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  1. Article: L'autophagie sélective au cours des infections virales.

    Daussy, Coralie F / Espert, Lucile

    Virologie (Montrouge, France)

    2020  Volume 20, Issue 4, Page(s) 196–206

    Abstract: Autophagy is a major catabolic pathway involved in several important cellular functions including homeostasis, development, differentiation and immunity. Consequently, deregulations of this process have been observed in several pathologies. Autophagy ... ...

    Title translation Selective autophagy during viral infections.
    Abstract Autophagy is a major catabolic pathway involved in several important cellular functions including homeostasis, development, differentiation and immunity. Consequently, deregulations of this process have been observed in several pathologies. Autophagy leads to the lysosomal degradation of cellular components after their sequestration in vacuoles called autophagosomes. During nutrient starvation, autophagy degrades randomly cytoplasmic components, but it is now well established that this process can be highly selective thanks to proteins that allow the specific targeting of substrates to autophagosomes. These proteins, called autophagy receptors, are able to bind specific substrates and the members of the "ATG8-like" family (divided in two subfamilies: LC3 and GABARAP in mammals), which are decorating autophagosomes. The role of selective autophagy during viral infection is not extensively studied yet. However, the literature shows that viruses have evolved to block, divert or use this process to promote their replication.
    Language English
    Publishing date 2020-04-10
    Publishing country France
    Document type Journal Article
    ISSN 1267-8694
    ISSN 1267-8694
    DOI 10.1684/vir.2016.0665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: LC3B conjugation machinery promotes autophagy-independent HIV-1 entry in CD4

    Pradel, Baptiste / Cantaloube, Guilhem / Villares, Marie / Deffieu, Maïka S / Robert-Hebmann, Véronique / Lucansky, Vincent / Faure, Mathias / Chazal, Nathalie / Gaudin, Raphaël / Espert, Lucile

    Autophagy

    2024  , Page(s) 1–12

    Abstract: HIV-1 entry into ... ...

    Abstract HIV-1 entry into CD4
    Language English
    Publishing date 2024-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2024.2338573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Regulation of Innate Immune Responses by Autophagy: A Goldmine for Viruses.

    Pradel, Baptiste / Robert-Hebmann, Véronique / Espert, Lucile

    Frontiers in immunology

    2020  Volume 11, Page(s) 578038

    Abstract: Autophagy is a lysosomal degradation pathway for intracellular components and is highly conserved across eukaryotes. This process is a key player in innate immunity and its activation has anti-microbial effects by directly targeting pathogens and also by ...

    Abstract Autophagy is a lysosomal degradation pathway for intracellular components and is highly conserved across eukaryotes. This process is a key player in innate immunity and its activation has anti-microbial effects by directly targeting pathogens and also by regulating innate immune responses. Autophagy dysfunction is often associated with inflammatory diseases. Many studies have shown that it can also play a role in the control of innate immunity by preventing exacerbated inflammation and its harmful effects toward the host. The arms race between hosts and pathogens has led some viruses to evolve strategies that enable them to benefit from autophagy, either by directly hijacking the autophagy pathway for their life cycle, or by using its regulatory functions in innate immunity. The control of viral replication and spread involves the production of anti-viral cytokines. Controlling the signals that lead to production of these cytokines is a perfect way for viruses to escape from innate immune responses and establish successful infection. Published reports related to this last viral strategy have extensively grown in recent years. In this review we describe several links between autophagy and regulation of innate immune responses and we provide an overview of how viruses exploit these links for their own benefit.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Autophagy/drug effects ; Autophagy-Related Proteins/metabolism ; Host-Pathogen Interactions ; Humans ; Immunity, Innate/drug effects ; Inflammation Mediators ; Signal Transduction ; Viruses/drug effects ; Viruses/immunology ; Viruses/pathogenicity
    Chemical Substances Antiviral Agents ; Autophagy-Related Proteins ; Inflammation Mediators
    Keywords covid19
    Language English
    Publishing date 2020-10-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.578038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells.

    Papin, Laure / Lehmann, Martin / Lagisquet, Justine / Maarifi, Ghizlane / Robert-Hebmann, Véronique / Mariller, Christophe / Guerardel, Yann / Espert, Lucile / Haucke, Volker / Blanchet, Fabien P

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: Dendritic cells (DC) are critical cellular mediators of host immunity, notably by expressing a broad panel of pattern recognition receptors. One of those receptors, the C-type lectin receptor DC-SIGN, was previously reported as a regulator of endo/ ... ...

