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  1. Article ; Online: Why we have transplant reunions.

    Forman, Stephen J

    Transplantation and cellular therapy

    2023  Volume 29, Issue 8, Page(s) 477–479

    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2023.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5082: Show issues Location:
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  2. Book ; Online ; E-Book: Thomas' hematopoietic cell transplantation

    Appelbaum, Frederick R. / Forman, Stephen J. / Negrin, Robert S. / Antin, Joseph H.

    stem cell transplantation

    2016  

    Title variant Hematopoietic cell transplantation
    Author's details edited by Frederick R. Appelbaum, Stephen J. Forman, Robert S. Negrin, Joseph H. Antin
    Keywords Hematopoietic Stem Cell Transplantation ; Transplantation Immunology
    Language English
    Dates of publication 2016-9999
    Size 1 Online-Ressource (xxxi, 1342 Seiten)
    Edition Fifth edition
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note 2 bibliografische Bände in einer Online-Ressource
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018975694
    ISBN 978-1-118-41612-9 ; 9781118416006 ; 1-118-41612-0 ; 1118416007
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article ; Online: Reflections: A New Monthly Feature in Transplantation and Cellular Therapy.

    Sullivan, Keith M / Forman, Stephen J / Korngold, Robert / Porter, David L

    Transplantation and cellular therapy

    2023  Volume 29, Issue 7, Page(s) 403

    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2023.06.002
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  4. Article ; Online: How I treat adults with advanced acute lymphoblastic leukemia eligible for CD19-targeted immunotherapy.

    Aldoss, Ibrahim / Forman, Stephen J

    Blood

    2019  Volume 135, Issue 11, Page(s) 804–813

    Abstract: CD19-targeted immunotherapies have drastically improved outcomes for relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (ALL) patients. Such therapies, including blinatumomab and CD19 chimeric antigen receptor (CD19CAR) T cells, yield high ... ...

    Abstract CD19-targeted immunotherapies have drastically improved outcomes for relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (ALL) patients. Such therapies, including blinatumomab and CD19 chimeric antigen receptor (CD19CAR) T cells, yield high remission rates and can bridge to more definitive consolidation therapy with curative intent. Both treatments are approved by the US Food and Drug Administration (FDA) for r/r ALL (CD19CAR T-cell approval is restricted to patients ≤25 years old). Although availability of blinatumomab and CD19CAR T cells has extended options for the treatment of r/r ALL, prioritizing the sequence of these agents on an individual-patient basis may be difficult for the treating physician. Considering each therapy's advantages, limitations, and challenges is necessary when choosing between them. Although patients may receive both blinatumomab and CD19CAR T cells sequentially in cases that fail to respond or subsequently relapse, a proportion of patients treated with CD19-targeted immunotherapy will lose expression of CD19 and will be excluded from receiving the alternative CD19-targeted therapy. Thus, weighing all considerations for each patient before selecting a CD19-targeted immunotherapy is crucial. Here, we discuss real-life scenarios of adults with r/r ALL, in which we selected either blinatumomab or CD19CAR T-cell therapy, and the rationale behind each decision.
    MeSH term(s) Adult ; Aged ; Antigens, CD19/immunology ; Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Combined Modality Therapy ; Female ; Humans ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/etiology ; Lymphoma, B-Cell/pathology ; Male ; Middle Aged ; Molecular Targeted Therapy/methods ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/etiology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/etiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; Recurrence ; Treatment Outcome ; Young Adult
    Chemical Substances Antigens, CD19 ; Antineoplastic Agents, Immunological ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2019-12-30
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2019002132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Show issues

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  5. Book: Bone marrow transplantation

    Forman, Stephen J.

    1994  

    Author's details ed. by Stephen J. Forman
    Keywords Bone Marrow Transplantation ; Knochenmarktransplantation
    Subject Knochenmark
    Language English
    Size XXIII, 942 S. : Ill., graph. Darst.
    Publisher Blackwell Scientific
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    New title 2. Aufl. u.d.T. Hematopoietic cell transplantation
    HBZ-ID HT006297622
    ISBN 0-86542-253-2 ; 978-0-86542-253-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1994 A 2450 order for loan Magazin

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  6. Article ; Online: Air pollution: Consequences for cellular redox signaling, antioxidant defenses and disease.

    Mudway, Ian S / Holgate, Stephen / Forman, Henry J / Kelly, Frank J

    Free radical biology & medicine

    2020  Volume 151, Page(s) 1

    MeSH term(s) Air Pollutants/toxicity ; Air Pollution/adverse effects ; Antioxidants ; Oxidation-Reduction
    Chemical Substances Air Pollutants ; Antioxidants
    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2020.04.030
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  7. Article ; Online: Multiple donor-derived leukemias in a recipient of allogeneic hematopoietic cell transplantation for myeloid malignancy.

    Aldoss, Ibrahim / Song, Joo Y / Curtin, Peter T / Forman, Stephen J

    Blood advances

    2020  Volume 4, Issue 19, Page(s) 4798–4801

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia ; Transplantation, Homologous
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2020002803
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  8. Article ; Online: Development of CMV-CD19 bi-specific CAR T cells with post-infusion in vivo boost using an anti-CMV vaccine.

