilar. ArtroplastÃa de rodilla ; Public aspects of medicine ; RA1-1270 ; Internal medicine ; RC31-1245
Language	English
Publishing date	2023-04-01T00:00:00Z
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Document type	Article ; Online
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Article ; Online: Patient and Surgical Risk Factors for Surgical Site Infection in Lower-Extremity Oncological Endoprosthetic Reconstruction: A Secondary Analysis of the PARITY Trial Data.

Slawaska-Eng, David / Gazendam, Aaron M / Kendal, Joseph / Schneider, Patricia / Becker, Ricardo G / Freitas, Joao Paulo / Bernthal, Nicholas / Ghert, Michelle

The Journal of bone and joint surgery. American volume

2023 Volume 105, Issue Suppl 1, Page(s) 41–48

Abstract: Background: The specific risk factors for surgical site infection (SSI) in orthopaedic oncology patients undergoing endoprosthetic reconstruction have not previously been evaluated in a large prospective cohort. In the current study, we aimed to define ... ...

Abstract	Background: The specific risk factors for surgical site infection (SSI) in orthopaedic oncology patients undergoing endoprosthetic reconstruction have not previously been evaluated in a large prospective cohort. In the current study, we aimed to define patient- and procedure-specific risk factors for SSI in patients who underwent surgical excision and endoprosthetic reconstruction for lower-extremity bone or soft-tissue tumors using the prospectively collected data of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial. Methods: PARITY was a multicenter, blinded, randomized controlled trial with a parallel 2-arm design that aimed to determine the effect of a long duration (5 days) versus short duration (24 hours) of postoperative prophylactic antibiotics on the rate of SSI in patients undergoing surgical excision and endoprosthetic reconstruction of the femur or tibia. In this secondary analysis of the PARITY data, a multivariate Cox proportional hazards regression model was constructed to explore predictors of SSI within 1 year postoperatively. Results: A total of 96 (15.9%) of the 604 patients experienced an SSI. Of the 23 variables analyzed in the univariate analysis, 4 variables achieved significance: preoperative diagnosis, operative time, volume of muscle excised, and hospital length of stay (LOS). However, only hospital LOS was found to be independently predictive of SSI in the multivariate regression analysis (hazard ratio per day = 1.03; 95% confidence interval = 1.01 to 1.05; p < 0.001). An omnibus test of model coefficients demonstrated that the model showed significant improvement over the null model (χ2 = 78.04; p < 0.001). No multicollinearity was found. Conclusions: This secondary analysis of the PARITY study data found that the only independent risk factor for SSI on multivariate analysis was hospital LOS. It may therefore be reasonable for clinicians to consider streamlined discharge plans for orthopaedic oncology patients to potentially reduce the risk of SSI. Level of evidence: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
MeSH term(s)	Humans ; Lower Extremity ; Neoplasms ; Prospective Studies ; Risk Factors ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	220625-0
ISSN	1535-1386 ; 0021-9355
ISSN (online)	1535-1386
ISSN	0021-9355
DOI	10.2106/JBJS.22.01135
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Article ; Online: Dominance of photo over chromatic acclimation strategies by habitat-forming mesophotic red algae.

Voerman, Sofie E / Marsh, Beauregard C / Bahia, Ricardo G / Pereira-Filho, Guilherme H / Becker, Ana Clara F / Amado-Filho, Gilberto M / Ruseckas, Arvydas / Turnbull, Graham A / Samuel, Ifor D W / Burdett, Heidi L

Proceedings. Biological sciences

2023 Volume 290, Issue 2008, Page(s) 20231329

Abstract: ... of photoprotection to 65 m depth, while optimal light levels were met at 86 m. Changes to the light environment (e.g ...

