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Article: Andrew Moir: an Aberdeen anatomist.

Bayliss, R A

1980 Volume 25, Issue 4, Page(s) 315–319

MeSH term(s)	Anatomy/history ; History, 19th Century ; Humans ; Scotland
Language	English
Publishing date	1980-10
Publishing country	Scotland
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	414085-0
ISSN	2045-6441 ; 0036-9330
ISSN (online)	2045-6441
ISSN	0036-9330
DOI	10.1177/003693308002500415
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Book ; Online: Reading Faces and Bodies: Behavioral and Neural Processes Underlying the Understanding of,and Interaction with, Others

Actis-Grosso, Rossana / Bayliss, Andrew P. / Ricciardelli, Paola

2017

Abstract: The aim of this Research Topic was to offer an interdisciplinary forum for researchers interested in the interplay of face, eye gaze, and body perception in the understanding of others, with an emphasis on behavioural and neural processing. The papers ... ...

Abstract	The aim of this Research Topic was to offer an interdisciplinary forum for researchers interested in the interplay of face, eye gaze, and body perception in the understanding of others, with an emphasis on behavioural and neural processing. The papers included in this topic come from cognitive, neuroscience and social psychology perspectives and shed new light on how facial and body cues interact with each other and with social, ecological and contextual factors (such as for example social identification and group membership) to form a unified representation that can guide our perceptions and responses to other people. Altogether, they provide an up-to-date picture of advances in this fascinating research field
Keywords	Psychology ; Science (General)
Size	1 electronic resource (156 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020095067
ISBN	9782889451456 ; 2889451453
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Enzymatic browning: The role of substrates in polyphenol oxidase mediated browning.

Tilley, Andrew / McHenry, Mark P / McHenry, Julia Anwar / Solah, Vicky / Bayliss, Kirsty

Current research in food science

2023 Volume 7, Page(s) 100623

Abstract: Enzymatic browning is a biological process that can have significant consequences for fresh produce, such as quality reduction in fruit and vegetables. It is primarily initiated by polyphenol oxidase (PPO) (EC 1.14.18.1 and EC 1.10.3.1) which catalyses ... ...

Abstract	Enzymatic browning is a biological process that can have significant consequences for fresh produce, such as quality reduction in fruit and vegetables. It is primarily initiated by polyphenol oxidase (PPO) (EC 1.14.18.1 and EC 1.10.3.1) which catalyses the oxidation of phenolic compounds. It is thought that subsequent non-enzymatic reactions result in these compounds polymerising into dark pigments called melanins. Most work to date has investigated the kinetics of PPO with anti-browning techniques focussed on inhibition of the enzyme. However, there is substantially less knowledge on how the subsequent non-enzymatic reactions contribute to enzymatic browning. This review considers the current knowledge and recent advances in non-enzymatic reactions occurring after phenolic oxidation, in particular the role of non-PPO substrates. Enzymatic browning reaction models are compared, and a generalised redox cycling mechanism is proposed. The review identifies future areas for mechanistic research which may inform the development of new anti-browning processes.
Language	English
Publishing date	2023-10-20
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2665-9271
ISSN (online)	2665-9271
DOI	10.1016/j.crfs.2023.100623
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Article ; Online: From Gaze Perception to Social Cognition: The Shared-Attention System.

Stephenson, Lisa J / Edwards, S Gareth / Bayliss, Andrew P

Perspectives on psychological science : a journal of the Association for Psychological Science

2021 Volume 16, Issue 3, Page(s) 553–576

Abstract: When two people look at the same object in the environment and are aware of each other's attentional state, they find themselves in a shared-attention episode. This can occur through intentional or incidental signaling and, in either case, causes an ... ...