    Wang, Xiuli / Diamond, Don J / Forman, Stephen J / Nakamura, Ryotaro

    International journal of hematology

    2021  Volume 114, Issue 5, Page(s) 544–553

    Abstract: Adoptive transfer of in vitro expanded, chimeric antigen receptor (CAR)-redirected CD19-specific T cells can induce dramatic disease regression in patients with leukemia and lymphomas. However, the full potential of this emerging modality is hampered in ... ...

    Abstract Adoptive transfer of in vitro expanded, chimeric antigen receptor (CAR)-redirected CD19-specific T cells can induce dramatic disease regression in patients with leukemia and lymphomas. However, the full potential of this emerging modality is hampered in some cancer settings by a significant rate of therapeutic failure arising from the attenuated engraftment and persistence of CAR-redirected T cells, and tumor relapse following adoptive transfer. Here, we discuss an advanced strategy that facilitates post-infusion in vivo boosting of CAR T cells via CMV vaccination, to mediate durable remission of B cell malignancies by engrafting a CAR molecule onto a CMV-specific T cell. We also discuss a feasible and unique platform for the generation of the CMV-CD19CAR T cells for clinical application. This new approach would overcome multiple challenges in current CAR T cell technology including: short T cell persistence, limited duration of response, and inability to re-stimulate T cells after relapse or persistent disease.
    MeSH term(s) Animals ; Antigens, CD19/immunology ; Combined Modality Therapy ; Cytomegalovirus Infections/etiology ; Cytomegalovirus Infections/prevention & control ; Cytomegalovirus Vaccines/administration & dosage ; Cytomegalovirus Vaccines/immunology ; Disease Management ; Disease Susceptibility ; Genetic Engineering ; Humans ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Leukemia/complications ; Leukemia/etiology ; Leukemia/therapy ; Lymphoma/complications ; Lymphoma/etiology ; Lymphoma/therapy ; Prognosis ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Translational Research, Biomedical ; Treatment Outcome
    Chemical Substances Antigens, CD19 ; CD19-specific chimeric antigen receptor ; Cytomegalovirus Vaccines ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2021-09-24
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-021-03215-6
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    Zs.A 269: Show issues Location:
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  9. Book: Bone marrow transplantation

    Forman, Stephen J.

    (Hematology, oncology clinics of North America ; 4,3)

    1990  

    Author's details Stephen L. Forman, guest ed
    Series title Hematology, oncology clinics of North America ; 4,3
    Collection
    Keywords Bone Marrow Transplantation ; Knochenmarktransplantation
    Subject Knochenmark
    Size XII S., S. 507 - 714 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003620516
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 1077 -4,3- verfügbar in Königswinter Königswinter

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  10. Article ; Online: Body composition and late-occurring chronic health conditions after autologous stem cell transplantation for lymphoma.

    Giri, Smith / Harmon, Christian / Landier, Wendy / Chen, Yanjun / Wu, Jessica / Hageman, Lindsey / Balas, Nora / Francisco, Liton / Bosworth, Alysia / Weisdorf, Daniel J / Forman, Stephen J / Armenian, Saro H / Williams, Grant R / Bhatia, Smita

    Cancer

    2024  

    Abstract: Background: Autologous peripheral blood stem cell transplantation (aPBSCT) is the standard of care for adults with relapsed lymphoma, yet recipients remain at risk of developing chronic health conditions (CHCs). It was hypothesized that body composition ...

    Abstract Background: Autologous peripheral blood stem cell transplantation (aPBSCT) is the standard of care for adults with relapsed lymphoma, yet recipients remain at risk of developing chronic health conditions (CHCs). It was hypothesized that body composition measurements of skeletal muscle and fat are associated with late-onset CHCs and nonrelapse mortality after aPBSCT.
    Methods: Leveraging the Blood or Marrow Transplant Survivor Study, we examined association between pre-aPBSCT body composition and new-onset grade 3-5 CHCs among 187 adults with lymphoma treated with aPBSCT (2011-2014) surviving ≥2 years after aPBSCT. Using computed tomography scans at the L3 level, skeletal muscle mass (skeletal muscle area and skeletal muscle density [SMD]) and body fat (subcutaneous adipose tissue and visceral adipose tissue) were measured and quantified as sex-specific z-scores. Competing risk models were built to study the impact of body composition on incident grade 3 through 5 CHCs and nonrelapse mortality (NRM) adjusting for confounders.
    Results: The study cohort had a median age at aPBSCT of 57 years with 63% males, 77% non-Hispanic Whites and 81% with non-Hodgkin lymphoma. The 5-year cumulative incidence of grade 3 through 5 CHCs was 47% (95% Confidence Interval, CI, 38%-56%). Each SD increase in SMD was associated with 30% reduced risk of grade 3 through 5 CHCs (95% CI, 0.50-0.96). The 10-year cumulative incidence of NRM was 16% (95% CI, 10-22). No body composition measure was associated with NRM.
    Conclusions: The association between SMD and grade 3 through 5 CHCs following aPBSCT could inform development of prognostic models to identify adults with lymphoma at greatest risk of morbidity following aPBSCT.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.35298
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