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Article ; Online: "If we don't forgive, it's like holding on to them": A qualitative study of religious and spiritual coping on psychological recovery in older crime victims.

Satchell, Jessica / Dalrymple, Nicola / Leavey, Gerard / Serfaty, Marc

Psychological trauma : theory, research, practice and policy

2023

Abstract: ... to explore spiritual and/or religious (S/R) beliefs in a sample of older victims and understand how ... We assessed the breadth of S/R beliefs in a large sample (: Results: Over two-thirds (67%) identified as S ... by clarifying the role of S/R. Further research, especially on non-Christian religious victims, is needed ...

Abstract	Objective: There is growing need to strengthen support for older crime victims. We aimed to explore spiritual and/or religious (S/R) beliefs in a sample of older victims and understand how this shapes psychological responding and coping with crime. Method: Qualitative study with supplementary descriptive statistics nested within a clinical trial. We explored psychological responding and coping in-depth through semistructured interviews with 27 older victims of police-reported crime, purposefully sampled to achieve maximum variation. We inductively analyzed data using a reflexive thematic analysis. We assessed the breadth of S/R beliefs in a large sample ( Results: Over two-thirds (67%) identified as S/R, but psychological distress scores were similar, irrespective of religiosity. Our qualitative analysis suggests that crime may impact religious identity or practice in some older victims (hate crime) but influences attitudes or coping in others. Positive coping included acceptance, forgiveness, and/or turning to prayer or faith communities. Negative coping included fixation on retribution, superstition, perceived abandonment by God, or an inability to accommodate the crime within their beliefs, amplifying psychological distress. Conclusions: Understanding the psychological impact on older crime victims is enhanced by clarifying the role of S/R. Further research, especially on non-Christian religious victims, is needed. Cultural awareness training for trauma counselors and trauma awareness training for faith leaders is recommended. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Language	English
Publishing date	2023-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0001420
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Article ; Online: Adiponectin reduces glomerular endothelial glycocalyx disruption and restores glomerular barrier function in a mouse model of type 2 diabetes.

Fawaz, Sarah / Martin Alonso, Aldara / Qiu, Yan / Ramnath, Raina / Stowell-Connolly, Holly / Gamez, Monica / May, Carl / Down, Colin / Coward, Richard J / Butler, Matthew J / Welsh, Gavin I / Satchell, Simon C / Foster, Rebecca R

Diabetes

2024

Abstract: Adiponectin has vascular anti-inflammatory and protective effects. Whilst adiponectin is known to protect against the development of albuminuria, historically the focus has been on podocyte protection within the glomerular filtration barrier (GFB). The ... ...

Abstract	Adiponectin has vascular anti-inflammatory and protective effects. Whilst adiponectin is known to protect against the development of albuminuria, historically the focus has been on podocyte protection within the glomerular filtration barrier (GFB). The first barrier to albumin in the GFB is the endothelial glycocalyx (eGlx), a surface gel-like barrier covering glomerular endothelial cells (GEnC). In diabetes, eGlx dysfunction occurs before podocyte damage, hence we hypothesized that adiponectin could protect from eGlx damage to prevent early vascular damage in diabetic kidney disease (DKD). Globular adiponectin (gAd) activated AMPK signalling in human GEnC through AdipoR1. It significantly reduced eGlx shedding and the TNFα-mediated increase in syndecan-4 (SDC4) and MMP2 mRNA expression in GEnC in vitro. It protected against increased TNFα mRNA expression in glomeruli isolated from db/db mice, and genes associated with glycocalyx shedding (SDC4, MMP2 and MMP9). In addition, gAd protected against increased glomerular albumin permeability (Ps'alb) in glomeruli isolated from db/db mice, when administered to mice (i.p) and when applied directly to glomeruli (ex vivo). Ps'alb was inversely correlated with eGlx depth in vivo. In summary, adiponectin restored eGlx depth, which was correlated with improved glomerular barrier function, in diabetes.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db23-0455
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Article ; Online: Author Correction: The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling.