Abstract	When two people look at the same object in the environment and are aware of each other's attentional state, they find themselves in a shared-attention episode. This can occur through intentional or incidental signaling and, in either case, causes an exchange of information between the two parties about the environment and each other's mental states. In this article, we give an overview of what is known about the building blocks of shared attention (gaze perception and joint attention) and focus on bringing to bear new findings on the initiation of shared attention that complement knowledge about gaze following and incorporate new insights from research into the sense of agency. We also present a neurocognitive model, incorporating first-, second-, and third-order social cognitive processes (the shared-attention system, or SAS), building on previous models and approaches. The SAS model aims to encompass perceptual, cognitive, and affective processes that contribute to and follow on from the establishment of shared attention. These processes include fundamental components of social cognition such as reward, affective evaluation, agency, empathy, and theory of mind.
MeSH term(s)	Attention ; Awareness ; Fixation, Ocular ; Humans ; Social Cognition ; Social Perception
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2224911-4
ISSN	1745-6924 ; 1745-6916
ISSN (online)	1745-6924
ISSN	1745-6916
DOI	10.1177/1745691620953773
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Article ; Online: α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif.

Batchelor, Matthew / Dawber, Robert S / Wilson, Andrew J / Bayliss, Richard

The Biochemical journal

2022 Volume 479, Issue 5, Page(s) 687–700

Abstract: How cellular functions are regulated through protein phosphorylation events that promote or inhibit protein-protein interactions (PPIs) is key to understanding regulatory molecular mechanisms. Whilst phosphorylation can orthosterically or allosterically ... ...

Abstract	How cellular functions are regulated through protein phosphorylation events that promote or inhibit protein-protein interactions (PPIs) is key to understanding regulatory molecular mechanisms. Whilst phosphorylation can orthosterically or allosterically influence protein recognition, phospho-driven changes in the conformation of recognition motifs are less well explored. We recently discovered that clathrin heavy chain recognizes phosphorylated TACC3 through a helical motif that, in the unphosphorylated protein, is disordered. However, it was unclear whether and how phosphorylation could stabilize a helix in a broader context. In the current manuscript, we address this challenge using poly-Ala-based model peptides and a suite of circular dichroism and nuclear magnetic resonance spectroscopies. We show that phosphorylation of a Ser residue stabilizes the α-helix in the context of an Arg(i-3)pSeri Lys(i+4) triad through charge-reinforced side chain interactions with positive co-operativity, whilst phosphorylation of Thr induces an opposing response. This is significant as it may represent a general method for control of PPIs by phosphorylation; basic kinase-substrate motifs are common with 55 human protein kinases recognizing an Arg at a position -3 from the phosphorylated Ser, whilst the Arg(i-3)Seri Lys(i+4) is a motif found in over 2000 human proteins.
MeSH term(s)	Cell Cycle Proteins ; Circular Dichroism ; Humans ; Microtubule-Associated Proteins ; Phosphorylation ; Phosphoserine ; Protein Conformation, alpha-Helical
Chemical Substances	Cell Cycle Proteins ; Microtubule-Associated Proteins ; TACC3 protein, human ; Phosphoserine (17885-08-4)
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2969-5
ISSN	1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
ISSN (online)	1470-8728
ISSN	0006-2936 ; 0306-3275 ; 0264-6021
DOI	10.1042/BCJ20210812
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Article ; Online: Standing out from the crowd: Both cue numerosity and social information affect attention in multi-agent contexts.

Capozzi, Francesca / Bayliss, Andrew P / Ristic, Jelena

Quarterly journal of experimental psychology (2006)

2021 Volume 74, Issue 10, Page(s) 1737–1746

Abstract: Groups of people offer abundant opportunities for social interactions. We used a two-phase task to investigate how social cue numerosity and social information about an individual affected attentional allocation in such multi-agent settings. The learning ...

Abstract	Groups of people offer abundant opportunities for social interactions. We used a two-phase task to investigate how social cue numerosity and social information about an individual affected attentional allocation in such multi-agent settings. The learning phase was a standard gaze-cuing procedure in which a stimulus face could be either uninformative or informative about the upcoming target. The test phase was a group-cuing procedure in which the stimulus faces from the learning phase were presented in groups of three. The target could either be cued by the group minority (i.e., one face) or majority (i.e., two faces) or by uninformative or informative stimulus faces. Results showed an effect of cue numerosity, whereby responses were faster to targets cued by the group majority than the group minority. However, responses to targets cued by informative identities included in the group minority were as fast as responses to targets cued by the group majority. Thus, previously learned social information about an individual was able to offset the general enhancement of cue numerosity, revealing a complex interplay between cue numerosity and social information in guiding attention in multi-agent settings.
MeSH term(s)	Attention ; Cues ; Fixation, Ocular ; Humans ; Reaction Time
Language	English
Publishing date	2021-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	219170-2
ISSN	1747-0226 ; 0033-555X ; 1747-0218
ISSN (online)	1747-0226
ISSN	0033-555X ; 1747-0218
DOI	10.1177/17470218211013028
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Article ; Online: How does feedback from phage infections influence the evolution of phase variation in Campylobacter?