    Abstract Dendritic cells (DC) are critical cellular mediators of host immunity, notably by expressing a broad panel of pattern recognition receptors. One of those receptors, the C-type lectin receptor DC-SIGN, was previously reported as a regulator of endo/lysosomal targeting through functional connections with the autophagy pathway. Here, we confirmed that DC-SIGN internalization intersects with LC3
    MeSH term(s) Humans ; HIV-1/physiology ; Antiviral Agents/metabolism ; Dendritic Cells ; Lectins, C-Type/metabolism ; Autophagy
    Chemical Substances DC-specific ICAM-3 grabbing nonintegrin ; Antiviral Agents ; Lectins, C-Type
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24109008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Measles virus-imposed remodeling of the autophagy machinery determines the outcome of bacterial coinfection.

    Claviere, Mathieu / Lavedrine, Aude / Lamiral, Guénaëlle / Bonnet, Mariette / Verlhac, Pauline / Petkova, Denitsa S / Espert, Lucile / Duclaux-Loras, Rémi / Lucifora, Julie / Rivoire, Michel / Boschetti, Gilles / Nancey, Stéphane / Rozières, Aurore / Viret, Christophe / Faure, Mathias

    Autophagy

    2022  Volume 19, Issue 3, Page(s) 858–872

    Abstract: Although it is admitted that secondary infection can complicate viral diseases, the consequences of viral infection on cell susceptibility to other infections remain underexplored at the cellular level. We though to examine whether the sustained ... ...

    Abstract Although it is admitted that secondary infection can complicate viral diseases, the consequences of viral infection on cell susceptibility to other infections remain underexplored at the cellular level. We though to examine whether the sustained macroautophagy/autophagy associated with measles virus (MeV) infection could help cells oppose invasion by
    MeSH term(s) Humans ; Autophagy/genetics ; Sequestosome-1 Protein/metabolism ; Coinfection ; Measles virus/metabolism ; Salmonella typhimurium ; Carrier Proteins
    Chemical Substances Sequestosome-1 Protein ; Carrier Proteins
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2022.2107309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: HIV-1 Env induces pexophagy and an oxidative stress leading to uninfected CD4

    Daussy, Coralie F / Galais, Mathilde / Pradel, Baptiste / Robert-Hebmann, Véronique / Sagnier, Sophie / Pattingre, Sophie / Biard-Piechaczyk, Martine / Espert, Lucile

    Autophagy

    2020  Volume 17, Issue 9, Page(s) 2465–2474

    Abstract: The immunodeficiency observed in HIV-1-infected patients is mainly due to uninfected bystander ... ...

    Abstract The immunodeficiency observed in HIV-1-infected patients is mainly due to uninfected bystander CD4
    MeSH term(s) Autophagy ; CD4-Positive T-Lymphocytes ; Cell Death ; HIV-1 ; Humans ; Macroautophagy ; Oxidative Stress ; T-Lymphocytes
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2020.1831814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: La phagocytose associée à LC3 (LAP) - Phagocytose ou autophagie ?

    Galais, Mathilde / Pradel, Baptiste / Vergne, Isabelle / Robert-Hebmann, Véronique / Espert, Lucile / Biard-Piechaczyk, Martine

    Medecine sciences : M/S

    2019  Volume 35, Issue 8-9, Page(s) 635–642

    Abstract: Phagocytosis and macroautophagy, named here autophagy, are two essential mechanisms of lysosomal degradation of diverse cargos into membrane structures. Both mechanisms are involved in immune regulation and cell survival. However, phagocytosis triggers ... ...

    Title translation LAP (LC3-associated phagocytosis): phagocytosis or autophagy?
    Abstract Phagocytosis and macroautophagy, named here autophagy, are two essential mechanisms of lysosomal degradation of diverse cargos into membrane structures. Both mechanisms are involved in immune regulation and cell survival. However, phagocytosis triggers degradation of extracellular material whereas autophagy engulfs only cytoplasmic elements. Furthermore, activation and maturation of these two processes are different. LAP (LC3-associated phagocytosis) is a form of phagocytosis that uses components of the autophagy pathway. It can eliminate (i) pathogens, (ii) immune complexes, (iii) threatening neighbouring cells, dead or alive, and (iv) cell debris, such as POS (photoreceptor outer segment) and the midbody released at the end of mitosis. Cells have thus optimized their means of elimination of dangerous components by sharing some fundamental elements coming from the two main lysosomal degradation pathways.
    MeSH term(s) Animals ; Autophagy/physiology ; Humans ; Immune Evasion/physiology ; Infections/immunology ; Infections/metabolism ; Infections/pathology ; Macrophages/immunology ; Microtubule-Associated Proteins/physiology ; Phagocytosis/physiology ; Phagosomes/immunology
    Chemical Substances MAP1LC3A protein, human ; Microtubule-Associated Proteins
    Language French
    Publishing date 2019-09-18
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2019129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2872: Show issues Location:
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  8. Article ; Online: Autophagy restricts HIV-1 infection.