Riu, Federica / Slater, Sadie C / Garcia, Eva Jover / Rodriguez-Arabaolaza, Iker / Alvino, Valeria / Avolio, Elisa / Mangialardi, Giuseppe / Cordaro, Andrea / Satchell, Simon / Zebele, Carlo / Caporali, Andrea / Angelini, Gianni / Madeddu, Paolo

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7132

Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56932-3
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Book: Asset management

Satchell, Stephen

portfolio construction, performance and returns

2016

Abstract: ... portfolio construction; S Satchell and A Scowcroft -- 3) Tracking error: Ex ante versus ex post measures; S ... Hwang and S Satchell -- 4) Hedge Fund Survival Lifetimes; G N Gregoriou -- 5) Performance clustering and ... construction; S Ceria and R A Stubbs -- 10) Best-practice pension fund governance; G L Clark and R Urwin -- 11 ...

Author's details	edited by Stephen Satchell (Professor, Sydney University, Australia)
Abstract	Introduction; Stephen Satchell -- 1) Performance of UK equity unit trusts; G Quigley and R A Sinquefield -- 2) A demystification of the Black-Litterman model: Managing quantitative and traditional portfolio construction; S Satchell and A Scowcroft -- 3) Tracking error: Ex ante versus ex post measures; S Hwang and S Satchell -- 4) Hedge Fund Survival Lifetimes; G N Gregoriou -- 5) Performance clustering and incentives in the UK pension fund industry; D Blake, B N Lehmann and A Timmermann -- 6) Do hedge funds add value to a passive portfolio? Correcting for non-normal returns and disappearing funds?; R Kourwenberg -- 7) The performance of value and momentum investment portfolios: Recent experience in the major European markets; R Bird and J Whitaker -- 8) Measuring investor sentiment in equity markets; A Bandopadhyaya and A L Schnader -- 9) Incorporating estimation errors into portfolio selection: Robust portfolio construction; S Ceria and R A Stubbs -- 10) Best-practice pension fund governance; G L Clark and R Urwin -- 11) Fundamental indexation in Europe; J Hemminiki and V Puttonen -- 12) Fundamental indexation: An active value strategy in disguise; D Blitz and L Swinkels -- 13) Emerging markets of South-East and Central Asia: Do they still offer a diversification benefit; C L Dunis and G Shannon -- 14) A robust optimization approach to pension fund management; G Iyengar and A K C Ma This book presents a series of contributions on key issues in the decision-making behind the management of financial assets. It provides insight into topics such as quantitative and traditional portfolio construction, performance clustering and incentives in the UK pension fund industry, pension fund governance, indexation, and tracking errors. Markets covered include major European markets, equities, and emerging markets of South-East and Central Asia
Keywords	Portfolio-Management ; Kapitalmarktrendite ; Anlageverhalten ; Institutioneller Investor ; Europa
Language	Undetermined
Size	xix, 369 Seiten, Illustrationen
Publisher	Palgrave Macmillan
Publishing place	Switzerland
Document type	Book
Note	Enthält 14 Beiträge
ISBN	3319307932 ; 9783319307930 ; 9783319307947 ; 3319307940
Database	ECONomics Information System

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Article ; Online: Biochemical and Structural Analysis of the Bacterial Enzyme Succinyl-Diaminopimelate Desuccinylase (DapE) from

Kelley, Emma H / Minasov, George / Konczak, Katherine / Shuvalova, Ludmilla / Brunzelle, Joseph S / Shukla, Shantanu / Beulke, Megan / Thabthimthong, Teerana / Olsen, Kenneth W / Inniss, Nicole L / Satchell, Karla J F / Becker, Daniel P

ACS omega

2024 Volume 9, Issue 3, Page(s) 3905–3915

Abstract: ... diaminopimelate desuccinylase (DapE, E.C. 3.5.1.18) has emerged as a promising bacterial enzyme target. DapE from ...