Sandhu, Simran K / Bayliss, Christopher D / Morozov, Andrew Yu

PLoS computational biology

2021 Volume 17, Issue 6, Page(s) e1009067

Abstract: Campylobacter jejuni (C. jejuni) causes gastroenteritis following the consumption of contaminated poultry meat, resulting in a large health and economic burden worldwide. Phage therapy is a promising technique for eradicating C. jejuni from poultry ... ...

Abstract	Campylobacter jejuni (C. jejuni) causes gastroenteritis following the consumption of contaminated poultry meat, resulting in a large health and economic burden worldwide. Phage therapy is a promising technique for eradicating C. jejuni from poultry flocks and chicken carcasses. However, C. jejuni can resist infections by some phages through stochastic, phase-variable ON/OFF switching of the phage receptors mediated by simple sequence repeats (SSR). While selection strength and exposure time influence the evolution of SSR-mediated phase variation (PV), phages offer a more complex evolutionary environment as phage replication depends on having a permissive host organism. Here, we build and explore several continuous culture bacteria-phage computational models, each analysing different phase-variable scenarios calibrated to the experimental SSR rates of C. jejuni loci and replication parameters for the F336 phage. We simulate the evolution of PV rates via the adaptive dynamics framework for varying levels of selective pressures that act on the phage-resistant state. Our results indicate that growth reducing counter-selection on a single PV locus results in the stable maintenance of the phage, while compensatory selection between bacterial states affects the evolutionary stable mutation rates (i.e. very high and very low mutation rates are evolutionarily disadvantageous), whereas, in the absence of either selective pressure the evolution of PV rates results in mutation rates below the basal values. Contrastingly, a biologically-relevant model with two phase-variable loci resulted in phage extinction and locking of the bacteria into a phage-resistant state suggesting that another counter-selective pressure is required, instance, the use of a distinct phage whose receptor is an F336-phage-resistant state. We conclude that a delicate balance between counter-selection and phage-attack can result in both the evolution of phase-variable phage receptors and persistence of PV-receptor-specific phage.
MeSH term(s)	Animals ; Bacteriophage Receptors/genetics ; Bacteriophage Receptors/physiology ; Campylobacter Infections/microbiology ; Campylobacter Infections/therapy ; Campylobacter Infections/virology ; Campylobacter jejuni/genetics ; Campylobacter jejuni/virology ; Computational Biology ; Computer Simulation ; Evolution, Molecular ; Gene Expression Regulation, Bacterial ; Genes, Bacterial ; Humans ; Microbial Interactions/genetics ; Microbial Interactions/physiology ; Microsatellite Repeats ; Models, Biological ; Mutation ; Phage Therapy/methods ; Phage Therapy/statistics & numerical data
Chemical Substances	Bacteriophage Receptors
Language	English
Publishing date	2021-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1009067
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Article ; Online: Seeing eye-to-eye: Social gaze interactions influence gaze direction identification.

Edwards, S Gareth / Bayliss, Andrew P

Attention, perception & psychophysics

2019 Volume 81, Issue 8, Page(s) 2755–2765

Abstract: We tested whether gaze direction identification of individual faces can be modulated by prior social gaze encounters. In two experiments, participants first completed a joint-gaze learning task using a saccade/antisaccade paradigm. Participants would ... ...