Abstract	Red coralline algae are the deepest living macroalgae, capable of creating spatially complex reefs from the intertidal to 100+ m depth with global ecological and biogeochemical significance. How these algae maintain photosynthetic function under increasingly limiting light intensity and spectral availability is key to explaining their large depth distribution. Here, we investigated the photo- and chromatic acclimation and morphological change of free-living red coralline algae towards mesophotic depths in the Fernando do Noronha archipelago, Brazil. From 13 to 86 m depth, thalli tended to become smaller and less complex. We observed a dominance of the photo-acclimatory response, characterized by an increase in photosynthetic efficiency and a decrease in maximum electron transport rate. Chromatic acclimation was generally stable across the euphotic-mesophotic transition with no clear depth trend. Taxonomic comparisons suggest these photosynthetic strategies are conserved to at least the Order level. Light saturation necessitated the use of photoprotection to 65 m depth, while optimal light levels were met at 86 m. Changes to the light environment (e.g. reduced water clarity) due to human activities therefore places these mesophotic algae at risk of light limitation, necessitating the importance of maintaining good water quality for the conservation and protection of mesophotic habitats.
MeSH term(s)	Humans ; Animals ; Coral Reefs ; Ecosystem ; Photosynthesis ; Rhodophyta ; Acclimatization ; Anthozoa/physiology
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2023.1329
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Article ; Online: Ecosystem engineer morphological traits and taxon identity shape biodiversity across the euphotic-mesophotic transition.

Voerman, Sofie E / Marsh, Beauregard C / Bahia, Ricardo G / Pereira-Filho, Guilherme H / Yee, Thomas W / Becker, Ana Clara F / Amado-Filho, Gilberto M / Ruseckas, Arvydas / Turnbull, Graham A / Samuel, Ifor D W / Burdett, Heidi L

Proceedings. Biological sciences

2022 Volume 289, Issue 1969, Page(s) 20211834

Abstract: The euphotic-mesophotic transition is characterized by dramatic changes in environmental conditions, which can significantly alter the functioning of ecosystem engineers and the structure of their associated communities. However, the drivers of ... ...

Abstract	The euphotic-mesophotic transition is characterized by dramatic changes in environmental conditions, which can significantly alter the functioning of ecosystem engineers and the structure of their associated communities. However, the drivers of biodiversity change across the euphotic-mesophotic transition remain unclear. Here, we investigated the mechanisms affecting the biodiversity-supporting potential of free-living red coralline algae-globally important habitat creators-towards mesophotic depths. Across a 73 m depth gradient, we observed a general decline in macrofaunal biodiversity (fauna abundance, taxon richness and alpha diversity), but an increase in beta-diversity (i.e. variation between assemblages) at the deepest site (86 m depth, where light levels were less than 1% surface irradiance). We identified a gradient in abundance decline rather than distinct ecological shifts, driven by a complex interaction between declining light availability, declining size of the coralline algal host individuals and a changing host taxonomy. However, despite abundance declines, high between-assemblage variability at deeper depths allowed biodiversity-supporting potential to be maintained, highlighting their importance as coastal refugia.
MeSH term(s)	Biodiversity ; Coral Reefs ; Ecosystem ; Humans ; Phenotype ; Refugium
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2021.1834
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Article ; Online: Artificial Intelligence Assistive Software Tool for Automated Detection and Quantification of Amyloid-Related Imaging Abnormalities.

JAMA network open

2024 Volume 7, Issue 2, Page(s) e2355800

Abstract: Importance: Amyloid-related imaging abnormalities (ARIA) are brain magnetic resonance imaging (MRI) findings associated with the use of amyloid-β-directed monoclonal antibody therapies in Alzheimer disease (AD). ARIA monitoring is important to inform ... ...

