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  1. Article ; Online: The COVID-19 immunology masterclass enters its fourth year.

    Altmann, Daniel M

    Nature immunology

    2023  Volume 24, Issue 2, Page(s) 201–202

    MeSH term(s) Humans ; COVID-19/immunology
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01393-x
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    Zs.A 5294: Show issues Location:
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  2. Article ; Online: Arming up against Omicron subvariants.

    Altmann, Daniel M / Boyton, Rosemary J

    Cell host & microbe

    2024  Volume 32, Issue 2, Page(s) 147–148

    Abstract: The rapid evolution of COVID-19 Omicron variants is driven by evasion of neutralizing antibodies. Breakthrough infections are common, even in highly vaccinated populations, making it vital to understand immune cross-protective repertoires to variants. ... ...

    Abstract The rapid evolution of COVID-19 Omicron variants is driven by evasion of neutralizing antibodies. Breakthrough infections are common, even in highly vaccinated populations, making it vital to understand immune cross-protective repertoires to variants. Two studies in this issue show that the primed T cell repertoire comprises strong cross-recognition of current variants.
    MeSH term(s) Humans ; Antibodies, Neutralizing ; COVID-19 ; Antibodies, Viral
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2024.01.010
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  3. Article ; Online: Children and the return to school: how much should we worry about covid-19 and long covid?

    Altmann, Daniel M

    BMJ (Clinical research ed.)

    2021  Volume 372, Page(s) n701

    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n701
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  4. Article ; Online: Imprinted hybrid immunity against XBB reinfection.

    Boyton, Rosemary J / Altmann, Daniel M

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 7, Page(s) 764–765

    MeSH term(s) Humans ; Reinfection ; Adaptive Immunity
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00138-X
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  5. Article ; Online: Redirected vaccine imprinting by co-administration of COVID-19 and influenza vaccines.

    Boyton, Rosemary J / Altmann, Daniel M

    The Lancet regional health. Europe

    2023  Volume 29, Page(s) 100644

    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2023.100644
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  6. Article ; Online: Long covid: where are we, what does it say about our pandemic response, and where next?

    Altmann, Daniel M / Pagel, Christina

    BMJ (Clinical research ed.)

    2023  Volume 383, Page(s) 2972

    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; Pandemics/prevention & control ; COVID-19
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p2972
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  7. Article ; Online: Outsourcing covid-19 vaccination to the private sector will increase health inequalities.

    Altmann, Daniel M / Boyton, Rosemary J

    BMJ (Clinical research ed.)

    2023  Volume 382, Page(s) 2012

    MeSH term(s) Humans ; Private Sector ; COVID-19 Vaccines ; Outsourced Services ; COVID-19/prevention & control ; Health Inequities
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p2012
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  8. Article ; Online: Narrating the natural history of live infection by SARS CoV-2 VOC in animal models.

    Altmann, Daniel M

    EBioMedicine

    2021  Volume 74, Page(s) 103704

    MeSH term(s) Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; COVID-19/pathology ; COVID-19 Vaccines/immunology ; Cricetinae ; Disease Models, Animal ; Ferrets ; Humans ; Macaca ; Mice ; Mice, Transgenic ; SARS-CoV-2/growth & development ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology
    Chemical Substances COVID-19 Vaccines ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-11-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103704
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  9. Article ; Online: A new immunology forum for a new age of immunology.

    Altmann, Daniel M

    Oxford open immunology

    2020  Volume 1, Issue 1, Page(s) iqaa002

    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Editorial
    ISSN 2633-6960
    ISSN (online) 2633-6960
    DOI 10.1093/oxfimm/iqaa002
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  10. Article ; Online: Adaptive immunity to SARS-CoV-2.

    Altmann, Daniel M

    Oxford open immunology

    2020  Volume 1, Issue 1, Page(s) iqaa003

    Abstract: The majority of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 exposed individuals mount an antibody response within around 2-weeks and spike antigen-binding responses correlate well with functional virus neutralization. A minority makes ... ...

    Abstract The majority of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 exposed individuals mount an antibody response within around 2-weeks and spike antigen-binding responses correlate well with functional virus neutralization. A minority makes little detectable antibody, generally those with either very mild/asymptomatic disease or those with severe/lethal infection. However, in general, antibody titre correlates with viral load and duration of exposure. There is evidence for cross-reactivity with the other human coronaviruses, though the functional impact of this is as yet unclear. Therapeutic use of neutralizing monoclonal antibodies offers potential for clinical use. While there is evidence for neutralizing antibody as a correlate of protection, some cases indicate the potential for full recovery in the absence of antibody. Studies of T-cell immunity following acute infection show CD4 and CD8 responses to epitopes across diverse viral antigens, possible cross-reactivity with epitopes from the common cold human coronaviruses and large-scale activation. However, in severe cases, there is evidence for T-cell lymphopaenia as well as expression of exhaustion markers. Analysis of serum biomarkers of disease severity implicates a hyperinflammatory contribution to pathogenesis, though this has not been mechanistically delineated beyond a likely role of raised IL-6, considered a therapeutic target. Despite rapid progress, there remain pressing unknowns. It seems likely that immune memory to SARS-CoV-2 may be relatively short lived, but this will need longitudinal investigation. Also, this is a disease of highly variable presentation and time course, with some progressing to protracted, chronic symptoms, which are not understood. The contribution of immunopathological mechanisms to tissue damage, whether in the lung, kidney, heart or blood vessels, is unclear. The immunology underlying the differential susceptibility between the very young and the very old is unresolved, a question with ramifications for vaccine roll-out. The greatest challenge relates to rapid generation, testing and manufacture of vaccines that are immunogenic, protective (at least from symptomatic disease) and safe-a challenge that looks achievable.
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2633-6960
    ISSN (online) 2633-6960
    DOI 10.1093/oxfimm/iqaa003
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