Abstract	We tested whether gaze direction identification of individual faces can be modulated by prior social gaze encounters. In two experiments, participants first completed a joint-gaze learning task using a saccade/antisaccade paradigm. Participants would encounter some 'joint-gaze faces' that would consistently look at the participants saccade goal before participants looked there (Experiment 1) or would follow the participants gaze to the target (Experiment 2). 'Non-joint-gaze faces' would consistently look in the opposite direction. Participants then completed a second task in which they judged the gaze direction of the faces they had previously encountered. Participants were less likely to erroneously report faces with slightly deviated gaze as looking directly at them if the face had previously never engaged in joint gaze with them. However, this bias was only present when those faces had looked first (Experiment 1) and not when the faces looked after participants (Experiment 2). Comparing these data with gaze identification responses of a control group that did not complete any joint-gaze learning phase revealed that the difference in gaze identification in Experiment 1 is likely driven by a lowering of direct gaze bias in response to non-joint-gaze faces. Thus, previous joint-gaze experiences can affect gaze direction judgements at an identity-specific level. However, this modulation may rely on the socio-cognitive information available from viewing other's initiation behaviours, especially when they fail to engage in social contact.
MeSH term(s)	Adult ; Attention/physiology ; Facial Recognition/physiology ; Female ; Fixation, Ocular/physiology ; Humans ; Interpersonal Relations ; Learning/physiology ; Male ; Young Adult
Language	English
Publishing date	2019-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2464550-3
ISSN	1943-393X ; 1943-3921
ISSN (online)	1943-393X
ISSN	1943-3921
DOI	10.3758/s13414-019-01671-1
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Article ; Online: Inhibition of Aurora-A/N-Myc Protein-Protein Interaction Using Peptidomimetics: Understanding the Role of Peptide Cyclization.

Dawber, Robert S / Gimenez, Diana / Batchelor, Matthew / Miles, Jennifer A / Wright, Megan H / Bayliss, Richard / Wilson, Andrew J

Chembiochem : a European journal of chemical biology

2023 Volume 25, Issue 2, Page(s) e202300649

Abstract: ... Using N- ... ...

Abstract	Using N-Myc
MeSH term(s)	Peptidomimetics/pharmacology ; N-Myc Proto-Oncogene Protein ; Cyclization ; Peptides/chemistry ; Protein Binding
Chemical Substances	Peptidomimetics ; N-Myc Proto-Oncogene Protein ; Peptides
Language	English
Publishing date	2023-11-27
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202300649
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Article ; Online: The journey of Zika to the developing brain.

Rombi, Francesca / Bayliss, Richard / Tuplin, Andrew / Yeoh, Sharon

Molecular biology reports

2020 Volume 47, Issue 4, Page(s) 3097–3115

Abstract: Zika virus is a mosquito-borne Flavivirus originally isolated from humans in 1952. Following its re-emergence in Brazil in 2015, an increase in the number of babies born with microcephaly to infected mothers was observed. Microcephaly is a ... ...

Abstract	Zika virus is a mosquito-borne Flavivirus originally isolated from humans in 1952. Following its re-emergence in Brazil in 2015, an increase in the number of babies born with microcephaly to infected mothers was observed. Microcephaly is a neurodevelopmental disorder, characterised phenotypically by a smaller than average head size, and is usually developed in utero. The 2015 outbreak in the Americas led to the World Health Organisation declaring Zika a Public Health Emergency of International Concern. Since then, much research into the effects of Zika has been carried out. Studies have investigated the structure of the virus, its effects on and evasion of the immune response, cellular entry including target receptors, its transmission from infected mother to foetus and its cellular targets. This review discusses current knowledge and novel research into these areas, in hope of developing a further understanding of how exposure of pregnant women to the Zika virus can lead to impaired brain development of their foetus. Although no longer considered an epidemic in the Americas, the mechanism by which Zika acts is still not comprehensively and wholly understood, and this understanding will be crucial in developing effective vaccines and treatments.
MeSH term(s)	Brain/embryology ; Brain/virology ; Brazil/epidemiology ; Disease Outbreaks ; Female ; Humans ; Infant ; Microcephaly/epidemiology ; Microcephaly/virology ; Pregnancy ; Public Health ; Zika Virus/metabolism ; Zika Virus/pathogenicity ; Zika Virus Infection/epidemiology ; Zika Virus Infection/physiopathology ; Zika Virus Infection/transmission
Language	English
Publishing date	2020-03-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-020-05349-y
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