Abstract	Importance: Amyloid-related imaging abnormalities (ARIA) are brain magnetic resonance imaging (MRI) findings associated with the use of amyloid-β-directed monoclonal antibody therapies in Alzheimer disease (AD). ARIA monitoring is important to inform treatment dosing decisions and might be improved through assistive software. Objective: To assess the clinical performance of an artificial intelligence (AI)-based software tool for assisting radiological interpretation of brain MRI scans in patients monitored for ARIA. Design, setting, and participants: This diagnostic study used a multiple-reader multiple-case design to evaluate the diagnostic performance of radiologists assisted by the software vs unassisted. The study enrolled 16 US Board of Radiology-certified radiologists to perform radiological reading with (assisted) and without the software (unassisted). The study encompassed 199 retrospective cases, where each case consisted of a predosing baseline and a postdosing follow-up MRI of patients from aducanumab clinical trials PRIME, EMERGE, and ENGAGE. Statistical analysis was performed from April to July 2023. Exposures: Use of icobrain aria, an AI-based assistive software for ARIA detection and quantification. Main outcomes and measures: Coprimary end points were the difference in diagnostic accuracy between assisted and unassisted detection of ARIA-E (edema and/or sulcal effusion) and ARIA-H (microhemorrhage and/or superficial siderosis) independently, assessed with the area under the receiver operating characteristic curve (AUC). Results: Among the 199 participants included in this study of radiological reading performance, mean (SD) age was 70.4 (7.2) years; 105 (52.8%) were female; 23 (11.6%) were Asian, 1 (0.5%) was Black, 157 (78.9%) were White, and 18 (9.0%) were other or unreported race and ethnicity. Among the 16 radiological readers included, 2 were specialized neuroradiologists (12.5%), 11 were male individuals (68.8%), 7 were individuals working in academic hospitals (43.8%), and they had a mean (SD) of 9.5 (5.1) years of experience. Radiologists assisted by the software were significantly superior in detecting ARIA than unassisted radiologists, with a mean assisted AUC of 0.87 (95% CI, 0.84-0.91) for ARIA-E detection (AUC improvement of 0.05 [95% CI, 0.02-0.08]; P = .001]) and 0.83 (95% CI, 0.78-0.87) for ARIA-H detection (AUC improvement of 0.04 [95% CI, 0.02-0.07]; P = .001). Sensitivity was significantly higher in assisted reading compared with unassisted reading (87% vs 71% for ARIA-E detection; 79% vs 69% for ARIA-H detection), while specificity remained above 80% for the detection of both ARIA types. Conclusions and relevance: This diagnostic study found that radiological reading performance for ARIA detection and diagnosis was significantly better when using the AI-based assistive software. Hence, the software has the potential to be a clinically important tool to improve safety monitoring and management of patients with AD treated with amyloid-β-directed monoclonal antibody therapies.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Retrospective Studies ; Artificial Intelligence ; Alzheimer Disease/drug therapy ; Amyloid beta-Peptides ; Amyloid ; Software ; Antibodies, Monoclonal/therapeutic use
Chemical Substances	Amyloid beta-Peptides ; Amyloid ; Antibodies, Monoclonal
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.55800
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Article ; Online: Out of Asia? Expansion of Eurasian Lyme borreliosis causing genospecies display unique evolutionary trajectories.

Rollins, Robert E / Sato, Kozue / Nakao, Minoru / Tawfeeq, Mohammed T / Herrera-Mesías, Fernanda / Pereira, Ricardo J / Kovalev, Sergey / Margos, Gabriele / Fingerle, Volker / Kawabata, Hiroki / Becker, Noémie S

Molecular ecology

2022 Volume 32, Issue 4, Page(s) 786–799

Abstract: ... groups (e.g., rodents, birds) including humans where they cause Lyme borreliosis, the most common ...