Abstract	There is an urgent need for new antibiotics given the rise of antibiotic resistance, and succinyl-diaminopimelate desuccinylase (DapE, E.C. 3.5.1.18) has emerged as a promising bacterial enzyme target. DapE from
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c08231
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Article ; Online: Spin-orbit driven superconducting proximity effects in Pt/Nb thin films.

Flokstra, Machiel / Stewart, Rhea / Yim, Chi-Ming / Trainer, Christopher / Wahl, Peter / Miller, David / Satchell, Nathan / Burnell, Gavin / Luetkens, Hubertus / Prokscha, Thomas / Suter, Andreas / Morenzoni, Elvezio / Bobkova, Irina V / Bobkov, Alexander M / Lee, Stephen

Nature communications

2023 Volume 14, Issue 1, Page(s) 5081

Abstract: Manipulating the spin state of thin layers of superconducting material is a promising route to generate dissipationless spin currents in spintronic devices. Approaches typically focus on using thin ferromagnetic elements to perturb the spin state of the ... ...

Abstract	Manipulating the spin state of thin layers of superconducting material is a promising route to generate dissipationless spin currents in spintronic devices. Approaches typically focus on using thin ferromagnetic elements to perturb the spin state of the superconducting condensate to create spin-triplet correlations. We have investigated simple structures that generate spin-triplet correlations without using ferromagnetic elements. Scanning tunneling spectroscopy and muon-spin rotation are used to probe the local electronic and magnetic properties of our hybrid structures, demonstrating a paramagnetic contribution to the magnetization that partially cancels the Meissner screening. This spin-orbit generated magnetization is shown to derive from the spin of the equal-spin pairs rather than from their orbital motion and is an important development in the field of superconducting spintronics.
Language	English
Publishing date	2023-08-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40757-1
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Article ; Online: Smartphone and Tablet Software Apps to Collect Data in Sport and Exercise Settings: Cross-sectional International Survey.

Shaw, Matthew Peter / Satchell, Liam Paul / Thompson, Steve / Harper, Ed Thomas / Balsalobre-Fernández, Carlos / Peart, Daniel James

JMIR mHealth and uHealth

2021 Volume 9, Issue 5, Page(s) e21763

Abstract: Background: Advances in smartphone technology have facilitated an increase in the number of commercially available smartphone and tablet apps that enable the collection of physiological and biomechanical variables typically monitored in sport and ... ...

Abstract	Background: Advances in smartphone technology have facilitated an increase in the number of commercially available smartphone and tablet apps that enable the collection of physiological and biomechanical variables typically monitored in sport and exercise settings. Currently, it is not fully understood whether individuals collect data using mobile devices and tablets, independent of additional hardware, in their practice. Objective: This study aims to explore the use of smartphone and tablet software apps to collect data by individuals working in various sport and exercise settings, such as sports coaching, strength and conditioning, and personal training. Methods: A total of 335 practitioners completed an electronic questionnaire that surveyed their current training practices, with a focus on 2 areas: type of data collection and perceptions of reliability and validity regarding app use. An 18-item questionnaire, using a 5-point Likert scale, evaluated the perception of app use. Results: A total of 204 respondents reported using apps to directly collect data, with most of them (196/335, 58.5%) collecting biomechanical data, and 41.2% (138/335) respondents reported using at least one evidence-based app. A binomial general linear model determined that evidence accessibility (β=.35, 95% CI 0.04-0.67; P=.03) was significantly related to evidence-based app use. Age (β=-.03, 95% CI -0.06 to 0.00; P=.03) had a significant negative effect on evidence-based app use. Conclusions: This study demonstrates that practitioners show a greater preference for using smartphones and tablet devices to collect biomechanical data such as sprint velocity and jump performance variables. When it is easier to access information on the quality of apps, practitioners are more likely to use evidence-based apps. App developers should seek independent research to validate their apps. In addition, app developers should seek to provide clear signposting to the scientific support of their software in alternative ways.
MeSH term(s)	Computers, Handheld ; Cross-Sectional Studies ; Humans ; Mobile Applications ; Reproducibility of Results ; Smartphone
Language	English
Publishing date	2021-05-13
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2719220-9
ISSN	2291-5222 ; 2291-5222
ISSN (online)	2291-5222
ISSN	2291-5222
DOI	10.2196/21763
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Article ; Online: 'Free' inhibin α subunit is expressed by bovine ovarian theca cells and its knockdown suppresses androgen production.