    Daussy, Coralie F / Beaumelle, Bruno / Espert, Lucile

    Oncotarget

    2015  Volume 6, Issue 25, Page(s) 20752–20753

    MeSH term(s) Animals ; Autophagy ; CD4-Positive T-Lymphocytes/virology ; Dendritic Cells/virology ; HIV Infections/pathology ; HIV Infections/therapy ; HIV-1 ; Humans ; Lysosomes/metabolism ; Macrophages/virology ; Virus Replication ; tat Gene Products, Human Immunodeficiency Virus/metabolism
    Chemical Substances tat Gene Products, Human Immunodeficiency Virus
    Language English
    Publishing date 2015-08-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.5123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Autophagy in Mycobacterium tuberculosis and HIV infections.

    Espert, Lucile / Beaumelle, Bruno / Vergne, Isabelle

    Frontiers in cellular and infection microbiology

    2015  Volume 5, Page(s) 49

    Abstract: Human Immunodeficiency Virus (HIV) and Mycobacterium tuberculosis (M.tb) are among the most lethal human pathogens worldwide, each being responsible for around 1.5 million deaths annually. Moreover, synergy between acquired immune deficiency syndrome ( ... ...

    Abstract Human Immunodeficiency Virus (HIV) and Mycobacterium tuberculosis (M.tb) are among the most lethal human pathogens worldwide, each being responsible for around 1.5 million deaths annually. Moreover, synergy between acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) has turned HIV/M.tb co-infection into a major public health threat in developing countries. In the past decade, autophagy, a lysosomal catabolic process, has emerged as a major host immune defense mechanism against infectious agents like M.tb and HIV. Nevertheless, in some instances, autophagy machinery appears to be instrumental for HIV infection. Finally, there is mounting evidence that both pathogens deploy various countermeasures to thwart autophagy. This mini-review proposes an overview of the roles and regulations of autophagy in HIV and M.tb infections with an emphasis on microbial factors. We also discuss the role of autophagy manipulation in the context of HIV/M.tb co-infection. In future, a comprehensive understanding of autophagy interaction with these pathogens will be critical for development of autophagy-based prophylactic and therapeutic interventions for AIDS and TB.
    MeSH term(s) Autophagy ; HIV Infections/immunology ; Humans ; Tuberculosis/immunology
    Language English
    Publishing date 2015
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2015.00049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Interplay of HIV and Autophagy in Early Infection.

    Cabrera-Rodríguez, Romina / Pérez-Yanes, Silvia / Estévez-Herrera, Judith / Márquez-Arce, Daniel / Cabrera, Cecilia / Espert, Lucile / Blanco, Julià / Valenzuela-Fernández, Agustín

    Frontiers in microbiology

    2021  Volume 12, Page(s) 661446

    Abstract: HIV/AIDS is still a global threat despite the notable efforts made by the scientific and health communities to understand viral infection, to design new drugs or to improve existing ones, as well as to develop advanced therapies and vaccine designs for ... ...

    Abstract HIV/AIDS is still a global threat despite the notable efforts made by the scientific and health communities to understand viral infection, to design new drugs or to improve existing ones, as well as to develop advanced therapies and vaccine designs for functional cure and viral eradication. The identification and analysis of HIV-1 positive individuals that naturally control viral replication in the absence of antiretroviral treatment has provided clues about cellular processes that could interact with viral proteins and RNA and define subsequent viral replication and clinical progression. This is the case of autophagy, a degradative process that not only maintains cell homeostasis by recycling misfolded/old cellular elements to obtain nutrients, but is also relevant in the innate and adaptive immunity against viruses, such as HIV-1. Several studies suggest that early steps of HIV-1 infection, such as virus binding to CD4 or membrane fusion, allow the virus to modulate autophagy pathways preparing cells to be permissive for viral infection. Confirming this interplay, strategies based on autophagy modulation are able to inhibit early steps of HIV-1 infection. Moreover, autophagy dysregulation in late steps of the HIV-1 replication cycle may promote autophagic cell-death of CD4
    Language English
    Publishing date 2021-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.661446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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