Abstract	Vector-borne pathogens exist in obligate transmission cycles between vector and reservoir host species. Host and vector shifts can lead to geographic expansion of infectious agents and the emergence of new diseases in susceptible individuals. Three bacterial genospecies (Borrelia afzelii, Borrelia bavariensis, and Borrelia garinii) predominantly utilize two distinct tick species as vectors in Asia (Ixodes persulcatus) and Europe (Ixodes ricinus). Through these vectors, the bacteria can infect various vertebrate groups (e.g., rodents, birds) including humans where they cause Lyme borreliosis, the most common vector-borne disease in the Northern hemisphere. Yet, how and in which order the three Borrelia genospecies colonized each continent remains unclear including the evolutionary consequences of this geographic expansion. Here, by reconstructing the evolutionary history of 142 Eurasian isolates, we found evidence that the ancestors of each of the three genospecies probably have an Asian origin. Even so, each genospecies studied displayed a unique substructuring and evolutionary response to the colonization of Europe. The pattern of allele sharing between continents is consistent with the dispersal rate of the respective vertebrate hosts, supporting the concept that adaptation of Borrelia genospecies to the host is important for pathogen dispersal. Our results highlight that Eurasian Lyme borreliosis agents are all capable of geographic expansion with host association influencing their dispersal; further displaying the importance of host and vector association to the geographic expansion of vector-borne pathogens and potentially conditioning their capacity as emergent pathogens.
MeSH term(s)	Animals ; Humans ; Asia ; Borrelia/genetics ; Borrelia/physiology ; Borrelia burgdorferi Group/genetics ; Borrelia burgdorferi Group/physiology ; Ixodes/microbiology ; Ixodes/physiology ; Lyme Disease/microbiology ; Lyme Disease/transmission ; Europe ; Arachnid Vectors/microbiology ; Arachnid Vectors/physiology ; Animal Distribution/physiology ; Adaptation, Biological/genetics ; Adaptation, Biological/physiology
Language	English
Publishing date	2022-12-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.16805
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Article ; Online: Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.

Sawa, Mariko / Overk, Cassia / Becker, Ann / Derse, Dominique / Albay, Ricardo / Weldy, Kim / Salehi, Ahmad / Beach, Thomas G / Doran, Eric / Head, Elizabeth / Yu, Y Eugene / Mobley, William C

Alzheimer's & dementia : the journal of the Alzheimer's Association

2021 Volume 18, Issue 6, Page(s) 1203–1234

Abstract: Introduction: People with Down syndrome (DS) are predisposed to Alzheimer's disease (AD). The amyloid hypothesis informs studies of AD. In AD-DS, but not sporadic AD, increased APP copy number is necessary, defining the APP gene dose hypothesis. Which ... ...

Abstract	Introduction: People with Down syndrome (DS) are predisposed to Alzheimer's disease (AD). The amyloid hypothesis informs studies of AD. In AD-DS, but not sporadic AD, increased APP copy number is necessary, defining the APP gene dose hypothesis. Which amyloid precursor protein (APP) products contribute needs to be determined. Methods: Brain levels of full-length protein (fl-hAPP), C-terminal fragments (hCTFs), and amyloid beta (Aβ) peptides were measured in DS, AD-DS, non-demented controls (ND), and sporadic AD cases. The APP gene-dose hypothesis was evaluated in the Dp16 model. Results: DS and AD-DS differed from ND and AD for all APP products. In AD-DS, Aβ42 and Aβ40 levels exceeded AD. APP products were increased in the Dp16 model; increased APP gene dose was necessary for loss of vulnerable neurons, tau pathology, and activation of astrocytes and microglia. Discussion: Increases in APP products other than Aβ distinguished AD-DS from AD. Deciphering AD-DS pathogenesis necessitates deciphering which APP products contribute and how.
MeSH term(s)	Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Protein Precursor/genetics ; Animals ; Disease Models, Animal ; Down Syndrome/genetics ; Gene Dosage ; Humans ; Mice
Chemical Substances	Amyloid beta-Peptides ; Amyloid beta-Protein Precursor
Language	English
Publishing date	2021-11-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.12463
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Article ; Online: The (in)visible Brazilians: A perspective review on the need for brain health and dementia research with Brazilian immigrants in the United States.

Alzheimer's & dementia (New York, N. Y.)

2023 Volume 9, Issue 3, Page(s) e12425

Abstract: ... traditional (e.g., PubMed) sources and databases generated by U.S. and Brazilian governments, as well ...