Laird, Mhairi / Glister, Claire / Cheewasopit, Warakorn / Satchell, Leanne S / Bicknell, Andrew B / Knight, Phil G

Scientific reports

2019 Volume 9, Issue 1, Page(s) 19793

Abstract: ... subunit, presumed to be of granulosal origin, but its role(s) remains obscure. Here, we report ... α subunit having a significant role in modulating androgen production. Role(s), if any, played ...

Abstract	Inhibins are ovarian dimeric glycoprotein hormones that suppress pituitary FSH production. They are synthesised by follicular granulosa cells as α plus βA/βB subunits (encoded by INHA, INHBA, INHBB, respectively). Inhibin concentrations are high in follicular fluid (FF) which is also abundant in 'free' α subunit, presumed to be of granulosal origin, but its role(s) remains obscure. Here, we report the unexpected finding that bovine theca cells show abundant INHA expression and 'free' inhibin α production. Thus, theca cells may contribute significantly to the inhibin α content of FF and peripheral blood. In vitro, knockdown of thecal INHA inhibited INSL3 and CYP17A1 expression and androgen production while INSL3 knockdown reduced INHA and inhibin α secretion. These findings suggest a positive role of thecal inhibin α on androgen production. However, exogenous inhibin α did not raise androgen production. We hypothesised that inhibin α may modulate the opposing effects of BMP and inhibin on androgen production. However, this was not supported experimentally. Furthermore, neither circulating nor intrafollicular androgen concentrations differed between control and inhibin α-immunized heifers, casting further doubt on thecal inhibin α subunit having a significant role in modulating androgen production. Role(s), if any, played by thecal inhibin α remain elusive.
MeSH term(s)	Androgens/metabolism ; Animals ; Cattle ; Endocrine System ; Female ; Follicular Fluid/metabolism ; Gene Expression Profiling ; Granulosa Cells/metabolism ; Inhibin-beta Subunits/metabolism ; Inhibins/metabolism ; RNA Interference ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Theca Cells/metabolism
Chemical Substances	Androgens ; inhibin beta A subunit ; inhibin-alpha subunit ; Inhibins (57285-09-3) ; Inhibin-beta Subunits (93443-12-0)
Language	English
Publishing date	2019-12-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-55829-w
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Article ; Online: Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.

Cardiovascular diabetology

2024 Volume 23, Issue 1, Page(s) 50

Abstract: Background: Diabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular complications, with huge global health implications. Therapeutic interventions that can be applied to multiple ... ...