Abstract	Introduction: The Brazilian population in the United States (U.S.), a Latinx subgroup, is rapidly growing and aging but remains underrepresented in U.S. health research. In addition to group-specific genetic and environmental risks, Brazilian immigrants and their offspring in the U.S. likely have cumulative risks for health inequities.It is estimated that 71% of Brazilian immigrants in the U.S. are undocumented, which may limit healthcare access/utilization. Furthermore, mental health is reported as a health priority by Brazilian immigrants in the U.S., and there is a lack of research on Alzheimer's disease and related dementia (AD/ADRD) in this population. Methods: We reviewed the scientific literature using traditional (e.g., PubMed) sources and databases generated by U.S. and Brazilian governments, as well as international organizations, and press articles. Results: This perspective review lists recommendations for researchers, health providers, and policymakers to promote greater inclusion of U.S. Brazilian populations in health research and care. The review identifies research areas in need of attention to address health inequities and promote mental/brain health in Brazilian immigrants and their offspring living in the U.S. These research areas are: 1) epidemiological studies to map the prevalence and incidence of mental/brain health conditions; 2) research on aging and AD/ADRD risk factors among Brazilian populations in the U.S.; and 3) the need for greater representation of U.S-residing Brazilian population in other relevant research areas involving genetics, neuropathology, and clinical trials. Conclusions: The recommendation and research efforts proposed should help to pave the way for the development of community-engagement research and to promote mental/brain health education, improvement of mental/brain health and AD/ADRD services, and the development of culturally-informed intervention to the U.S.-residing Brazilian communities. Highlights: The Brazilian population in the United States is growing but is underrepresented in U.S. health research.Approximately 71% of Brazilian immigrants in the United States are undocumented, with an increased risk for health inequities.Mental health is reported as a central health priority by Brazilian immigrants in the United States.There is a lack of research on Alzheimer's disease and other dementias (ADRD) in Brazilian immigrants in the United States.Epidemiological research is needed to map the prevalence/incidence of mental health conditions and ADRD risk factors among Brazilian immigrants in the United States.
Language	English
Publishing date	2023-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832891-7
ISSN	2352-8737 ; 2352-8737
ISSN (online)	2352-8737
ISSN	2352-8737
DOI	10.1002/trc2.12425
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Article ; Online: Canine parvovirus type 2 (CPV-2) serological and molecular patterns in dogs with viral gastroenteritis from southern Brazil.

Truyen, Lotta Henni / Flores, Rafael Sartori / de Oliveira Santana, Weslei / Abreu, Muriel Becker / Brambatti, Gustavo / Lunge, Vagner Ricardo / Streck, André Felipe

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2024

Abstract: Canine Parvovirus type 2 (CPV-2) is a highly contagious virus that can cause severe systemic disease with gastroenteric symptoms in dogs, particularly in young puppies. Originating from the feline parvovirus in the late 1970s, it swiftly propagated ... ...

Abstract	Canine Parvovirus type 2 (CPV-2) is a highly contagious virus that can cause severe systemic disease with gastroenteric symptoms in dogs, particularly in young puppies. Originating from the feline parvovirus in the late 1970s, it swiftly propagated globally, instigating a pandemic in dogs. Despite vaccination advancements, CPV-2 remains a substantial challenge for veterinary professionals and pet owners. This study aimed to contribute knowledge about the current situation of CPV-2 among dogs in southern Brazil. In this study, the sera of 125 dogs (mostly with gastroenteritis symptoms) were screened for antibodies against CPV-2 and their faeces for the virus itself. The results showed that 40% (50/125) of dogs were infected with CPV-2. Most animals (65.5%) had previously been exposed to CPV-2 (with serotitres equal or above 1:40), and only 37.6% had protective antibody titres equal or above 1:80. The findings have also demonstrated that vaccination against CPV-2 significantly reduced the risk of infection, with positive cases decreasing from 56.9% (unvaccinated) to 2.0% (fully vaccinated). Furthermore, the prevalence of CPV-2 decreased as dogs aged, with younger dogs and those with an incomplete or non-existent vaccination history at the highest risk of infection. In conclusion, this study provides valuable insight into the prevalence and risk factors associated with CPV-2 infection in dogs in southern Brazil, thereby providing valuable knowledge for the improvement of veterinary care and pet health.
Language	English
Publishing date	2024-02-26
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-024-01290-5
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