Abstract	Background: Diabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular complications, with huge global health implications. Therapeutic interventions that can be applied to multiple vascular beds are urgently needed. Diabetic retinopathy (DR) and diabetic kidney disease (DKD) are characterised by early microvascular permeability changes which, if left untreated, lead to visual impairment and renal failure, respectively. The heparan sulphate cleaving enzyme, heparanase, has previously been shown to contribute to diabetic microvascular complications, but the common underlying mechanism which results in microvascular dysfunction in conditions such as DR and DKD has not been determined. Methods: In this study, two mouse models of heparan sulphate depletion (enzymatic removal and genetic ablation by endothelial specific Exotosin-1 knock down) were utilized to investigate the impact of endothelial cell surface (i.e., endothelial glycocalyx) heparan sulphate loss on microvascular barrier function. Endothelial glycocalyx changes were measured using fluorescence microscopy or transmission electron microscopy. To measure the impact on barrier function, we used sodium fluorescein angiography in the eye and a glomerular albumin permeability assay in the kidney. A type 2 diabetic (T2D, db/db) mouse model was used to determine the therapeutic potential of preventing heparan sulphate damage using treatment with a novel heparanase inhibitor, OVZ/HS-1638. Endothelial glycocalyx changes were measured as above, and microvascular barrier function assessed by albumin extravasation in the eye and a glomerular permeability assay in the kidney. Results: In both models of heparan sulphate depletion, endothelial glycocalyx depth was reduced and retinal solute flux and glomerular albumin permeability was increased. T2D mice treated with OVZ/HS-1638 had improved endothelial glycocalyx measurements compared to vehicle treated T2D mice and were simultaneously protected from microvascular permeability changes associated with DR and DKD. Conclusion: We demonstrate that endothelial glycocalyx heparan sulphate plays a common mechanistic role in microvascular barrier function in the eye and kidney. Protecting the endothelial glycocalyx damage in diabetes, using the novel heparanase inhibitor OVZ/HS-1638, effectively prevents microvascular permeability changes associated with DR and DKD, demonstrating a novel systemic approach to address diabetic microvascular complications.
MeSH term(s)	Animals ; Mice ; Glycocalyx/metabolism ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/prevention & control ; Heparitin Sulfate/metabolism ; Heparitin Sulfate/pharmacology ; Albumins/pharmacology ; Diabetic Angiopathies/etiology ; Diabetic Angiopathies/prevention & control ; Diabetic Angiopathies/metabolism ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Glucuronidase
Chemical Substances	heparanase (EC 3.2.1.-) ; Heparitin Sulfate (9050-30-0) ; Albumins ; Glucuronidase (EC 3.2.1.31)
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-024-02133-1
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Article ; Online: Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations.

Finch, Natalie C / Fawaz, Sarah S / Neal, Chris R / Butler, Matthew J / Lee, Vivian K / Salmon, Andrew J / Lay, Abigail C / Stevens, Megan / Dayalan, Lusyan / Band, Hamid / Mellor, Harry H / Harper, Steven J / Shima, David T / Welsh, Gavin I / Foster, Rebecca R / Satchell, Simon C

Journal of the American Society of Nephrology : JASN

2022 Volume 33, Issue 6, Page(s) 1120–1136

Abstract: Background: Glomerular endothelial cell (GEnC) fenestrations are recognized as an essential component of the glomerular filtration barrier, yet little is known about how they are regulated and their role in disease.: Methods: We comprehensively ... ...

Abstract	Background: Glomerular endothelial cell (GEnC) fenestrations are recognized as an essential component of the glomerular filtration barrier, yet little is known about how they are regulated and their role in disease. Methods: We comprehensively characterized GEnC fenestral and functional renal filtration changes including measurement of glomerular Results: Loss of GEnC fenestration density was associated with decreased filtration function in diabetic nephropathy. We identified increased diaphragmed fenestrations in diabetes, which are posited to increase resistance to filtration and further contribute to decreased GFR. We identified decreased glomerular EHD3 expression in diabetes, which was significantly correlated with decreased fenestration density. Reduced fenestrations in EHD3 knockdown b.End5 cells Conclusions: This study demonstrates the critical role of GEnC fenestrations in renal filtration function and suggests EHD3 may be a key regulator, loss of which may contribute to declining glomerular filtration function through aberrant GEnC fenestration regulation. This points to EHD3 as a novel therapeutic target to restore filtration function in disease.
MeSH term(s)	Animals ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Nephropathies/metabolism ; Endothelial Cells/metabolism ; Kidney Glomerulus/metabolism ; Mice ; Urinary Tract Physiological Phenomena
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2021030294
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